DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NimB2 and Pear1

DIOPT Version :9

Sequence 1:	NP_723857.1	Gene:	NimB2 / 260645	FlyBaseID:	FBgn0028543	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001128431.1	Gene:	Pear1 / 295293	RGDID:	1305653	Length:	1033	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	119/497 - (23%)
Similarity:	161/497 - (32%)	Gaps:	211/497 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LQLAG--NSSESG----WRSYNQSSYGWSTQNQSNYAWNQQNHVEQGSAGFVRAEVFQPVTLPPL 98
            |:|||  ||::..    |.|:..::              :::|:             :|.:|||.
  Rat    13 LRLAGTLNSNDPNVCTFWESFTTTT--------------KESHL-------------RPFSLPPA 50

  Fly    99 YGHYVQPVTPPAHRVQVLDETALFINKTRSAMASGVCYKEVPTASLLRNSRDQFVGNGTTPDMSR 163
            .. ..:|...|....|.:                 |.|:.|....:..:||            .|
  Rat    51 ES-CDRPWEDPHTCAQPM-----------------VVYRTVYRQVVKMDSR------------PR 85

  Fly   164 IQVCCDGYERNPHIYRRCEPICADDCRNGICTAPNTCVCIPGHVRTAEGKCISTCPLG------- 221
            :| ||.||..:.   ..|.|:||.:|.:|.|.|||.|.|.||   .....|.|.|..|
  Rat    86 LQ-CCGGYYESS---GACVPLCAQECVHGRCVAPNRCQCAPG---WRGDDCSSECAPGMWGPQCD 143

  Fly   222 ----CGN-GVCDERN-ECKCREGYSLEPETRKYCQPEC---------KPGCSFG-RCVAPNKCAC 270
                ||| ..||.|: .|.|..|  |:|       |:|         .|.|.|. .|...: |..
  Rat   144 RLCLCGNSSSCDPRSGVCFCPSG--LQP-------PDCLQPCPDGHYGPACQFDCHCYGAS-CDP 198

  Fly   271 LDGYRLAADGSCEPVCD----------------SCENGKCT--APGHCNCNAGYLKLQGRCEPIC 317
            .||......|...|.|:                .|:||...  :.|.|:|..|::.:      ||
  Rat   199 RDGACFCPPGRTGPSCNVPCSQGTDGFFCPRTYPCQNGGVPQGSQGSCSCPPGWMGV------IC 257

  Fly   318 SIPCKNG----------RCIGPDICE-------CASGFEWDRKSAE---------CLPKCDLPCL 356
            |:||..|          ||....:|:       ||.|:..||...|         |...||  |.
  Rat   258 SLPCPEGFHGPNCTQECRCHNGGLCDRFTGQCHCAPGYIGDRCREECPVGRFGQDCAETCD--CA 320

  Fly   357 NGV-CV-GNNQCDCKTGYVRD------------------------EHQRNI--------CQP--- 384
            .|. |. .|..|.|:.|:..|                        ||..:.        |||
  Rat   321 PGARCFPANGACLCEHGFTGDRCTERLCPDGRYGLSCQDPCTCDPEHSLSCHPMHGECSCQPGWA 385

  Fly   385 ------HCPQ-----GCQ-------NGYCSAPN-FCICRPGF 407
                  .|||     |||       .|.|.|.: .|.|.||:
  Rat   386 GLHCNESCPQDTHGAGCQEHCLCLHGGVCLADSGLCRCAPGY 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimB2	NP_723857.1	None
Pear1	NP_001128431.1	EMI	25..93	CDD:284877	20/125 (16%)
		EGF_CA	535..580	CDD:304395
		Laminin_EGF	620..665	CDD:278482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900