Protein Alignment Pzl and Piezo1

DIOPT Version :10

• Sequence 1: NP_001303493.1
• Gene: Pzl / 26067051
• FlyBaseID: FBgn0267430
• Length: 2161
• Species: Drosophila melanogaster
• Sequence 2: NP_001344278.1
• Gene: Piezo1 / 234839
• MGIID: 3603204
• Length: 2547
• Species: Mus musculus
• Alignment Length: 2697
• Identity: 729/2697 - (27%)
• Similarity: 1189/2697 - (44%)
• Gaps: 560/2697 - (20%)

  Fly    12 IFLPLTLILVSLVRPVGLSYFYLLTFFLSPWL--LQSNSLKQRTFLNVFIIFLCVLSTFGIVGHI 74
            :.||.||:..||:|...||..|||...|.|||  ...:|:...|. .:....|| ||...:|.|:
Mouse    13 LLLPCTLLAASLLRFNALSLVYLLFLLLLPWLPGPSRHSIPGHTG-RLLRALLC-LSLLFLVAHL 75

  Fly    75 IFNLINLFFVDLSSKNSFSFILRQFGFLYFKGLSFVSI-----------AHWILPDIIVLLNTIV 128
            .|.:.      |.:.......|.|.|.|:.|....:.:           ...:.||:.|||.:.:
Mouse    76 AFQIC------LHTVPHLDQFLGQNGSLWVKVSQHIGVTRLDLKDIFNTTRLVAPDLGVLLASSL 134

  Fly   129 FF-----IFSEIKYKREKRVIQNDD--------DVFYKKSKELKGALKVAEINRVLIIVYIRSVL 180
            ..     :..:.:..|..:.:|:||        |:....:..||||..:|...|:.:....|...
Mouse   135 CLGLCGRLTRKARQSRRTQELQDDDDDDDDDDEDIDAAPAVGLKGAPALATKRRLWLASRFRVTA 199

  Fly   181 KTSLIFS-----LIVLYFAATLRPSLPGSLYFCMFIIAGSYWAL-FRQRKMYYSVIFMIVALL-- 237
            ...|:.|     :::|..|....||...|:|..:|:...::|:. |....:.::.:.::|:..
Mouse   200 HWLLMTSGRTLVIVLLALAGIAHPSAFSSVYLVVFLAICTWWSCHFPLSPLGFNTLCVMVSCFGA 264

  Fly   238 VHITCIFAYQLPVLQNTINCDKLWTRLMGMEVLIRL-NKDNRNGKILELNPKLNLDSYLSP-IAL 300
            .|:.|::.||.|.:|:.:....:|.||.|::..:.| |..:.|.  |.||.|.....|:|| |.|
Mouse   265 GHLICLYCYQTPFIQDMLPPGNIWARLFGLKNFVDLPNYSSPNA--LVLNTKHAWPIYVSPGILL 327

  Fly   301 MLAYFATTLSLINRS-QYEISFNTIRMNLGPKSNSIY----DNIQPSNEENE----EISIFTEPS 356
            :|.|.||:|..:::| ..|:...|      |:.:..:    |:::|..:..:    |:.:.|||.
Mouse   328 LLYYTATSLLKLHKSCPSELRKET------PREDEEHELELDHLEPEPQARDATQGEMPMTTEPD 386

  Fly   357 MLEQFFYI------------------------VYELSSFVYKNSYILLNIIMMIWSIVYHSWLTF 397
            :.....::                        ::.|...:...||:...|.||:|||:|||||||
Mouse   387 LDNCTVHVLTSQSPVRQRPVRPRLAELKEMSPLHGLGHLIMDQSYVCALIAMMVWSIMYHSWLTF 451

  Fly   398 VLLIWANILWMIPNQRRSMMRSSLFVVFYSQILLLAQYIYGMNLYESELPTKVTSCGLNLEQIGF 462
            |||:||.::|.:.::.:..|..|..::.|...|...:|::.|.|  .||||  |...::|.|:|.
Mouse   452 VLLLWACLIWTVRSRHQLAMLCSPCILLYGLTLCCLRYVWAMEL--PELPT--TLGPVSLHQLGL 512

  Fly   463 VHPQSKDSLPWIPLTVKTVFLFVFWVTSRQYFREISLDRQQ--SDLLQQIFATHRSRSEHLLSKK 525
            .|.:    .|.:.|....::|..||:..||:.:|..|.:|:  :.||:...|.         ::.
Mouse   513 EHTR----YPCLDLGAMLLYLLTFWLLLRQFVKEKLLKKQKVPAALLEVTVAD---------TEP 564

