DRSC/TRiP Functional Genomics Resources

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Protein Alignment GIGYF2 and gigyf2

DIOPT Version :10

Sequence 1:NP_001096617.1 Gene:GIGYF2 / 26058 HGNCID:11960 Length:1320 Species:Homo sapiens
Sequence 2:XP_002933400.2 Gene:gigyf2 / 100487831 XenbaseID:XB-GENE-5870324 Length:1309 Species:Xenopus tropicalis


Alignment Length:1410 Identity:866/1410 - (61%)
Similarity:1013/1410 - (71%) Gaps:191/1410 - (13%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDK 65
            |.|||||||||||||||||||||:.|||||||||||||||:||||||||||::||||:|.|||||
 Frog     1 MTAETQTLNFGPEWLRALSSGGSVISPPLSPALPKYKLADFRYGREEMLALYVKDNKVPLDLLDK 65

Human    66 EFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGR---GGGGTVVGAPRGRSSSRGRG 127
            ||||||.:|||.||||||||||||||||||||||||||||.|   ||||||||||||||||||||
 Frog    66 EFLPILNDEPLLPLALVPFTEEEQRNFSMSVNSAAVLRLTNRGSSGGGGTVVGAPRGRSSSRGRG 130

Human   128 RGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGKKNGYYCMYSPVLL 192
            |||||.|||||||||||..||| |.||||||||||||||||||||.||:            ||  
 Frog   131 RGRGESGFYQRSFDEVESGFGR-GAREMHRSQSWEERGDRRFEKPTRKE------------PV-- 180

Human   193 LGQPLCQGRPNFEEGGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGG--WRLAGSRRDGERWR 255
                    ||.|||||....|||||||||||.|||..|||.|||:|:||  ||.:..||||||||
 Frog   181 --------RPTFEEGGTAPAGRKHEFIRSESGNWRSLREEMNGEEEEGGGVWRASAPRRDGERWR 237

Human   256 PHSPDGPRSAGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMG 320
            .|||||.|.:||||..:|||||::|.|:|:|||||||.||||||.:|:|||||||||:|||:|.|
 Frog   238 SHSPDGARGSGWREIPDRRRRFDYDLREREDERGYRRARSGSGSAEDERDSLPEWCLDDAEDETG 302

Human   321 TFDSSGAFLS---LKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKKEGEKTD 382
            ||||||||||   .|||||||||||||:||||..:|.:.|||:||..|||||.|....:......
 Frog   303 TFDSSGAFLSSKPSKKVQKEPIPEEQELDFRPSMDGADNSDSDGSQTEEAKETDPVQSRTDNDLS 367

Human   383 RVGVASEETPQTSSSSARPGTP---SDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVP 444
            |.|....:.  |||...|..:|   :|..|:.|:|  :...|  ..:.|.|.:.|.::......|
 Frog   368 RNGYTVVQA--TSSPDHRIPSPVPRTDKTSETANQ--KAASP--HLSCKTEIDVRSQSPSSPPTP 426

Human   445 SRGDEMVADVQQPLSQIPSDTASPLLILPP------------------------PVPN-PSPTLR 484
            |:..|..|.:....||   :.:||.:..||                        |||. .:||: 
 Frog   427 SKHKEDAASLSHQGSQ---EKSSPCIPHPPSPAFSQRSPARQPDPHKVPAMSSVPVPQLDTPTV- 487

Human   485 PVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHRAKGVSIPL 549
            |..:.|..||||..:..|||:|:||:||||||::|||||||..|||:||..|:.:.|.||.|:  
 Frog   488 PAHSTVCAAPGMEPMPPEPDEEDGLEHLEQQAQQMVAYLQDGTLDDDRLLVKVLDQRVKGPSL-- 550

Human   550 MHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFS 614
              :..||||||||||||||||:|:|||||:|||||.|:||::|.||::||.||||:|.|||||||
 Frog   551 --DNQQKWYYKDPQGEIQGPFSNREMAEWYQAGYFPMTLLLRRVCDDAFQSLGDIIKKWGRVPFS 613

Human   615 PGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLAL 679
            . |..|..:|:||.|||:||||:||||||.||:|||||.||||| |||||||||||| |||||.|
 Frog   614 T-PPTPTRLGDLDPERLSRQQEITALYQMHHLRYQQFLFQQQYA-VLAQQQKAALSS-QQQQLPL 675

