DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pzl and Piezo

DIOPT Version :10

Sequence 1:NP_001303493.1 Gene:Pzl / 26067051 FlyBaseID:FBgn0267430 Length:2161 Species:Drosophila melanogaster
Sequence 2:XP_061514988.1 Gene:Piezo / 1280241 VectorBaseID:AGAMI1_002955 Length:3133 Species:Anopheles gambiae


Alignment Length:3183 Identity:880/3183 - (27%)
Similarity:1387/3183 - (43%) Gaps:952/3183 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LLFIITRIFLPLTLILVSLVRPVGLSYFYLLTFFLSPWLLQSNSLKQRTFLNVFIIFLCVLSTFG 69
            |..::.|:.|||.|....|:|||||:..||:...:.|::..:|....:....:|:..|.:.....
Mosquito     6 LCLVVQRLVLPLILATCVLMRPVGLAIPYLICLLVIPYVPVANKKTIQGPTGLFMRLLILFVVLD 70

  Fly    70 IVGHIIFNLINLFFVDLSSKNSFS---FILRQFGFLYFKGLSFVSIAHWILPDIIVLLNTI-VFF 130
            :...|:|.||.:.|.. ||..|.|   .|||..|.:.|.||....:.:|:.|:.|:|:..: |..
Mosquito    71 LAAVIVFQLILISFPG-SSVESCSLGEIILRHIGLVSFNGLGAWMVVYWLAPEAILLVGAVTVHI 134

  Fly   131 IFSEI------KYKREKRVIQN---DDDVFYKKSKELKGALKVAEINRVLIIVYIRSVLKTSLI- 185
            :..::      :.:|.:|....   :||.  ::..:.:|....||..        .|..:|||| 
Mosquito   135 VLRKLTGVIVPRRRRRRRGADGNTAEDDT--EQGADAEGEGPAAETE--------ESEPQTSLIS 189

  Fly   186 -------------FSLIVLYFAATLRPSLPGSLYFCMFIIAGSYWALFRQRKMYYSVI--FMIVA 235
                         .|:.:|.....::||....:||.:|:.|.|:|..:::....:.::  .::|.
Mosquito   190 PERLPFFTTLGVLLSMCMLCVVGIIQPSAISGVYFVVFLGAASWWGCYKKLDRAFGIVLKIVLVV 254

  Fly   236 LLVHITCIFAYQLPVLQNTINCDKLWTRLMGMEVLIRLNKDNRNG---KILELNPKLNLDSYLSP 297
            |::||..:.|||.|..|..:..:....|::.::.::..:.:..||   :.:..|..|:.|.||:|
Mosquito   255 LVIHIVLLLAYQNPWPQEVLYFNDTAARVLALKPILNSSCNLANGTDIRDVHFNSDLDTDVYLNP 319

  Fly   298 IALMLAYFATTL--SLINRS-----------------------QYEISFNTIRMNLGPK------ 331
            |.|:|.|:..|:  ||:.|:                       |.:|||...|.|:..|      
Mosquito   320 IFLLLCYYTLTMTSSLLLRTRSDTTKDRKRLDLSSQLENGIRLQNQISFRMQRKNILRKTLTSDR 384

  Fly   332 ----------------------SNSIYDNIQ------PSNEENEEISIFTEP-SMLEQFFYIVYE 367
                                  :|...|..|      .|.|.|:.||...|| |..||....:..
Mosquito   385 WRGAARKVKLMRRGTHRIRDASANDGKDCAQTDQIALESLETNKTISEEEEPSSFFEQALLAIRN 449

  Fly   368 LSSFVYKNSYILLNIIMMIWSIVYHSWLTFVLLIWANILWMIPNQRRSMMRSSLFVVFYSQILLL 432
            ::|::||||||..|:|||:|||:||||||||||:|||::|::||.|::|:.||.|:|.|:::||:
Mosquito   450 VASYIYKNSYIFTNVIMMVWSIMYHSWLTFVLLLWANLIWILPNHRKNMLNSSPFLVIYAEVLLI 514

  Fly   433 AQYIYGMNLYESELPTKVTSCGLNLEQIGFVHPQSKDSLPWIPLTVKTVFLFVFWVTSRQYFREI 497
            ||::|||||.|:||||.|...|:||||:|||.   :...|.:||.||::|..:||::.||..:|.
Mosquito   515 AQFLYGMNLTEAELPTVVEGSGINLEQLGFVR---RTEYPIVPLLVKSLFTTMFWISLRQLIQEK 576

