DRSC/TRiP Functional Genomics Resources

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Protein Alignment ANKRD17 and Ank2

DIOPT Version :10

Sequence 1:NP_115593.3 Gene:ANKRD17 / 26057 HGNCID:23575 Length:2603 Species:Homo sapiens
Sequence 2:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster


Alignment Length:1715 Identity:379/1715 - (22%)
Similarity:609/1715 - (35%) Gaps:597/1715 - (34%)


- Green bases have known domain annotations that are detailed below.


Human   293 VEDRGIKGD-ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
            |.:.|.:|| .|..:.||..|:::.|...|.:..|:|..::.|..||..|...|::.||..||..
  Fly     2 VTENGAQGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRR 66

Human   357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS-NEFKESALTLACYKGHLEMVRFL 420
            ||.::...:.|:|.|..|..||..||.:||||:.|.:|..| |.|  :.|.:|..:.|..:||.|
  Fly    67 GAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGF--TPLYMAAQENHDAVVRLL 129

Human   421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLL--DSGAQVNMPADSFESPLTLAACGGHVELA 483
            |..||:|...|::..|.|..|...||.:|..:||  |:..:|.:||      |.:||....|:.|
  Fly   130 LSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPA------LHIAAKKDDVKAA 188

Human   484 ALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLE 548
            .||::...:.:..:..|:|||..|:..|::.:..||:.:||::|...:. ..:.|.:|...|...
  Fly   189 TLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKH-NISPLHVAAKWGKTN 252

Human   549 VADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHT 610
            :...|::.|.:||....   |||..||:.||.::|..||..||.:.|.|..|...|..|.:..|.
  Fly   253 MVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHV 317

Human   611 DVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGG 675
            |.|.:||...|.::..:....|.|..||..|||...:.|:.:.|:.| ..|.|..|.|.:||...
  Fly   318 DAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADAN-ARALNGFTPLHIACKKN 381

Human   676 HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHD 740
            .|.||||||.|||..:...:.|.|.|..||..|..::|.|||                    .||
  Fly   382 RLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLL--------------------QHD 426

Human   741 LNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHLP--ANSQDVQGYITNQS 803
            .:                  ||.|.....|.|              ||.  ||..|:        
  Fly   427 AS------------------PDVPTVRGETPL--------------HLAARANQTDI-------- 451

Human   804 PESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELNKTREEQIQKKQKILEE 868
                              |:..:...||:.:                  :.||:|          
  Fly   452 ------------------IRILLRNGAQVDA------------------RAREQQ---------- 470

Human   869 LQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVD 933
                                                        ||:.:.        :||..||
  Fly   471 --------------------------------------------TPLHIA--------SRLGNVD 483

Human   934 PVLLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLAGL 998
            .|:                                                              
  Fly   484 IVM-------------------------------------------------------------- 486

Human   999 GQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISP 1063
                       |::...||                                              
  Fly   487 -----------LLLQHGAQ---------------------------------------------- 494

Human  1064 SAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH 1128
                       :||.|:..: |||.:|...|.:|:...|:|.||:::...|||||||.|.|..||
  Fly   495 -----------VDATTKDMY-TALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGH 547

Human  1129 VGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
            :.|.::||...||::||. :...|||.:||....|:|..|||.:||:......:.:|||.:||..
  Fly   548 IKVAQLLLQKEADVDAQG-KNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARK 611

Human  1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL 1258
            ..::|...||..||..|:.  ||.|.:||.|::..||                            
  Fly   612 NQMDIATTLLEYGALANAE--SKAGFTPLHLSSQEGH---------------------------- 646

Human  1259 ACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1323
                  .|:.:||::.||.|.|.||.||||                                   
  Fly   647 ------AEISNLLIEHKAAVNHPAKNGLTP----------------------------------- 670

Human  1324 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKIT 1388
            :.:.|.:.:....|:|...||:||:..|.|.|||.:|::.|..::|:.|:|.||:||||.:...|
  Fly   671 MHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYT 735

Human  1389 PLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEAN 1453
            ||....::||..:|..|::.                                          :||
  Fly   736 PLHQTAQQGHCHIVNLLLEH------------------------------------------KAN 758

Human  1454 KNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAA--Q 1516
            .||..:..:..|    ..:|:|...:                  .|:.::...||: |..||  |
  Fly   759 ANAQTVNGQTPL----HIARKLGYIS------------------VLDSLKTITKED-ETAAAPSQ 800

Human  1517 EKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENV 1581
            .:||.:|. .||.:.|              ::.:.:...|..:|.::....:      .:|.:.:
  Fly   801 AEEKYRVV-APEAMHE--------------SFMSDSEEEGGEDNMLSDQPYR------YLTVDEM 844