Human   680 LLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPAL 744
            .|   |:|.|||.:..:||.|.|::||||:.|:|||.|.|:||.||||.||||||::....|...
 Frog   676 PL---QSLSMRIPEHTVIPPVARALSVPDSTSLWELPPAAAQPAVWEGSSVWDLPVEPANQGTTR 737

Human   745 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEE-LAR 808
            |||:|:||.||||:||||||||:|||:||||::|            |:::||||||||||| |||
 Frog   738 EQLEQMEKVKAAKMEQERREAELRAKQEEEEQRR------------RQEEEEERKRREEEEQLAR 790

Human   809 RKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE-------- 865
            |||||.||||:  |:||::|.||||||::|| ||.||||||:||||::.||.:|:||        
 Frog   791 RKQEETLRRQK--ELALQKQMEEEERQRKEE-LRLLEERRRQEEERKRLEEEIRRQEEEKRRQEE 852

Human   866 ---------------------------------EEAAKWAREEEEAQRRLEENRLRMEEEAARLR 897
                                             ||||:||||||||.|||      :||  |||:
 Frog   853 ERKRAEDEKRRREEEKKREEEERRQREEIQRKQEEAARWAREEEEAARRL------LEE--ARLK 909

Human   898 HEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQ-SNTTACQS 961
            .||||||::| |.||||||.|||||||||||||||||||||||||||||||||||| |.|||  |
 Frog   910 AEEEERKKRE-EAQRQKELQRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQVSPTTA--S 971

Human   962 QATLSLAEIQKLEEERER-QLREEQRRQQRELMKAL--QQQQQQQQQKLSGWGNVSKPSGTTKSL 1023
            |:.||||||||||||||| ||:|.|||||:|| |.|  ||||||||||:.|||:||||.|:||||
 Frog   972 QSALSLAEIQKLEEERERQQLQEHQRRQQQEL-KILQQQQQQQQQQQKIPGWGSVSKPVGSTKSL 1035

Human  1024 LEIQQEEARQMQKQQQQQQQHQQPNRA-------RNNTHSNLHTSIGNSVWGSINTGPPNQWASD 1081
            |||||||||||||.|||..:::..|.:       .|:..|......|:|||||:|.....||:||
 Frog  1036 LEIQQEEARQMQKTQQQPVRNRPANISVPVAPVVNNHISSTSVAGSGSSVWGSLNNNLSPQWSSD 1100

Human  1082 LVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLF 1146
            .:|||||:.:.|.|::||||||||||.|||:|:||||.|  |||.|.::||:||||:|||||:||
 Frog  1101 SMSSIWSSTEVKGSSVGFWDDAVKEVTPRNATSKNKNTA--SKSAGPNSRQSKKVEQEEKLLRLF 1163

Human  1147 QGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQ 1211
            ||.||.||||||||||.|||:|||::||||||||||:|||||||||||:|||||||.|||:|:||
 Frog  1164 QGANKCQDGFTQWCEQTLHAINTAHSLDVPTFVSFLREVESPYEVHDYVRAYLGDTPEAKDFSKQ 1228

Human  1212 FLERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNHSTLHSVFQTNQSNNQQSNF 1276
            |:|||.||||:||.                     .|||..|        ...||:|:|:||:..
 Frog  1229 FIERRTKQKASQQH---------------------PQQDVAW--------VTCQTSQANSQQTAL 1264

Human  1277 EAVQ-SGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY 1320
            |..| :|:|||||||||||||||||||||||||||||||||::||
 Frog  1265 EVAQCAGRKKKKQKMVRADPSLLGFSVNASSERLNMGEIETVEDY 1309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GIGYF2NP_001096617.1 4EHP-binding motif. /evidence=ECO:0000269|PubMed:22751931 40..50 8/9 (89%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..131 18/18 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 236..269 22/34 (65%)
DDX6 binding motif. /evidence=ECO:0000269|PubMed:31439631 302..332 25/32 (78%)
GYF 554..609 CDD:238027 40/54 (74%)
Required for GRB10-binding. /evidence=ECO:0000250 568..584 12/15 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 754..814 39/60 (65%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 866..887 15/20 (75%)
Required for interaction with SARS-CoV-2 non-structural protein 2 (nsp2). /evidence=ECO:0000269|PubMed:35878012 881..940 42/58 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 893..912 11/18 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 938..957 17/19 (89%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 978..1018 31/42 (74%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1030..1069 17/45 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1105..1133 17/27 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1216..1251 9/34 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1268..1292 14/24 (58%)
gigyf2XP_002933400.2 GYF 555..608 CDD:238027 39/52 (75%)

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