DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-lambda and PRTG

DIOPT Version :9

Sequence 1:	NP_001334747.1	Gene:	DIP-lambda / 26067049	FlyBaseID:	FBgn0267428	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_776175.2	Gene:	PRTG / 283659	HGNCID:	26373	Length:	1150	Species:	Homo sapiens

Alignment Length:	440	Identity:	98/440 - (22%)
Similarity:	154/440 - (35%)	Gaps:	115/440 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 AKLSNTTVPIGRDISFT----CVVDNLGH----YRVAWIKSDSKAILGIHTHMVSLNPRLSVTHN 110
            ::||....|  :|::.|    .|:|...|    .:|.|:|:.:|         :|.|.|:.|..|
Human    37 SELSFVKEP--QDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAK---------MSENKRIEVLSN 90

  Fly   111 GHNTWKLHISRV-----QINDSGSYMCQVNTDPMKSLSGYLDVVVPPDILNHPEHNPEDGVCQEG 170
            |    .|:||.|     :.:|.|.|.|.........||....:.:  ..::..|..|......||
Human    91 G----SLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLAL--STISAFEVQPISTEVHEG 149

  Fly   171 GSISLMCSVTGVPRPKVLWRREAGKEIILRTDGRD---KTGFKSVEGERLVLTNVQRSDMGGYNC 232
            |.....|.::..|...:.|  |..:..:..|..|.   .||.       |.:.:|.:.|.|.|.|
Human   150 GVARFACKISSHPPAVITW--EFNRTTLPMTMDRITALPTGV-------LQIYDVSQRDSGNYRC 205

  Fly   233 IAS-------------NGIPPSVSKRFNVYVNFSPTVKAISQLVGAPVEREVTLECIVEVFPKPL 284
            ||:             ..||...||.|:     :||:.|..|.:...:.:.|.|||:....|||:
Human   206 IAATVAHRRKSMEASLTVIPAKESKSFH-----TPTIIAGPQNITTSLHQTVVLECMATGNPKPI 265

  Fly   285 NGWYRSEGNIKLHNGNKYNISEEVINIYTWHL----NLTIRHLTKSDFGTYSCSSVNALGKSESL 345
            ..|.|              :..:.|:::...:    ||.|..:.....|.|.|.:... |.....
Human   266 ISWSR--------------LDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTP-GTRNFT 315

  Fly   346 IRLQELRL---------PPKLTT--------------TPTPHMQTTGKSRRKHPASHKKGLNEVL 387
            :.:..|.:         |..||.              .|:|.|......|:.|.....|..|..|
Human   316 VAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKL 380

  Fly   388 RFQETHFANQIQQENEDHNEGFDLLKFTNSENSNIVLESGHINSMINKED 437
                  ..|||..|:       |.:....:|||...:.|....:::..||
Human   381 ------VINQIIPED-------DAIYQCMAENSQGSILSRARLTVVMSED 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-lambda	NP_001334747.1	None
PRTG	NP_776175.2	Ig	40..130	CDD:299845	27/104 (26%)
		Ig	139..223	CDD:299845	20/92 (22%)
		IG_like	141..223	CDD:214653	20/90 (22%)
		IG_like	241..323	CDD:214653	19/96 (20%)
		IGc2	250..309	CDD:197706	16/72 (22%)
		I-set	327..412	CDD:254352	20/97 (21%)
		Ig	345..412	CDD:299845	17/79 (22%)
		FN3	419..512	CDD:238020
		FN3	517..610	CDD:238020
		fn3	624..699	CDD:278470
		FN3	726..814	CDD:238020
		FN3	821..911	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	981..1002
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1086..1150
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100