Protein Alignment Pzl and Piezo

DIOPT Version :9

• Sequence 1: NP_001303493.1
• Gene: Pzl / 26067051
• FlyBaseID: FBgn0267430
• Length: 2326
• Species: Drosophila melanogaster
• Sequence 2: NP_001303314.1
• Gene: Piezo / 34112
• FlyBaseID: FBgn0264953
• Length: 2973
• Species: Drosophila melanogaster
• Alignment Length: 3044
• Identity: 1048/3044 - (34%)
• Similarity: 1519/3044 - (49%)
• Gaps: 815/3044 - (26%)

  Fly     8 IITRIFLPLTLILVSLVRPVGLSYFYLLTFFLSPWLLQSNSLKQRTFLNVFIIFLCVLSTFGIVG 72
            ::.||.:|..|:|.:|:||||:|:.|||.||:||::..:.....:..:..|.|.|..|||..::|
  Fly     9 VLQRIVVPAVLVLAALMRPVGISFVYLLMFFVSPFVPLATRRNFKGSVTAFFIILLTLSTLVLLG 73

  Fly    73 HIIFNLINLFFVDLSSKNSFS-FILRQFGFLYFKGLSFVSIAHWILPDIIVLLNTIVFFIFSEIK 136
            ||...::.:.........||| .:||..||:.|..|...:|..|::|:::|       |..|...
  Fly    74 HITLQILAVSLTLPIYNCSFSERLLRHIGFVSFIDLQPFAIIEWLVPEVLV-------FATSLGS 131

  Fly   137 YKREKRV---------IQNDDDV-FYKKSKELKGALKVAEIN----------------------R 169
            |...|||         ::|.:.| ...::.:.......|:.|                      |
  Fly   132 YLTVKRVASQPVGAEQLENGEVVDGQAENAQTSSQPSAADANGGDVQQATVTTPLQQQQQQLRKR 196

  Fly   170 VLII---VYIRSVLKTSLIFSLIVLYFAATLRPSLPGSLYFCMFIIAGSYWALFRQRKMYYSVIF 231
            |.:|   ::...::|.|.:|.|..|:|||.||||:||..||.:|:::|:|||..:..:..::::.
  Fly   197 VSMISQHIHFEGLVKISPLFCLATLFFAAVLRPSVPGGFYFLIFLLSGTYWATCQTLQRGFALLL 261

  Fly   232 --MIVALLVHITCIFAYQLPVLQNTINCDKLWTRLMGMEVLIR--LNKDNRNGKILELNPKLNLD 292
              ::|.|::|...|.:||.|.:|:.:|...|..||:|:|.||.  .:.|.|   :...|.||:||
  Fly   262 RCVMVVLVLHSLSIVSYQTPWMQSHLNHTTLTARLIGLEPLIESYCSPDIR---VFLYNNKLSLD 323

  Fly   293 SYLSPIALMLAYFATTLS--------LINRSQYEI-------SFNTIRMNLGPKSN--SIYDNIQ 340
            |||:|.||..||||..|:        |:.:|..:.       |.:::..::..:.|  .:....|
  Fly   324 SYLNPFALFFAYFALALTTKHLIKPRLVRQSTRKARTPQPLESGSSVAPSVTQRGNDMQLESMEQ 388

  Fly   341 PSNEENEEISIFTEPSMLEQFFYIVYELSSFVYKNSYILLNIIMMIWSIVYHSWLTFVLLIWANI 405
            .|.:||      |..|:|:|..|....:..|:|:||||..||:||.||||||||||||||:.||:
  Fly   389 RSEQEN------TTTSILDQISYGFVSVGGFIYQNSYIFTNILMMAWSIVYHSWLTFVLLLSANV 447

