DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-lambda and Cntn4

DIOPT Version :9

Sequence 1:	NP_001334747.1	Gene:	DIP-lambda / 26067049	FlyBaseID:	FBgn0267428	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001103219.1	Gene:	Cntn4 / 269784	MGIID:	1095737	Length:	1026	Species:	Mus musculus

Alignment Length:	599	Identity:	130/599 - (21%)
Similarity:	206/599 - (34%)	Gaps:	202/599 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SEEIDPQFLAKLSN------TTVPI--GRDISFTC-VVDNLGHYRVAWIKSDSKAILGIHTHMVS 100
            |.|...|| |.|.|      :||.:  |:.:...| ...:.|....|||
Mouse   111 SREAKLQF-AYLENFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWI---------------- 158

  Fly   101 LNPRLSVTHN----GHNTWKLHISRVQINDSGSYMCQV-NTDPMKSLSGYLDVVVPPD--ILNHP 158
            .|...|...|    ...|..|:|::|:.:|.|:|.|.| ||.....:.|      ||.  ||.:.
Mouse   159 FNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLG------PPTPLILRND 217

  Fly   159 ----EHNPEDGV-------CQEGGSISLMCSVTGVPRPKVLWRREAGKEIILRTDGRDKTGFKSV 212
                |:.|:..|       .::|.::.|.|...|.|.|.:||||..||.|..:.......|.
Mouse   218 GVMGEYEPKIEVQFPETVPAEKGTTVKLECFALGNPVPTILWRRADGKPIARKARRHKSNGI--- 279

  Fly   213 EGERLVLTNVQRSDMGGYNCIASNGIPPSVSK-RFNVYVNFSPTVKAISQLVGAPVEREVTLECI 276
                |.:.|.|:.|.|.|.|:|.|....:|:| :...|.  .|....|...:...:|..|..||.
Mouse   280 ----LEIPNFQQEDAGSYECVAENSRGKNVAKGQLTFYA--QPNWVQIINDIHVAMEESVFWECK 338

  Fly   277 VEVFPKPLNGWYR------SEGNIKLHNG--------------------NKYNI----------- 304
            ....|||...|.:      :...|::..|                    ||:.:
Mouse   339 ANGRPKPTYRWLKNGDPLLTRDRIQIEQGTLNITIVNLSDAGMYQCVAENKHGVIFSSAELSVIA 403

  Fly   305 -------------------SEEVIN---------IYTWHL-----------------NLTIRHLT 324
                               .|.||.         :|||..                 ||.|.::|
Mouse   404 ESPDFSRTLLKRVTLVKVGGEVVIECKPKASPRPVYTWRKGREILRENERITISEDGNLRIINVT 468

  Fly   325 KSDFGTYSCSSVNALGKSESLIRLQELRLPPKLTTTPTPHMQTTGKSRRKHPASHKKGLNEVLRF 389
            |||.|:|:|.:.|..|.:.|...: .::.|.|:...|:....|.|:|             .||..
Mouse   469 KSDAGSYTCIATNHFGTASSTGNV-IVKDPTKVMVPPSSMDVTVGES-------------IVLPC 519

  Fly   390 QETHFANQIQQENEDHNEGFDLLKFTNSENSNIV---LESGHINSMINKE--------DVNIYHP 443
            |.||          ||:  .|:: ||.:.|.:::   .:..|...:..::        ::.:.|.
Mouse   520 QVTH----------DHS--LDIV-FTWTFNGHLIDFDKDGDHFERVGGQDSAGDLMIRNIQLKHA 571

  Fly   444 KQY---GQEKTNK-----------PSGTIPSTRTPWILTNAGSQ---RPALTSYATVALITSFWL 491
            .:|   .|...:|           |.|. |...|...:|:..:|   ||...:::.:.:    ::
Mouse   572 GKYVCMVQTSVDKLSVAADLIVRGPPGP-PEAVTIDEITDTTAQLSWRPGPDNHSPITM----YV 631

  Fly   492 FFWRVFHSLDWDAI 505
            ...|...|:.|.|:
Mouse   632 IQARTPFSVGWQAV 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-lambda	NP_001334747.1	None
Cntn4	NP_001103219.1	Ig	25..118	CDD:386229	2/6 (33%)
		Ig	120..213	CDD:386229	27/114 (24%)
		Ig	225..313	CDD:386229	27/94 (29%)
		Ig	318..401	CDD:386229	13/82 (16%)
		Ig	422..494	CDD:386229	19/72 (26%)
		Ig6_Contactin-4	513..597	CDD:143261	17/109 (16%)
		FN3	597..690	CDD:238020	11/54 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..710
		FN3	703..792	CDD:238020
		FN3	804..896	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..906
		FN3	904..989	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910