DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GIGYF2 and Gyf

DIOPT Version :9

Sequence 1:	NP_001096617.1	Gene:	GIGYF2 / 26058	HGNCID:	11960	Length:	1320	Species:	Homo sapiens
Sequence 2:	NP_001162827.1	Gene:	Gyf / 43842	FlyBaseID:	FBgn0039936	Length:	1574	Species:	Drosophila melanogaster

Alignment Length:	1745	Identity:	408/1745 - (23%)
Similarity:	631/1745 - (36%)	Gaps:	605/1745 - (34%)

- Green bases have known domain annotations that are detailed below.

Human     5 TQTLNFGPEWLRALSS--------------------GGSITSPPLSPALPKYKLADYRYGREEML 49
            |.::.|||||||.:|:                    ||.......:.:..:....:|||||||||
  Fly     2 TDSMKFGPEWLRNMSAEPSGSPSTYNVGNAAQNNSIGGHNLGNNTAASASRNLFPEYRYGREEML 66

Human    50 ALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNS-AAVLRLTGRGGGGTV 113
            :||.::..:|..|  ..|..:..|:...||||.|.:||:....|:..|| .|.|:.:..|.|...
  Fly    67 SLFDRNCLLPQIL--PSFKKLFVEKVQCPLALTPSSEEDINQNSLGNNSRPAWLQRSPSGFGSAS 129

Human   114 VGAPRGRSSSRGRGRGRGEC-GFYQRS---FDEVEGVFGRGGGREMHRSQSWEER---GDRRFEK 171
            .|:.||.:..|||.||:... ..|||.   :||...|..:.       .::|.:|   ||.....
  Fly   130 RGSGRGGTVDRGRMRGKSAYHPIYQRPSGLYDESLSVISKA-------ERTWSDRNGTGDSAATT 187

Human   172 PGRKDVGKKNGYYCMYSPVLLLGQPLCQGRPNFEEGGPTSVGRK-----HEFIRSESENWRIFRE 231
            ......|..:.                       .|.|:|..||     |..:    ||||..|.
  Fly   188 TSTSGSGALDW-----------------------NGTPSSSPRKDYSNNHRNL----ENWRRTRN 225

Human   232 EQNGED-----------EDGGWR---LAGSRRDG-----ERWRPHSPDGPRSAGWREH------- 270
            |....|           :..|||   :.||...|     .||       .||..||:.
  Fly   226 EDGSGDGPSSSGSMSGPDIAGWRSGVVGGSTNAGFGTNSHRW-------GRSTSWRDEDPSVDNA 283

Human   271 MERRRRFEFDFRDRDDERGYRR-----VRSGSGSIDDDR---------------------DSLPE 309
            ...:|..........|..|..:     ...|.|||...|                     ::|||
  Fly   284 ASLQRSISTVATLSTDRTGNNKGSGIGAAEGVGSISHPRLSSSKISQLWTVNNAAGVDADENLPE 348

Human   310 WCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHN---------- 364
            |.:|:..:..|:||:||||             ..:.|.:|:         :.|||
  Fly   349 WAIENPSKLGGSFDASGAF-------------HGDTDLKPI---------KSSHNTLKTKSLDSY 391

Human   365 EEAKEPDKTNKKEGEKTDRVGVASEETPQTS--------------SSSARP-----------GTP 404
            ::.|.|...:..:.:.      .::.||:||              .||..|           |..
  Fly   392 DDVKRPKSKDLSDPDS------GNDITPETSLTKDTNTTAVQEEVESSLSPISSTTTKEVIHGDI 450

Human   405 SDHQSQEASQFER---KDEPKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQIPSDTA 466
            ||...:.|.:.|:   .|:.|....:...:.   .:...|.:|     .:||::  ::..||.||
  Fly   451 SDRIKEVADEVEKLIMDDDHKISSNQSQHQN---HDGFTAALP-----RMADIE--INVKPSVTA 505

Human   467 SPLLILPPPVPNPSPTLRPVE-TPV---VGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQDSA 527
                     |...:|:..|:: ||.   |..|....||.  .|.|.::|..
  Fly   506 ---------VHRQAPSTMPIQITPTITDVAPPSHAVVSF--SDHETMQHHN-------------- 545

Human   528 LDDERLASKLQEHRAKGVSIPLMH----EAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSL 588
                      ..|..:...||..|    ...:.|:|:|||..:||||:..||.||::||||..:|
  Fly   546 ----------MHHLPQFPMIPTPHIITPNLNELWFYRDPQANVQGPFSAVEMTEWYRAGYFNENL 600

Human   589 LVKRACDESFQPLGDIMKM-WGRVPF-------SP--------GPAPPPHMGELD---------- 627
            .|:|..|..|:|||:::|. .|.:||       ||        |..|.|....|.
  Fly   601 FVRRYSDNRFRPLGELIKFCHGNMPFTHSHLLPSPIELENIPVGQIPAPLTASLSITPHKPSPIP 665

Human   628 ------QERLTRQQE---------------------------------LTALYQM------QHLQ 647
                  :::|.:|::                                 ||..:||      ||.:
  Fly   666 IALSVVEQQLQQQRDEQLKANVTATAEALRAAIKGSFGGNSIGNTSHLLTMRFQMLQDQYIQHQE 730

Human   648 YQ---------------------------------QFLI-----------------QQQYAQVL- 661
            ||                                 ::||                 :|.|..|:
  Fly   731 YQILAELSKNECFQRLSAVEQETVVRRKVQLLGLPEYLISLNGLSNSLSVLNPVAGRQLYRAVVE 795