  Fly   406 LWMIPNQRRSMMRSSLFVVFYSQILLLAQYIYGMNLYESELPTKVTSCGLNLEQIGFVHPQSKDS 470
            ||||||||::|||||.|:|.|::.||:|||||||:|...||||.|.:.|:||:||||..|.....
  Fly   448 LWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYGMDLNNEELPTSVPTAGINLQQIGFERPIENQM 512

  Fly   471 LPWIPLTVKTVFLFVFWVTSRQYFREISLDRQQSDLLQQIFA-----THRSRSEHLLSKKSQTPQ 530
            .|.:||.|||.|:.:|||||||:|:| ..||::...|....|     ...:.|.:|::...:|.:
  Fly   513 RPCVPLIVKTAFVLMFWVTSRQFFKE-KRDRRRDSTLADFIAPLQITVGSAGSSYLINDGKKTSK 576

  Fly   531 IFIYILKSTSHFITRIWMWLLIFLIFLCAMIDRTMTGIRICYMSLFLLFLMVFQMSLQLWIRFLY 595
            ..........:.:.|:|:|||:.:|||||:....|||.|||||:|||.||:|||.|.:.|::.:|
  Fly   577 FLKKAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRICYMALFLFFLLVFQSSSKAWVKIMY 641

  Fly   596 GYWIFLIFYAMTILTAIYTYQFDHFDYYWEKFLKVHSTLQCDIGLRRYQTKDLFLHLLIPTLTVI 660
            |:|:|||||||:||..|||||||.||.||..:|.|.:|||.||||:|||||||||||:.||:.||
  Fly   642 GFWLFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQKDIGLKRYQTKDLFLHLVSPTIIVI 706

  Fly   661 FTVVQLHYFHRRFVESVRRP-------------------------------RSTEGQNFHLAPNA 694
            .||:|:||||:||:.|:::.                               |.::|.:...||.|
  Fly   707 LTVIQVHYFHKRFIASLQQQPLAGGSAQQKPTETTALEPAPSKRRGSAGSLRKSQGPSAEAAPGA 771

  Fly   695 ETRASQKTLDIHRQSWKVFFDAGYENVRAKGRQLFNPGKIVAWKFLEMHMIKTVTLASFYCAISE 759
            .|.......|:.|.|        :..::.|...:|...|.|.|:|||:|::|.|.:|:|.|::||
  Fly   772 TTDFETSVRDLVRIS--------FRKIKNKSEYIFKNFKDVFWRFLELHIMKAVYIAAFVCSVSE 828

  Fly   760 ICFLNLFLVILSLLGICGNRFLRRVIFRAVTFWISLLVLMKMIYQIKYLDQSHYNFKCG-NVTVN 823
            :|.|::..|...:||....:.::.||.|.::|.::::||.||||||:||..|.:|..|. |.|.|
  Fly   829 VCVLHIIFVGFCVLGATSRKAVQVVISRLISFIVTVIVLSKMIYQIEYLSHSQHNVVCSDNRTAN 893

  Fly   824 FAEWMGLRKTGTVFGVHLRYISSYIIYMILTSLHAVVKLR--DHLIRYSTHKQKDTKLLFPDITR 886
            .|||:||.|...|.|..:..:.:|||||::.::|||:.||  ...::........||||||:|.|
  Fly   894 NAEWIGLTKADKVTGGLMSLLRTYIIYMVIVTMHAVISLRQLQMRVKIGALNAPPTKLLFPNIIR 958

  Fly   887 QDAERDFPGLLKYVLNYGYFKFGFEITMIGLMSTIAHRRDLFALTYLIWLVLLLCLSRFRCARIW 951
            .|||:|..||:||:||:|::|||.||::|.|:|||.:|:|:.|:.|.:|||:||.|.|.:||:||
  Fly   959 ADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVVYALWLVVLLLLRRSQCAKIW 1023

