DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-lambda and Igsf9

DIOPT Version :9

Sequence 1:	NP_001334747.1	Gene:	DIP-lambda / 26067049	FlyBaseID:	FBgn0267428	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001100667.1	Gene:	Igsf9 / 304982	RGDID:	1304566	Length:	1179	Species:	Rattus norvegicus

Alignment Length:	350	Identity:	79/350 - (22%)
Similarity:	126/350 - (36%)	Gaps:	92/350 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 PQFLAKLSNTTVPIGRDISFTCVVD----NLGHYRVAWIKSDSKAILGIHTHMVSLNPRLSVTHN 110
            |..:...:|.||...:|:|..|..:    ||.:   :|.:......     |:..|..|:.:..:
  Rat   227 PVIVVPPNNNTVNASQDVSLACRAEAYPANLTY---SWFQDRINVF-----HISRLQSRVRILVD 283

  Fly   111 GHNTWKLHISRVQINDSGSYMC-QVNTDP-MKSLSGYLDVVVPPDILNHPEHNPEDGVCQEGGSI 173
            |    .|.:...|.:|:|.|.| ..|..| ..|.|.||.|:.|..:...|...|
  Rat   284 G----SLWLQATQPDDAGHYTCVPSNGFPHPPSASAYLTVLYPAQVTVMPPETP----------- 333

  Fly   174 SLMCSVTGVPR------PKVL---WRREAGKEIILRTDGRDKTGFKSV--EGERLVLTNVQRSDM 227
             |...:.||.|      |.:|   |.:: |:.:.|     ||....|:  ||. ||:.......:
  Rat   334 -LPIGMRGVIRCPVRANPPLLFVTWTKD-GQALQL-----DKFPGWSLGPEGS-LVIALGNEDAL 390

  Fly   228 GGYNCIASNGIPPSVSKRFNVYVNFSPT----VKAISQLVGAPVE-------REVTLECIVEVFP 281
            |.|:|...|.:..:.|         ||.    :||....:..|.|       |::.:.|.....|
  Rat   391 GEYSCTPYNSLGTAGS---------SPVTRVLLKAPPAFIDQPKEEYFQEVGRDLLIPCSARGDP 446

  Fly   282 KPLNGWYR----SEGNIKLHNGNKYNISEEVINIYTWHLNLTIRHLTKSDFGTYSCSSVNALGKS 342
            .|:..|.:    .:|..::.:.|                :|.:|.|||...|.:.||:.||:...
  Rat   447 PPIVSWAKVGRGLQGQAQVDSNN----------------SLILRPLTKEAHGRWECSARNAVAHV 495

  Fly   343 ESLIRLQELRLPPKLTT----TPTP 363
            .....:..|...|.:.|    .|.|
  Rat   496 TISTNVYVLGTSPHVVTNVSVVPLP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-lambda	NP_001334747.1	None
Igsf9	NP_001100667.1	IG	28..110	CDD:214652
		Ig strand A	136..139	CDD:409353
		IG_like	143..223	CDD:214653
		Ig strand A'	145..148	CDD:409353
		Ig strand B	154..161	CDD:409353
		Ig strand C	167..172	CDD:409353
		Ig strand C'	175..177	CDD:409353
		Ig strand D	183..187	CDD:409353
		Ig strand E	189..193	CDD:409353
		Ig strand F	202..210	CDD:409353
		Ig strand G	213..223	CDD:409353
		Ig_3	226..305	CDD:404760	20/89 (22%)
		putative Ig strand A	226..230	CDD:409353	1/2 (50%)
		putative Ig strand A'	235..239	CDD:409353	2/3 (67%)
		putative Ig strand B	241..251	CDD:409353	3/9 (33%)
		putative Ig strand C'	267..270	CDD:409353	0/7 (0%)
		putative Ig strand D	279..282	CDD:409353	0/2 (0%)
		putative Ig strand E	284..290	CDD:409353	2/9 (22%)
		putative Ig strand F	297..305	CDD:409353	3/7 (43%)
		putative Ig strand G	310..319	CDD:409353	4/8 (50%)
		Ig	322..407	CDD:416386	24/112 (21%)
		Ig strand A'	324..328	CDD:409353	0/3 (0%)
		Ig strand B	333..347	CDD:409353	5/25 (20%)
		Ig strand C	353..359	CDD:409353	2/5 (40%)
		Ig strand C'	362..364	CDD:409353	0/1 (0%)
		Ig strand D	371..374	CDD:409353	0/2 (0%)
		Ig strand E	378..382	CDD:409353	2/4 (50%)
		Ig strand F	391..399	CDD:409353	3/7 (43%)
		Ig	418..503	CDD:416386	19/100 (19%)
		Ig strand A	418..421	CDD:409353	0/2 (0%)
		Ig strand A'	427..430	CDD:409353	0/2 (0%)
		Ig strand B	436..443	CDD:409353	1/6 (17%)
		Ig strand C	449..454	CDD:409353	1/4 (25%)
		Ig strand C'	457..459	CDD:409353	0/1 (0%)
		Ig strand D	462..466	CDD:409353	0/3 (0%)
		Ig strand E	469..473	CDD:409353	2/19 (11%)
		Ig strand F	482..490	CDD:409353	3/7 (43%)
		Ig strand G	493..503	CDD:409353	0/9 (0%)
		FN3	508..599	CDD:238020	3/12 (25%)
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..807
		PHA03247	<777..1062	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..979
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100