DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pzl and piezo2b

DIOPT Version :10

Sequence 1:NP_001303493.1 Gene:Pzl / 26067051 FlyBaseID:FBgn0267430 Length:2161 Species:Drosophila melanogaster
Sequence 2:XP_021323945.2 Gene:piezo2b / 100534973 ZFINID:ZDB-GENE-130530-810 Length:3001 Species:Danio rerio


Alignment Length:3132 Identity:723/3132 - (23%)
Similarity:1205/3132 - (38%) Gaps:955/3132 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 AEPLLFIITRIFLPLTLILVSLVRPVGLSYFYLLTFFLSPWLLQSNSLKQRTFLNVFIIFLCVLS 66
            :|.:..::.|:.||:.|....|.|..|||:.|||...|.|...:.:|:..|......:..||..|
Zfish     3 SEVVCGLVFRVLLPVCLAAACLFRFNGLSFIYLLFLLLIPLFPEPSSITMRGQTGYLLKSLCCCS 67

  Fly    67 TFGIVGHIIF-----NLINLFFVDLSSKNS-FSFILRQFGFLYFKGLSFVSIAHWILPDIIVLLN 125
            ...:..|||:     :|:....||.....| :...:||.||....|....:.....||||.:.:.
Zfish    68 VTFLFFHIIYQITVHSLLARGRVDSGFNCSVWEKSIRQIGFESVIGADAGNGIRVFLPDIGMFMA 132

  Fly   126 TI-VFFIFSEIKYKREKRVIQNDDDVFYKKSKELK------------------------------ 159
            :: |:.:..::.::|....:..|:..|..:.||.:                              
Zfish   133 SLGVWLLCRKLLHQRPTEDMAQDNQQFLSEEKEEENEKLENEEDENDNNDDDDDEMLFDEDFDAE 197

  Fly   160 ----------GAL-----------KVAEINRVLIIVYIRSV---LKTSL---------IFSLIVL 191
                      |.|           :|.|..::.|:..:..|   ||..:         :...|:|
Zfish   198 DEAEEEDGEAGRLEEEEEEEEEEEEVQESTKMKILRAVGGVAAKLKEIIGNLITTAGQVVVTIML 262

  Fly   192 YFAATLRPSLPGSLYFCMFIIAGSYWALFRQ-RKMYYSVIFMIVALLV--HITCIFAYQLPVLQN 253
            .......|||..::||.:|:...::|:|.:. .|:.:|.:.:::|:..  |:..::..|...||.
Zfish   263 GMTGVTLPSLSSAVYFFVFLGLCTWWSLCKTFDKLLFSCLCVLMAIFSAGHLIVLYINQFQFLQE 327

  Fly   254 TI------------------NCDKLWTRLM--GME------------------VLIRL------- 273
            .|                  :|...|...:  |::                  .||||       
Zfish   328 AISPTDGYTSVFGISSIIYTDCSSTWKLAVRSGLKWHHFVNPIMILVLYYTLATLIRLWLQDPMM 392

  Fly   274 NKDNRNGKILELNPKLNLDSYLSPIALMLAY------------------FATTLSLI---NRSQY 317
            .:|:.:|:::|.|..:..:.:.:.|...|.:                  ::|:..|:   |.:.:
Zfish   393 MEDSEDGEVIEGNEAMENNVHHTSIRKRLLWWKAHQKTEERNLISTQDGYSTSEVLVVTSNGTSF 457

  Fly   318 EISFNTIRMNLGPKSNSIYDNIQ--------------------------------PSNEENEEIS 350
            :. .:.:.:..||.|..||...|                                ...||.||..
Zfish   458 DY-VSAVPIENGPVSLDIYSTPQYKVDQSVEYDEKTDENTNEVLDSQLEEEEEKTDEEEEAEEEE 521

  Fly   351 IFTEPSMLEQFFYIVYELSSFVYKNSYILLNIIMMIWSIVYHSWLTFVLLIWANILWMIPNQRRS 415
            ....|:.|.:.|       .|:.|.|||...|.||.|||.|.||||||.|||:..|||:.::|:.
Zfish   522 QGGPPAALVKVF-------KFIMKQSYICALIAMMAWSITYVSWLTFVFLIWSCTLWMVRDRRKY 579

