DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-lambda and Vsig10

DIOPT Version :9

Sequence 1:	NP_001334747.1	Gene:	DIP-lambda / 26067049	FlyBaseID:	FBgn0267428	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001028483.2	Gene:	Vsig10 / 231668	MGIID:	2448533	Length:	558	Species:	Mus musculus

Alignment Length:	498	Identity:	99/498 - (19%)
Similarity:	156/498 - (31%)	Gaps:	169/498 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 VAWIKSDSKAILGIHTHMVSLN-------PRLSVTHNGHNTWKLHISRVQINDSGSYMCQ----- 133
            |.|.::||:.     ..:||.|       ||.|:...|    .|.|..:::.|.|:|.||
Mouse    75 VTWYRNDSEP-----AFLVSFNSSLPPAAPRFSLEDAG----ALRIEALRLEDDGNYTCQEVLNE 130

  Fly   134 VNTDPMK----SLSGYLDV------VVPPDILNHPEHNPEDGVCQEGGSISLMCSVTGVPRPKVL 188
            .:..|::    |...|::|      .:|...|          ....|..:...|.....|.|:|.
Mouse   131 THWFPVRLRVASGPAYVEVNISATGTLPNGTL----------YAARGSQVDFNCCSAAQPPPEVE 185

  Fly   189 WRREAGKEIILRTDGRDKTGFKSVEGERLVLTNVQRSDMGGYNCIASN---GIPPSVSKRFNVYV 250
            |        .::|....:...|::......|..:.::..|.|.|.|:|   |....|:....||
Mouse   186 W--------WIQTHSIPEFLGKNLSANSFTLMLMSQNLQGNYTCSATNVLSGRQRKVTTELLVY- 241

  Fly   251 NFSPTVKAISQLVGAPVEREVTLECIVEV----------------FPKPLNGWYRSEGNIKLHNG 299
             :.|.        .||       :|.|||                :|.|...|....|...:.|.
Mouse   242 -WPPP--------SAP-------QCSVEVSSESTTLELACNWDGGYPDPTFLWTEEPGGTIMGNS 290

  Fly   300 NKYNISEEVINIYTWHLNLTIRHLTKSDFGTYSCSSVNALGKSESLIRLQELRL----------- 353
            ....:|...: :..........|:...:.|. ||    .:..|..|:..|.:|.
Mouse   291 KLQTLSPAQL-LEGKKFKCVGNHILGPESGA-SC----VVKLSSPLLPSQPMRTCFVGGNVTLTC 349

  Fly   354 ------PPK----LTTTPTPHMQTTGKSRRKHPASHKKGLNEVLRFQETHFANQIQQENEDHNEG 408
                  ||.    |.....|.:|         |:||     .::..|....:..|...::|.:||
Mouse   350 EVSGANPPARIQWLRNLTQPAIQ---------PSSH-----YIITQQGQSSSLTIHNCSQDLDEG 400

  Fly   409 FDLLKFTNSEN------SNIVLESGHINSMINKEDVNIYHPKQYGQEKTNKPSGTIPSTRTPWIL 467
            |   .:..:||      :||.|..        ||.:||               |.|..|....:|
Mouse   401 F---YYCQAENLVGVRATNIWLSV--------KEPLNI---------------GGIVGTVVSLLL 439

  Fly   468 TNAGSQRPALTSYATVALITSFWLFFWR---VFHSLDWDAIRV 507
            ...     |:.|..|:....:||   |:   .|...|...:.|
Mouse   440 LGL-----AVVSGLTLYYSPAFW---WKGGSTFRGQDMGDVMV 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-lambda	NP_001334747.1	None
Vsig10	NP_001028483.2	Ig	47..135	CDD:299845	18/68 (26%)
		IG_like	55..140	CDD:214653	19/73 (26%)
		IG_like	160..240	CDD:214653	17/97 (18%)
		Ig	<184..238	CDD:299845	12/61 (20%)
		IG_like	341..421	CDD:214653	19/96 (20%)
		Ig	345..418	CDD:143165	17/89 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..515
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..558
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100