DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pzl and piezo2a

DIOPT Version :10

Sequence 1:NP_001303493.1 Gene:Pzl / 26067051 FlyBaseID:FBgn0267430 Length:2161 Species:Drosophila melanogaster
Sequence 2:XP_073797454.1 Gene:piezo2a / 100334952 ZFINID:ZDB-GENE-131119-76 Length:2753 Species:Danio rerio


Alignment Length:2946 Identity:719/2946 - (24%)
Similarity:1168/2946 - (39%) Gaps:834/2946 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAEPLLF-IITRIFLPLTLILVSLVRPVGLSYFYLLTFFLSPWLLQSNSLKQRTFLNVFIIFLCV 64
            ||..||. :|.|:.||:.|....|.|...||:.||:...|.|...:.............:..||:
Zfish     3 MASELLCGLIFRLLLPVCLAAACLFRYNWLSFVYLVFLLLIPLFAEPTHATMTGHTGRLLKVLCL 67

  Fly    65 LSTFGIVGHIIFNL-INLFFVDLSSK-----NSFSFILRQFGFLYFKGLSFVSIAHWILPDIIVL 123
            .|...::.||||.: :|......|.:     :|:...:||.||...:|....:.....:|||.:.
Zfish    68 TSVTFLLLHIIFQITVNSLIAGESIQPRFNCSSWERSIRQIGFESVRGADAGNGIRVFIPDIGMF 132

  Fly   124 LNTIVFFIF----------------------------SEIKYKREKRVIQN----------DDDV 150
            :.::|.::.                            .|....||||.:::          |.|.
Zfish   133 VVSLVTWLLCRSLEKPSIKEDSQHNSDFEVDNQEKEDEEEDENREKRELEDELLFEDFELRDGDC 197

  Fly   151 FYKKSKELK--------GALKVAEI-----NRVL-IIVYIRSVLKT---SLIFS------LIVLY 192
            ...:::|.:        |.|:..:|     .|:| .|....|.||.   :||.|      .::|.
Zfish   198 ELPENEEEEEEAADADDGDLEEPDIEESTKTRILRQIADAASKLKEIVGNLITSAGKVVVTVLLG 262

  Fly   193 FAATLRPSLPGSLYFCMFIIAGSYWALFRQ-RKMYYSVIFMIVALLV--HITCIFAYQLPVLQNT 254
            ....:.|||..|:||..|:...::|:..|. ..:.:|.:.:::|:..  |:..::.||....|..
Zfish   263 LTGMMLPSLTSSVYFFTFLGLCTWWSFCRSFDPLLFSCLCVLMAIFSAGHLVFLYLYQFQFFQEA 327

  Fly   255 INCDKLWTRLMGMEVLIRLNKDNRNGKILELNPKLNLDSYLSPIALMLAYFATTLSLINRSQYEI 319
            :.....:..|.|:..:::  .|..:..:.::||.|....:::||.|::.|:  ||:.:.|...:.
Zfish   328 VPPGNTYASLFGISPVVQ--TDCSHTWMFKVNPALEWHHFVNPIMLLVLYY--TLATLIRLWLQE 388

  Fly   320 SFNT-IRMNLGPKSNSIYDNIQPSNEENEEISIFT----------------------------EP 355
            |.:| :|   ..::....|...|   ||.:|:::|                            .|
Zfish   389 SEDTQVR---DAEAEGKDDAASP---ENTDINVYTADQRRQLWRMAHYHTDERNLLTAQEAYNSP 447

  Fly   356 SML-----------------------EQFFYI-------------------VYELSS-------- 370
            .:|                       |:..|.                   ||.:.|        
Zfish   448 EVLIVTSNGASLDFTSVSHEKRTKCVERNLYSTPHYKADQPESDTQSLDCGVYRIDSAYVELSEL 512

  Fly   371 ---------------FVYKNSYILLNIIMMIWSIVYHSWLTFVLLIWANILWMIPNQRRSMMRSS 420
                           |:.|.|||...|.||.|||.|.||||||.|||:..|||:.::|:..|.:|
Zfish   513 PVAVVRVNSVVKVFRFIMKQSYICALIAMMAWSITYVSWLTFVFLIWSCTLWMVRDRRKYSMVTS 577

  Fly   421 LFVVFYSQILLLAQYIYGMNLYESELPTKVTSCGLNLEQIGFVHPQSKDSLPWIPLTVKTVFLFV 485
            .|:|||..:|::.|||:.   :|...|..    ||.|          |..:|:..|..||:.|..
Zfish   578 PFMVFYGNLLIILQYIWS---FECLQPVP----GLFL----------KKEVPFRELGSKTLCLLS 625

