DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-lambda and ncam2

DIOPT Version :9

Sequence 1:	NP_001334747.1	Gene:	DIP-lambda / 26067049	FlyBaseID:	FBgn0267428	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_012811963.1	Gene:	ncam2 / 100151722	XenbaseID:	XB-GENE-1217730	Length:	865	Species:	Xenopus tropicalis

Alignment Length:	466	Identity:	104/466 - (22%)
Similarity:	168/466 - (36%)	Gaps:	92/466 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GTLACSIAFILIKAITITKCHAVAHIHGKG---ESEEIDPQFLAKLSNTTVPIGRDISFTCVV-- 73
            |||:..:..|:          .|::.:..|   .|.:...|....||...:.:|:...|||.|
Frog    21 GTLSLHLLLIM----------KVSYFYLLGLLVSSGQALMQVTISLSKVEISVGQSKYFTCTVIG 75

  Fly    74 --DNLGHYRVAWIKSDSKAILGIHTHMVSLNPRLSVTHNGHNTWKLHISRVQINDSGSYMCQVNT 136
              ||     :.|.....:.|:.        ..|:.|...|..:| |.|.:..::|:|.|.||. |
Frog    76 EADN-----IDWFNPQGEKIIS--------GQRVVVQREGIRSW-LTIYKANVDDAGIYRCQA-T 125

  Fly   137 DPMKSLSGYLDVVVPPDILNHP--EHNPEDGVCQEGGSISLMCSVTGVPRPKVLW--RREAGKEI 197
            |   |.....:..|..:|....  |..|.....:.|.:..::|.|:..|.|.|.|  .||...:|
Frog   126 D---SKGHAQEATVVLEIYQKLTFEDVPSPQEFKRGENAEVLCLVSSSPAPMVRWLNNREDVTDI 187

  Fly   198 ILRTDGRDKTGFKSVEGERLVLTNVQRSDMGGYNCIASNGIPPSVSKR-FNVYVNFSPTVKAISQ 261
                   |...|..:....|.:.|:.:.|.|.|.|.....:...:..| .:|.||..|.:.|..:
Frog   188 -------DDRRFAMLPNNNLQIKNISKRDEGIYRCEGRVEVRGEIDFRDISVIVNVPPEILAQQR 245

  Fly   262 LVGAPVER--EVTLECIVEVFPKPLNGWYRSEGNIKLHNGN-KYNISEEVINIYTWHLNLTIRHL 323
            ...|..:|  ::||.|.....|||...|:|   |.||...| ||::.|:       :..||::::
Frog   246 SFNATADRLEDITLFCRATGSPKPYITWHR---NGKLVEENEKYDLRED-------NTELTVKNI 300

  Fly   324 TKSDFGTYSCSSVNALGKSESLIRLQELRLPPKLTTTPTPHMQTTGKSRRKHPASHKKGLNEVLR 388
            ..:|.|.|.|.:.|..|.:|....||....|                        |...|.....
Frog   301 ISTDSGLYVCRATNKAGFTEKQSFLQVFVQP------------------------HIVQLQNETT 341

  Fly   389 FQETHFANQIQQENED--------HNEGFDLLKFTNSENSNIVLESGHINSMINKEDVNIYHPKQ 445
            .:..|.....:.|.|.        .::|........|::..|.....|..|.::.:.|.:....:
Frog   342 IEHGHVTLTCEAEGEPIPEITWKRSSDGMIFYDGDKSQDGRIESTGHHGKSSLHIKSVMLSDAGR 406

  Fly   446 YGQEKTNKPSG 456
            |..|..::..|
Frog   407 YDCEAASRIGG 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-lambda	NP_001334747.1	None
ncam2	XP_012811963.1	Ig	50..141	CDD:386229	27/108 (25%)
		IG_like	150..234	CDD:214653	21/90 (23%)
		Ig	237..330	CDD:386229	30/102 (29%)
		Ig	329..426	CDD:386229	15/113 (13%)
		IG_like	442..520	CDD:214653
		FN3	525..617	CDD:238020
		fn3	623..706	CDD:365830
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I11918
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010