  Fly   952 EMLQLYFVLSIFVQYVYLLNFPPNLCNVISYN--------SLWS-ISGSKNYTNRSNIMFDYIVL 1007
            .:.|.:|.:||..||:.|:..||:.|.|..::        ..|: :.|:.::.:...::||:|||
  Fly  1024 GVFQAFFAISILTQYIVLVGLPPSSCLVFPWDEGPFGEGIQRWAMLPGALHFNHVPKLIFDFIVL 1088

  Fly  1008 LLISRQRKSFRVEMRHINDLSYRGGVNTNVVHNIAKLGHVYFENPTHDFCTYVRNYADVLKTAIF 1072
            ::::||:..|.:|.|:.::..|.||.|.:|:.:||:||.|.|:|||||||:|:|||:|:||..:.
  Fly  1089 VILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTHDFCSYIRNYSDILKNGVL 1153

  Fly  1073 FSFFWITLAIVFLGGVCSTDILSLGYIIFALIFLLQGSEIYLQNIHFIICRWNCLIAFNIFNIIV 1137
            ..|:|.|||:|||.|....|:|:|||:|.|.|||.|||:.||:.||.||.||..|:|||:.||::
  Fly  1154 CGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILI 1218

  Fly  1138 KVA------IIVLEGTIN---LEHKSILSIVFNVMHQTAPCENIMDGKFFEINEISEKKYCYGPS 1193
            |.:      :.:.:.|.:   |.|...::...||:     .|.||      :.|.:|.....|..
  Fly  1219 KTSFQMAGCLFMTQLTKDCCWLVHMLGITCTSNVL-----TEQIM------LPEEAELALKPGEC 1272

  Fly  1194 DMI-FKNTLVWHAIIFSFVVFQYRIFGSYYFCHVIMDTQANTILASRGAAIIENLHYKQIYDRRK 1257
            ..| .:..|:|..|.|:|::||.|||.|:||||:|.||:||.|||||||.|||:|.:|||..|..
  Fly  1273 PKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHD 1337

  Fly  1258 NEQSVLERVKMKMERIRITNRRHQKQATGLDFQPH----KPPSS--------IIH---------- 1300
            :|:.||.::|.||||||.|   .||....||.|.|    :.||.        ::|
  Fly  1338 HEKQVLHKIKRKMERIRAT---QQKMLRPLDKQTHFDGRRTPSEHAMSDVAPLVHNSSFTSCQGS 1399

  Fly  1301 ------VH--------------------------------------------------------- 1302
                  .|
  Fly  1400 GYLTPDEHSSATSGTSSPARASILSSSGGSVESVDSADAAVIIEPEINVMPCDEITDYVDVQSVS 1464

  Fly  1303 ---------------------YRAEEKSK--------LKTLNNE--------------------- 1317
                                 :::.|.||        |.||..|
  Fly  1465 EEETTVAMPKKDLSCQSKECVFKSPEPSKPTTPSTDALSTLLTEGFLEPKRISLGLAPPELSPPV 1529

  Fly  1318 -----------FLTTIKQAERDTYFSRSLKP------RR-------------------------- 1339
                       :.|.:..:...:..|.:|.|      ||
  Fly  1530 GMQCLAPPLAAYATAMASSAASSVLSTNLTPNLRREHRRQSSTNAAVSWNETVSIKRSPMKKQMS 1594

  Fly  1340 ---------RDLSLH------------------------------------------PH------ 1347
                     |..|||                                          ||
  Fly  1595 ADKEEVVTMRHKSLHRRHQSMGNASYSLDEASQSQRKRLSSNLSGARDEAALRSAQRPHSWGPVG 1659

  Fly  1348 ---------------------AVRTGDYYMFNELDDDDDLD-VYEEYDFLEKEDVRARQMRQSLR 1390
                                 :.|.||||||.|:||..:|| :::|.||||:|::...:|:...|
  Fly  1660 TSSYMESLMCAFYEPALLHGPSTRAGDYYMFEEMDDKFELDLIHDEIDFLEEENITESEMKMQRR 1724

