DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pzl and Piezo1

DIOPT Version :9

Sequence 1:NP_001303493.1 Gene:Pzl / 26067051 FlyBaseID:FBgn0267430 Length:2326 Species:Drosophila melanogaster
Sequence 2:XP_008770848.1 Gene:Piezo1 / 361430 RGDID:1308822 Length:2537 Species:Rattus norvegicus


Alignment Length:2685 Identity:726/2685 - (27%)
Similarity:1195/2685 - (44%) Gaps:546/2685 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 IFLPLTLILVSLVRPVGLSYFYLLTFFLSPWL--LQSNSLKQRTFLNVFIIFLCVLSTFGIVGHI 74
            :.||.||:..||:|...||..|||...|.|||  ...:|:...|. .:....|| ||...:|.|:
  Rat    13 LLLPCTLLAASLLRFNALSLVYLLFLLLLPWLPGPSRHSIPGHTG-RLLRALLC-LSLLFLVAHV 75

  Fly    75 IFNL-------INLFFVDLSSKNSFSF---ILRQFGFLYFKGLSFVSIAHWILPDIIVLLNTIVF 129
            .|.:       :|    .|..:|..|.   :.:..|..........:....:.||:.||:.:.:.
  Rat    76 AFQICLHTMPRLN----QLLGQNCSSLWANVSQHIGVTRLDLKDIFNTTRLVAPDLGVLVASSLC 136

  Fly   130 F-----IFSEIKYKREKRVIQNDDDVFYKKSKELKGALKVAEINRVLIIVYIRSVLKTSLIFS-- 187
            .     :..:.:..:..:.:|.:||:....:..|:||..:|...|:.:....|......|:.|  
  Rat   137 LGLCGRLTRKARQSQRTQELQEEDDIDAAPAAGLQGAPTLATKRRLWLAPRFRITAHWLLVTSGR 201

  Fly   188 ---LIVLYFAATLRPSLPGSLYFCMFIIAGSYWAL-FRQRKMYYSVIFMIVALL--VHITCIFAY 246
               :::|..|....||...|:|..:|:...::|:. |....:.::.:.::|:..  .|:.|::.|
  Rat   202 MLVIVLLALAGIAHPSAFSSVYLMVFLAICTWWSCHFPLSSLGFNTLCVMVSCFGAGHLVCLYCY 266

  Fly   247 QLPVLQNTINCDKLWTRLMGMEVLIRL-NKDNRNGKILELNPKLNLDSYLSP-IALMLAYFATTL 309
            |.|.:|:.:....||.||.|::..:.: |..:.|  :|.||.|.....|:|| |.|:|.|.||:|
  Rat   267 QTPFVQSVLLPGSLWARLFGLKNFVDIPNCSSPN--VLVLNTKHAWPIYVSPGILLLLYYTATSL 329

  Fly   310 SLINRSQYEISFNTIRMNLGPKSNSIY----DNIQPSNE-----------------ENEEISIFT 353
            ..:.:.:    |:.:|..: |:.:..:    |.::|..:                 :|..:.:.|
  Rat   330 LKLRKGR----FSELRKEI-PREDEEHELELDQLEPEPQARGTTQGATPTTTGPDIDNCTVHVLT 389

  Fly   354 EPSMLEQ-----------FFYIVYELSSFVYKNSYILLNIIMMIWSIVYHSWLTFVLLIWANILW 407
            ..|.:.|           ....::.|...:...||:...|.||:|||:||||||||||:||.::|
  Rat   390 SQSPVRQRPVRPRLAELKEMSPLHGLGHLILDQSYVCALIAMMVWSIMYHSWLTFVLLLWACLIW 454

  Fly   408 MIPNQRRSMMRSSLFVVFYSQILLLAQYIYGMNLYESELPTKVTSCGLNLEQIGFVHPQSKDSLP 472
            .:.::.:..|..|..::.|...|...:|::.|.|  .||||  |...::|.|:|..|.:    .|
  Rat   455 TVRSRHQLAMLCSPCILLYGLTLCCLRYVWAMEL--PELPT--TLGPVSLHQLGLEHTR----YP 511

  Fly   473 WIPLTVKTVFLFVFWVTSRQYFREISLDRQQ--SDLLQQIFATHRSRSEHLLSKKSQTPQIFIYI 535
            .:.|....::|..||:..||:.:|..|.:::  |.||:...:.         ::.:||..    :
  Rat   512 CLDLGAMLLYLLTFWLLLRQFVKEKLLKKRKAPSTLLEVTVSD---------TEPTQTQT----L 563