  Fly   498 SLDRQQSDLLQQIFATHR--------------SRSEHLLSKKSQTPQIFIYILKSTSHFITRIWM 548
            ..:|::| ::..:.|..:              |.:|..|.|||..  |...:.|....|:.:.|:
Mosquito   577 QTERRES-MIANMAAPLQLPVGAATTAATGPPSATERPLEKKSSA--IVDRMAKFFRSFMIKFWI 638

  Fly   549 WLLIFLIFLCAMIDRTMTGIRICYMSLFLLFLMVFQMSLQLWIRFLYGYWIFLIFYAMTILTAIY 613
            |::...:||.|:|...||..||.||.|||.||:.||.|..:|.|.::.:||.:|.|:|.||..:|
Mosquito   639 WVVALTLFLSAIIGNRMTVFRIVYMVLFLCFLLSFQFSFSVWRRVMFTFWITVILYSMAILILVY 703

  Fly   614 TYQFDHFDYYWEKFLKVHSTLQCDIGLRRYQTKDLFLHLLIPTLTVIFTVVQLHYFHRRFV---- 674
            .:||:.|..||.. :.:...||.||||..::|..|||||:.|||.||.||:||||.|.||:    
Mosquito   704 LHQFEQFPRYWAA-IGISKELQEDIGLEIFKTGQLFLHLVNPTLVVIITVIQLHYCHDRFLIISE 767

  Fly   675 -------------ESVRRP--RSTEGQNFHLAPNAETRA-------------------------- 698
                         |..:.|  .:|:|..:....||:..|                          
Mosquito   768 IPSVQTEAEQSDEEDKQEPVAPATDGPAYGTFTNADNGAIKDSGEAVPPATDTTVGQKADAQPAR 832

  Fly   699 ---------------------------SQKTLDIHRQSWKVFFDAGYENVRAKGRQLFNPGKIVA 736
                                       .|:.....|::||:..|            |..    :.
Mosquito   833 EKLPLEEDDDDEEQIEKIEDFRFRKLSRQEITGFARKAWKMALD------------LLE----LT 881

  Fly   737 WKFLEMHMIKTVTLASFYCAISEICFLNLFLVILSLLGI----CGNRFLRRV----IFRAVTFWI 793
            |.|.|:|::|.|.:.:|..:::.:.||:|..|:||:..:    .|...|..:    |.|.::.:.
Mosquito   882 WLFFEIHLLKIVLIVAFSLSVNSVNFLHLLYVVLSVFTVKAHTSGKDSLTYIYQIRITRIMSLFS 946

  Fly   794 SLLVLMKMIYQIKYLDQSHYNFKCGNV-------TVNFAEWMGLRKTGTVFGVHLR-YISSYIIY 850
            ::::::.||||:||:.:..:..:|.|:       .:|.|:|:|:||||:  |..|. .:..|::|
Mosquito   947 AIMLIITMIYQVKYIKEGDFQSECPNIDANTTLMDMNNAKWIGMRKTGS--GETLSDLLRPYLVY 1009

  Fly   851 MILTSLHAVVKLRD--HLIRYSTHKQKDTKLLFPDITRQDAERDFPGLLKYVLNYGYFKFGFEIT 913
            ::|.::|.|:.||.  |.:|.. ...|...|:||:|.|.||::|.|.::||:.||||:|||.||:
Mosquito  1010 ILLVTVHQVIILRQTIHRMRLG-RSPKTPSLMFPNIVRADADKDIPRMIKYLFNYGYYKFGIEIS 1073

  Fly   914 MIGLMSTIAHRRDLFALTYLIWLVLLLCLSRFRCARIWEMLQLYFVLSIFVQYVYLLNFPPNLCN 978
            ::.|:..:.:|.|:.::.|.|||.::..::|....|:|..|..:.|..|.:|||..:..||..| 
Mosquito  1074 LVALIVVVGNRMDVLSIFYAIWLAVMFHMTRDGLQRLWRWLTWFIVTVIPIQYVLFVGLPPFAC- 1137

