DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DIP-lambda and NTM

DIOPT Version :9

Sequence 1:NP_001334747.1 Gene:DIP-lambda / 26067049 FlyBaseID:FBgn0267428 Length:548 Species:Drosophila melanogaster
Sequence 2:NP_001338930.1 Gene:NTM / 50863 HGNCID:17941 Length:367 Species:Homo sapiens


Alignment Length:395 Identity:111/395 - (28%)
Similarity:162/395 - (41%) Gaps:79/395 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KTARIKMYNGTLACSIAFILIKAITITKCHAVAHIHG----KGESEEIDPQFLAKLSNTTVPIGR 65
            ||.:.||:|     ||::.:...:.     |:....|    .|     |..|...:.|.||..|.
Human     2 KTIQPKMHN-----SISWAIFTGLA-----ALCLFQGVPVRSG-----DATFPKAMDNVTVRQGE 51

  Fly    66 DISFTCVVDNLGHYRVAWIKSDSKAILGIHTHMVSLNPRLSVTHNGHNTWKLHISRVQINDSGSY 130
            ..:..|.:|| ...||||:  :...||........|:||:.:..|....:.:.|..|.:.|.|.|
Human    52 SATLRCTIDN-RVTRVAWL--NRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPY 113

  Fly   131 MCQVNTD--PMKSLSGYLDVVVPPDILNHPEHNPEDGVCQEGGSISLMCSVTGVPRPKVLWRREA 193
            .|.|.||  | |:...:|.|.|.|.|:    ....|....||.:|||.|..||.|.|.|.||..:
Human   114 TCSVQTDNHP-KTSRVHLIVQVSPKIV----EISSDISINEGNNISLTCIATGRPEPTVTWRHIS 173

  Fly   194 GKEIILRTDGRDKTGFKSVEGERLVLTNVQRSDMGGYNCIASNGIPPSVSKRFNVYVNFSPTVKA 258
            .|.:          ||.| |.|.|.:..:.|...|.|.|.|||.:...|.:|..|.||:.|.:..
Human   174 PKAV----------GFVS-EDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISE 227

  Fly   259 ISQLVGAPVEREVTLECIVEVFPKPLNGWYRSEGNIKLHNGNK---------------YNISEEV 308
             ::..|.||.::.||:|.....|.....||:.:.  :|..|.|               :|:||. 
Human   228 -AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK--RLIEGKKGVKVENRPFLSKLIFFNVSEH- 288

  Fly   309 INIYTWHLNLTIRHLTKSDFGTYSCSSVNALGKSESLIRLQELRLPPKLTTTPTPHMQTTGKSRR 373
                              |:|.|:|.:.|.||.:.:.|.|.||..|  .::|....::||..:..
Human   289 ------------------DYGNYTCVASNKLGHTNASIMLFELNEP--TSSTLLQEVKTTALTPW 333

  Fly   374 KHPAS 378
            |.|.:
Human   334 KGPGA 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-lambdaNP_001334747.1 None
NTMNP_001338930.1 Ig 44..132 CDD:416386 29/91 (32%)
Ig strand A' 44..49 CDD:409353 3/4 (75%)
Ig strand B 51..59 CDD:409353 1/7 (14%)
CDR1 59..63 CDD:409353 2/4 (50%)
FR2 64..70 CDD:409353 4/7 (57%)
Ig strand C 64..70 CDD:409353 4/7 (57%)
CDR2 71..83 CDD:409353 2/11 (18%)
Ig strand C' 72..76 CDD:409353 1/3 (33%)
Ig strand C' 80..83 CDD:409353 0/2 (0%)
FR3 84..118 CDD:409353 10/33 (30%)
Ig strand D 87..94 CDD:409353 1/6 (17%)
Ig strand E 97..103 CDD:409353 0/5 (0%)
Ig strand F 110..118 CDD:409353 3/7 (43%)
CDR3 119..123 CDD:409353 2/3 (67%)
Ig strand G 123..132 CDD:409353 3/9 (33%)
FR4 125..132 CDD:409353 1/6 (17%)
Ig_3 136..205 CDD:404760 28/83 (34%)
Ig strand A' 142..147 CDD:409353 1/4 (25%)
Ig strand B 153..160 CDD:409353 4/6 (67%)
Ig strand C 166..171 CDD:409353 2/4 (50%)
Ig strand D 177..180 CDD:409353 1/12 (8%)
Ig strand E 184..190 CDD:409353 2/5 (40%)
Ig strand F 197..204 CDD:409353 3/6 (50%)
Ig strand G 211..219 CDD:409353 3/7 (43%)
Ig_3 222..299 CDD:404760 20/98 (20%)
putative Ig strand A 223..229 CDD:409353 1/6 (17%)
Ig strand B 239..243 CDD:409353 2/3 (67%)
Ig strand C 252..256 CDD:409353 0/3 (0%)
Ig strand E 278..282 CDD:409353 0/3 (0%)
Ig strand F 292..297 CDD:409353 2/4 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 45 1.000 Domainoid score I12195
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 141 1.000 Inparanoid score I4481
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265311at33208
OrthoFinder 1 1.000 - - FOG0000150
OrthoInspector 1 1.000 - - mtm8497
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X97
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.970

Return to query results.
Submit another query.