  Fly   416 MMRSSLFVVFYSQILLLAQYIYGMNLYESELPTKVTSCGLNLEQIGFVHPQSKDSLPWIPLTVKT 480
            .|.:|.|:|.|...||:.|||:   .:|...|..           ||.   .|..:|:..|:.|.
Zfish   580 AMLTSPFMVAYGNFLLVLQYIW---CFEKLKPVS-----------GFF---VKMEVPFTELSTKV 627

  Fly   481 VFLFVFWVTSRQYFREISLDRQQSDLLQQIFATHRSRSEHLLSKKSQTPQIFIYILKSTSHFITR 545
            :....||:..||...|....:::...|..|....:.:.|....::.....:...:.|.....:.:
Zfish   628 LCQLSFWLLLRQTLMERQERKEEEAALSDIKVDEQKKVEEKSEEEVDENDLMQVLGKLVMALLVK 692

  Fly   546 IWMWLLIFLIFLCAMIDRTMTGIRICYMSLFLLFLMVFQMSLQLWIRFLYGYWIFLIFYAMTILT 610
            .|:::...:.|..: .:..|...:|.||.:.|..:.::|:..:.|.|.|..:|:.::.|.|.:|.
Zfish   693 YWIYVCGGMFFFVS-FEGDMATYKIIYMMMLLSCVALYQVHYEYWRRILKYFWMSVVVYTMLVLI 756

  Fly   611 AIYTYQFDHFDYYWEKFLKVHSTLQCDIGLRRYQTKDLFLHLLIPTLTVIFTVVQLHYFHRRFVE 675
            .|||.||:.....|.:...:...:..||||.::...:||..:.|||..::..::.|||||..|:|
Zfish   757 LIYTSQFEDGIPTWTRMTGLDKDVLKDIGLEKFSLSNLFTRIFIPTSFLLVCILHLHYFHDHFLE 821

  Fly   676 ------SVRRPRST-------EGQNFHLAPNAETR--ASQKTL---------------------- 703
                  .|.:..||       .|:.:.:..:.:.:  :||..|                      
Zfish   822 LTDLKAVVSKQESTIYSYAKVSGRIYLIVDSIKQKISSSQSKLAHPDGSLADLTIVSSSPEPLLK 886

  Fly   704 -------------------------------------DIHRQS------------------WKVF 713
                                                 |:|:.|                  |.:.
Zfish   887 DEKEKESLNEVLVVDCVGEEKKKDSLSIYSAQMSSQEDVHQSSAATDPELPSEQSSEMKNKWHLV 951

  Fly   714 FDAGYENVRAKGRQLFNPGKIVAWKFLEMHMIKTVTLASFYCAISEICFLNLFLVILSLLGICGN 778
            .|. ...:..|..:.|:..|:..|..||||:||.|.......::.|:..||...:|.....:...
Zfish   952 VDR-LTVLFLKFLEYFHKLKLFVWWLLEMHIIKIVATYIILLSVKEVSLLNFVFLISWAFALPYK 1015

  Fly   779 RFLRRVIFRAV-TFWISLLVLMKMIYQIKYLDQSHYNFKC--GNVT----------------VNF 824
            :|  ||:..:| |.|..::::.|:.||:|.::.::|:..|  .|.|                |:.
Zfish  1016 QF--RVLSSSVCTVWTCVIIVCKLFYQLKTINPANYSSDCIMPNYTETEKKDMKTSLLYRDPVDP 1078

  Fly   825 AEWMGLRKTGTVFGVHLRYISSYIIYMILTSLHAVV-------KLRDHLIRYSTHKQKDTKLLFP 882
            |.|:||||..  .|:.|..:.:.::.:.|.:....:       :||:.|      ....::.:|.
Zfish  1079 ANWVGLRKFD--HGIILPNLRNNLLMLALLAFEVTIYRHQEFFRLRNKL------SPPPSRTIFH 1135

