DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NimB2 and MEGF6

DIOPT Version :9

Sequence 1:	NP_723857.1	Gene:	NimB2 / 260645	FlyBaseID:	FBgn0028543	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_011539187.1	Gene:	MEGF6 / 1953	HGNCID:	3232	Length:	1603	Species:	Homo sapiens

Alignment Length:	430	Identity:	118/430 - (27%)
Similarity:	152/430 - (35%)	Gaps:	146/430 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 WRSYNQSSYGWSTQNQSNYAWNQQNHVEQGSAGFVRAEVFQPVTLPPLYGHYVQPVTPPAHRV-- 113
            |:    :..||.       ||         ..|..|..|:        |..|.|..|..|..|
Human   135 WK----AGCGWQ-------AW---------CVGHERRTVY--------YMGYRQVYTTEARTVLR 171

  Fly   114 ------QVLDETALFINKTRSAMASGVCYKEVPTASLLRNSRDQFVGNGTTPDMSRIQVCCDGYE 172
                  |..||..              |.....:|||.      |.|....|..::...|..|::
Human   172 CCRGWMQQPDEEG--------------CLSAECSASLC------FHGGRCVPGSAQPCHCPPGFQ 216

  Fly   173 RNPHIYRRCEPICADDCR--NGIC-----TAPNT--CVCIPG-HVRTAEGKC--ISTCPLGCGNG 225
             .|    ||: ...|:||  ||.|     ..|.:  |.|.|| .:.|....|  |::|.|  |||
Human   217 -GP----RCQ-YDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCAL--GNG 273

  Fly   226 VCDE--------RNECKCREGYSLEPETRKYC---------QPECKPGCSFGRCVAPNKCACLDG 273
            .|..        |:.|:||.|:.|: |..::|         ...|...|...|.:|  :|.|..|
Human   274 GCQHHCVQLTITRHRCQCRPGFQLQ-EDGRHCVRRSPCANRNGSCMHRCQVVRGLA--RCECHVG 335

  Fly   274 YRLAADG-SCEPVCD------SCENGKCTAPG--HCNCNAGY-LKLQGR-C-----EPICSIPCK 322
            |:||||| :||.|.:      .|.:|.....|  .|.|:||| |...|| |     |.:.|....
Human   336 YQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEAN 400

  Fly   323 NGRC--------IGPDICECASGFEWDRKSAECL--PKC-DLPCLNGVCV---GNNQCDCKTGYV 373
            ||.|        .|| :|.|..|:|.|.....|:  ..| |.||...||.   |..:|.|..||.
Human   401 NGGCSHGCSHTSAGP-LCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYR 464

  Fly   374 R----------DE--HQRNICQPHCPQ-------GCQNGY 394
            .          ||  ..|..|:.||..       .|:.||
Human   465 LSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGY 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimB2	NP_723857.1	None
MEGF6	XP_011539187.1	EMI	108..176	CDD:284877	14/68 (21%)
		vWFA	<215..261	CDD:294047	15/51 (29%)
		FXa_inhibition	268..304	CDD:291342	13/38 (34%)
		vWFA	<342..384	CDD:294047	13/41 (32%)
		FXa_inhibition	397..432	CDD:291342	10/35 (29%)
		vWFA	<432..469	CDD:294047	12/36 (33%)
		vWFA	<472..511	CDD:294047	9/33 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900