  Fly   486 FWVTSRQYFRE----ISLDRQQSDL--------LQQIFATHRSRSEHLLSKKSQTPQIFIYILKS 538
            ||:..||:..|    .:.|.|.||:        ||...|.||...|.|.|              |
Zfish   626 FWLLLRQFLTERREKHTDDPQLSDVTVDGHKLGLQDEAAGHREMMEVLGS--------------S 676

  Fly   539 TSHFITRIWMWLLIFLIFLCAMIDRTMTGIRICYMSLFLLFLMVFQMSLQLWIRFLYGYWIFLIF 603
            ....:.:.|:::...:.|..:...|.:. .:|.||.:||..:.::|:..:.|...|..:|:.::.
Zfish   677 LMAMLNKYWIYICGGMFFFVSFEGRIVM-YKIIYMMMFLFCVALYQLHYERWRWMLKYFWMSVVV 740

  Fly   604 YAMTILTAIYTYQFDHFDYYWEKFLKVHSTLQCDIGLRRYQTKDLFLHLLIPTLTVIFTVVQLHY 668
            |.|.:|..:||:||:.....|.....:......|:||.::....||..:.|||..::..::.|||
Zfish   741 YTMLVLILVYTFQFESSINVWSNMTGMSREKLEDLGLEKFSVPALFTRIFIPTWFLLVCILHLHY 805

  Fly   669 FHRRFV-----------------------------------------ESVRRPRSTEGQNFH--- 689
            ||.||:                                         |.|.:....|..|:|   
Zfish   806 FHERFLELTDIKTVADKQKSTISRLVHLDGSLVDISMIKPTFNSTNEEEVEKQEDEEDNNYHNED 870

  Fly   690 ---------------------------LAPNAETRASQKTLDIHRQSWKV-----------FFDA 716
                                       ..|.......::|.:: :..|.:           |.|.
Zfish   871 EDEDERVELEEEDVKQTEEQKMEDSLFTCPMTADPVLEQTSEL-KSKWHLVVERLTVLFLKFLDC 934

  Fly   717 GYENVRAKGRQLFNPGKIVAWKFLEMHMIKTVTLASFYCAISEICFLNLFLVI--LSLLGICGNR 779
                  .:..|||      .|..||:|:||.|:....:..:.|:...|...|:  ...|..|..|
Zfish   935 ------IQKLQLF------IWWILELHIIKIVSSYIIWVCVKEVSLFNYVFVVSWAFALPFCQFR 987

  Fly   780 FLRRVIFRAVTFWISLLVLMKMIYQIKYLDQSHYNFKCG---NVT----------------VNFA 825
            .|...:   .|.|..::::.||:||:..:..:.|...|.   |.|                |:.|
Zfish   988 PLASSV---CTVWTCIIIVCKMLYQLTSISPAAYARNCSMPDNYTEAQRMDMAKSLLYIGPVDPA 1049

  Fly   826 EWMGLRKTGTVFGVHLRYISSYIIYMILTSLHAVVKLRDHLIRYSTH-KQKDTKLLFPDITRQDA 889
            .|:||||    |...|.|:.:.::.:.|.:....:.......|...: ....|:.:|.:||||..
Zfish  1050 NWIGLRK----FSPLLEYLRNNLLMLALLAFEVTIYRHQDFYRMKNNITPPVTRTIFHNITRQHL 1110

  Fly   890 ERDFPGLLKYVLNYGYFKFGFEITMIGLMSTIAHRRDLFALTYLIWLVLLLCLSRFRC-ARIWEM 953
            :.......||.:||.::|||.|...:..::.|..|.|.||:.:...|:.::...|.:. |.:|..
Zfish  1111 DDGIVNCAKYFINYFFYKFGLETCFLLAVNVIGQRMDFFAMLHAFGLIAVMYQRRRKAIAHVWSK 1175

  Fly   954 LQLYFVLSIFVQYVYLLNFPPNLC--------------NVISY----------NSLWSISGSKNY 994
            ...:....:..||:..:..||..|              |||.:          |||:        
Zfish  1176 YCCFLACLLSFQYLMCIGIPPAACTDYPWRRSSSSMDSNVIKWLYFPDFHTKPNSLF-------- 1232

  Fly   995 TNRSNIMFDYIVLLLISRQRKSFRVEMRHINDLSYRGGVNTNVVHNI--AKLGHVYFENPTHDFC 1057
                 :::|:::||..|.|.:.|..|.  ::.:....|.|..:..::  |....   .||..|| 
Zfish  1233 -----LLYDFMLLLCASLQGRVFEEEC--VSPVQLLAGDNVEICRDLDAATFSQ---HNPVPDF- 1286

  Fly  1058 TYVRNYADVLKTAIFFSFFWITLAIVFLGGVCSTDILSLGYIIFALIFLLQGSEIYLQNIHFIIC 1122
            .:.|:|.|:||..:|...||..|.|:|:.|.....|..:||::....||:.|.|:.|:.|..|:.
Zfish  1287 IHCRSYLDMLKVMVFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLIFGGELLLKPIKSILH 1351

  Fly  1123 RWNCLIAFNIFNIIVK-VAIIVLEGTIN---LEH---KSILSIVFNVMHQTAPCENIMDGKFFEI 1180
            .|:.|||:|:|.|.:| :..|...|.|.   ..|   ..:.|:...:...:.|            
Zfish  1352 YWDFLIAYNVFVITMKNILSIAACGYIKALVANHCWLIQLFSLACTIKGYSKP------------ 1404

  Fly  1181 NEISEKKYCYGPSDMIFKNTLVWHAIIFSFVVFQYRIFGSYYFCHVIMDTQANTILASRGAAIIE 1245
             |....|.|..|||   :..::|.:|.|:|::.|.|:|.||||.||:.|.:::.:||||||.:.:
Zfish  1405 -EQQANKQCELPSD---EAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIRSSQLLASRGAELFQ 1465

  Fly  1246 NLHYKQIYDRRKNEQSVLERVKMKMERIRITNRRHQKQATGLDFQPHKPPSSIIHVHYRAEEKSK 1310
            ....|.:..|.:.|:..::.:|.:|:||:   .|.||...|.:           .:...|:|..:
Zfish  1466 ATIVKAVKARIEEEKKSMDLLKRQMDRIK---SRQQKFKRGKE-----------RMLSLAQESGE 1516

  Fly  1311 LKTLNNEFLTTIKQAERDTYFSRSLKPRRRDLSLHP---HA--VRTGDYYMF-----NELDDDDD 1365
            ..::..|     ::.|.:...|:..|..:|.....|   ||  ||:|:||:|     .|.:|:|.
Zfish  1517 RHSVLKE-----EEEEEEEESSKEKKKGKRKQWWRPWVDHASMVRSGNYYLFETDSEEEEEDEDR 1576

  Fly  1366 LD----------VY------------------------------------------EEYD----- 1373
            .|          ||                                          ||.|     
Zfish  1577 KDEEPKRSAFQFVYHAWITDSKTAMKERRKEKRRFWQKYTESNTNKREQKEANVTVEEGDQDGVT 1641

  Fly  1374 -------------------------FL-------------------------------------- 1375
                                     ||                                      
Zfish  1642 EDELSDSPDNMMKRVFNMVKFSWVLFLALLDSFTAWLNSICQEHIDISSVLRIERCMLTHEAKKG 1706

  Fly  1376 ---EKEDVRARQMRQSLRSRASNYNRSKSFLNDENSDTDTKKLETHP------------------ 1419
               .::.:|....||..|..::    ..|....|.:.:|...|.|.|                  
Zfish  1707 NVPSRDSIRMYYQRQMCRPAST----QSSLEPTEEAYSDFSPLRTDPDLPPQEHTELQTSTENLA 1767

  Fly  1420 VIILTSELIVLLTFRLNRLSKNFRFVHKML--------------SAEKKKLQNISIMNRLGLSNT 1470
            .:...|.::...|....|:.|..:.....|              :|..::.|...:.:|.|.|:|
Zfish  1768 SVYTESSIVEDSTLDEERVLKTSQRSRPKLCRISGVDVPSSADSAASSERTQGTELYSRQGTSDT 1832

  Fly  1471 AAMFKFLNKSLNNKVIKEAGSYYV-SQDNDFTTLDHND--------------------------- 1507
                           ::|.|:..: |..:|.....|.|                           
Zfish  1833 ---------------VEECGADTLWSSASDLLQTPHRDVPPSYSRATGLDCICDERKLKIQTPED 1882

  Fly  1508 -----------------------------------------FVQMLIALWYALIANTETICYLVV 1531
                                                     .:|:..:|:..|:::::.:||||:
Zfish  1883 SSSGTPQTSSHRLTASELLQTRMFYDADLEQSERFYRSQPQLLQLCYSLYNVLVSHSQMVCYLVI 1947

  Fly  1532 FLNQAANSSVISLPMPFLVLCWGALTLPRPSKTFWVTLITYNLTMIFVKSIMHQRVLLDQQLVSR 1596
            .||...::||.:|.:|.|:..|..|::|||||.||:|.|.|....|.:|...........|.:..
Zfish  1948 ILNHMISASVATLVLPVLIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPFNQSIEV 2012

  Fly  1597 SNSLSFE------LIMKRGRAVYDLLLLVVLFWHQYMLKKQGIW--------------------- 1634
            ..|..|.      :..|.|...|||:.|:.||:|:.:||..|:|                     
Zfish  2013 DKSKPFHPPNIIGVEKKEGYVHYDLVQLLALFFHRSILKCYGLWDEEEPRSVSPHTHSGAEEKAE 2077