  Fly   979 VISYN---------SLWSISGSKNYTNRS---NIMFDYIVLLLISRQRKSFRVEMRHINDLSYRG 1031
             ::|.         .:|::....:|..||   .::.|:::|:.:.||...||:|..  ....:.|
Mosquito  1138 -VNYPWFVPQLDHFRIWAMLPENSYEFRSFANKMVSDFVLLMFLCRQTVVFRLERE--PPRRFGG 1199

  Fly  1032 GVNTNVVHNIAKLGHVYFENPTHDFCTYVRNYADVLKTAIFFSFFWITLAIVFLGGVCSTDILSL 1096
            |.|.:|:.:..||....|:|||.||.|.|||:.|:||..:|...||.|||:|||.|....::.|:
Mosquito  1200 GSNQSVLGDFQKLDEGNFQNPTPDFITKVRNWLDMLKRTLFLVSFWFTLAVVFLSGSSRVNLFSI 1264

  Fly  1097 GYIIFALIFLLQGSEIYLQNIHFIICRWNCLIAFNIFNIIVKVAIIVLEGTINLEHKSILSIVFN 1161
            ||:|.|..||.||::.||.:|.:|:.|||.||.:|:|.|..| |.:.|.|.:.||     .:|.|
Mosquito  1265 GYLIGAFFFLWQGTDFYLHSIEYILKRWNILICYNVFVIGAK-AFLQLFGCLFLE-----QLVNN 1323

  Fly  1162 VMHQTAPCENIMDGKFFEINEISEK------------KYCYGP--SDMIFKNTLVWHAIIFSFVV 1212
                     |....:.|.:|.:|..            :.|..|  ||.    .|.|..:.|:|::
Mosquito  1324 ---------NCWVMQLFGMNCLSSALPPLPPGTVDPGEQCNIPPASDA----GLFWDGMCFAFLL 1375

  Fly  1213 FQYRIFGSYYFCHVIMDTQANTILASRGAAIIENLHYKQIYDRRKNEQSVLERVKMKMERIRITN 1277
            .|.|:|.|:||||:|.:::|:..||||||.:||.|..|:.....:.|:.:||::|.||:||:.|.
Mosquito  1376 LQRRLFSSHYFCHIINESKASKYLASRGAELIEELRIKESAQEAERERQILEKIKAKMDRIKATQ 1440

  Fly  1278 RR---------------------------------------------------HQKQATG----- 1286
            ::                                                   :|.|...     
Mosquito  1441 QKILEAVQDPATHAIGYHTPIEDELAANSMFIEGEGLSDMPSDNGGLTVGRGSYQTQIPSPSSAL 1505

  Fly  1287 --------LDFQ--------------------------------PHKPPSSIIHVHYRA------ 1305
                    ||.|                                |.:|.||:...:...      
Mosquito  1506 MTVSLDAYLDPQRMSFDSPNDLMARVCSPDDTFPVFSPPPFEKDPREPLSSVAAPYVATTTANTL 1570

  Fly  1306 --EEKSKLKT---------------LNNEFLTTIK-------------------------QAERD 1328
              ..|:.|:|               .|||...:.|                         |:.|.
Mosquito  1571 MPPPKTALQTRQHRRQSSLNAVSWPANNELTVSPKAQHRAVPSGNINIPTEDPTTEQQPSQSPRS 1635

  Fly  1329 TYFSRSL-----KPRRRDLSL-------------------------------------------- 1344
            ....||.     :||.|.||.                                            
Mosquito  1636 PRSPRSATFAPNQPRHRRLSSMGSGSGLPDELTAGGDAIGARRRSSFLVSLFVDEDNTTRYDEVT 1700

  Fly  1345 ------------------------------------------------------------HPHAV 1349
                                                                        .|.|:
Mosquito  1701 TTANGGPTSRRRSRSRSYWGPVGEAGLRDSIRSARSRSPVSHHEYTVDHRSSLKRKISEHRPTAI 1765

  Fly  1350 RTGDYYMFNELDDDDDLDVYEEYDFLEKEDVRARQMRQSLRSRAS-------------------N 1395
            |:||||||.:::.:.:||:.|.:::.::.|.|: |..|.||.|.:                   .
Mosquito  1766 RSGDYYMFEDVEQEFELDLMEPHEYDDELDERS-QKDQRLRRRLTLGRLAAQLRKQRQQEVYELA 1829

