DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-lambda and chl1b

DIOPT Version :9

Sequence 1:	NP_001334747.1	Gene:	DIP-lambda / 26067049	FlyBaseID:	FBgn0267428	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_017212175.2	Gene:	chl1b / 100318566	ZFINID:	ZDB-GENE-091105-1	Length:	1294	Species:	Danio rerio

Alignment Length:	449	Identity:	99/449 - (22%)
Similarity:	172/449 - (38%)	Gaps:	93/449 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CSIAFILIKAITITKCHAVAHI-------------HGKGESE---EIDPQFLAKL---SNTTVPI 63
            |..||..|:  ||.:..|::.:             .|:|.:.   |..|..||..   |:|.:..
Zfish   213 CFAAFPRIR--TIVQKTAMSMVVKSNKLMKDSSSGSGRGYANSLLERKPSLLAPTGMESHTRLVK 275

  Fly    64 GRDISFTCVVDNLGHYRVAWIKSDSKAILGIHTHMVSLNPRLSVTHNGHNTWKLHISRVQINDSG 128
            |.|:...|:.:.....:|.|:|      :|.:    .|..|:.|..:|.   .|.:..|...|.|
Zfish   276 GEDLQLECIAEGFPTPKVEWVK------IGFN----KLPERVVVESHGK---LLTVEMVNEEDEG 327

  Fly   129 SYMCQVNTDPMKSLSGYLDVVV--PPDILNHPEHNPEDGVCQEGGSISLMCSVTGVPRPKVLWRR 191
            .|||:.. :|...:..:..|.|  ||:.    |..|:..:...|..:.:.|.|.|.|:|.|.||.
Zfish   328 KYMCRAK-NPHGEVVHHFHVTVEEPPEF----EIEPQSQLVTIGADVLIKCVVKGNPQPTVGWRV 387

  Fly   192 EAGKEIILRTDGRDKTGFKSVEGERLVLTNVQRSDMGGYNCIASNGIPPSVSKRFNVYVNFSPTV 256
            .......:.|..|     |.::...:.:.|....:...|.|.|:|.....::....:.:|..|.:
Zfish   388 NGRPLNEVPTSNR-----KILKDGTISIHNANPENSAVYQCEATNKHGTILANANIMIMNIQPLI 447

  Fly   257 KAISQLVGAPVE-REVTLECIVEVFPKPLNG--WYRSEGNIKLHNGNKYNISEEVINIYTWHLN- 317
            ...:.|....|| :.|.:.|  :||..|.:.  |.::: :.....|.::.:          |.|
Zfish   448 LTENNLQYMAVEGKSVVMHC--KVFSSPASSITWSKAD-SANAVEGERFTV----------HQNG 499

  Fly   318 -LTIRHLTKSDFGTYSCSSVNALGKSESLIRLQELRLPPKLTTTPTPHMQTTGKSRRKHPASHKK 381
             |.|.::.|.|.|.|||.:.|..|| .::....|::.|.::...|                   :
Zfish   500 SLEIHNVMKEDMGEYSCFAQNTEGK-VAIAATLEVKDPTRIVDPP-------------------R 544

  Fly   382 GLNEVLRFQETHFANQIQQENEDHNEGFDLL------KFTNSENSNIVLESGHINSMIN 434
            .| .||......|:.| .:.:....:.|::|      ....||:...:||.| :..:||
Zfish   545 DL-RVLAGTTIQFSCQ-PEFDPSFGDDFEVLWEKDGIALNGSEDGRYILEDG-VLEIIN 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-lambda	NP_001334747.1	None
chl1b	XP_017212175.2	Ig	61..135	CDD:325142
		Ig	138..231	CDD:325142	7/19 (37%)
		Ig	279..348	CDD:325142	18/82 (22%)
		Ig	366..438	CDD:325142	17/76 (22%)
		IG	454..533	CDD:214652	22/92 (24%)
		I-set	538..628	CDD:333254	15/85 (18%)
		FN3	632..722	CDD:238020
		FN3	734..815	CDD:238020
		FN3	832..931	CDD:238020
		fn3	942..1022	CDD:306538
		FN3	1070..1142	CDD:214495
		Bravo_FIGEY	1196..1279	CDD:316405
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100