DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pzl and piezo1

DIOPT Version :10

Sequence 1:NP_001303493.1 Gene:Pzl / 26067051 FlyBaseID:FBgn0267430 Length:2161 Species:Drosophila melanogaster
Sequence 2:XP_002933721.3 Gene:piezo1 / 100488940 XenbaseID:XB-GENE-6050252 Length:2474 Species:Xenopus tropicalis


Alignment Length:2671 Identity:689/2671 - (25%)
Similarity:1166/2671 - (43%) Gaps:581/2671 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 IFLPLTLILVSLVRPVGLSYFYLLTFFLSPWLLQSNSLKQR--------TFLNVFIIFLCVLSTF 68
            :.||.:|:...|.|...||..||....|.||....|....|        ..|...|:|||     
 Frog    13 LLLPGSLLAACLFRYNSLSLVYLFYLLLLPWFAGPNPCSMRGHTGRLMKALLATSILFLC----- 72

  Fly    69 GIVGHIIFNLINLFFV----DLSSKN--SFSFILRQFGFLYFKGLSFVSIAHWILPDI-IVLLNT 126
               .|:||. |.|:.:    ||...|  |:..:.|..|..........::...:.||. :.:::.
 Frog    73 ---AHLIFQ-ICLYTIPELDDLLGHNCSSWDVLARHVGINRLDLSDIPNMVRQVSPDFGMFVVSA 133

  Fly   127 IVFFIFSEIKYKREKRVIQNDDDVFYKKSK-----------------ELKGALKVAEINRVL--- 171
            :...:.:.:..|:.:   |.....|.::.:                 |:.|.|.....:|:|   
 Frog   134 LCLGLCNRLVTKKRR---QRSSGYFEQEEERTELNLKYESRECDTEFEVGGDLHSVPRDRLLGSW 195

  Fly   172 ---IIVYIRSVLKTSLIFSLIVLYFAATLRPSLPGSLYFCMFIIAGSYWAL-FRQRKMYYSVIFM 232
               ....:...::.||  ::::|..|....||...:.|:.:||...::||. |...::.::.|.:
 Frog   196 LRKAAYRLLETVEKSL--AVLLLALAGITDPSAFSAPYYVVFIGLCTWWACHFPISQLGFNTICV 258

  Fly   233 IVALLV--HITCIFAYQLPVLQNTINCDKLWTRLMGMEVLIRLNKDNRNGKILE-----LNPKLN 290
            ||....  |:.|::.||.|.:|...:.::||.||.|:..:|      .:..|.:     ||..|:
 Frog   259 IVGFFTGGHMICLYIYQTPFIQQMFHPEQLWARLFGLHNII------SHSNITDCTHDSLNQNLD 317

  Fly   291 LDSYLSPIALMLAYFA------------------------------TTLSLINRSQYEISFNT-- 323
            ...|:.|..|:|.|::                              |.:..:::.||.....|  
 Frog   318 WPVYVHPGILLLLYYSLLSILKLKSSDKKRISGCDLRKSQQEDMELTDIEPVSKEQYSAGEETKP 382

  Fly   324 --IRMN----LGPKSNSIYDNIQPSNEENEEISIFTEPSMLEQFFYIVYELSSFVYKNSYILLNI 382
              .|||    ..|:..:::...:.||:..||:.. .|||   ||..:::.:.|    .|||...|
 Frog   383 MLQRMNTEEEAKPQDCTVHVIRRNSNQLPEELET-KEPS---QFHLMIHVILS----QSYICALI 439

  Fly   383 IMMIWSIVYHSWLTFVLLIWANILWMIPNQRRSMMRSSLFVVFYSQILLLAQYIYGMNLYESELP 447
            .||:|||.||||||||||:||.::||:.|:|:..|..|.|::.|...|...||::.|:|.| |||
 Frog   440 AMMVWSITYHSWLTFVLLLWACLIWMVRNRRQFAMLCSPFILMYGVTLCSLQYVWSMDLRE-ELP 503

  Fly   448 TKVTSCGLNLEQIGFVHPQSKDSLPWIPLTVKTVFLFVFWVTSRQYFREISLDRQQ--SDLLQQI 510
            |::..  :.|.|:|.|    :...|.:.:....::...||:...|:..|..|.|::  |.|| ::
 Frog   504 TQLGF--MKLSQLGLV----RAPYPCLNMGALLLYTLTFWLLLHQFVTEKFLKRKKFMSPLL-EV 561

  Fly   511 FATHRSRSEHLLSKKSQTPQIFIYILKSTSHFITRIWMWLLIFLIFLCAMIDRTMTGIRICYMSL 575
            ......:.::||.:..:.       :||   |..:.|:::...:..:.:...|.:. .:|.||.|
 Frog   562 TVADAGKEKNLLKRFGEQ-------VKS---FYAKYWIYVCGGMFIVVSFAGRLVV-YKIVYMLL 615