  Fly   536 LKSTSHFITRIWM--WLLIFL-IFLCAMIDRTMTGIRICYMSLFLLFLMVFQMSLQLWIRFLYGY 597
            |:|....:|.|::  |:.:.. :|:.......:...:|.||.||||.|.:||:...||.:.|..:
  Rat   564 LRSLGELVTGIYVKYWIYVCAGMFIVVSFAGRLVVYKIVYMFLFLLCLTLFQVYYTLWRKLLRVF 628

  Fly   598 WIFLIFYAMTILTAIYTYQFDHFDYYWEKFLKVHSTLQCDIGLRRYQTKDLFLHLLIPTLTVIFT 662
            |..::.|.|.:|.|:||:||..|..||............|:||.::...:||..:|||...::..
  Rat   629 WWLVVAYTMLVLIAVYTFQFQDFPTYWRNLTGFTDEQLGDLGLEQFSVSELFSSILIPGFFLLAC 693

  Fly   663 VVQLHYFHRRFVE----------SVRRPRSTEGQNFHLAPNAETRASQKTLDIHRQSWKVFFDAG 717
            ::|||||||.|::          ..||.|....|:         ..|:..|..|::..:||    
  Rat   694 ILQLHYFHRPFMQLTDLEHVPPPGTRRLRWAHRQD---------TVSEAPLLQHQEEEEVF---- 745

  Fly   718 YENVRAKGRQLFNP--------GKIVAWK--------------------------FLEMHMIKTV 748
                |..|:.:..|        |....|.                          .||:|:.|.|
  Rat   746 ----RDDGQSMDGPHQTTQVPEGTASKWGLVADRLLDLASSFSAVLTRIQVFVRCLLELHVFKLV 806

  Fly   749 TLASFYCAISEICFLNLFLVILSLLGICGNRFLRRVIFRAVTFWISLLVLMKMIYQIKYLDQSHY 813
            .|.:.:.|:.|:..:||.||:|....:...|| |.:.....|.|..::::.||:||:|.::...|
  Rat   807 ALYTVWVALKEVSVMNLLLVVLWAFALPYPRF-RPMASCLSTVWTCIIIVCKMLYQLKIVNPHEY 870

  Fly   814 NFKC-----GNVT---------------VNFAEWMGLRKTGTVFGV-HLRYISSYIIYMILTSLH 857
            :..|     .|..               |:.|.|.|:||     |. :|.||.:::..::|....
  Rat   871 SSNCTEPFPNNTNLQPLEISQSLLYRGPVDPANWFGVRK-----GYPNLGYIQNHLQILLLLVFE 930

  Fly   858 AVV-KLRDHLIRYSTHKQKDTKLLFPDITRQDAERDFPGLLKYVLNYGYFKFGFEITMIGLMSTI 921
            ||| :.::|..|.........:.|..|.|||..::|....|||.:|:.::|||.||..:..::.|
  Rat   931 AVVYRRQEHYRRQHQQAPLPAQALCADGTRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVI 995

  Fly   922 AHRRDLFALTYLIWLVLLLCLSRFRC-ARIWEMLQLYFVLSIFVQYVYLLNFPPNLCNVISYNSL 985
            ..|.:...:.:..|||.:|...|... ||:|....|:..|.:..||:..|..||.||  |.|...
  Rat   996 GQRMNFMVILHGCWLVAILTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMPPALC--IDYPWR 1058

  Fly   986 WSISGSKNYT--------------NRSNIMFDYIVLLLISRQRKSFRVEMRHINDLSYRGGVNTN 1036
            ||.:...|..              |.:|::.|:::||..|:|.:.|..|  ...:.....||||:
  Rat  1059 WSQAIPMNSALIKWLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAE--QTEEWQRMAGVNTD 1121

  Fly  1037 VVHNIAKLGHVYFENPTHDFCTYVRNYADVLKTAIFFSFFWITLAIVFLGGVCSTDILSLGYIIF 1101
              |.....|.   .||..:| .:.|:|.|:||.|:|...||:.|.:||:.|.....|..|||::.
  Rat  1122 --HLEPLRGE---PNPIPNF-IHCRSYLDMLKVAVFRYLFWLVLVVVFVTGATRISIFGLGYLLA 1180

  Fly  1102 ALIFLLQGSEIYLQNIHFIICRWNCLIAFNIFNIIVKVAIIVLEGTINLEHKSILSIVFNVMHQT 1166
            ....||.|:.:..::....:..|:|||.:|:..||.|..:            |:||.||....|:
  Rat  1181 CFYLLLFGTTLLQKDTRAQLVLWDCLILYNVTVIISKNML------------SLLSCVFVEQMQS 1233

  Fly  1167 APCENIMDGKFFEINEISEKKYCYGPSDM----------IFKNTLVWHAIIFSFVVFQYRIFGSY 1221
            ..|..|   :.|.:  :...|..|.|.:|          :.:..::|.:|.|.|::.|.|:|.|:
  Rat  1234 NFCWVI---QLFSL--VCTVKGYYDPKEMKTRDRDCLLPVEEAGIIWDSICFFFLLLQRRVFLSH 1293

