DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pzl and pezo-1

DIOPT Version :9

Sequence 1:NP_001303493.1 Gene:Pzl / 26067051 FlyBaseID:FBgn0267430 Length:2326 Species:Drosophila melanogaster
Sequence 2:NP_001293980.1 Gene:pezo-1 / 182492 WormBaseID:WBGene00007505 Length:2442 Species:Caenorhabditis elegans


Alignment Length:2648 Identity:657/2648 - (24%)
Similarity:1113/2648 - (42%) Gaps:547/2648 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PLL-FIITRIFLPLTLILVSLVRPVGLSYFYLLTFFLS---PWLLQSNSLKQRTFLNVFIIFL-C 63
            ||| ..:.::.||..|:..:::||..||..|:|...:|   |.:.:|.:|.:.....|.|.|| |
 Worm     5 PLLKSCVVKLLLPAALLAAAIIRPSFLSIGYVLLALVSAVLPPIRKSLALPKLVGTFVIITFLFC 69

  Fly    64 VLSTFGIVGHIIFNLINLFFVDLSSKNSFSFI--------LRQFGFLYFKGLSFVSIAHWILPDI 120
            :....|:..:.|..       .:..||..::|        .|..|.:.|............||:|
 Worm    70 LAVALGVGSYQISE-------QVVHKNDRTYICNRSDTTLFRSIGLVRFHPTGTFESTRAFLPEI 127

  Fly   121 I---VLLNTIVFFIFSEIKYKREKRVIQND-DDVFYKKSKELKGALKVAEINRVLIIVYIRSVLK 181
            |   ..|.||:..:|  :.::.|:..:..| ..|..:..:|.:...|:|.|....|...:|.:  
 Worm   128 IATSAALLTIIIVMF--LSHRDEQLDVVGDVVTVRSESGREQRRQRKLAAIMWSAIGNSLRRL-- 188

  Fly   182 TSLIFSLIVLYFAATLRPSLPGSLYFCMFIIAGSYWALFRQ-RKMYYSVI--FMIVALLVHITCI 243
            |:.:..|...| ...::|||..|:||..|:...::|:.:.. |...|:.|  |:|....:|...:
 Worm   189 TNFVLFLFTAY-VGIVKPSLSNSIYFLAFLFISTWWSTYTPLRHGVYNQIKKFLIFYSALHFLVL 252

  Fly   244 FAYQLPVLQNT-INCDKLWTRLMGMEVLIRLNKDN---RNGKILELNPKLNLDS-------YLSP 297
            :.||:|::.:: :.......||.|:.||:    |:   ...|...:.|..|.|.       |.:|
 Worm   253 YTYQIPIVHHSWLPTGSFLPRLFGLTVLM----DSSCPEWWKFPFVAPDFNDDDLIMKWPLYANP 313

  Fly   298 IALMLAYFAT----------TLSLINRSQYE--------ISFNTIRMN----------------- 327
            |.:::.::.|          :...|:.::|.        :|..|:..|                 
 Worm   314 IVVLVFFYLTVAQYKFTRNGSREYIDDNEYGSSVHEERFVSAGTVETNVDDVGQLISISESTASA 378

  Fly   328 -----------LGPKSNSIYDNIQ-------PSNEENEEISI--------FTEPSMLEQFFYI-- 364
                       |...|:|..|:.|       |.....|:.||        ..:.:.|...|..  
 Worm   379 PSGRGRGNTLLLSNASSSANDDEQGRARSRSPLRNGEEQGSIPLRKVTSQVVDRNKLSNIFNTTA 443

  Fly   365 -----------VYELSSFVYKNSYILLNIIMMIWSIVYHSWLTFVLLIWANILWMIPNQRRSMMR 418
                       :..:.:||..:||.:....||.|:::|||....:|||...|||:..:.|:|...
 Worm   444 PGDKESAASKGMIAVMTFVIFHSYSIALTAMMTWALLYHSIFGLILLILTCILWIFRDTRKSSFA 508

  Fly   419 SSLFVVFYSQILLLAQYIYGMNLYESEL--PTKVTSCGLNLEQIGFVHPQSKDSLPWIPLTVKT- 480
            .:..::.|.:.||:.||...|::: :|:  |..:...|:....:. ||..       |.|.|:| 
 Worm   509 MAPIILMYIEFLLILQYFLSMDIH-AEIGDPAWMNFVGIEWTTLP-VHAV-------IILCVQTL 564