Human  1582 QIIFDDPLPISYSQPEKVNGESKSSS--------------------TSESGDS-----DNMRISS 1621
            :.:.||.|||..::.|:::....:.|                    |...|.|     |.:.|::
  Fly   845 KSLGDDSLPIDVTRDERMDSNRMTQSAEYASGVPPTIGEEVISPHKTQVYGSSPKATVDGVYIAN 909

Human  1622 CSDESSNSNSSRKSD--------------------NHSPAVVTTTVSSKKQPS-VLVTFPKEER- 1664
            .|......:..||..                    .||...:.....|..||: |...:.|.:| 
  Fly   910 GSGHDEPPHVGRKLSWKSFLVSFLVDARGGAMRGCRHSGVRMIIPSRSTCQPTRVTCRYVKPQRT 974

Human  1665 ----KSVSGKASIKLSETISEGTSNSLSTCTKS--GPSPLSSPNGKLTVASPKRGQKRE------ 1717
                :.:.|:|   |:..:.|     |..|:..  ||..:..|:     .:..||::||      
  Fly   975 MHPPQLMEGEA---LASRVLE-----LGPCSTKFIGPVVMEVPH-----FASLRGKEREIIILRS 1026

Human  1718 ---EGWKE-VVRRSKKVSVPSTVISRVIGRGGC----NINAIREFTGAHIDIDKQKDKTGDRIIT 1774
               |.|:| .:..|::      :|..|:.:  |    .|..:.|..|.|:          .|.:|
  Fly  1027 DNGETWREHTIDNSEE------IIHDVLQQ--CFEPEEIAQLEEQAGNHV----------CRFVT 1073

Human  1775 IRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTT 1839
            .        ...|.. |::....:|:..:.|:..:.||:...::.:..|.........:|::...
  Fly  1074 Y--------DFPQYF-AVVSRIRQEVHAIGPEGGMVSSTVVPQVQAVFPQGALTKKIKVGLQAQP 1129

Human  1840 VALSSTSQ-TATALTVPAISSASTHKTIKNPVNNVRP---GFPVSLPLAYPPPQFAHALLAAQTF 1900
            |....|:: ....:.|             :|:..|.|   .|..::.|:.|.|: ||:......:
  Fly  1130 VDPDLTAKLLGRGVAV-------------SPIVTVEPRRRKFHKAITLSMPAPK-AHSQGMINQY 1180

Human  1901 QQIRPP-RLPMTHFGGTFPPAQSTW 1924
            ....|. ||..:..||   |:::.|
  Fly  1181 SGNTPTLRLLCSITGG---PSRAQW 1202