  Fly   883 DITRQDAERDFPGLLKYVLNYGYFKFGFEITMIGLMSTIAHRRDLFALTYLIWLVLLLCLSRFRC 947
            |||||..:.......||.:||.::|||.|:..:..::.:..|.|.:::.:.:.|.:::...|.:.
Zfish  1136 DITRQHLDNGIIECAKYFINYFFYKFGLEVCFLLAINVMGQRMDFYSMVHGLALAVVMFRRRRKA 1200

  Fly   948 -ARIWEMLQLYFVLSIFVQYVYLLNFPPNLC--------------NVISYNSLWSISGSKNYTNR 997
             |.||.....:....|..||...:..||..|              |||.:..|...     :|..
Zfish  1201 IAEIWPKYCCFLACMITFQYFICIGIPPAACADYPWRFPNSSMTSNVIKWLYLPDF-----HTPP 1260

  Fly   998 SNIM--FDYIVLLLISRQRKSFRVEMRHINDLSYR--GGVNTNVVHNIAKLGHVYFENPTHDFCT 1058
            |::.  :|:::||..|.||:.|..|    |..:.|  .|.|..:..:: ........||..|| .
Zfish  1261 SSMFLGYDFMLLLCASLQRQVFDEE----NKAAVRLMAGDNVEICRDL-DAASFSVHNPVPDF-I 1319

  Fly  1059 YVRNYADVLKTAIFFSFFWITLAIVFLGGVCSTDILSLGYIIFALIFLLQGSEIYLQNIHFIICR 1123
            :.|:|.|:||..:|...||..|.|:|:.|.....|..:||::....|||.|.::.|:.|..|:..
Zfish  1320 HCRSYLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGQLLLKPIKEILRY 1384

  Fly  1124 WNCLIAFNIFNIIVKVAIIVLE-GTINLEHKS------ILSIVFNVMHQTAPCENIMDGKFFEIN 1181
            |:.|||:|:|.|.:|....:|. |.||...|:      :||:...:                   
Zfish  1385 WDFLIAYNVFVITMKNVFAILACGYINSLVKNSCWLIQLLSLACTI------------------- 1430

  Fly  1182 EISEKKY----------CYGPSDMIFKNTLVWHAIIFSFVVFQYRIFGSYYFCHVIMDTQANTIL 1236
                |.|          |..|.|   :..::|.:|.|:|::.|.|:|.||||.|||.|.:|..||
Zfish  1431 ----KDYQPKTDLPGVDCELPKD---EAGIIWDSICFTFLLLQRRVFMSYYFLHVIADIRAGQIL 1488

  Fly  1237 ASRGAAIIENLHYKQIYDRRKNEQSVLERVKMKMERIRITNRRHQK---------QATGLDFQPH 1292
            |||||.:.:....|.:..|.:.|:..:|::|.:|:||:...::.::         |.:| |.:..
Zfish  1489 ASRGAELFQASIVKAVRARLEEEKKSMEQLKRQMDRIKTRQQKFKRGKEKMLSIAQESG-DGEKL 1552

  Fly  1293 KPPSSIIHVHYRAEEKSKLKTLNNEFLTTIKQAERDTYFSRSLKPRRRDLSLHPHAVRTGDYYMF 1357
            .||  :.:.....|||.|.|....::.                    |....|...||:||||:|
Zfish  1553 IPP--VDNEEEEDEEKKKNKVQKKQWW--------------------RPWVDHASMVRSGDYYLF 1595

  Fly  1358 NELDDDDDLDVYEEYDFLEKEDVRARQMRQSLRS------------------------RASNY-- 1396
             |.|.:::   .||.:..::|..:....::::|.                        ||:.:  
Zfish  1596 -ETDSEEE---EEEEEKKDEEPPKRSAFQRAIRKFASALVALPRSIIKLPKTILQYLIRAAKFVY 1656

  Fly  1397 --------------NRSKSFL---------------------NDENSDTDTKKLE---------- 1416
                          .:.|.|.                     .||...::.:|.:          
Zfish  1657 HTWIAESKAALKERGKGKRFWKRYGRRHKKEKKEEHVAIEIGEDERQSSEEEKTDGPDNIIKRVF 1721