  Fly   526 SQTPQIFIYILKSTSHFITRIWM--WLLIFL-IFLCAMIDRTMTGIRICYMSLFLLFLMVFQMSL 587
            :||..    :|:|....:|.|::  |:.:.. :|:.......:...:|.||.||||.|.:||:..
Mouse   565 TQTQT----LLRSLGELVTGIYVKYWIYVCAGMFIVVSFAGRLVVYKIVYMFLFLLCLTLFQVYY 625

  Fly   588 QLWIRFLYGYWIFLIFYAMTILTAIYTYQFDHFDYYWEKFLKVHSTLQCDIGLRRYQTKDLFLHL 652
            .||.:.|..:|..::.|.|.:|.|:||:||..|..||............|:||.::...:||..:
Mouse   626 TLWRKLLRVFWWLVVAYTMLVLIAVYTFQFQDFPTYWRNLTGFTDEQLGDLGLEQFSVSELFSSI 690

  Fly   653 LIPTLTVIFTVVQLHYFHRRFVE----------SVRRPRSTEGQNFHLAPNAETRASQKTLDIHR 707
            |||...::..::|||||||.|::          ..|.||....|:         ..|:..|..|:
Mouse   691 LIPGFFLLACILQLHYFHRPFMQLTDLEHVPPPGTRHPRWAHRQD---------AVSEAPLLEHQ 746

  Fly   708 QSWKVFFDAGYENVRAKGRQLFNP--------GKIVAW--------------------------K 738
            :..:||        |..|:.:..|        |....|                          :
Mouse   747 EEEEVF--------REDGQSMDGPHQATQVPEGTASKWGLVADRLLDLAASFSAVLTRIQVFVRR 803

  Fly   739 FLEMHMIKTVTLASFYCAISEICFLNLFLVILSLLGICGNRFLRRVIFRAVTFWISLLVLMKMIY 803
            .||:|:.|.|.|.:.:.|:.|:..:||.||:|....:...|| |.:.....|.|..::::.||:|
Mouse   804 LLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFALPYPRF-RPMASCLSTVWTCIIIVCKMLY 867

  Fly   804 QIKYLDQSHYNFKC-----GNVT---------------VNFAEWMGLRKTGTVFGV-HLRYISSY 847
            |:|.::...|:..|     .|..               |:.|.|.|:||     |. :|.||.::
Mouse   868 QLKIVNPHEYSSNCTEPFPNNTNLQPLEINQSLLYRGPVDPANWFGVRK-----GYPNLGYIQNH 927

  Fly   848 IIYMILTSLHAVV-KLRDHLIRYSTHKQKDTKLLFPDITRQDAERDFPGLLKYVLNYGYFKFGFE 911
            :..::|....||| :.::|..|.........:.:..|.|||..::|....|||.:|:.::|||.|
Mouse   928 LQILLLLVFEAVVYRRQEHYRRQHQQAPLPAQAVCADGTRQRLDQDLLSCLKYFINFFFYKFGLE 992

  Fly   912 ITMIGLMSTIAHRRDLFALTYLIWLVLLLCLSRFRC-ARIWEMLQLYFVLSIFVQYVYLLNFPPN 975
            |..:..::.|..|.:...:.:..|||.:|...|... ||:|....|:..|.:..||:..|..||.
Mouse   993 ICFLMAVNVIGQRMNFMVILHGCWLVAILTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMPPA 1057

  Fly   976 LCNVISYNSLWSISGSKNYT--------------NRSNIMFDYIVLLLISRQRKSFRVEMRHIND 1026
            ||  |.|...||.:...|..              |.:|::.|:::||..|:|.:.|..|  ...:
Mouse  1058 LC--IDYPWRWSKAIPMNSALIKWLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAE--RTEE 1118

  Fly  1027 LSYRGGVNTNVVHNIAKLGHVYFENPTHDFCTYVRNYADVLKTAIFFSFFWITLAIVFLGGVCST 1091
            .....|:||:  |.....|.   .||..:| .:.|:|.|:||.|:|...||:.|.:||:.|....
Mouse  1119 WQRMAGINTD--HLEPLRGE---PNPIPNF-IHCRSYLDMLKVAVFRYLFWLVLVVVFVAGATRI 1177

  Fly  1092 DILSLGYIIFALIFLLQGSEIYLQNIHFIICRWNCLIAFNIFNIIVKVAIIVLEGTINLEHKSIL 1156
            .|..|||::.....||.|:.:..::....:..|:|||.:|:..||.|..:            |:|
Mouse  1178 SIFGLGYLLACFYLLLFGTTLLQKDTRAQLVLWDCLILYNVTVIISKNML------------SLL 1230