  Fly   576 FLLFLMVFQMSLQLWIRFLYGYWIFLIFYAMTILTAIYTYQFDHFDYYWEKFLKVHSTLQCDIGL 640
            |||.|::||:...||.:.|..:|..::.|.|.:|..|||:||:.|..||:....:......||||
 Frog   616 FLLCLVLFQVYYSLWRKLLTFFWWLVVAYTMLVLITIYTFQFEEFPEYWKNLTNLTDEQLGDIGL 680

  Fly   641 RRYQTKDLFLHLLIPTLTVIFTVVQLHYFHRRFVESVRRPRSTEGQNFHLAPNAETRASQKTL-- 703
            .|:...:||..:|||...::..::|||||||.|:.......::...:||...:.:.:..::..  
 Frog   681 ERFSVSELFTSILIPGFFLLACILQLHYFHRPFMHMTNLAHASCQGSFHSHESEQPKEEEEKAGA 745

  Fly   704 ------------------------DIHRQSWKVFFDAGYENVRAKGRQLFNPGKIVAWKFLEMHM 744
                                    |:..|...|        :..|..:|.:..::..|:.||:|:
 Frog   746 CSDAAADEEEDEEESAHGADLSKWDLVTQRLSV--------LSFKFSELLHRLQVFLWRLLELHV 802

  Fly   745 IKTVTLASFYCAISEICFLNLFLVILSLLGICGNRFLRRVIFRAVTFWISLLVLMKMIYQIKYLD 809
            :|.|.|.|.:.|:.|:..:|...|:|....:..:|| :.:.....|.|.|::::.||:||:..::
 Frog   803 LKLVALYSVWVALQEVSVMNFLFVVLWAFAMPFSRF-QHMASCLCTIWTSIIIVCKMLYQLTVVN 866

  Fly   810 QSHYNFKCGNVTVNF--------------------AEWMGLRKTGTVFGV-HLRYISSYIIYMIL 853
            ...|:..|....:|.                    |.|.|:||     |. :|.||.:::..::|
 Frog   867 PLEYSSNCTQPPLNNTSLLEDEILNSTLYREPIDPANWFGIRK-----GYPNLGYIQNHLQILLL 926

  Fly   854 TSLHAVVKLRDHLIRYSTHKQK-DTKLLFPDITRQDAERDFPGLLKYVLNYGYFKFGFEITMIGL 917
            ....|:|.......|.....:| ..:.:|||:.|:..::.....:||.:||.::|||.||..:..
 Frog   927 LVFEAIVYRHQEFYRKQYQLEKPHIQAVFPDVYREHLDQGLFSCIKYFINYSFYKFGLEICFLLT 991

  Fly   918 MSTIAHRRDLFALTYLIWLVLLLC-LSRFRCARIWEMLQLYFVLSIFVQYVYLLNFPPNLCNVIS 981
            ::.|..|.:...:.:..||:::|. ..|...|::|....::.:..:..||:..|..||.||  |.
 Frog   992 VNVIGQRMNFMVIFHGCWLIVILTRRQRVNIAKLWPKYCVFLIFFLLWQYMICLGIPPVLC--ID 1054

  Fly   982 YNSLWSISGSKN------------YTNRS--NIMFDYIVLLLISRQRKSFRVEMRHINDLS---Y 1029
            |...|......|            ||...  |::.|:::|:.:::|.|.|      ||:..   |
 Frog  1055 YPWRWDTFVPVNSALIKWLYLPDFYTTPKSVNLISDFVLLIGVAQQWKVF------INEKKEEWY 1113

  Fly  1030 RGGVNTNVVHNIAKLGHVYFE------NPTHDFCTYVRNYADVLKTAIFFSFFWITLAIVFLGGV 1088
                 |....|:.:     :|      ||..:|.. .::|.|::|.|:|...||..|.:||:.|.
 Frog  1114 -----TMAGENVEE-----YEAPKDRPNPVPNFIN-CQSYLDMVKVAVFRYLFWFVLTVVFITGA 1167

  Fly  1089 CSTDILSLGYIIFALIFLLQGSEIYLQNIHFIICRWNCLIAFNIFNIIVKVAIIVLEGTINLEHK 1153
            ....:..|||::.....||.|:.:..:.:...:..|:|||.:||..|:.|..:            
 Frog  1168 TRISVFGLGYLMSCFYLLLSGTTLLQKPMKAKLVLWDCLILYNITVILSKNML------------ 1220