  Fly  1417 -----THPVIILTSELIVLLTFRLNRLSKNF-------RFVHKMLSAEKKK-------------- 1455
                 |..:.:.|.|.|   |..||.:.:.:       |....||:.|.||              
Zfish  1722 NIIKFTWALFLTTVESI---TKWLNSVCREYIDISTVLRIERCMLTREVKKGNVPSRESIHVYYQ 1783

  Fly  1456 ------------LQNI----SIMNR---------------------------------------- 1464
                        |..|    |..||                                        
Zfish  1784 KQMKLNGSRESGLDRISEEDSASNRERRRRAQHSLDSFASRDSISSAYTEATMLFSRQSTLDDLD 1848

  Fly  1465 ----------------------LGLSNTAA----------------------------------- 1472
                                  |.:||::|                                   
Zfish  1849 DMPQNIPKTSERARPKLRKMYGLDMSNSSADSGSSVISSEATQCVTLFSRQGTNDTIDEAEDERE 1913

  Fly  1473 ----------------------------------------------------------------- 1472
                                                                             
Zfish  1914 QLEHKQKTEEAELRDKPEEEQEVETSDQGKQEVLPVSHLVTQEVKEDVLPVSDQLTGEVTEEVEE 1978

  Fly  1473 -------MFKFLNKSLNNKVIKEA------------------------------GSYYVSQD--- 1497
                   |.:.:.|.:..||.||.                              |...:.||   
Zfish  1979 EVEVVKEMEEEVEKEIGAKVEKEVEAEKEEEVGEEVQWDLVDPEEAEECVSDGEGGEQMQQDEGE 2043

  Fly  1498 ----------------------------------------------------------------- 1497
                                                                             
Zfish  2044 WSGVENVVSGPLFTPDTDAPNTSDADVPPSYSKAVSFDRLSVSSDDSDSDKRLMLMTPDSKSDLD 2108

  Fly  1498 --------NDFTT-------------LDHND--------FVQMLIALWYALIANTETICYLVVFL 1533
                    .|.|.             ||.:|        .:|:..||:..|:|::|.:||||:.|
Zfish  2109 DPLLPSMTTDMTASELLLNKMFYDEMLDSSDRFYKSQPLGLQLCYALYNLLVAHSEMVCYLVIIL 2173

  Fly  1534 NQAANSSVISLPMPFLVLCWGALTLPRPSKTFWVTLITYNLTMIFVKSIMHQRVL-LDQQL-VSR 1596
            |...::|:.:|.:|.|:..|..|::|||||.||:|.|.|....|.:|........ .:|.| |::
Zfish  2174 NHMISASMATLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFSFFPFNQNLEVNK 2238

  Fly  1597 S------NSLSFELIMKRGRAVYDLLLLVVLFWHQYMLKKQGIW--------------------- 1634
            .      |.|..|  .|.|...|||:.|:.||:|:.:||..|:|                     
Zfish  2239 GKPYHPPNILGTE--KKDGYVHYDLVQLLALFFHRSILKCHGLWDEDDPKVPRKDECPRQESVDD 2301

  Fly  1635 -------------------TIQRTNSELLLLEKKRNHYKRSFSKERPE-----------NIRKLL 1669
                               :::..|.. :.::..:.|.:..:.::||.           :.|...
Zfish  2302 GKLSVVMSPDEDRKSSPAYSLKSMNLG-MSVDSSQVHIQMRYPEQRPYLRRQSTSGSHFSHRSSA 2365

  Fly  1670 REEGGGEQVKAVRPNAIEFKREMDDILLPALENK-YVYQNIESEYYRKAMQGLANKGGLLSGFRK 1733
            |.:.|....:    ::...:....:..:|....| .:.:.|..:..:..:..|..........|:
Zfish  2366 RSKRGSTSTR----HSTHGENSTTESEVPQKSRKEMIMEKIREQLIKAKVYLLKRLVEFYQPIRQ 2426

  Fly  1734 FFLALRHKSRLS-TDVYTLLFLCDFISFFILLFGFPKFVYRYKYSTSVLETYIQGNKVPFTFLLM 1797
            ||..|.|....: ||||.|:||.|.:.|.|::|||  :.:......:.:.:.:..::||..||:|
Zfish  2427 FFYNLVHPEYSAVTDVYVLMFLADTVDFIIIVFGF--WAFGKHQGGADITSSLSEDQVPGPFLVM 2489