  Fly  1396 Y-NRSKSFLNDENSDTDTKKLETHPVIILTSEL--------------------IVL--------- 1430
            | .|..:..:|::.|.||......|:.:.:|:|                    :||         
Mosquito  1830 YGKRDANEPDDDDDDDDTNAAVDQPLTLASSDLPAEEDPAQPPALRRRRLSSPVVLRRDHPTHTD 1894

  Fly  1431 ----------------------------------------------------------------- 1430
                                                                             
Mosquito  1895 HRGTDDRTAALERSALSEPLPPIEAQYPPPPPQPLPTLPQTAHSGTRLRKPTALDAPDAQTAGPS 1959

  Fly  1431 ----------------------------------------------------------LTFRLNR 1437
                                                                      :|.||:|
Mosquito  1960 KELHAQHSITDEEARLLSDEEDEVEGRKEADVAEEKKSKFSLSGLALIPAFLAGVVGSVTLRLHR 2024

  Fly  1438 LSKNFRFVHKMLSAEKKKLQ-----NISIMNRLG------------------------------- 1466
            .|:|:|:|.::|:.||:.|:     .:.:.::.|                               
Mosquito  2025 ASRNYRYVMRVLTREKQVLKETPGFGVGVRDKDGVWTHYISRSGSSTSPKPEESPPPSGGTVRSG 2089

  Fly  1467 ----------LSNTAAMFKFLNKSLNNKVI----------------------------------- 1486
                      ||:.......|::.|::..|                                   
Mosquito  2090 GSSSDGGGDSLSSRTGSLASLSRQLHSSNINDNTDYERDYAEAEQPASAVPSSPAVTFTVSEVQP 2154

  Fly  1487 ---------------------------------------------------KEAGSYY------- 1493
                                                               :|..|||       
Mosquito  2155 DTATESDAKANTIRDLQVYTGAERQPVDDGLHTVSGLGAALAMISRKDPLREEIESYYQHRRRST 2219

  Fly  1494 --------------------------------------------------VSQDNDFTTLDHNDF 1508
                                                              ||.:.||::..|:..
Mosquito  2220 SLLPEILISAPSAERGLDEDGIPYRYYSNDTLDSKTDGSSTEAVKRTLDEVSSEEDFSSRKHSVL 2284

  Fly  1509 VQMLIALWYALIANTETICYLVVFLNQAANSSVISLPMPFLVLCWGALTLPRPSKTFWVTLITYN 1573
            .::..|.|||::::|:.|||.||||||..::|::|||:|.||..||.||.|||::|||..||.|.
Mosquito  2285 FELFQAAWYAIMSHTDFICYFVVFLNQVNSASLLSLPLPLLVTLWGTLTFPRPAQTFWTMLIAYT 2349

  Fly  1574 LTMIFVKSIMHQRVLLDQQLVSRSN-----SLSFELIMKRGRAVYDLLLLVVLFWHQYMLKKQGI 1633
            ..::.||.|....:....|....||     :..|.:..|.|.|.|||:||::|:.|:::||..|:
Mosquito  2350 QMVVLVKCIGQFEMFWWNQTPIPSNQPFHVARLFGIERKDGYATYDLILLLMLYCHRFILKSLGL 2414

  Fly  1634 WTIQRTNSELLLLEKKRNHYKRSFSKERPENIRKLLREEGGGEQVKAVRP-------NAIEFKRE 1691
            |....|....|    ....|:...:.||.:.:..|..|.....:...:||       :.::...:
Mosquito  2415 WKSDPTEEPAL----SEGLYQVDPNDERAKALMALAEENEKKCETLEIRPPEELTGLSMVKINEK 2475

  Fly  1692 MDDILLPAL--ENKYVYQNIESEYYRKAMQGLANKGGL--LSGFRKFFL-ALRHKSRLSTDVYTL 1751
            ...|:...:  |:..:..:|..|..:|....:|.:..|  .:..:.||: .|..:||.:||||..
Mosquito  2476 AGTIVEEPIGEESNVLCVSIHPEPAKKYFPQIAKEAFLRYSAALKAFFVQLLDRQSRKTTDVYGY 2540

