DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pzl and LOC100334952

DIOPT Version :9

Sequence 1:NP_001303493.1 Gene:Pzl / 26067051 FlyBaseID:FBgn0267430 Length:2326 Species:Drosophila melanogaster
Sequence 2:XP_021325930.1 Gene:LOC100334952 / 100334952 -ID:- Length:2752 Species:Danio rerio


Alignment Length:2931 Identity:718/2931 - (24%)
Similarity:1176/2931 - (40%) Gaps:805/2931 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAEPLLF-IITRIFLPLTLILVSLVRPVGLSYFYLLTFFLSPWLLQSNSLKQRTFLNVFIIFLCV 64
            ||..||. :|.|:.||:.|....|.|...||:.||:...|.|...:.............:..||:
Zfish     3 MASELLCGLIFRLLLPVCLAAACLFRYNWLSFVYLVFLLLIPLFAEPTHATMTGHTGRLLKVLCL 67

  Fly    65 LSTFGIVGHIIFNL-INLFFVDLSSK-----NSFSFILRQFGFLYFKGLSFVSIAHWILPDIIVL 123
            .|...::.||||.: :|......|.:     :|:...:||.||...:|....:.....:|||.:.
Zfish    68 TSVTFLLLHIIFQITVNSLIAGESIQPRFNCSSWERSIRQIGFESVRGADAGNGIRVFIPDIGMF 132

  Fly   124 LNTIVFFIF----------------------------SEIKYKREKRVIQN----------DDDV 150
            :.::|.::.                            .|....||||.:::          |.|.
Zfish   133 VVSLVTWLLCRSLEKPSIKEDSQHNSDFEVDNQEKEDEEEDENREKRELEDELLFEDFELRDGDC 197

  Fly   151 FYKKSKELK--------GALKVAEI-----NRVL-IIVYIRSVLKT---SLIFS------LIVLY 192
            ...:::|.:        |.|:..:|     .|:| .|....|.||.   :||.|      .::|.
Zfish   198 ELPENEEEEEEAADADDGDLEEPDIEESTKTRILRQIADAASKLKEIVGNLITSAGKVVVTVLLG 262

  Fly   193 FAATLRPSLPGSLYFCMFIIAGSYWALFRQ-RKMYYSVIFMIVALLV--HITCIFAYQLPVLQNT 254
            ....:.|||..|:||..|:...::|:..|. ..:.:|.:.:::|:..  |:..::.||....|..
Zfish   263 LTGMMLPSLTSSVYFFTFLGLCTWWSFCRSFDPLLFSCLCVLMAIFSAGHLVFLYLYQFQFFQEA 327

  Fly   255 INCDKLWTRLMGMEVLIRLNKDNRNGKILELNPKLNLDSYLSPIALMLAYFATTLSLINRSQYEI 319
            :.....:..|.|:..:::  .|..:..:.::||.|....:::||.|::.|:  ||:.:.|...:.
Zfish   328 VPPGNTYASLFGISPVVQ--TDCSHTWMFKVNPALEWHHFVNPIMLLVLYY--TLATLIRLWLQE 388

  Fly   320 SFNTIRMNLGPKSNSIYDNIQPSNEENEEISIFT------------------------------- 353
            |.:|:|   ..::....|...|   ||.:|:::|                               
Zfish   389 SEDTVR---DAEAEGKDDAASP---ENTDINVYTADQRRQLWRMAHYHTDERNLLTAQEAYNSPE 447

  Fly   354 --------------------EPSMLEQFFYI-------------------VYELSS--------- 370
                                .|..:|:..|.                   ||.:.|         
Zfish   448 VLIVTSNGASLDFTSVSHEKRPKCVERNLYSTPHYKADQPESDTQSLDCGVYRIDSAYVELSELP 512

