Protein Alignment AUTS2 and auts2a

DIOPT Version :10

• Sequence 1: XP_011514312.1
• Gene: AUTS2 / 26053
• HGNCID: 14262
• Length: 1266
• Species: Homo sapiens
• Sequence 2: XP_073770954.1
• Gene: auts2a / 368890
• ZFINID: ZDB-GENE-030616-571
• Length: 1276
• Species: Danio rerio
• Alignment Length: 1338
• Identity: 817/1338 - (61%)
• Similarity: 952/1338 - (71%)
• Gaps: 134/1338 - (10%)

Human     1 MDGPTRGHGLRKKRRSRSQRDRERRSRGGLGAGAAGGGGAGRTRALSLASSSGSDKEDNGKPPSS 65
            |||| |..|:||||:|||.|:|||.|.|...         ...|...|..||.|:|||....|||
Zfish     1 MDGP-RCSGIRKKRKSRSVRNRERISNGIRN---------NHVRGSVLRFSSDSEKEDGSTNPSS 55

Human    66 APSRPRPPRRKRRESTSAEEDIIDGFAMTSFVTFEALEKDVALKPQERVEKRQTPLTKKKREALT 130
            : ||||||||||:||:||||||||||::..|:|.||||||:.|||.||.:.:..||.|||...:.
Zfish    56 S-SRPRPPRRKRKESSSAEEDIIDGFSIAGFMTLEALEKDMTLKPHERRQNQAGPLRKKKPGRVA 119

Human   131 NGLSFHSKKSRLSHPHHYSSDRENDRNLCQHLGKRKK---MPKALRQLKPGQNSCRDSDSESASG 192
            ||||....|.||:|.:|..||:||:..|.:...|:||   :.|..|.||||||:|:||||||.||
Zfish   120 NGLSLDLHKDRLNHSNHQHSDQENNPRLARTHSKKKKKKHLQKKHRPLKPGQNNCKDSDSESVSG 184

Human   193 ESKGFHRSSSRERLSDSSAPSSLGTGYFCDSDSDQEEKASDASSEKLFNTVIVNKDPELGVGTLP 257
            |||...|||||:||:|            |||:||||:|.|||||||||:|..| |.|:..|.||.
Zfish   185 ESKPSIRSSSRDRLTD------------CDSESDQEDKGSDASSEKLFSTAAV-KVPDFSVDTLS 236

Human   258 EHDSQD-AGPIVPKISGLERSQEKSQDCCKE----------------PIFEPVVLKDPCPQVAQP 305
            .:.||: .|..:||:|||||||||||:..:|                |:..|:.|:.|......|
Zfish   237 TNASQELRGLGIPKVSGLERSQEKSQETSREISSATPPLVPTSHPKPPLPAPLHLQPPPSSRGLP 301

Human   306 IPQPQTEPQLRAPSPDPDLVQRTEAPP------QPPPLSTQPP---QGPPEAQLQPAP--QPQV- 358
            :|....:.|    :|.|:...|..:||      |...||..||   |.|||:...|.|  .|.:
Zfish   302 LPSRPAQTQ----NPCPERTLRPLSPPIALPQSQGQELSQAPPHQSQHPPESPSHPKPPRTPSIY 362

Human   359 QRPPRP-----QSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQ-P 417
            ..||.|     |:|||       |||..|.::...:|:||| |.||:||.|||||||||.|.. |
Zfish   363 HHPPSPALPAQQNPTQ-------PVQHRPPSRCHQRPISAY-SGSLTLNGLSSSRSSTPGKPPGP 419

Human   418 AP-PHISHH------PSAS-PFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTS 474
            :| ||:.||      .||| |.||| .|.:..|:|.|:|......||.||||.|.||||||||||
Zfish   420 SPAPHLHHHQPAPTGASASFPLPLS-ANPTASHTFPPSLPSSTLPHHTNMFASPAALPPPPPLTS 483

Human   475 GSLQVAGHPAGSTYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEF----HQHQHQHQHTH 535
            .:|.|.||||||.|||||||||||||||||||||||||||||||||||||    |||||||||||
Zfish   484 NTLPVPGHPAGSAYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHQHQHTH 548

Human   536 QHTHQHTFTPFPHAIPPTAIMPTPAPPMVRTPGRNFDKYPTKVDPFYRHSLFHSYPPAVSGIPPM 600
            |||||||||||||     ||||||||||||||.|||:|||||||||||||||||||||||||||:
Zfish   549 QHTHQHTFTPFPH-----AIMPTPAPPMVRTPARNFEKYPTKVDPFYRHSLFHSYPPAVSGIPPV 608