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANKRD17NP_115593.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..143
ANKYR 184..465 CDD:440430 62/175 (35%)
ANK 1 233..262
ANK repeat 238..264 CDD:293786
ANK repeat 266..298 CDD:293786 1/4 (25%)
ANK 2 266..295 1/1 (100%)
ANK 3 300..329 9/29 (31%)
ANK repeat 303..331 CDD:293786 8/27 (30%)
ANK repeat 333..364 CDD:293786 11/30 (37%)
ANK 4 333..362 11/28 (39%)
ANK 5 366..395 13/28 (46%)
ANK repeat 366..394 CDD:293786 13/27 (48%)
ANKYR 385..666 CDD:440430 92/286 (32%)
ANK repeat 400..431 CDD:293786 11/30 (37%)
ANK 6 400..429 11/28 (39%)
ANK 7 433..462 10/30 (33%)
ANK repeat 435..464 CDD:293786 10/30 (33%)
ANK repeat 466..497 CDD:293786 7/30 (23%)
ANK 8 466..495 7/28 (25%)
ANK repeat 499..529 CDD:293786 11/29 (38%)
ANK 9 499..528 10/28 (36%)
ANK repeat 532..561 CDD:293786 5/28 (18%)
ANK 10 533..562 6/28 (21%)
ANK 11 563..592 12/31 (39%)
ANK repeat 566..594 CDD:293786 13/27 (48%)
ANK repeat 596..627 CDD:293786 9/30 (30%)
ANK 12 596..625 9/28 (32%)
ANK repeat 629..658 CDD:293786 9/28 (32%)
ANK 13 629..658 9/28 (32%)
Ank_2 634..719 CDD:463710 35/84 (42%)
ANK repeat 663..693 CDD:293786 15/29 (52%)
ANK 14 663..692 15/28 (54%)
ANK 15 696..725 10/28 (36%)
OmpH 794..>893 CDD:461098 7/98 (7%)
Smc <805..>1008 CDD:440809 13/202 (6%)
Ank_2 <1075..1113 CDD:463710 13/37 (35%)
ANK 16 1082..1111 10/28 (36%)
ANK repeat 1084..1113 CDD:293786 10/28 (36%)
ANKYR 1102..1390 CDD:440430 90/287 (31%)
ANK repeat 1115..1147 CDD:293786 17/31 (55%)
ANK 17 1115..1144 15/28 (54%)
ANK repeat 1149..1180 CDD:293786 12/30 (40%)
ANK 18 1149..1178 12/28 (43%)
ANK repeat 1182..1213 CDD:293786 11/30 (37%)
ANK 19 1182..1211 10/28 (36%)
ANK repeat 1217..1247 CDD:293786 6/29 (21%)
ANK 20 1217..1246 6/28 (21%)
ANK repeat 1250..1282 CDD:293786 7/31 (23%)
ANK 21 1251..1280 6/28 (21%)
ANK repeat 1284..1313 CDD:293786 4/28 (14%)
ANK 22 1284..1313 4/28 (14%)
ANK 23 1319..1348 6/28 (21%)
ANK repeat 1321..1350 CDD:293786 7/28 (25%)
ANK repeat 1352..1383 CDD:293786 14/30 (47%)
ANK 24 1352..1381 12/28 (43%)
ANK 25 1385..1414 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1479..1500 0/20 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1517..1717 43/252 (17%)
KH-I_ANKRD17 1726..1796 CDD:411930 12/73 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1906..1995 6/20 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2011..2192
Atrophin-1 <2082..>2337 CDD:460830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2273..2332
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2381..2423
Ank2NP_001189070.1 ANKYR 10..308 CDD:440430 100/306 (33%)
ANK repeat 10..41 CDD:293786 9/30 (30%)
ANK repeat 43..74 CDD:293786 11/30 (37%)
ANK repeat 76..107 CDD:293786 14/30 (47%)
ANK repeat 109..134 CDD:293786 9/26 (35%)
ANK repeat 175..202 CDD:293786 8/32 (25%)
ANKYR 190..473 CDD:440430 98/434 (23%)
ANK repeat 204..235 CDD:293786 11/30 (37%)
ANK repeat 237..268 CDD:293786 7/31 (23%)
ANK repeat 270..300 CDD:293786 12/29 (41%)
ANK repeat 303..367 CDD:293786 19/64 (30%)
ANK repeat 369..400 CDD:293786 15/30 (50%)
ANKYR 383..671 CDD:440430 123/648 (19%)
ANK repeat 402..433 CDD:293786 14/68 (21%)
ANK repeat 435..466 CDD:293786 10/88 (11%)
ANK repeat 468..497 CDD:293786 12/220 (5%)
ANK repeat 501..530 CDD:293786 10/29 (34%)
ANK repeat 535..565 CDD:293786 15/29 (52%)
ANK repeat 567..598 CDD:293786 12/30 (40%)
PHA03100 599..>773 CDD:476869 67/290 (23%)
ANK repeat 600..630 CDD:293786 11/29 (38%)
ANK repeat 633..662 CDD:293786 12/62 (19%)
ANK repeat 666..697 CDD:293786 11/65 (17%)
ANK repeat 699..730 CDD:293786 14/30 (47%)
ANK repeat 732..762 CDD:293786 10/71 (14%)
ZU5 930..1027 CDD:459941 21/109 (19%)
UPA_2 1253..1384 CDD:375346
Death_ank 1417..1497 CDD:260029
PTZ00121 <1443..2235 CDD:173412
PTZ00449 <3292..3611 CDD:185628
PTZ00449 <4400..4857 CDD:185628
PTZ00449 <4908..5267 CDD:185628
PTZ00108 <5179..5374 CDD:240271
PTZ00108 <6034..6230 CDD:240271
PTZ00449 <6620..6979 CDD:185628
PTZ00108 <7119..7314 CDD:240271
PTZ00108 <7347..7544 CDD:240271
PTZ00108 <7651..7848 CDD:240271
PTZ00449 <7804..8119 CDD:185628
PTZ00108 <8183..8381 CDD:240271
PTZ00449 <8430..8745 CDD:185628
PTZ00449 <8784..9125 CDD:185628
PTZ00449 <9028..9353 CDD:185628
PHA03307 9225..>9575 CDD:223039
PHA03307 9903..>10259 CDD:223039
PTZ00108 <10177..10451 CDD:240271
Blue background indicates that the domain is not in the aligned region.

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