  Fly  1222 YFCHVIMDTQANTILASRGAAIIENLHYKQIYDRRKNEQSVLERVKMKMERIRITNRRH-QKQAT 1285
            ||.||..|.:|..:.||||.|:....:.|.|...|:.|:..|.::|.:|:|||....:: |.||:
  Rat  1294 YFLHVSADLKATALQASRGFALYNAANIKNINFHRQTEERSLAQLKRQMKRIRAKQEKYRQSQAS 1358

  Fly  1286 GLDFQ---PHKP-PSSIIHVHYRAEEKSKLKTLNNEFLTTIKQAERDTYFSRSLKPRR---RDLS 1343
            ....|   |.:| |.|.                                 ..|..||.   |...
  Rat  1359 RGQLQSTDPQEPGPDSP---------------------------------GGSSPPRTQWWRPWQ 1390

  Fly  1344 LHPHAVRTGDYYMFNELDDDDDLDVYEE-------------YD-FLEKEDVRARQMRQSLRSRAS 1394
            .|...:.:|||::| |.|.:::.:...|             |. ::.......||.|:..|...:
  Rat  1391 DHATVIHSGDYFLF-ESDSEEEEEALPEDPRPAAQSAFQMAYQAWVTNAQTVLRQRREQARRDRA 1454

  Fly  1395 NYNRSKSFLNDENSDTDTKKLE----THPV--IILTSELI-VL-------LTFRLNRLSKNFRFV 1445
            ....|...|:.|....|..:.|    :|.:  ::.|.:.: ||       ||..|...:|:.|.:
  Rat  1455 EQLASGGDLSPEVEPVDVPENEMAGRSHVMQRVLSTMQFLWVLGQATVDGLTRWLRTFTKDHRTM 1519

  Fly  1446 HKMLSAEKKKL-QNI-------------------------SIMNRLGLSNTAA------------ 1472
            ..:|.||:..| |.:                         .:.||.|.|..::            
  Rat  1520 SDVLCAERYLLTQELLRGGEVHRGVLDQLYVSEDEIALSGPVENRDGPSTASSGLGAEEPLSSMT 1584

  Fly  1473 -------MFKFLNKSLNNKVIKEAG------SYYVSQD---NDFTTL------------------ 1503
                   ...:..:|.:.::|.:.|      |.:.||:   |..|.:                  
  Rat  1585 DDTGSPLSTGYNTRSGSEEIITDTGGLQAGTSLHGSQELLANARTRMRTASELLLDRRLRIPELE 1649

  Fly  1504 DHNDF-------VQMLIALWYALIANTETICYLVVFLNQAANSSVISLPMPFLVLCWGALTLPRP 1561
            :...|       :::|.|::..:.|::|.:||.::.||....:|..||.:|.||..|..||:|||
  Rat  1650 EAEQFEAQQGRTLRLLRAMYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRP 1714

  Fly  1562 SKTFWVTLITYNLTMIFVKSIM----------------HQRVLLDQQLVSRSNSLSFELIMKRGR 1610
            ||.||:|.|.:...|:..|.:.                ..:.....:::....:.|:        
  Rat  1715 SKRFWMTAIVFTEVMVVTKYLFQFGFFPWNSYIVLRRYENKPYFPPRILGLEKTDSY-------- 1771

  Fly  1611 AVYDLLLLVVLFWHQYMLKKQGIWTIQRTNSELLLLEKKRNHYKRSFSKERPENIRKLLREEGGG 1675
            ..|||:.|:.||:|:..|...|:|..:...   :..:..|:..|...::|..|...:...|.|.|
  Rat  1772 IKYDLVQLMALFFHRSQLLCYGLWDHEEDG---VPKDHCRSSEKDQEAEEESEAKLESQPETGTG 1833

  Fly  1676 ---EQVKAVRP-NAIEFK---REMDDILLPALENKYVYQN--------------------IESEY 1713
               |.|....| :.|:.|   |..|:|..|..:.|..::.                    :|:|:
  Rat  1834 HPEEPVLTGTPKDHIQGKGSVRSKDEIQDPPEDLKPQHRRHISIRFRRRKETQGPKGAAVVEAEH 1898

  Fly  1714 --------------YRKAMQGLANK------GGLLSGF------------RKFFLALRH-KSRLS 1745
                          .|:..:||..:      |..|..|            |:||..:.| |.|.:
  Rat  1899 EEGEEGREAAGRKRLRRPREGLKIREKMKAAGRRLQSFCLSLAQSFYQPLRRFFHDILHTKYRAA 1963

