DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-lambda and DIP-gamma

DIOPT Version :9

Sequence 1:	NP_001334747.1	Gene:	DIP-lambda / 26067049	FlyBaseID:	FBgn0267428	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster

Alignment Length:	402	Identity:	150/402 - (37%)
Similarity:	220/402 - (54%)	Gaps:	45/402 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KMYNGTLACSIAFILIKAITITKC--HAVAHIHGKGESE-EIDPQFLAKLSNTTVPIGRDISFTC 71
            |:...||     |:::  |..|||  .:..:.|.:..|: :.||:|:..::|.|.|.||:....|
  Fly     3 KLLQSTL-----FVIL--IMATKCGSGSTQNQHHESSSQLDPDPEFIGFINNVTYPAGREAILAC 60

  Fly    72 VVDNLGHYRVAWIKSDSKAILGIHTHMVSLNPRLSVTHNGHNTWKLHISRVQINDSGSYMCQVNT 136
            .|.|||..:|.|:::..:.:|.:...:|:.|.|:||.|...:||||.||:::.:|.|.||||:||
  Fly    61 SVRNLGKNKVGWLRASDQTVLALQGRVVTHNARISVMHQDMHTWKLKISKLRESDRGCYMCQINT 125

  Fly   137 DPMKSLSGYLDVVVPPDILNHPEHNPEDGVCQEGGSISLMCSVTGVPRPKVLWRREAGKEIILRT 201
            .|||...|.:||.|||||:|  |.:..|...|||...:|.|..||.|:|:|.||||.|:.|::|.
  Fly   126 SPMKKQVGCIDVQVPPDIIN--EESSADLAVQEGEDATLTCKATGNPQPRVTWRREDGEMILIRK 188

  Fly   202 DG-RDKTGFKSVEGERLVLTNVQRSDMGGYNCIASNGIPPSVSKRFNVYVNFSPTVKAISQLVGA 265
            .| |:....:|..|..|.|..::|..||.|.|||||.:||:||||.::.|.|:|.|:|.|||:|.
  Fly   189 PGSRELMKVESYNGSSLRLLRLERRQMGAYLCIASNDVPPAVSKRVSLSVQFAPMVRAPSQLLGT 253

  Fly   266 PVEREVTLECIVEVFPKPLNGWYR-------------------SEGNIKLHNGNKYNISEEVINI 311
            |:..:|.|||.||..|.|::.|.:                   |.|...|.:|.||.|:|. .:.
  Fly   254 PLGSDVQLECQVEASPSPVSYWLKGARTSNGFASVSTASLESGSPGPEMLLDGPKYGITER-RDG 317

  Fly   312 YTWHLNLTIRHLTKSDFGTYSCSSVNALGKSESLIRLQELRLPPKLTTTPTPHMQTTGKSRRKHP 376
            |...:.|.:|..:.||.|||.|.|.|:||::|..:||.|::|.|..:.:...|:...|
  Fly   318 YRGVMLLVVRSFSPSDVGTYHCVSTNSLGRAEGTLRLYEIKLHPGASASNDDHLNYIG------- 375

  Fly   377 ASHKKGLNEVLR 388
                 ||.|..|
  Fly   376 -----GLEEAAR 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-lambda	NP_001334747.1	None
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	39/91 (43%)
		Ig	47..129	CDD:299845	34/81 (42%)
		Ig	140..238	CDD:299845	45/99 (45%)
		IG_like	247..355	CDD:214653	37/108 (34%)
		Ig	256..351	CDD:299845	31/95 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	40	1.000	Domainoid score	I12510
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4644
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8732
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	8	8.070