  Fly   481 ----VFLFVFWVTSRQYFREIS-LDRQQSDLLQQIFATHRSRSEHLLSKKSQTPQ-----IFI-Y 534
                |||.:......:::..:| .:||:.......|...::.:..:...|.|.|:     .|: |
 Worm   565 LTLPVFLLLRLARREKFYESLSDYERQRRINSYGTFGASKTGAGGVAVAKFQDPKSRKFAAFVEY 629

  Fly   535 ILKSTSHFITRIWMWLLIFLIFLCAMIDRTMTG---IRICYMSLFLLFLMVFQMSLQLWIRFLYG 596
            :....|.:        .||::.:..::..|...   ..|.:.:|:.|.|:..:.|.:|:....|.
 Worm   630 LSNKVSVY--------FIFVVSVVLLVVSTCFAPNFYNILFFALWALNLIYLKFSFRLYRGLAYA 686

  Fly   597 YWIFLIFYAMTILTAIYTYQFDHFDYYWEKFLKVHSTLQCDIGLRRY----QTKDLFLHLLIPTL 657
            :|:.|.||...::.|:|.|||.....:..:...:.......|||..:    ::..|||.||.|..
 Worm   687 FWLTLTFYTSIVIIALYIYQFPGVSQWIIRNTSLSQEWLNAIGLVDFRAIGESGALFLQLLAPIA 751

  Fly   658 TVIFTVVQLHYFHRRFVESVRRPRSTEGQNFHLAPNAETRASQKTLDIHRQSWKVFFDAGYENVR 722
            ..:.|::||.:||..:..:. .||..|..    .|.:.|.|:........|...   .|..:.:.
 Worm   752 LFVVTMLQLKFFHGPWSRAT-SPRRAEND----PPTSTTEAAAVASTSGTQGRA---HAAGDTLV 808

  Fly   723 AKGRQLFNPGKIVAWKFLEMHMIKTVTLASFYCAISEICFLNLFLVILSLLGICGNRFLRRVIFR 787
            .|..:|.|....:.|:|.|:|:.|.|.:.......:.|..|.:.||||..|.||.......:...
 Worm   809 KKLHKLANQTIELLWRFFEVHISKIVFVIIAIFIANNINALYIPLVILLSLAICLPSAADGIFSL 873

  Fly   788 AVTFWISLLVLMKMIYQ------IKYLDQSHYNFKCGNVTVNFAEWMGLRK--TGT-----VFGV 839
            .:..::.|:.|.|||||      :..:|:......|.:..::..||.||:|  .||     :|||
 Worm   874 FMCAYLFLVALSKMIYQLDIVPELSQIDRGVGADNCSHGNISMPEWFGLKKEVEGTEPIYMLFGV 938

  Fly   840 HLRYISSYIIYMILTSLHAVVKLRDHLIRYSTHKQKDTKL-LFPDITRQDAERDFPGLLKYVLNY 903
                    |:.:|..:..::|..|....|.|....:..:. :|||......:|.....::::::|
 Worm   939 --------IVSIIALAFQSIVIYRQRHYRASLGLPESMRAKVFPDFHHSHFDRSLKNAIQFLIDY 995

  Fly   904 GYFKFGFEITMIGLMSTIAHRRDLFALTYLIWLVLLLCLSRFRCARIWEMLQLYFVLSIFVQYVY 968
            |::|||.|||||.:...|.:|.|..|.....||||.....|....|||....:|..:...:|:..
 Worm   996 GFYKFGLEITMIAIGIDIFNRMDALAAIQCFWLVLFALNKRVFVRRIWVFYVIYMAILYPLQFFS 1060

  Fly   969 LLNFPPNLCNVISYN-SLWSISGSKNYTNRSNIMF------------------DYIVLLLISRQR 1014
            .:..||:.|  |.|. |.|..|.|.:  .|.|:.:                  |:.||||.|.|.
 Worm  1061 YVGLPPDSC--IEYPWSYWIPSYSDD--ARFNLSYLLNLSIYGVNWPSAYLIGDFFVLLLASCQL 1121

  Fly  1015 KSFRVEMRHINDLSYRGGVNTNVVHNIAKLGHVYFENPTHDFCTYVRNYADVLKTAIFFSFFWIT 1079
            ..||.|... ||..|..|   |.|        :..|||.:||....::|.|..|:.:|....|||
 Worm  1122 AVFRREGED-NDSIYNDG---NFV--------IKPENPQYDFIDTKKSYVDYFKSFVFHYGHWIT 1174