  Fly  1391 S--------------RASNYNRSKSFL---------------------------NDENSDT---- 1410
            .              |...|.|.:|:.                           :||:.||
  Fly  1725 KTLYDVWKDLNDAEYRRHFYMRERSYASEPGSRILLKLDDEKEKIGPDLGLASDHDEDDDTIECD 1789

  Fly  1411 ----------------------------------------------------------------- 1410
                                                                             
  Fly  1790 LGMRTSTLSEPLDFGRRSQTLLEVKSKDAPTGEFPSTSKGISKERDAATASSSASPAPTRDVGDL 1854

  Fly  1411 --------------------DTK-KLE----------------THPVIILTSELIVLLTFRLNRL 1438
                                |:| |:|                |:|:|.|....:|.||.||||.
  Fly  1855 PVIPPPSTGLGREQTSKETSDSKSKMEVDSGEVTAKDSDEDFDTNPIIRLLEGFLVTLTIRLNRF 1919

  Fly  1439 SKNFRFVHKMLSAEKKKLQNISIMNRLGLSNTAAMFKFLNKSLNN-------------------- 1483
            |:|:|||:::|:.|||.|:..|.:||||||:.||||.||..:|.:
  Fly  1920 SRNYRFVNRILAGEKKTLKESSSLNRLGLSSAAAMFHFLKSNLESDESEPPASSSTPRRVVIAPP 1984

  Fly  1484 -----------------------------------------------------KVIK-------- 1487
                                                                 ::|:
  Fly  1985 NATEHSDPTSTTLNTNTTTTPLSPPEPLQPLQPLQPNTTSTPQQQHQHIRAAEEIIELPVDTVDG 2049

  Fly  1488 -------------------------------------EAGSYYVS-------------------- 1495
                                                 |.|::|..
  Fly  2050 VAHRKQSINSSPPAKGTMLSRKSDCGLPEIRIKAPSIERGAHYYHNHHSGGGSGSLSKHWSYEQV 2114

  Fly  1496 --------QDNDFTTLDHNDFVQMLIALWYALIANTETICYLVVFLNQAANSSVISLPMPFLVLC 1552
                    ::.:|...||:..|::||:.||||:|||:.|||:|||:||..|:|:||||:|.:|..
  Fly  2115 DSAGEFNLEEENFAQRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFL 2179

  Fly  1553 WGALTLPRPSKTFWVTLITYNLTMIFVKSIMHQRVL------LDQQLVSRSNSLSFELIMKRGRA 1611
            ||.|:||||:||||||||.|...::.:|.|...:::      |..|.::.:.....|  .|...|
  Fly  2180 WGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQPLTPAKIFGVE--NKAHYA 2242

  Fly  1612 VYDLLLLVVLFWHQYMLKKQGIWTIQRTNSELLLLEKKRNHYK---RSFSKERPENIRKLLREEG 1673
            :|||:||:|||.|:|:||.||:|               ::.||   ..|:|
  Fly  2243 IYDLILLLVLFLHRYLLKSQGLW---------------KSGYKDTDNQFTK-------------- 2278

  Fly  1674 GGEQVKAVRPNA-IEFKREMDDILLPALE--NKYVYQNIESEYYRKAMQGLA--NKGGL------ 1727
                     |.| |:.:.:.|::..|...  |....|.:..:..:.::.|..  :|.|:
  Fly  2279 ---------PTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERT 2334

  Fly  1728 --LSGFRKFFLALRHKSRLSTDVYTLLFLCDFISFFILLFGFPKFVYRYKYSTSVLETYIQGNKV 1790
              .|...|||.:|.|||||:||||.|:|||||::||:|||||..|..:...|...::||:..|||
  Fly  2335 KYTSSLYKFFFSLVHKSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKV 2399

