DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NimB2 and megf6b

DIOPT Version :9

Sequence 1:	NP_723857.1	Gene:	NimB2 / 260645	FlyBaseID:	FBgn0028543	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_009304569.1	Gene:	megf6b / 557764	ZFINID:	ZDB-GENE-101112-3	Length:	1589	Species:	Danio rerio

Alignment Length:	525	Identity:	124/525 - (23%)
Similarity:	157/525 - (29%)	Gaps:	216/525 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLAICSLGQGQFKTAGIKTRQPPSGNLQLAGNSSESGWRSYNQSSYGWSTQNQSNYAWNQQNHVE 78
            ||..|..| |.........|.||..:.:|..:....|       .||.....:.|.|.|.:.|..
Zfish   595 LLCKCKNG-GVCDPVSGSCRCPPGVSGELCQDGCPKG-------LYGKFCNKRCNCANNGRCHRT 651

  Fly    79 QGSAGFVRAEVFQPVTLPPLYGHYVQPVTPPAHRVQVLDETALFINKTRSAMASGVCYKEVPTAS 143
            .|:.          :..|.|||.:                                |:...|
Zfish   652 YGAC----------LCDPGLYGRF--------------------------------CHLPCP--- 671

  Fly   144 LLRNSRDQFVGNGTTPDMSRIQ-------------VCCDGYERNPHIYRRCEPICADDCRNGI-- 193
                  ....|.|.:.:...:|             :|..||..:         .|.|:|.:|.
Zfish   672 ------KWMFGPGCSEECQCVQQNTIECHRHHGDCICKPGYRGH---------TCKDECESGFFG 721

  Fly   194 CTAPNTCVCIPG----HVRTAEGKCISTCPLG------------------------CGNGVCDE- 229
            ....|.|.|.||    ||   .|.|...||.|                        |....||:
Zfish   722 SACENKCSCPPGVTCDHV---TGACQPKCPAGKTGDKCDQDCVEGRFGIGCSQSCDCSGAPCDKV 783

  Fly   230 RNECKCREGYSLEPETRKYCQPECKPG------------C-SFGRCVAPN-KCACLDGY--RLAA 278
            ..:|.|..|     ...|.|:.||..|            | :.|||...| .|.|..|:  || .
Zfish   784 TGQCTCPAG-----TFGKRCEKECPEGRWGLGCQEWCPVCENGGRCDRRNGTCVCSPGFIGRL-C 842

  Fly   279 DGSCEP-----------VCD---SCE--NGKCTAP----GH-CN--CNAGYLKLQGRCEPICSIP 320
            ..||..           |||   .|.  :|:|:.|    || |.  |:||...|.  ||.:|.
Zfish   843 QNSCPAGRFGVGCQLRCVCDLGVRCNPVSGRCSCPPGWTGHNCRKVCDAGRWGLD--CESVCD-- 903

  Fly   321 CKN---------GRCIGPDICECASGFEWDRKSAECLPKCDL----PCLNGVCVGNNQ------- 365
            |:|         ||      |.|.:||    ..|.|..||..    |.....|...||
Zfish   904 CRNADGVCDAQTGR------CHCEAGF----TGARCDQKCPAGSFGPGCKHRCQCENQASCDHVG 958

  Fly   366 --CDCKTGYVRDEHQRNICQPHCPQG-----CQ-------NGYCS-APNFCICRPGFIKSGIKGR 415
              |.||||:.     ...|:..||||     ||       .|.|. ....|.|:.|:|  |.:..
Zfish   959 GACTCKTGWT-----GTFCEKPCPQGFYGLDCQQKCVCLNGGLCDHVSGQCFCKAGWI--GTRCN 1016

  Fly   416 QTCQA 420
            |||.|
Zfish  1017 QTCPA 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
NimB2	NP_723857.1	None
megf6b	XP_009304569.1	EMI	33..102	CDD:284877
		FXa_inhibition	152..187	CDD:291342
		vWFA	<184..227	CDD:294047
		FXa_inhibition	234..270	CDD:291342
		FXa_inhibition	276..311	CDD:291342
		vWFA	<308..350	CDD:294047
		FXa_inhibition	363..398	CDD:291342
		vWFA	<396..436	CDD:294047
		FXa_inhibition	445..480	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900