  Fly  1157 SIVFNVMHQTAPCENIMDGKFFEINEISEKKYCYGPSDMIFKNT----------LVWHAIIFSFV 1211
            |.||....|:..|..|   :.|.:  :...|..|.|.:|:.::.          ::|.:|.|.|:
Mouse  1231 SCVFVEQMQSNFCWVI---QLFSL--VCTVKGYYDPKEMMTRDRDCLLPVEEAGIIWDSICFFFL 1290

  Fly  1212 VFQYRIFGSYYFCHVIMDTQANTILASRGAAIIENLHYKQIYDRRKNEQSVLERVKMKMERIRIT 1276
            :.|.|||.|:||.||..|.:|..:.||||.|:....:.|.|...|:.|:..|.::|.:|:|||..
Mouse  1291 LLQRRIFLSHYFLHVSADLKATALQASRGFALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAK 1355

  Fly  1277 NRRH-QKQATGLDFQPHKP--PSSIIHVHYRAEEKSKLKTLNNEFLTTIKQAERDTYFSRSLKPR 1338
            ..:: |.||:....|...|  ||                           |.........|..||
Mouse  1356 QEKYRQSQASRGQLQSKDPQDPS---------------------------QEPGPDSPGGSSPPR 1393

  Fly  1339 R---RDLSLHPHAVRTGDYYMFNELDDDDDLDVYEE-------------YD-FLEKEDVRARQMR 1386
            |   |....|...:.:|||::| |.|.:::.:...|             |. ::.......||.|
Mouse  1394 RQWWRPWLDHATVIHSGDYFLF-ESDSEEEEEALPEDPRPAAQSAFQMAYQAWVTNAQTVLRQRR 1457

  Fly  1387 QSLRSRASNYNRSKSFLNDENSDTDTKKLE----THPV--IILTSELI-VL-------LTFRLNR 1437
            :..|...:....|...||.:....|..:.|    :|.:  ::.|.:.: ||       ||..|..
Mouse  1458 ERARQERAEQLASGGDLNPDVEPVDVPEDEMAGRSHMMQRVLSTMQFLWVLGQATVDGLTRWLRA 1522

  Fly  1438 LSKNFRFVHKMLSAEK----KKLQNI-----SIMNRLGLSNTAAMFK------------------ 1475
            .:|:.|.:..:|.||:    ::|..:     .::::|.:....|...
Mouse  1523 FTKHHRTMSDVLCAERYLLTQELLRVGEVRRGVLDQLYVGEDEATLSGPMETRDGPSTASSGLGA 1587

  Fly  1476 ------------------FLNKSLNNKVIKEAG------SYYVSQD---NDFTTL---------- 1503
                              :..:|.:.:::.:||      |.:.||:   |..|.:
Mouse  1588 EEPLSSMTDDTSSPLSTGYNTRSGSEEIVTDAGDLQAGTSLHGSQELLANARTRMRTASELLLDR 1652

  Fly  1504 ---------------DHNDFVQMLIALWYALIANTETICYLVVFLNQAANSSVISLPMPFLVLCW 1553
                           .....:::|.|.:..:.|::|.:||.::.||....:|..||.:|.||..|
Mouse  1653 RLHIPELEEAERFEAQQGRTLRLLRAGYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLW 1717

  Fly  1554 GALTLPRPSKTFWVTLITYNLTMIFVKSIM-------HQRVLLDQ---------QLVSRSNSLSF 1602
            ..||:|||||.||:|.|.:...|:..|.:.       :..|:|.:         :::....:.|:
Mouse  1718 AMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPWNSYVVLRRYENKPYFPPRILGLEKTDSY 1782

  Fly  1603 ELIMKRGRAVYDLLLLVVLFWHQYMLKKQGIWTIQRTNSELLLLEKKRNHYKRSF----SKERPE 1663
                    ..|||:.|:.||:|:..|...|:|..:..       ...::|.:.|.    :||.||
Mouse  1783 --------IKYDLVQLMALFFHRSQLLCYGLWDHEED-------RYPKDHCRSSVKDREAKEEPE 1832

  Fly  1664 NIRKLLREEGGG---EQVKAVRPN------------------------------AIEFKREMDDI 1695
            ...:...|.|.|   |.|.|..|.                              :|.|:|..:
Mouse  1833 AKLESQSETGTGHPKEPVLAGTPRDHIQGKGSIRSKDVIQDPPEDLKPRHTRHISIRFRRRKE-- 1895