  Fly  1080 LAIVFLGGVCSTDILSLGYIIFALIFLLQGSEIYLQN-----IHFIICRWNCLIAFNIFNIIVKV 1139
            |......|:..|.:.:||||||.|..|..|:.:|:.|     ....:.|||.|:.:.:|.|.:||
 Worm  1175 LMSTLAAGIAGTSLFALGYIIFTLTMLWSGNNLYVMNSTLRSFEHTLKRWNALLGYTLFTITMKV 1239

  Fly  1140 AIIVLEGTINLEH--------------KSILSI--VFNVMHQTAPCENIMDGKFFEINEISEKKY 1188
            .:.:. |.:.|..              :.:.||  |.|..|.....|:.......|..|      
 Worm  1240 CLQIF-GCVFLSWFDQSGGWGKTLCIVRQLFSITCVNNECHVLKELEDFSKACAVETKE------ 1297

  Fly  1189 CYGPSDMIFKNTLVWHAIIFSFVVFQYRIFGSYYFCHVIMDTQANTILASRGAAIIENLHYKQIY 1253
                      ..:.:..|..||:|||.|||.|:||.|.:::.::..|||:|||.:...|..|::.
 Worm  1298 ----------GNIGFDVIALSFLVFQIRIFHSWYFQHCMVEYRSEVILANRGAVLKNQLIEKEMK 1352

  Fly  1254 DRRKNEQSVLERVKMKMERIRITNRRHQKQ----ATGLDFQPHKPPSSIIHVHYRAEEKSKLKTL 1314
            ::.:.:::....::.:.|.||   .|:|||    |...||:|                       
 Worm  1353 EQNEQQKAKFNDIRRRTEAIR---ERYQKQIERGAAERDFEP----------------------- 1391

  Fly  1315 NNEFLTTIKQAERDTYFSRSLKPRRRDLSLHPHAVRTGDYYMFNELDDDDDL----DVY------ 1369
                         .||               .||.|.||||||....::|||    |.:      
 Worm  1392 -------------VTY---------------GHAKRAGDYYMFKYDPENDDLVEPVDSFVPEVDP 1428

  Fly  1370 --EEYDFLEKEDVR----------ARQMRQSLRSRASNYNRSKSFL-----------------ND 1405
              ..||.|:...:.          |:.::|..:........|::.:                 .|
 Worm  1429 KATAYDRLDPGQIMYAATAHDLDLAKTVQQVKKGDTIKDPDSRALIAVSEPEARKPGGTEETDGD 1493

  Fly  1406 ENSDTDTKKLETHPVII--LTSELIVLLTFRLNRLSKNFRFVHKMLSAEKKKLQNISIMNRLGLS 1468
            |:.|....|:|:....|  :.:..:.|.:..||:|.:..|:|..:||.||:||::   .:...||
 Worm  1494 EDEDNKDSKVESTAKFIQKMIASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKS---GHSESLS 1555

  Fly  1469 NTAAMFKFLNKSLNNKVIKEAGSYYVSQDNDFTTLD---------HNDFVQMLIALWYALIANTE 1524
            ||:.....:..:::...::     .|...||...::         .:...::|.|:...:.|:|:
 Worm  1556 NTSRKLTDIRSAVDLPSLQ-----LVQSANDVEKMETAVSVDWQQKSSATRLLNAVVNCIGAHTD 1615

  Fly  1525 TICYLVVFLNQAANSSVISLPMPFLVLCWGALTLPRPSKTFWVTLITYNLTMIFVKSIMHQRVL- 1588
            .:||....:.|.....:|:||:|.:.|.||.|:.|||||.||||:|||...:|.:|.:.....: 
 Worm  1616 ILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMP 1680

  Fly  1589 -------LDQQLVSRSNSLSFELIMKRGRAVYDLLLLVVLFWHQYMLKKQGIWTIQRTNSELLLL 1646
                   .:.|:...|....|.:..:...|::|::||..||:|:|||:|.|:|..........|.
 Worm  1681 YNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLK 1745

  Fly  1647 EKKRNHYKRSFSKERPENIRKLLRE-----------EG--GGEQVKAVRPNAIEFKREMDDILLP 1698
            |:     .||.|.....:.:|:.:|           ||  |||.|....|||:....|:|  ..|
 Worm  1746 EE-----PRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELD--CEP 1803