  Fly  1154 SILSIVFNVMHQTAPCENIMDGKFFEINEISEKKYCYGPSDM---------IFKNTLVWHAIIFS 1209
            |:||.||....||..|..|   :.|.:  :...|..|.|.||         :.:..::|.:|.|.
 Frog  1221 SLLSCVFVQQMQTNFCWVI---QLFSL--VCTVKGYYNPQDMDKDRDCSLPVEEAGIIWDSICFL 1280

  Fly  1210 FVVFQYRIFGSYYFCHVIMDTQANTILASRG-----AAIIENLHYKQIYDRRKNEQSVLERVKMK 1269
            |::.|.|:|.|.||.||::|.:|:::..|||     |:|.:|:.:.|..:||.     |.:::.:
 Frog  1281 FLLLQRRVFLSCYFRHVVLDLRASSLQTSRGFELFMASIRKNVFFHQESERRS-----LNQLRKQ 1340

  Fly  1270 MERIRITNRRH---QKQATGLDFQPHKPPSSIIHVHYRAEEKSKLKTLNNEFLTTIKQAERDTYF 1331
            |||||....|:   ::|......:..:|.|.      :...:.|:                  ::
 Frog  1341 MERIRAKQERYHEGRRQTDSSQVKEGEPGSK------KGSSRQKI------------------HW 1381

  Fly  1332 SRSLKPRRRDLSLHPHAVRTGDYYMFNELDDDDDLD-----------------VYEEYDFLEKED 1379
            ||....       |...:.:|||::| |.|.::|.:                 .|:.:....|..
 Frog  1382 SRPWLD-------HASVLHSGDYFLF-ESDSEEDEESLLEQDQRPPKQSAFQLAYQAWVTSAKSA 1438

  Fly  1380 VRARQMRQSLRS------------------RASNYNRSKSFLNDENSDTDTKKLETHPVIILTSE 1426
            ::.|:.||..||                  ..:...|.|....|.|.:.....:....:.:|...
 Frog  1439 LKERKSRQKERSGKVEMVTVENNEAGGGTESHTQEPREKGEDKDLNEERGGSNVVQRILDVLKFL 1503

  Fly  1427 LIVLLTF------RLNRLSKNFRFVHKMLSAEK----KKLQNISIMNRLGL-------------- 1467
            .::||..      .|..|:|....:..:|..|:    :||.....:||..|              
 Frog  1504 WVLLLAMVDGLINWLGTLTKQHVDMSTVLWVERYIITQKLSKGEDINRRDLEKVYETGQDVREPR 1568

  Fly  1468 -------------------------------------------------------------SNTA 1471
                                                                         |.||
 Frog  1569 ISSPPTDMSTSIASSGCEEEELICSTAECTENITQLSTGYNTRSNSLDSIRGFPEIKPSHRSRTA 1633

  Fly  1472 AMFKFLNKSLNNKVIKEAGSYYVSQDNDFTTLDHNDFVQMLIALWYALIANTETICYLVVFLNQA 1536
            :.. .|::.|:...:.|:..::.||..         .:::|:||:..:.|::|.:||.::.||..
 Frog  1634 SEL-LLSRPLDFPELSESQHFFQSQSR---------ILRLLLALYNFVAAHSELLCYFIIILNNM 1688

  Fly  1537 ANSSVISLPMPFLVLCWGALTLPRPSKTFWVTLITYNLTMIFVKSIM--------HQRVLLDQQ- 1592
            .::|:|||.:|.|:..||.|::.:|||.||:|.|.:...|:.:|.:.        :..:|:..: 
 Frog  1689 VSASLISLFLPILIFLWGMLSIHKPSKRFWMTAIIFTEVMVVIKYLFQFGFFPWNNYTILVRNEG 1753

  Fly  1593 -------LVSRSNSLSFELIMKRGRAVYDLLLLVVLFWHQYMLKKQGIW---------------- 1634
                   ::....|.|:        ..|||:.|::||:|:.:|...|:|                
 Frog  1754 KPFFPPRVLGLEKSDSY--------IKYDLIQLLMLFFHRSLLMSYGLWDRKDLDLEERTPGKDK 1810

  Fly  1635 ----TIQRT-------NSELLLLEKKRNHYKRSFSKERPENIRKLLREEGGGEQVKAVRPNAIEF 1688
                .||.:       .|...|.::||...:.|..:      |..|:|:....|.|.....|:..
 Frog  1811 GSKTEIQASQDLEPAGGSSSSLRQRKRKESQGSVQE------RDSLKEKSLDVQKKKKGRVALRV 1869