Human   601 IPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAW 665
            |||||||||||||||||||||:|||||||.||||||||||||||||||:||||||||||||||||
Zfish   609 IPPTGPFGSLQGAFQPKTSNPLDVAARPGAVPHTLLQKDPRLTDPFRPVLRKPGKWCAMHVHIAW 673

Human   666 QIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGT 730
            ||||||||||:|||.||||||||||||||||||||:||||||||||||||::||||||:.||...
Zfish   674 QIYHHQQKVKQQMQVDPHKLDFGLKPEFLSRPPGPTLFGAIHHPHDLARPASLFSAAGSTHPAAA 738

Human   731 PFGPPPHH-SNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSV-QNF 793
            |||.|||| ||||.||.|||||:||.:|.|||::...||||||||::..||:|||||.||. |:|
Zfish   739 PFGHPPHHPSNFLTPAPHLEPFSRPPSFGGLASLSTAAFGGLGNPALASNSVFGHKDSPSAQQHF 803

Human   794 SNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAH--------DRDRDVDKRDSSVSKDDKE 850
            |.||||||||||||||||||||||||||.|||||.::|        :|:||:|||||||:|||||
Zfish   804 SGPHEPWNRLHRTPPSFPTPPPWLKPGESERSASVSSHERERERDRERERDLDKRDSSVNKDDKE 868

Human   851 RESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEA---REKDKPKERERDHSESR-KDL 911
            ||.|||||.:|.||.||.|:..|||||.| |..|.|:::..   ::|||||:||||...|. ||.
Zfish   869 REPVEKRHQNHQSPLPVNPLTLLGHTRPS-EPSRNHISSSEPRDKDKDKPKDRERDREHSDWKDS 932

Human   912 AADEHKAKEGHLPEKDGHG-HEGRAAGEEAKQLARV-PSPYVRTPVVESARPNSTSSREAEPRKG 974
            ..||||.||.|..:||... |:||.:  |.|...|: .|||:|...::  |.|...:|:...:|.
Zfish   933 NTDEHKLKENHHSDKDTPVIHDGRVS--EDKPANRITASPYMRPGGMD--RVNGGLTRDILEKKA 993

Human   975 EPAYENPKKSSEVKVKEERKEDHDLPPEAPQTHRAS--EPPPPNSSSSVHPGPLASMPMTVGVTG 1037
            |..||  ||:|||||||||||:.|.|.|.....|::  .||||   :::||.  :|||:.:|:..
Zfish   994 EITYE--KKNSEVKVKEERKEEQDGPTERSPEQRSTPQAPPPP---AALHPP--SSMPVPMGMAS 1051

Human  1038 IHPMNSISSLDRTRMMTPFMGISPLPGGERFPYPSFHWDPIRDPLRDPYRELDIHRRDPLGRDFL 1102
            :||:||||||:||||:.||||||.:||.||||||:|||    ||:|||||.|||||||||.|:.|
Zfish  1052 MHPINSISSLERTRMVAPFMGISAIPGAERFPYPAFHW----DPMRDPYRGLDIHRRDPLARELL 1112

Human  1103 LRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLSVDPRREHERGGHLDERERLHMLRE 1167
            |||||||||:.||||||:||:|||||||:   :..|.|.|:::.|||.|| .||:||||||:|||
Zfish  1113 LRNDPLHRLAAPRLYEAERSYRDREPHDF---NRDHPHVLTLEQRREQER-AHLEERERLHLLRE 1173

Human  1168 DYEHTRLHSVHPASLDGHLPHPSLITPGLPSMHYPRISPT----AGNQNGLLNKTPPTAALSAPP 1228
            |||..|||.:|...||||||||.|:.||||||||||:||:    |..|||:||||||||:|||||
Zfish  1174 DYEQGRLHPMHHPVLDGHLPHPGLMAPGLPSMHYPRVSPSSAVAAAAQNGILNKTPPTASLSAPP 1238

Human  1229 PLISTLGGRPVSPRRTTPLSAEIRERPPSHTLKDIEAR 1266
            |||.|||.|..||||||||..:||:||||||.||||||
Zfish  1239 PLIPTLGARSSSPRRTTPLGPDIRDRPPSHTHKDIEAR 1276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AUTS2	XP_011514312.1	PHA03247	<298..456	CDD:223021	69/183 (38%)
		Auts2	652..864	CDD:464656	168/221 (76%)
		PTZ00121	<846..>1009	CDD:173412	81/168 (48%)
auts2a	XP_073770954.1	None