DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-lambda and NCAM2

DIOPT Version :9

Sequence 1:	NP_001334747.1	Gene:	DIP-lambda / 26067049	FlyBaseID:	FBgn0267428	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	440	Identity:	96/440 - (21%)
Similarity:	163/440 - (37%)	Gaps:	107/440 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 QFLAKLSNTTVPIGRDISFTCVVDNLGH-YRVAWIKSDSKAILGIHTHMVSLNPRLSVTHNGHNT 114
            |....||...:.:|....|||..  :|. ..:.|.....:.|:.        ..|:.|...|..:
Human    47 QVTISLSKVELSVGESKFFTCTA--IGEPESIDWYNPQGEKIIS--------TQRVVVQKEGVRS 101

  Fly   115 WKLHISRVQINDSGSYMCQVNTDP-------------MKSLSGYLDVVVPPDILNHPEHNPEDGV 166
             :|.|....|.|:|.|.||. ||.             .:.|: :.:||.|.:.
Human   102 -RLTIYNANIEDAGIYRCQA-TDAKGQTQEATVVLEIYQKLT-FREVVSPQEF------------ 151

  Fly   167 CQEGGSISLMCSVTGVPRPKVLWRREAGKEIILRTDGRDKTGFKSVEGERLVLTNVQRSDMGGYN 231
             ::|....::|.|:..|.|.|.|... .:|:...:|.|    |..:....|.:.|:.:||.|.|.
Human   152 -KQGEDAEVVCRVSSSPAPAVSWLYH-NEEVTTISDNR----FAMLANNNLQILNINKSDEGIYR 210

  Fly   232 C---IASNG------------IPPSVS---KRFNVYVNFSPTVKAISQLVGAPVER--EVTLECI 276
            |   :.:.|            :||::|   |.||                 |..||  |:|..|.
Human   211 CEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFN-----------------ATAERGEEMTFSCR 258

  Fly   277 VEVFPKPLNGWYRSEGNIKLHNGNKYNISEEVINIYTWHLNLTIRHLTKSDFGTYSCSSVNALGK 341
            ....|:|...|:|        ||.....:|:.| :...:..||:|::..||.|.|.|.:.|..|:
Human   259 ASGSPEPAISWFR--------NGKLIEENEKYI-LKGSNTELTVRNIINSDGGPYVCRATNKAGE 314

  Fly   342 SESLIRLQELRLPPKLTTTPTPHMQTTGKSRRKHPASHKKGLNEVLRFQETHFANQIQQENEDHN 406
            .|....||         ....||:     .:.|:..:::.|...::...|.....:|..:..  .
Human   315 DEKQAFLQ---------VFVQPHI-----IQLKNETTYENGQVTLVCDAEGEPIPEITWKRA--V 363

  Fly   407 EGFDLLKFTNSENSNIVLESGHINSMINKEDVNIYHPKQYGQEKTNKPSG 456
            :||...:...|.:..|.::..|.:|.::.:||.:....:|..|..::..|
Human   364 DGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGG 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-lambda	NP_001334747.1	None
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274	23/101 (23%)
		I-set	47..136	CDD:254352	23/100 (23%)
		I-set	142..218	CDD:254352	21/93 (23%)
		IGc2	153..214	CDD:197706	18/65 (28%)
		Ig	233..326	CDD:299845	33/127 (26%)
		I-set	240..323	CDD:254352	30/117 (26%)
		Ig5_NCAM-2	325..422	CDD:143278	17/96 (18%)
		IG_like	333..420	CDD:214653	15/83 (18%)
		IG_like	438..515	CDD:214653
		IGc2	439..507	CDD:197706
		FN3	521..613	CDD:238020
		fn3	619..703	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100