  Fly  1699 ALENKYVYQNIESEYYRKAMQGLANKGGLLSG-FRKFFLALRH-KSRLSTDVYTLLFLCDFISFF 1761
            .:..|.                        || ..:|...|.| |.|...|:|.::|..|.|.|.
 Worm  1804 PIPEKQ------------------------SGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFL 1844

  Fly  1762 ILLFGFPKFVYRYKYSTSVLETYIQGNKVPFTFLLMLIVQFITIVTERAIYLRKALIYKIFFHFI 1826
            |:.||:..|  ....|.:||:. ::.:::|.|.::||:...:.|:.:||:||||:::.|:.:..:
 Worm  1845 IMTFGYSAF--GEGGSGNVLDD-VKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVL 1906

  Fly  1827 SVLGIHIWMFFLVPYITSHS--FGETAPVLFYLIKCLHMLLSAYQIRCGYPKRILGNVFTKGYSL 1889
            .:..:|||:|.::|.:|..|  ....|..| |:||..:.|:||:|||.|||:..:||:.|..|.:
 Worm  1907 MIAFLHIWVFLVLPNMTRRSAISNHVAQAL-YVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGM 1970

  Fly  1890 ANYIAFKIYMEIPFLYILRTMLDWVCIDTTLTVMEWIKMEDIFQSVFIVRCYRQMDTDFPVLRGE 1954
            .|.||||::|.||||:.|||.:||...||::.:.::..||:.:..:|.::|.||.:..:|..||.
 Worm  1971 TNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGI 2035

  Fly  1955 PKALYSKLLIGGTIILILIALIWSPLFLFALVGTVGKPNIPQKADITVKINHYEPIYVSQSNSDI 2019
            ||....|.::|..||:.::..|:|||.|::|:..:|..::|:|..:.:.|..|.|:|..::    
 Worm  2036 PKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEA---- 2096

  Fly  2020 LQFSNSDFQKL-----------------------TNHIILDNYASDSMMLYDAVDVTAIKFYENS 2061
             |.||.|..:|                       ||.|:....:...:..|...|:..::|...|
 Worm  2097 -QGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPES 2160

  Fly  2062 ISLWNMPPPDKERLLHDLSNGETLDIHLTLTLKCNLTPEAVIYETTYTLTENKV--HTRDKLIRL 2124
            ...|.:....:..::..||...:::..::|.           :...|...||..  |::..|:.:
 Worm  2161 EIYWPISQDSRNAMIDKLSRNTSVNFEVSLE-----------FTRPYDPNENAALKHSKSWLVPI 2214

  Fly  2125 MSNNFSNEK------------VIIPNILPKFITVQRQ-------QANAKFIKDYDGKFNRP---- 2166
            ..:.....|            ::||..:|.||.|..|       ......|.|.:.:.|..    
 Worm  2215 SLDMTIRAKIQSALRGDPGHPILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPRINTTGMEK 2279

  Fly  2167 -----------IILTKIGKSQ--VYWWEMNDYCND----------------RFYTEILSALPLSN 2202
                       .:..:.||||  ..|...:::..|                |.|.:::.      
 Worm  2280 SDEARAWFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVG------ 2338

  Fly  2203 CENGVVLYVFNDKSFPSAMSFLEKTGIIGLYTTFVYVVSR-IIRSLIANNHRRIMFEDLPYVDRV 2266
                     |.|::|||.::.:.|.|:|.:|.:.:.||.| ::|.:...:...:||.:||..|.:
 Worm  2339 ---------FIDRAFPSFLAKVFKGGVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHL 2394

  Fly  2267 LKLCTDIYLVRETQEYRLEEDLYGKLIFLYRSPETLIKWTRFKEDISE 2314
            ||:|.|||||||.:::.||:||:.|||||:|||.|||:|||..:...|
 Worm  2395 LKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSKKKQE 2442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PzlNP_001303493.1 PIEZO <1201..1388 CDD:292539 51/212 (24%)
Piezo_RRas_bdg 1901..2308 CDD:288978 124/484 (26%)
pezo-1NP_001293980.1 PIEZO 1244..1460 CDD:406366 62/286 (22%)
Piezo_RRas_bdg 1982..2435 CDD:403405 123/483 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 314 1.000 Domainoid score I697
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 836 1.000 Inparanoid score I232
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46055
OrthoDB 1 1.010 - - D13738at2759
OrthoFinder 1 1.000 - - FOG0001637
OrthoInspector 1 1.000 - - otm14131
orthoMCL 1 0.900 - - OOG6_102664
Panther 1 1.100 - - O PTHR13167
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1528
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.980

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