DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NimB2 and Megf10

DIOPT Version :9

Sequence 1:NP_723857.1 Gene:NimB2 / 260645 FlyBaseID:FBgn0028543 Length:421 Species:Drosophila melanogaster
Sequence 2:NP_001001979.1 Gene:Megf10 / 70417 MGIID:2685177 Length:1147 Species:Mus musculus


Alignment Length:521 Identity:125/521 - (23%)
Similarity:163/521 - (31%) Gaps:207/521 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SSSCQLVTLGVLLAICSLGQGQFKTAGIKTRQPPSGNLQLAGNSSESGWRSYNQSSYGWSTQNQS 67
            ||||    ||:   ||||......||         .:|.|...:..|.|.||:            
Mouse     5 SSSC----LGL---ICSLLCHWVGTA---------SSLNLEDPNVCSHWESYS------------ 41

  Fly    68 NYAWNQQNHVEQGSAGFVRAEVFQPVTLPPLYGHYVQPVTPPAHRVQVLDETAL--FINKTRSAM 130
                                     ||:...|.|       |..::.....|.:  :...||..:
Mouse    42 -------------------------VTVQESYPH-------PFDQIYYTSCTDILNWFKCTRHRI 74

  Fly   131 ASGVCYKEVPTASLLRNSRDQFVGNGTTPDMSRIQVCCDGYERNPHIYRRCEPICADDCRNGICT 195
            :....|:........|.|:                 ||.|:..:..:   |.|.|||.|.:|.|.
Mouse    75 SYRTAYRHGEKTMYRRKSQ-----------------CCPGFYESRDM---CVPHCADKCVHGRCI 119

  Fly   196 APNTCVCIPGHVRT------------------------------------AEG----KCISTCPL 220
            |||||.|.||...|                                    |.|    :|...|..
Mouse   120 APNTCQCEPGWGGTNCSSACDGDHWGPHCSSRCQCKNRALCNPITGACHCAAGYRGWRCEDRCEQ 184

  Fly   221 G-----------CGNG-VCDE-RNECKCREGYSLEPETRKYCQPECKPG-----CSFGRCVAPN- 266
            |           |.|| .||. ..||:|..||     |..:|:..|.||     |. .||...| 
Mouse   185 GTYGNDCHQRCQCQNGATCDHITGECRCSPGY-----TGAFCEDLCPPGKHGPHCE-QRCPCQNG 243

  Fly   267 --------KCACLDGYRLAADG----------SCEPVCDSCENGKC-TAPGHCNCNAGYL--KLQ 310
                    :|:|..|:.....|          :|...|.....|.| .|.|.|:|:.||.  :.|
Mouse   244 GVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQ 308

  Fly   311 GRCEPI------CSIPCK---NGRCIG-PDICECASGFEWDRKSAECLP------KCDLPCLNGV 359
            ..| |:      |:..|:   .|:|.. ...|.|.:||..:...|...|      |||..|   .
Mouse   309 DEC-PVGSYGVRCAEACRCVNGGKCYHVSGTCLCEAGFSGELCEARLCPEGLYGIKCDKRC---P 369

  Fly   360 CVGNN---------QCDCKTGYVRDEHQRNICQP-----HCPQ--GCQNGY-C-SAPNFCICRPG 406
            |..:|         :|.||.|: ...:....|.|     .|.|  .||||. | |....|.|.||
Mouse   370 CHLDNTHSCHPMSGECGCKPGW-SGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGRCACAPG 433

  Fly   407 F 407
            |
Mouse   434 F 434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NimB2NP_723857.1 None
Megf10NP_001001979.1 Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern. /evidence=ECO:0000250|UniProtKB:Q96KG7 1..857 125/521 (24%)
EMI 32..99 CDD:284877 18/127 (14%)
EGF_CA 281..326 CDD:304395 14/45 (31%)
EGF_CA 542..587 CDD:304395
Necessary for formation of large intracellular vacuoles. /evidence=ECO:0000250|UniProtKB:Q96KG7 945..1147
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1093..1147
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1218
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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