  Fly  1689 K---REMDDILLPALENKYVYQNIESEYYRKAMQGLANKGGLLSGFRKFFLALRH-KSRLSTDVY 1749
            |   .:|.......:.|  :||.:::                      ||..:.| |:|.:||||
 Frog  1870 KIMGMKMQQFFACIVRN--IYQPVKA----------------------FFHDILHTKNRAATDVY 1910

  Fly  1750 TLLFLCDFISFFILLFGFPKFVYRYKYSTSV-LETYIQGNKVPFTFLLMLIVQFITIVTERAIYL 1813
            ..:||.|.:.|.|::|||..|   .|:|.:. :.:.:..::||..||:|:::||.|:|.:||:||
 Frog  1911 AFMFLADVVDFVIIVFGFWAF---GKHSAAADIASSLSDDQVPEAFLVMVLIQFSTMVIDRALYL 1972

  Fly  1814 RKALIYKIFFHFISVLGIHIWMFFLVPYITSHSFGE-TAPVLFYLIKCLHMLLSAYQIRCGYPKR 1877
            ||.::.|:.|..|.|:|||:||||::|.:|...|.: |...|:|.:||::..|||||||||||.|
 Frog  1973 RKTVLGKLIFQVILVIGIHVWMFFILPAVTERMFNQNTVAQLWYFVKCIYFALSAYQIRCGYPTR 2037

  Fly  1878 ILGNVFTKGYSLANYIAFKIYMEIPFLYILRTMLDWVCIDTTLTVMEWIKMEDIFQSVFIVRCYR 1942
            ||||..||.|:..|...|:.:..:|||..||.::|||..||||::..|:.:|||:.::||::|.|
 Frog  2038 ILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSR 2102

  Fly  1943 QMDTDFPVLRGEPKALYSKLLIGGTIILILIALIWSPLFLFALV-GTVGKPNIPQKADITVKINH 2006
            :.:..:|..:|:.|....|..:||.||:.||.:||.||...:|| ..||..|.|....:|.|:..
 Frog  2103 ETEKKYPQPKGQKKKKIVKYGMGGLIIVFLICIIWFPLLFMSLVRSVVGVVNHPIDVTVTFKLGG 2167

  Fly  2007 YEPIY-VSQSNSDILQFSNSDFQKLTNHIILDNYASDSMMLYDAVDVTAIKFYENSISLWNMPPP 2070
            |||:: :|.....|..|:...::.||........|...:.||...|:...:...:|.|:|.:.||
 Frog  2168 YEPLFTMSAQQQSIQPFTPQQYEALTYEFERQPTAMQFITLYSYEDIVTARIEGSSGSVWGISPP 2232

  Fly  2071 DKERLLHDLSNGETLDIHLTLT--LKCNLTPEAVIYETTYTLTENKVHTRD---------KLIRL 2124
            .:|::..:|.||.: ||.|..|  .:.:|.....:..|      ::.||:|         :|..|
 Frog  2233 SREQMRKELQNGSS-DITLRFTWDFQRDLAKGGTVEHT------SEKHTKDLEPGSQERMELADL 2290

  Fly  2125 MSNNFSNEKVIIPNILPKFITV----------QRQQANAKFIKDYDGKFNRPIILTKIGKSQ-VY 2178
            : ....:..|.|.::.||:|..          |.|....:...|.:.:.||..:......|. |.
 Frog  2291 L-QGVRDTPVSIQHLFPKYIRAPNGPEANPVKQLQPDEEESYLDVEVQLNRMRVAEGNSTSSFVE 2354

  Fly  2179 WWEMNDYCNDRFYTEILSALPLSNCE----NGVVLYVFNDKSFPSAMSFLEKTGIIGLYTTFVYV 2239
            ||                .:.|.:||    |.:.:.:||||..|.::.||...||:|||.:.|.|
 Frog  2355 WW----------------VITLKDCEGEDCNILPMVIFNDKVSPPSLGFLAGYGIMGLYVSIVLV 2403

  Fly  2240 VSRIIRSLIANNHRRIMFEDLPYVDRVLKLCTDIYLVRETQEYRLEEDLYGKLIFLYRSPETLIK 2304
            :.:.:|...:.....||||:||.|||:||||.|||:|||..|..|||:||.|||||||||||:||
 Frog  2404 IGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIYVVRERGELELEEELYAKLIFLYRSPETMIK 2468

  Fly  2305 WTRFKE 2310
            ||..|:
 Frog  2469 WTVDKD 2474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PzlNP_001303493.1 PIEZO <1202..1391 CDD:464941 49/213 (23%)
Piezo_RRas_bdg 1901..2307 CDD:463481 146/433 (34%)
piezo1XP_002933721.3 PIEZO 1223..1445 CDD:464941 61/263 (23%)
Piezo_RRas_bdg 2060..2470 CDD:463481 145/433 (33%)

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