DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-lambda and Negr1

DIOPT Version :9

Sequence 1:NP_001334747.1 Gene:DIP-lambda / 26067049 FlyBaseID:FBgn0267428 Length:548 Species:Drosophila melanogaster
Sequence 2:XP_036019026.1 Gene:Negr1 / 320840 MGIID:2444846 Length:362 Species:Mus musculus


Alignment Length:332 Identity:92/332 - (27%)
Similarity:139/332 - (41%) Gaps:63/332 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 VPIGRDISFT-CVVDNL----------------GHYRVAWIKSDSKAILGIHTHMVSLNPRLSVT 108
            :|.|:.:.|. ..|||:                |..:.||:...|....|  ....|::||:|::
Mouse    26 LPAGQSVDFPWAAVDNMLVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAG--GDKWSVDPRVSIS 88

  Fly   109 HNGHNTWKLHISRVQINDSGSYMCQVNTD-PMKSLSGYLDVVVPP---DILNHPEHNPEDGVCQE 169
            ......:.|.|..|.:.|.|.|.|.|.|. ..:::..:|.|.|||   ||.|       |....|
Mouse    89 TLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISN-------DMTINE 146

  Fly   170 GGSISLMCSVTGVPRPKVLWRREAGKEIILRTDGRDKTGFKSVE-GERLVLTNVQRSDMGGYNCI 233
            |.:::|.|..||.|.|.:.||..:             ...|..| |:.|.:..:.|...|.|.|.
Mouse   147 GTNVTLTCLATGKPEPVISWRHIS-------------PSAKPFENGQYLDIYGITRDQAGEYECS 198

  Fly   234 ASNGIP-PSVSKRFNVYVNFSPTVKAISQLVGAPVEREVTLECIVEVFPKPLNGWYRSEGNIKLH 297
            |.|.:. |.| |:..|.|||:||::.|......| .|...:.|.....|.|...||:  |..:|.
Mouse   199 AENDVSFPDV-KKVRVIVNFAPTIQEIKSGTVTP-GRSGLIRCEGAGVPPPAFEWYK--GEKRLF 259

  Fly   298 NGNK----YNISEEVINIYTWHLNLTIRHLTKSDFGTYSCSSVNALGKSESLIRLQELRLPPKLT 358
            ||.:    .|.|...|        ||:.::|:..||.|:|.:.|.||.:.:.:.|.::..|...:
Mouse   260 NGQQGIIIQNFSTRSI--------LTVTNVTQEHFGNYTCVAANKLGTTNASLPLNQIIEPTTSS 316

  Fly   359 --TTPTP 363
              |:|.|
Mouse   317 PVTSPAP 323

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-lambdaNP_001334747.1 None
Negr1XP_036019026.1 FR1 38..55 CDD:409353 3/16 (19%)
Ig strand A' 40..46 CDD:409353 2/5 (40%)
IG_like 41..129 CDD:214653 20/89 (22%)
Ig strand B 48..56 CDD:409353 0/7 (0%)
CDR1 56..60 CDD:409353 0/3 (0%)
FR2 61..68 CDD:409353 2/6 (33%)
Ig strand C 61..67 CDD:409353 2/5 (40%)
CDR2 69..79 CDD:409353 2/11 (18%)
Ig strand C' 71..74 CDD:409353 0/2 (0%)
Ig strand C' 76..79 CDD:409353 0/2 (0%)
FR3 80..115 CDD:409353 11/34 (32%)
Ig strand D 84..91 CDD:409353 2/6 (33%)
Ig strand E 94..100 CDD:409353 1/5 (20%)
Ig strand F 107..115 CDD:409353 3/7 (43%)
CDR3 116..120 CDD:409353 1/3 (33%)
Ig strand G 120..129 CDD:409353 1/8 (13%)
FR4 122..129 CDD:409353 1/6 (17%)
Ig strand A' 139..144 CDD:409353 2/11 (18%)
IGc2 146..204 CDD:197706 20/70 (29%)
Ig strand B 150..157 CDD:409353 2/6 (33%)
Ig strand C 163..168 CDD:409353 1/4 (25%)
Ig strand C' 170..172 CDD:409353 0/14 (0%)
Ig strand E 180..186 CDD:409353 1/5 (20%)
Ig strand F 193..200 CDD:409353 3/6 (50%)
Ig_3 219..295 CDD:404760 24/86 (28%)
putative Ig strand A 219..225 CDD:409353 2/5 (40%)
Ig strand B 235..239 CDD:409353 0/3 (0%)
Ig strand C 248..252 CDD:409353 0/3 (0%)
Ig strand E 274..278 CDD:409353 2/11 (18%)
Ig strand F 288..293 CDD:409353 2/4 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 45 1.000 Domainoid score I12107
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 142 1.000 Inparanoid score I4449
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000150
OrthoInspector 1 1.000 - - mtm8732
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X97
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.960

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