Human   662 ---AQQQKAALSSQQQQQLALLLQQFQ-----TLKMRISDQNIIPSVTRSVSVPDTGSIWEL--- 715
               ..||....:::||:.:..||....     .:.::.|.|.:.|.|:....:...|:..:|
  Fly   796 HAKKDQQHIFANTEQQRSVGNLLDANNFILNAQIMIQQSQQEVGPLVSSVDCIMQGGTAADLNKP 860

Human   716 ----------------------QPTAS--QPTVWEGGSVWDLP-LDTTTPGPALEQLQ-----QL 750
                                  |||::  ||......:..:|| :|..|....||:..     .|
  Fly   861 NEIPRNELDLINEYNLRMLLRGQPTSTQQQPPALTNSATENLPGVDFLTETQLLERQNLMIPIWL 925

Human   751 EKAKAAKLEQERREAEM---------RAKREEEERKRQEELRRQQEEILRRQQEEERK------- 799
            ......:.|.:::.|||         .|...||..:.|:.|.::..|......|::.|
  Fly   926 PPNNNKQQETDQQWAEMSNADASLWETANLNEERNEDQQLLIQKSSEACFADTEKDVKIAQLFQV 990

Human   800 -------RREEEELARRKQEEALRRQREQEIALR-----RQREEEERQQQEEALRRLEERRREEE 852
                   ....|||.:..|.  |:....|:|...     :|...||....:..:::..::....:
  Fly   991 QSGNVVNHTALEELDQSPQN--LKGSHNQKIVKSLVSDIQQNHNEELNSHQHQVKQANKQNLNTK 1053

Human   853 ERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 917
            :...|..|.....|...|..:.||:.::|.|..|.::|::..|..:|.||:.|   ::|.:||
  Fly  1054 QNAAQSALKPINNENDRKREQTEEKKRQREERKRQQLEDDKRRALNESEEQTR---QIQEEKE-- 1113

Human   918 RQRQQQQEALRR-------------------LQQQQQQ--------QQLAQMKLPSSST--WGQQ 953
              ||||.:|.||                   |...|.:        :.....:|||:|.  |..|
  Fly  1114 --RQQQIQAQRRKALLGNVHSLSVQNGMSGTLASAQSKKNDDAKTAEPQVSSRLPSTSVAPWSFQ 1176

Human   954 SNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQ---QQQQQQKLSGWGNVSK 1015
            ...:   .::...|||||| .|.|||  |.:|:|.|..|.|.|:..   ..:....|..|.: :.
  Fly  1177 LQNS---MRSAPGLAEIQK-AERRER--RADQQRHQELLDKQLRANAAAAAEANDALLKWQS-TP 1234

Human  1016 PSGTTKSLLEIQQEEARQM-----QKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPP 1075
            .|....||.|||.||||::     .:|::::.:|.|....   :.:.|.||..:::||:.|
  Fly  1235 ASAPVMSLAEIQAEEARRLANDLVDRQRRRELEHHQQAPL---SSAVLVTSATSNIWGNAN---- 1292

Human  1076 NQWASDLVSSIWSNADTKNSNMGFWDD-------------------AVKEVGPRNSTNK------ 1115
            ..|:|....|:   :...:|..|.||:                   |....|..||.||
  Fly  1293 KAWSSSAAQSL---SLKTSSGTGLWDEPNPLGSNGSGTSGTSSVTAAAVLAGGLNSANKSTLQAQ 1354

Human  1116 NKNNA------SLSKS---VGVSN--RQNK----------------------KVEEEEKLLKL-- 1145
            ||::|      :|.||   ..:||  :.||                      .:||:::..||
  Fly  1355 NKSSALFASPRNLRKSQTLPALSNPEKSNKNGPGQRPEKQKLAQTRSKGAAVSIEEKDRERKLNA 1419

Human  1146 ----------FQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLG 1200
                      ...||:.::.||.||.:.|.  |.:..:||||||:||:::|:||||.||:|.|||
  Fly  1420 KSQQSSTDQAISKVNEYENEFTSWCIKSLD--NMSAKVDVPTFVAFLQDLEAPYEVKDYVRIYLG 1482

Human  1201 DTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNHSTLHSVFQ 1265
            |..::.:|||||||||:|.|:.|:.|:.......:..|...|                   |...
  Fly  1483 DGKDSLDFAKQFLERRSKYKSLQRAQKAHNDDMCKPAPAITP-------------------SAND 1528

Human  1266 TNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY 1320
            ...|.|:|         ||.||.||.:.|..:|||||.|:..|:|:|    :.||
  Fly  1529 YADSKNKQ---------KKIKKNKMTKMDARILGFSVTAAEGRINVG----IRDY 1570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GIGYF2	NP_001096617.1	4EHP-binding motif. /evidence=ECO:0000269\|PubMed:22751931	40..50		8/9 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..131		8/18 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..269		12/51 (24%)
		DDX6 binding motif. /evidence=ECO:0000269\|PubMed:31439631	302..332		13/50 (26%)
		GYF	554..609	CDD:238027	26/55 (47%)
		Required for GRB10-binding. /evidence=ECO:0000250	568..584		9/15 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..814		16/82 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..887		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	893..912		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	938..957		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	978..1018		11/42 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1030..1069		10/43 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1133		13/44 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1216..1251		7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1268..1292		9/23 (39%)
Gyf	NP_001162827.1	GYF	566..621	CDD:238027	26/54 (48%)
Gyf	NP_001162827.1	PKK	998..1112	CDD:289257	26/118 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145443
Domainoid	1	1.000	154	1.000	Domainoid score	I4260
eggNOG	1	0.900	-	-		E1_KOG1862
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3346
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001680
OrthoInspector	1	1.000	-	-		otm40590
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14445
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R738
SonicParanoid	1	1.000	-	-		X2990
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.880