  Fly  1798 LIVQFITIVTERAIYLRKALIYKIFFHFISVLGIHIWMFFLVPYITSHSFGE-TAPVLFYLIKCL 1861
            :::||.|:|.:||:||||.::.|:.|..|.|.|||.||||::|.||...|.: |...|:|.:||:
Zfish  2490 VLIQFGTMVVDRALYLRKTVVGKVIFQVILVFGIHFWMFFILPGITERRFSQNTIAQLWYFVKCI 2554

  Fly  1862 HMLLSAYQIRCGYPKRILGNVFTKGYSLANYIAFKIYMEIPFLYILRTMLDWVCIDTTLTVMEWI 1926
            :..|||||||||||.|||||..||.|:.||...|:.:..||||..||.::|||..||||::..||
Zfish  2555 YFGLSAYQIRCGYPTRILGNFLTKSYNYANLFLFQGFRLIPFLTELRAVMDWVWTDTTLSLSSWI 2619

  Fly  1927 KMEDIFQSVFIVRCYRQMDTDFPVLRGEPKALYSKLLIGGTIILILIALIWSPLFLFALVGTV-G 1990
            .:|||:..:||::|:|:.:..:|..||:.|....|..:||.|:::||.::|.||...:||.:| |
Zfish  2620 CVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAG 2684

  Fly  1991 KPNIPQKADITVKINHYEPIY-VSQSNSDILQFSNSDFQKLTNHIILDNYASDS---MML--YDA 2049
            ..|.|.:..:::.:...:||: :|...:.|...:.::|:|.|:|     |.|::   |.|  |..
Zfish  2685 VVNKPLEVSVSLTLGGLQPIFTMSAQQNHIKSVTGAEFKKFTDH-----YKSNANAIMFLESYFP 2744

  Fly  2050 VDVTAIKFYENSISLWNMPPPDKERLLHDLSN-GETLDIHLTLTLKCNLTPEAVIYETT----YT 2109
            .|:|......:|.|||.:.||.||.|.:.|:: .|...:..|.:::.||:..|.. ||.    :.
Zfish  2745 EDLTIAHLEGSSNSLWTISPPSKENLKNMLNDTREPFPLTFTWSIQRNLSLGAKA-ETAMGKYFI 2808

  Fly  2110 LTENKVHTRDKLIRLMSNNFSNEKVIIPNILPKFITVQRQQANAKFIKDY--DGKF-NRPIILTK 2171
            ..:|:  ||..|...:.|  |:::|.|..|.|::|... ..:|||.|...  ||:: :..:.|.|
Zfish  2809 ELDNE--TRKGLTDQLGN--SSQRVTIKKIFPRYIRAP-SDSNAKPIDQLYNDGEYMDITLFLNK 2868

  Fly  2172 IGKSQ--VYWWEMNDYCNDRFYTEILSALPLSNCENGVVLYVFNDKSFPSAMSFLEKTGIIGLYT 2234
            ...|:  ..||.:|...:        ..||..| .:|:.:|:.:|:..|.::.||...||:|||.
Zfish  2869 KNSSEGVQEWWIVNQTDS--------GPLPGLN-GSGLQIYIISDQVSPPSLGFLAGYGIMGLYM 2924

  Fly  2235 TFVYVVSRIIRSLIANNHRRIMFEDLPYVDRVLKLCTDIYLVRETQEYRLEEDLYGKLIFLYRSP 2299
            :.|.|:.:.:|...:.....||||:||.|||:|||||||:|||||.|..||||||.|||||||||
Zfish  2925 SVVLVIGKFVREFFSGISHTIMFEELPNVDRILKLCTDIFLVRETGELDLEEDLYAKLIFLYRSP 2989

  Fly  2300 ETLIKWTRFKED 2311
            ||:|||||.|.:
Zfish  2990 ETMIKWTREKSE 3001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PzlNP_001303493.1 PIEZO <1202..1391 CDD:464941 55/197 (28%)
Piezo_RRas_bdg 1901..2307 CDD:463481 155/422 (37%)
piezo2bXP_021323945.2 None

Return to query results.
Submit another query.