  Fly   371 --------------FVYKNSYILLNIIMMIWSIVYHSWLTFVLLIWANILWMIPNQRRSMMRSSL 421
                          |:.|.|||...|.||.|||.|.||||||.|||:..|||:.::|:..|.:|.
Zfish   513 VAVVRVNSVVKVFRFIMKQSYICALIAMMAWSITYVSWLTFVFLIWSCTLWMVRDRRKYSMVTSP 577

  Fly   422 FVVFYSQILLLAQYIYGMNLYESELPTKVTSCGLNLEQIGFVHPQSKDSLPWIPLTVKTVFLFVF 486
            |:|||..:|::.|||:.   :|...|..    ||.|          |..:|:..|..||:.|..|
Zfish   578 FMVFYGNLLIILQYIWS---FECLQPVP----GLFL----------KKEVPFRELGSKTLCLLSF 625

  Fly   487 WVTSRQYFRE----ISLDRQQSDL--------LQQIFATHRSRSEHLLSKKSQTPQIFIYILKST 539
            |:..||:..|    .:.|.|.||:        ||...|.||...|.|.|              |.
Zfish   626 WLLLRQFLTERREKHTDDPQLSDVTVDGHKLGLQDEAAGHREMMEVLGS--------------SL 676

  Fly   540 SHFITRIWMWLLIFLIFLCAMIDRTMTGIRICYMSLFLLFLMVFQMSLQLWIRFLYGYWIFLIFY 604
            ...:.:.|:::...:.|..:...|.:. .:|.||.:||..:.::|:..:.|...|..:|:.::.|
Zfish   677 MAMLNKYWIYICGGMFFFVSFEGRIVM-YKIIYMMMFLFCVALYQLHYERWRWMLKYFWMSVVVY 740

  Fly   605 AMTILTAIYTYQFDHFDYYWEKFLKVHSTLQCDIGLRRYQTKDLFLHLLIPTLTVIFTVVQLHYF 669
            .|.:|..:||:||:.....|.....:......|:||.::....||..:.|||..::..::.||||
Zfish   741 TMLVLILVYTFQFESSINVWSNMTGMSREKLEDLGLEKFSVPALFTRIFIPTWFLLVCILHLHYF 805

  Fly   670 HRRFV-----------------------------------------ESVRRPRSTEGQNFH---- 689
            |.||:                                         |.|.:....|..|:|    
Zfish   806 HERFLELTDIKTVADKQKSTISRLVHLDGSLVDISMIKPTFNSTNEEEVEKQEDEEDNNYHNEDE 870

  Fly   690 --------------------------LAPNAETRASQKTLDIHRQSWKV-----------FFDAG 717
                                      ..|.......::|.:: :..|.:           |.|. 
Zfish   871 DEDERVELEEEDVKQTEEQKMEDSLFTCPMTADPVLEQTSEL-KSKWHLVVERLTVLFLKFLDC- 933

  Fly   718 YENVRAKGRQLFNPGKIVAWKFLEMHMIKTVTLASFYCAISEICFLNLFLVI--LSLLGICGNRF 780
                 .:..|||      .|..||:|:||.|:....:.::.|:...|...|:  ...|..|..|.
Zfish   934 -----IQKLQLF------IWWILELHIIKIVSSYIIWVSVKEVSLFNYVFVVSWAFALPFCQFRP 987

  Fly   781 LRRVIFRAVTFWISLLVLMKMIYQIKYLDQSHYNFKCG---NVT----------------VNFAE 826
            |...:   .|.|..::::.||:||:..:..:.|...|.   |.|                |:.|.
Zfish   988 LASSV---CTVWTCIIIVCKMLYQLTSISPAAYARNCSMPDNYTEAQRMDMAKSLLYIGPVDPAN 1049

  Fly   827 WMGLRKTGTVFGVHLRYISSYIIYMILTSLHAVVKLRDHLIRYSTH-KQKDTKLLFPDITRQDAE 890
            |:||||    |...|.|:.:.::.:.|.:....:.......|...: ....|:.:|.:||||..:
Zfish  1050 WIGLRK----FSPLLEYLRNNLLMLALLAFEVTIYRHQDFYRMKNNITPPVTRTIFHNITRQHLD 1110