  Fly  1752 LFLCDFISFFILLFGFPKFVYRYKYST-----SVLETYIQGNKVPFTFLLMLIVQFITIVTERAI 1811
            :||||||:||::||||..|      .|     .|| :|.:.|:||.|||||||:||..||.:||:
Mosquito  2541 MFLCDFINFFVILFGFSSF------GTQDGDGGVL-SYFEENRVPVTFLLMLIIQFFLIVVDRAL 2598

  Fly  1812 YLRKALIYKIFFHFISVLGIHIWMFFLVPYITSHSFGETA-PVLFYLIKCLHMLLSAYQIRCGYP 1875
            ||||.:..||.|.||.::|:|:||||::|..|..:|..|. |||:|:|||.::|.||||||||||
Mosquito  2599 YLRKNIQGKIIFQFILIIGLHVWMFFVLPATTERNFNATTPPVLYYMIKCFYLLFSAYQIRCGYP 2663

  Fly  1876 KRILGNVFTKGYSLANYIAFKIYMEIPFLYILRTMLDWVCIDTTLTVMEWIKMEDIFQSVFIVRC 1940
            .|||||..|||:::||:..||::|.:|||:.|||::||:..||::|:.:|:||||||.:|:.::|
Mosquito  2664 ARILGNFLTKGFTMANFSGFKLFMTVPFLFELRTLMDWIWTDTSMTLFDWLKMEDIFSNVYQLKC 2728

  Fly  1941 YRQMDTDFPVLRGEPKALYSKLLIGGTIILILIALIWSPLFLFALVGTVGKPNIPQKADITVKIN 2005
            .||::.|.|..||:.|....|.|:||.::|.:|.|||.||.|||....||:||||....:.::|.
Mosquito  2729 MRQLEEDLPAPRGQKKGAMVKYLMGGGMMLGIIFLIWFPLALFAFSNAVGQPNIPHDVSVELRIG 2793

  Fly  2006 HYEPIY-VSQSNSDILQFSNSDFQKLTNHIILDNYASDSMMLYDAVDVTAIKFYENSISLWNMPP 2069
            .|||:| :|..|:.|...:.:::...|.. .::..|...:..|:..||.|::...:|.|:||:.|
Mosquito  2794 TYEPVYAMSAQNNSIYGLTPNNWSNFTAP-FMERSAQTFLSNYEPADVAAVQLGISSASIWNISP 2857

  Fly  2070 PDKERLLHDLSNGETLDIHLTLTLKCNLT-----PEAVIYETTYTLTENKVHTRDKLIRLMSNNF 2129
            ||:.|||:||.|..||......|:. .:|     |..:..|.||.|.:..  .|..||..:|...
Mosquito  2858 PDRNRLLYDLINNVTLTCRFRYTIS-RMTNSKENPGVISEERTYQLYDGP--ARQALINSLSRTK 2919

  Fly  2130 SNEKVIIPNILPKFITVQRQ---QANAKFIKDYDGKFN----RPIILTKI---GKSQVYWWEMND 2184
            .:|..::.||:|||:.||..   :...:.:|..||..:    |.:.|.::   ..|...||:..:
Mosquito  2920 PDEMAVLMNIMPKFLRVQNSGSIRPVHQLVKTADGDEDEENYRNMQLRQLYMDETSNTSWWQAME 2984

  Fly  2185 YCNDRFYTEILSALPLSNCENGVVLYVFNDKSFPSAMSFLEKTGIIGLYTTFVYVVSRIIR-SLI 2248
            .|.|..|.:..|.||.::|.|.:|:|:||||.|||.:|.:...||||:|:|.:.|.||::| |:.
Mosquito  2985 DCTDTLYEKYFSRLPYADCTNFLVIYMFNDKIFPSTISSIAAGGIIGIYSTMILVFSRMLRTSIF 3049

  Fly  2249 ANNHRRIMFEDLPYVDRVLKLCTDIYLVRETQEYRLEEDLYGKLIFLYRSPETLIKWTRFKED 2311
            :....:|||||||||||||:||.|||||||:.|:.|||||:.||:||||||||:|||||.|.:
Mosquito  3050 SGASSKIMFEDLPYVDRVLQLCLDIYLVRESSEFTLEEDLFAKLLFLYRSPETMIKWTRPKNE 3112

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PzlNP_001303493.1 PIEZO <1202..1391 CDD:464941 74/441 (17%)
Piezo_RRas_bdg 1901..2307 CDD:463481 173/422 (41%)
PiezoXP_061514988.1 None

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