  Fly  1635 ----------TIQRT--NSELLLLEKK---------------------------RNHYKRSFS-- 1658
                      |..||  ::.|.|..|:                           |:..:||.|  
Zfish  2078 CFSEKSPVEDTYTRTLSHTHLRLARKQQSSAGVRRQSSSISQRSARSKTGSSVSRSSVRRSLSAQ 2142

  Fly  1659 -KERPENIRKLLREEGGGEQVKAVRPNAIEFKREMDDILLPALENKYVYQNIESEYYRKAMQGLA 1722
             |.|.|.:.:.|||:       .:|......|..: |:.:|                        
Zfish  2143 QKSRKELLMEKLREQ-------LIRAKRFTVKTVL-DVYIP------------------------ 2175

  Fly  1723 NKGGLLSGFRKFFLALRHKSRLS-TDVYTLLFLCDFISFFILLFGFPKFVYRYKYSTSV-LETYI 1785
                    .::||.:|.|....: ||||.|:||.|.:.|.|::|||..|   .|:|.:. :.:.:
Zfish  2176 --------IKQFFYSLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAF---GKHSAAADITSSL 2229

  Fly  1786 QGNKVPFTFLLMLIVQFITIVTERAIYLRKALIYKIFFHFISVLGIHIWMFFLVPYITSHSFGE- 1849
            ..::||..||:|:::||.|:|.:||:||||.::.|:.|..|.|.|||.||||::|.:|...|.: 
Zfish  2230 SEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQN 2294

  Fly  1850 TAPVLFYLIKCLHMLLSAYQIRCGYPKRILGNVFTKGYSLANYIAFKIYMEIPFLYILRTMLDWV 1914
            |...|:|.:||::..|||||||||||.|:|||..||.|:..|...|:.:..:|||..||.::|||
Zfish  2295 TVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYLNLFLFQGFRLVPFLTELRAVMDWV 2359

  Fly  1915 CIDTTLTVMEWIKMEDIFQSVFIVRCYRQMDTDFPVLRGEPKALYSKLLIGGTIILILIALIWSP 1979
            ..||||::..||.:|||:..:|:::|:|:.:..:|..||:.|....|..:||.|:::||.::|.|
Zfish  2360 WTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFP 2424

  Fly  1980 LFLFALVGTV-GKPNIPQKADITVKINHYEPIY-VSQSNSDILQFSNSDFQKLTNHIILDNYASD 2042
            |...:||.:| |..|.|....:|:.:..::||: :|...:.:.:.:.|||:...|..   ||...
Zfish  2425 LLFMSLVKSVAGVVNKPLDVSVTITLGGFQPIFTMSAQQNQLKELTESDFKNFINSY---NYVPS 2486

  Fly  2043 SMML---YDAVDVTAIKFYENSISLWNMPPPDKERLLHDLSNGETLDIHLTLTLKCNL-----TP 2099
            :|..   |.|.|||..:...:|.|||.:.||.::.|:..||..:...:.:|.:::.||     :.
Zfish  2487 AMQFLEAYRAEDVTVAELEGSSNSLWTISPPSRKNLMDVLSKEDQFPVTMTWSIQRNLSLGAKSE 2551

  Fly  2100 EAVIYETTYTLTENKVHTRDKLIRLMSNNFSNEKVIIPNILPKFITVQRQQANAKFIKDY--DGK 2162
            .|:....||.    .:.||.:||.|: |...|..|:|..:.|.||... ..:|||.|:..  ||.
Zfish  2552 FAMDKHVTYL----DIKTRQELIALL-NGTRNTPVLIEQVFPCFIRAP-SDSNAKPIEQLYEDGD 2610

  Fly  2163 FNR-PIILTKIGKSQ---VYWWEMNDYCNDRFYTEILSALPLSNCENGVVLYVFNDKSFPSAMSF 2223
            :.. .:.|.:...|.   ..||.:::          |.:......|.|:.||||:||..|.::.|
Zfish  2611 YKSIQLDLERSANSSEDLQEWWIVDE----------LRSAQKQQREAGLQLYVFSDKVSPPSLGF 2665

  Fly  2224 LEKTGIIGLYTTFVYVVSRIIRSLIANNHRRIMFEDLPYVDRVLKLCTDIYLVRETQEYRLEEDL 2288
            |...||:|||.:.|.|:.:.:|...:.....||||:||.|||:|||||||:|||||.|..|||||
Zfish  2666 LAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEDL 2730

  Fly  2289 YGKLIFLYRSPETLIKWTRFK 2309
            |.|||||||||||:|||||.|
Zfish  2731 YAKLIFLYRSPETMIKWTREK 2751

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PzlNP_001303493.1 PIEZO <1202..1391 CDD:464941 61/321 (19%)
Piezo_RRas_bdg 1901..2307 CDD:463481 154/421 (37%)
piezo2aXP_073797454.1 None

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