  Fly   891 RDFPGLLKYVLNYGYFKFGFEITMIGLMSTIAHRRDLFALTYLIWLVLLLCLSRFRC-ARIWEML 954
            .......||.:||.::|||.|...:..::.|..|.|.||:.:...|:.::...|.:. |.:|...
Zfish  1111 DGIVNCAKYFINYFFYKFGLETCFLLAVNVIGQRMDFFAMLHAFGLIAVMYQRRRKAIAHVWSKY 1175

  Fly   955 QLYFVLSIFVQYVYLLNFPPNLC--------------NVISY----------NSLWSISGSKNYT 995
            ..:....:..||:..:..||..|              |||.:          |||:         
Zfish  1176 CCFLACLLSFQYLMCIGIPPAACTDYPWRRSSSSMDSNVIKWLYFPDFHTKPNSLF--------- 1231

  Fly   996 NRSNIMFDYIVLLLISRQRKSFRVEMRHINDLSYRGGVNTNVVHNI--AKLGHVYFENPTHDFCT 1058
                :::|:::||..|.|.:.|..|.  ::.:....|.|..:..::  |....   .||..|| .
Zfish  1232 ----LLYDFMLLLCASLQGRVFEEEC--VSPVQLLAGDNVEICRDLDAATFSQ---HNPVPDF-I 1286

  Fly  1059 YVRNYADVLKTAIFFSFFWITLAIVFLGGVCSTDILSLGYIIFALIFLLQGSEIYLQNIHFIICR 1123
            :.|:|.|:||..:|...||..|.|:|:.|.....|..:||::....||:.|.|:.|:.|..|:..
Zfish  1287 HCRSYLDMLKVMVFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLIFGGELLLKPIKSILHY 1351

  Fly  1124 WNCLIAFNIFNIIVK-VAIIVLEGTIN---LEH---KSILSIVFNVMHQTAPCENIMDGKFFEIN 1181
            |:.|||:|:|.|.:| :..|...|.|.   ..|   ..:.|:...:...:.|             
Zfish  1352 WDFLIAYNVFVITMKNILSIAACGYIKALVANHCWLIQLFSLACTIKGYSKP------------- 1403

  Fly  1182 EISEKKYCYGPSDMIFKNTLVWHAIIFSFVVFQYRIFGSYYFCHVIMDTQANTILASRGAAIIEN 1246
            |....|.|..|||   :..::|.:|.|:|::.|.|:|.||||.||:.|.:::.:||||||.:.:.
Zfish  1404 EQQANKQCELPSD---EAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIRSSQLLASRGAELFQA 1465

  Fly  1247 LHYKQIYDRRKNEQSVLERVKMKMERIRITNRRHQKQATGLDFQPHKPPSSIIHVHYRAEEKSKL 1311
            ...|.:..|.:.|:..::.:|.:|:||:   .|.||...|.:           .:...|:|..:.
Zfish  1466 TIVKAVKARIEEEKKSMDLLKRQMDRIK---SRQQKFKRGKE-----------RMLSLAQESGER 1516

  Fly  1312 KTLNNEFLTTIKQAERDTYFSRSLKPRRRDLSLHP---HA--VRTGDYYMF-----NELDDDDDL 1366
            .::..|     ::.|.:...|:..|..:|.....|   ||  ||:|:||:|     .|.:|:|..
Zfish  1517 HSVLKE-----EEEEEEEESSKEKKKGKRKQWWRPWVDHASMVRSGNYYLFETDSEEEEEDEDRK 1576

  Fly  1367 DVYEE-----YDFL-------------EKEDVRARQMRQSLRSRASNYNRSKSFLNDENSDTD-- 1411
            |  ||     :.|:             |:...:.|..::...|..:...:.::.:..|..|.|  
Zfish  1577 D--EEPKRSAFQFVYHAWITDSKTAMKERRKEKRRFWQKYTESNTNKREQKEANVTVEEGDQDGV 1639