  Fly  1791 PFTFLLMLIVQFITIVTERAIYLRKALIYKIFFHFISVLGIHIWMFFLVPYITSHSFGETA-PVL 1854
            |..||:||:|||:.||.:||:||||||:.||.|||.||:||||||||:||.:|..:|...| |::
  Fly  2400 PIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPII 2464

  Fly  1855 FYLIKCLHMLLSAYQIRCGYPKRILGNVFTKGYSLANYIAFKIYMEIPFLYILRTMLDWVCIDTT 1919
            ||:|||.:||||:|||:.|||||||||.||||:|:.|.||||:||:|||||.|||:|||||||:|
  Fly  2465 FYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDST 2529

  Fly  1920 LTVMEWIKMEDIFQSVFIVRCYRQMDTDFPVLRGEPKALYSKLLIGGTIILILIALIWSPLFLFA 1984
            :|:.:|:||||||.:::::||.||.:||||.:|.:.||..|||::||||:|:::..||.||.|||
  Fly  2530 MTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFA 2594

  Fly  1985 LVGTVGKPNIPQKADITVKINHYEPIYVSQSNSDILQFSNSDFQKLTNHIILDNYASDSMMLYDA 2049
            |...||..|:|....::::|..|:|||.:.:...|.:.:...:.::||..|.:..|...:..|||
  Fly  2595 LGNAVGTSNVPFHVSLSIRIGPYDPIYTTNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDA 2659

  Fly  2050 VDVTAIKFYENSISLWNMPPPDKERLLHDLSNGETLDIHLTLT---------LKCNLTPEAVIYE 2105
            .||.|::...||.||||:.|||::|||:||.|..||....:.:         ||.|:..|..|
  Fly  2660 TDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAPAKGLKENVGDEHAI-- 2722

  Fly  2106 TTYTLTENKVHTRDKLIRLMSNN------FSN-----------EKVIIPNILPKFITVQRQQANA 2153
               :|.|: ...|..||.::|..      :||           |.|:||.::||||.| ....:|
  Fly  2723 ---SLDES-FEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKV-LNSGDA 2782

  Fly  2154 KFI-----KDYDGKFNRPIILT--KIGKSQVYWWEMNDYCNDRFYTEILSALPLSNCENGVVLYV 2211
            ..:     |.||   .||:::.  :..::...|||:.|||||.||.|.||....|||.:|:|:|.
  Fly  2783 AVVSVLSPKHYD---YRPLVIKMHRDNETNGLWWEIRDYCNDTFYNETLSKFAYSNCTSGIVMYT 2844

  Fly  2212 FNDKSFPSAMSFLEKTGIIGLYTTFVYVVSRIIRSLIANNHRRIMFEDLPYVDRVLKLCTDIYLV 2276
            ||||.|||..|||...||||||||||.:.||.::|.|...:|:|||||||||||||:||.|||||
  Fly  2845 FNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLV 2909

  Fly  2277 RETQEYRLEEDLYGKLIFLYRSPETLIKWTRFKE----DISETAS-NSQLSIQR 2325
            ||..|:.|||||:.||:||||||||||||||.||    |..:|.| .|::|::|
  Fly  2910 REALEFALEEDLFAKLLFLYRSPETLIKWTRPKEEYVDDDGDTDSIPSRMSVRR 2963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pzl	NP_001303493.1	PIEZO	<1201..1388	CDD:292539	94/443 (21%)
		Piezo_RRas_bdg	1901..2308	CDD:288978	203/439 (46%)
Piezo	NP_001303314.1	PIEZO	1226..>1363	CDD:292539	60/150 (40%)
		Piezo_RRas_bdg	2511..2941	CDD:288978	203/439 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I1571
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I816
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46055
OrthoDB	1	1.010	-	-		D13738at2759
OrthoFinder	1	1.000	-	-		FOG0001637
OrthoInspector	1	1.000	-	-		mtm6604
orthoMCL	1	0.900	-	-		OOG6_102664
Panther	1	1.100	-	-	P	PTHR13167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1528
	10	9.980