  Fly  1696 LLP-------------------ALENKYVYQNIESEYYRKAMQGLANKGGLLSGF---------- 1731
             .|                   ..|.|......|...:|:.|:.   .|..|..|
Mouse  1896 -TPGPKGTAVMETEHEEGEGKETTERKRPRHTQEKSKFRERMKA---AGRRLQSFCVSLAQSFYQ 1956

  Fly  1732 --RKFFLALRH-KSRLSTDVYTLLFLCDFISFFILLFGFPKFVYRYKYSTSV-LETYIQGNKVPF 1792
              ::||..:.| |.|.:||||.|:||.|.:...|::|||..|   .|:|.:. :.:.:..::||.
Mouse  1957 PLQRFFHDILHTKYRAATDVYALMFLADIVDIIIIIFGFWAF---GKHSAATDIASSLSDDQVPQ 2018

  Fly  1793 TFLLMLIVQFITIVTERAIYLRKALIYKIFFHFISVLGIHIWMFFLVPYITSHSFGETAPV-LFY 1856
            .||.||:|||.|:|.:||:||||.::.|:.|..:.|:.|||||||::|.:|...|.:.|.. |:|
Mouse  2019 AFLFMLLVQFGTMVIDRALYLRKTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWY 2083

  Fly  1857 LIKCLHMLLSAYQIRCGYPKRILGNVFTKGYSLANYIAFKIYMEIPFLYILRTMLDWVCIDTTLT 1921
            .:||::..|||||||||||.|||||..||.|:..|...|:.:..:|||..||.::|||..||||:
Mouse  2084 FVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLS 2148

  Fly  1922 VMEWIKMEDIFQSVFIVRCYRQMDTDFPVLRGEPKALYSKLLIGGTIILILIALIWSPLFLFALV 1986
            :..|:.:|||:.::||::|.|:.:..:|..:|:.|....|..:||.|||.|||:||.||...:|:
Mouse  2149 LSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLI 2213

  Fly  1987 -GTVGKPNIPQKADITVKINHYEPIY-VSQSNSDILQFSNSDFQKLTNHIILDNY--ASDSMMLY 2047
             ..||..|.|....:|:|:..|||:: :|.....|:.|:...:::|:..  .|.|  |...:..|
Mouse  2214 RSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQ--FDPYPLAMQFISQY 2276

  Fly  2048 DAVDVTAIKFYENSISLWNMPPPDKERLLHDLSNGETLDIHLTLT------LKCNLTPEAVIYET 2106
            ...|:...:...:|.:||.:.||.:.::..:|.|| |.||.|..|      |....|.|....:.
Mouse  2277 SPEDIVTAQIEGSSGALWRISPPSRAQMKQELYNG-TADITLRFTWNFQRDLAKGGTVEYTNEKH 2340

  Fly  2107 TYTLTENKVHTRDKLIRLMSNNFSNEKVIIPNILPKFI---------TVQRQQANAKFIKDYDG- 2161
            |..|..|.. .|.:|.:|:... .::.|:||::.||:|         .|::.|.:.:  :||.|
Mouse  2341 TLELAPNST-ARRQLAQLLEGR-PDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEE--EDYLGV 2401

  Fly  2162 --KFNRPIILTKIGKSQ--------VYWWEMNDYCNDRFYTEILSALPLSNCE---NGVVLYVFN 2213
              :..|..:.|.....|        :.||                .:.|.:|:   |.:.:.:|:
Mouse  2402 RIQLRREQVGTGASGEQAGTKASDFLEWW----------------VIELQDCKADCNLLPMVIFS 2450

  Fly  2214 DKSFPSAMSFLEKTGIIGLYTTFVYVVSRIIRSLIANNHRRIMFEDLPYVDRVLKLCTDIYLVRE 2278
            ||..|.::.||...||:|||.:.|.||.:.:|...:.....||||:||.|||:||||.||:||||
Mouse  2451 DKVSPPSLGFLAGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRE 2515

  Fly  2279 TQEYRLEEDLYGKLIFLYRSPETLIKWTRFKE 2310
            |:|..|||:||.|||||||||||:|||||.:|
Mouse  2516 TRELELEEELYAKLIFLYRSPETMIKWTRERE 2547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pzl	NP_001303493.1	PIEZO	<1202..1391	CDD:464941	55/208 (26%)
		Piezo_RRas_bdg	1901..2307	CDD:463481	151/438 (34%)
Piezo1	NP_001344278.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	347..387		8/45 (18%)
		PIEZO	1230..1453	CDD:464941	64/255 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1354..1396		12/68 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1456..1480		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1567..1610		0/42 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1816..1931		20/117 (17%)
		Piezo_RRas_bdg	2127..2545	CDD:463481	152/440 (35%)