  Fly  1412 -TKKLETHP---------------VIILTSELIVLLTFRLNR-------LSKNFRFVHKMLSAEK 1453
             ..:|...|               |:.|.  |:...|..||.       :|...|....||:.|.
Zfish  1640 TEDELSDSPDNMMKRVFNMVKFSWVLFLA--LLDSFTAWLNSICQEHIDISSVLRIERCMLTHEA 1702

  Fly  1454 KKLQNISIMNRLGL-----------------------------------------------SNTA 1471
            || .|:...:.:.:                                               .|.|
Zfish  1703 KK-GNVPSRDSIRMYYQRQMCRPASTQSSLEPTEEAYSDFSPLRTDPDLPPQEHTELQTSTENLA 1766

  Fly  1472 AMF--------------KFLNKSLNNK-------------------------------------V 1485
            :::              :.|..|..::                                     .
Zfish  1767 SVYTESSIVEDSTLDEERVLKTSQRSRPKLCRISGVDVPSSADSAASSEHTQGTELYSRQGTSDT 1831

  Fly  1486 IKEAGSYYV-SQDNDFTTLDHND------------------------------------------ 1507
            ::|.|:..: |..:|.....|.|                                          
Zfish  1832 VEECGADTLWSSASDLLQTPHRDVPPSYSRATGLDCICDERKLKIQTPEDSSSGTPHTSSHRLTA 1896

  Fly  1508 --------------------------FVQMLIALWYALIANTETICYLVVFLNQAANSSVISLPM 1546
                                      .:|:..:|:..|:::::.:||||:.||...::||.:|.:
Zfish  1897 SELLQTRMFYDADLEQSERFYRSQPQLLQLCYSLYNVLVSHSQMVCYLVIILNHMISASVATLVL 1961

  Fly  1547 PFLVLCWGALTLPRPSKTFWVTLITYNLTMIFVKSIMHQRVLLDQQLVSRSNSLSFE------LI 1605
            |.|:..|..|::|||||.||:|.|.|....|.:|...........|.:....|..|.      :.
Zfish  1962 PVLIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPFNQSIEVDKSKPFHPPNIIGVE 2026

  Fly  1606 MKRGRAVYDLLLLVVLFWHQYMLKKQGIW---------------------------------TIQ 1637
            .|.|...|||:.|:.||:|:.:||..|:|                                 |..
Zfish  2027 KKEGYVHYDLVQLLALFFHRSILKCYGLWDEEEPRSVSPHTHSGAEEKAECFSEKSPVEDTYTHA 2091

  Fly  1638 RTNSELLLLEKK---------------------------RNHYKRSFS---KERPENIRKLLREE 1672
            .:::.|.|..|:                           |:..:||.|   |.|.|.:.:.|||:
Zfish  2092 LSHTHLRLARKQQSSAGVRRQSSSISQRSARSKTGSSVSRSSVRRSLSAQQKSRKELLMEKLREQ 2156

  Fly  1673 GGGEQVKAVRPNAIEFKREMDDILLPALENKYVYQNIESEYYRKAMQGLANKGGLLSGFRKFFLA 1737
                   .:|......|..: |:.:|                                .|:||.:
Zfish  2157 -------LIRAKRFTVKTVL-DVYIP--------------------------------IRQFFYS 2181

  Fly  1738 LRHKSRLS-TDVYTLLFLCDFISFFILLFGFPKFVYRYKYSTSV-LETYIQGNKVPFTFLLMLIV 1800
            |.|....: ||||.|:||.|.:.|.|::|||..|   .|:|.:. :.:.:..::||..||:|:::
Zfish  2182 LIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAF---GKHSAAADITSSLSEDQVPEAFLVMVLI 2243

  Fly  1801 QFITIVTERAIYLRKALIYKIFFHFISVLGIHIWMFFLVPYITSHSFGE-TAPVLFYLIKCLHML 1864
            ||.|:|.:||:||||.::.|:.|..|.|.|||.||||::|.:|...|.: |...|:|.:||::..
Zfish  2244 QFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQNTVAQLWYFVKCIYFG 2308

  Fly  1865 LSAYQIRCGYPKRILGNVFTKGYSLANYIAFKIYMEIPFLYILRTMLDWVCIDTTLTVMEWIKME 1929
            |||||||||||.|:|||..||.|:..|...|:.:..:|||..||.::|||..||||::..||.:|
Zfish  2309 LSAYQIRCGYPTRVLGNFLTKSYNYLNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVE 2373

  Fly  1930 DIFQSVFIVRCYRQMDTDFPVLRGEPKALYSKLLIGGTIILILIALIWSPLFLFALVGTV-GKPN 1993
            ||:..:|:::|:|:.:..:|..||:.|....|..:||.|:::||.::|.||...:||.:| |..|
Zfish  2374 DIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVN 2438

  Fly  1994 IPQKADITVKINHYEPIY-VSQSNSDILQFSNSDFQKLTNHIILDNYASDSMML---YDAVDVTA 2054
            .|....:|:.:..::||: :|...:.:.:.:.|||:...|..   ||...:|..   |.|.|||.
Zfish  2439 KPLDVSVTITLGGFQPIFTMSAQQNQLKELTESDFKNFINSY---NYVPSAMQFLEAYRAEDVTV 2500

  Fly  2055 IKFYENSISLWNMPPPDKERLLHDLSNGETLDIHLTLTLKCNL-----TPEAVIYETTYTLTENK 2114
            .:...:|.|||.:.||.::.|:..||..:...:.:|.:::.||     :..|:....||.    .
Zfish  2501 AELEGSSNSLWTISPPSRKNLMDVLSKEDQFPVTMTWSIQRNLSLGAKSEFAMDKHVTYL----D 2561

  Fly  2115 VHTRDKLIRLMSNNFSNEKVIIPNILPKFITVQRQQANAKFIKDY--DGKFNR-PIILTKIGKSQ 2176
            :.||.:||.|: |...|..|:|..:.|.||... ..:|||.|:..  ||.:.. .:.|.:...|.
Zfish  2562 IKTRQELIALL-NGTRNTPVLIEQVFPCFIRAP-SDSNAKPIEQLYEDGVYKSIQLDLERSANSS 2624

  Fly  2177 ---VYWWEMNDYCNDRFYTEILSALPLSNCENGVVLYVFNDKSFPSAMSFLEKTGIIGLYTTFVY 2238
               ..||.:::          |.:......|.|:.||||:||..|.::.||...||:|||.:.|.
Zfish  2625 EDLQEWWIVDE----------LRSAQKQQREAGLQLYVFSDKVSPPSLGFLAGYGIMGLYASVVL 2679

  Fly  2239 VVSRIIRSLIANNHRRIMFEDLPYVDRVLKLCTDIYLVRETQEYRLEEDLYGKLIFLYRSPETLI 2303
            |:.:.:|...:.....||||:||.|||:|||||||:|||||.|..||||||.|||||||||||:|
Zfish  2680 VIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMI 2744

  Fly  2304 KWTRFK 2309
            ||||.|
Zfish  2745 KWTREK 2750

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PzlNP_001303493.1 PIEZO <1201..1388 CDD:292539 56/214 (26%)
Piezo_RRas_bdg 1901..2308 CDD:288978 155/422 (37%)
LOC100334952XP_021325930.1 PIEZO 1373..1600 CDD:318189 65/263 (25%)
Piezo_RRas_bdg 2344..2749 CDD:314954 155/423 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 427 1.000 Domainoid score I585
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1038 1.000 Inparanoid score I263
OMA 1 1.010 - - QHG46055
OrthoDB 1 1.010 - - D13738at2759
OrthoFinder 1 1.000 - - FOG0001637
OrthoInspector 1 1.000 - - mtm6604
orthoMCL 1 0.900 - - OOG6_102664
Panther 1 1.100 - - O PTHR13167
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1528
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.980

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