  Fly  1746 TDVYTLLFLCDFISFFILLFGFPKFVYRYKYSTSV-LETYIQGNKVPFTFLLMLIVQFITIVTER 1809
            ||||.|:||.|.:...:::|||..|   .|:|.:. :.:.:..::||..||.||:|||.|:|.:|
  Rat  1964 TDVYALMFLADIVDIVVIIFGFWAF---GKHSAATDIASSLSDDQVPQAFLFMLLVQFGTMVIDR 2025

  Fly  1810 AIYLRKALIYKIFFHFISVLGIHIWMFFLVPYITSHSFGETAPV-LFYLIKCLHMLLSAYQIRCG 1873
            |:||||.::.|:.|..:.|:.||:||||::|.:|...|.:.|.. |:|.:||::..|||||||||
  Rat  2026 ALYLRKTVLGKLAFQVVLVVAIHLWMFFILPAVTERMFRQNAVAQLWYFVKCIYFALSAYQIRCG 2090

  Fly  1874 YPKRILGNVFTKGYSLANYIAFKIYMEIPFLYILRTMLDWVCIDTTLTVMEWIKMEDIFQSVFIV 1938
            ||.|||||..||.|:..|...|:.:..:|||..||.::|||..||||::..|:.:|||:.::||:
  Rat  2091 YPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFII 2155

  Fly  1939 RCYRQMDTDFPVLRGEPKALYSKLLIGGTIILILIALIWSPLFLFALV-GTVGKPNIPQKADITV 2002
            :|.|:.:..:|..:|:.|....|..:||.|||.|||:||.||...:|: ..||..|.|....:|:
  Rat  2156 KCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTL 2220

  Fly  2003 KINHYEPIY-VSQSNSDILQFSNSDFQKLTNHIILDNY--ASDSMMLYDAVDVTAIKFYENSISL 2064
            |:..|||:: :|.....|:.|:..|:::|:..  .|.|  |...:..|...|:...:...:|.:|
  Rat  2221 KLGGYEPLFTMSAQQPSIVPFTPEDYEELSQQ--FDPYPLAMQFISQYSPEDIVTAQIEGSSGAL 2283

  Fly  2065 WNMPPPDKERLLHDLSNGETLDIHLTLT--LKCNLTPEAVIYETTYTLTENKVHT---------R 2118
            |.:.||.:.::.|:|.|| |.||.|..|  .:.:|.....:   .||   |:.||         |
  Rat  2284 WRISPPSRAQMKHELYNG-TADITLRFTWNFQRDLAKGGSV---EYT---NEKHTLELAPNSTAR 2341

  Fly  2119 DKLIRLMSNNFSNEKVIIPNILPKFI---------TVQRQQANAKFIKDYDG---KFNRPIILTK 2171
            .:|.:|:... .::.|:||::.||:|         .|::.|.:.:  :||.|   :..|..:.|.
  Rat  2342 RQLAQLLEGR-PDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEE--EDYLGVRIQLRREQVGTG 2403

  Fly  2172 IGKSQ--------VYWWEMNDYCNDRFYTEILSALPLSNCE---NGVVLYVFNDKSFPSAMSFLE 2225
            ....|        :.||                .:.|.:|:   |.:.:.:|:||..|.::.||.
  Rat  2404 TSGEQAGTKASDFLEWW----------------VIELQDCQAECNLLPMVIFSDKVSPPSLGFLA 2452

  Fly  2226 KTGIIGLYTTFVYVVSRIIRSLIANNHRRIMFEDLPYVDRVLKLCTDIYLVRETQEYRLEEDLYG 2290
            ..||:|||.:.|.||.:.:|...::....||||:||.|||:||||.||:|||||:|..|||:||.
  Rat  2453 GYGIVGLYVSIVLVVGKFVRGFFSDISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYA 2517

  Fly  2291 KLIFLYRSPETLIKWTRFKE 2310
            |||||||||||:|||||.||
  Rat  2518 KLIFLYRSPETMIKWTREKE 2537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PzlNP_001303493.1 PIEZO <1201..1388 CDD:292539 53/208 (25%)
Piezo_RRas_bdg 1901..2308 CDD:288978 154/444 (35%)
Piezo1XP_008770848.1 PIEZO 1223..1445 CDD:292539 63/260 (24%)
Piezo_RRas_bdg 2117..2535 CDD:288978 154/445 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 407 1.000 Domainoid score I681
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1062 1.000 Inparanoid score I236
OMA 1 1.010 - - QHG46055
OrthoDB 1 1.010 - - D13738at2759
OrthoFinder 1 1.000 - - FOG0001637
OrthoInspector 1 1.000 - - mtm9141
orthoMCL 1 0.900 - - OOG6_102664
Panther 1 1.100 - - O PTHR13167
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1528
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1110.980

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