Protein Alignment AUTS2 and auts2

DIOPT Version :10

• Sequence 1: XP_011514312.1
• Gene: AUTS2 / 26053
• HGNCID: 14262
• Length: 1266
• Species: Homo sapiens
• Sequence 2: XP_031752079.1
• Gene: auts2 / 100498056
• XenbaseID: XB-GENE-987496
• Length: 1045
• Species: Xenopus tropicalis
• Alignment Length: 1052
• Identity: 792/1052 - (75%)
• Similarity: 876/1052 - (83%)
• Gaps: 44/1052 - (4%)

Human   230 KASDASSEKLFNTVIVNKDPELGVGTLPEHDSQDA-GPIVPKISGLERSQEKSQDCCKEPIFEPV 293
            :.|||||||||:| |.|.|.||||..|....|::| |.:|||:||||||||||||..||...:.:
 Frog    23 QVSDASSEKLFHT-ISNNDTELGVRLLTTRGSKNATGQVVPKVSGLERSQEKSQDSDKELQLDVL 86

Human   294 VLKDP-CPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPP---PLSTQPPQGP--PEAQLQP 352
            |.||| .|.:  |:.....|.:....||.|.|...||.|.|..   |..|...:.|  |:|.:|.
 Frog    87 VSKDPILPSL--PVVHADLESRPILVSPGPTLDSCTEIPLQTQSEFPHVTLDHEAPSQPQAPVQK 149

Human   353 APQPQV--QRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKT 415
            ||:||:  |.|..|..||         ||..|.:|:|.|.|.:|||||||:|||||||||||||:
 Frog   150 APKPQLLSQTPVLPSPPT---------VQQRPPSQNLPQSLCSYNSSSLSVNSLSSSRSSTPAKS 205

Human   416 QPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVA 480
            |....|:.||||.||:|||||:|||||.||||||||||.|||||||||||||||||||||:|||.
 Frog   206 QATSSHLGHHPSTSPYPLSLPSHSPLHRFTPTLQPPAHQHHPNMFAPPTALPPPPPLTSGTLQVP 270

Human   481 GHPAGSTYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEF--HQHQHQHQHTHQHTHQHTF 543
            ||||.|||||||:|||||||||||||||||||||||||||||||  |||||||||||||||||||
 Frog   271 GHPANSTYSEQDLLRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHQHTHQHTHQHTF 335

Human   544 TPFPHAIPPTAIMPTPAPPMVRTPGRNFDKYPTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPFG 608
            ||||||||||||||||||||       ||||||||||||||||||||||||||||||||||||||
 Frog   336 TPFPHAIPPTAIMPTPAPPM-------FDKYPTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPFG 393

Human   609 SLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQK 673
            |||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||
 Frog   394 SLQGAFQPKTSNPIDVAGRPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQK 458

Human   674 VKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIH---HPHDLARPSTLFSAAGAAHPTGTPFGPP 735
            ||||||:|||||||||||||||||||||||||||   ||||||||||||||||..||...|||||
 Frog   459 VKKQMQTDPHKLDFGLKPEFLSRPPGPSLFGAIHPHPHPHDLARPSTLFSAAGGTHPAAAPFGPP 523

Human   736 PHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPW 800
            |||||||||:||||.|||||||:|||||||:|||||||||||.||||.||:||::|:|:||||||
 Frog   524 PHHSNFLNPSAHLEQFNRPSTFSGLAAVGGSAFGGLGNPSVTSNSMFSHKEGPNMQSFNNPHEPW 588

Human   801 NRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHSSHPSPA 865
            |||||||||||||||||||||.|||:|.|:|  :||.|||::: :|||||||:||||||||||||
 Frog   589 NRLHRTPPSFPTPPPWLKPGESERSSSVASH--ERDADKRETA-TKDDKERENVEKRHSSHPSPA 650

Human   866 PVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHLPEKDGHG 930
            |:..||:.||.||.:||.|.:||.:.|||:|||||||:||:|.|:.:.:|||.|:.|:.|||...
 Frog   651 PINQVNSTGHNRSLSEQNRNNLNNDVREKEKPKEREREHSDSWKEASIEEHKTKDNHILEKDNLV 715

Human   931 HEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKGEPAYENPKKSSEVKVKEERKE 995
            ||.|.. :|||||.||||||||.|.:|:.||||.|:||.| ||.| .|:|.|||::|||||||||
 Frog   716 HESRTI-DEAKQLNRVPSPYVRPPTMENTRPNSNSNRETE-RKTE-TYDNQKKSNDVKVKEERKE 777

Human   996 DHDL-PPEAPQTHRASEPPPPNSSSSVHPGPLASMPMTVGVTGIHPMNSISSLDRTRMMTPFMGI 1059
            :||: .|:..|.||.||.|||.|:|:|||..|||:||.:||.|:||||||..|||||||||||||
 Frog   778 EHDIVVPDGSQIHRTSEQPPPISTSNVHPSHLASLPMAMGVAGMHPMNSIGGLDRTRMMTPFMGI 842

Human  1060 SPLPGGERFPYPSFHWDPIRDPLRDPYRELDIHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFR 1124
            ||:|||||||||||||||:|||||||||.|||||||||||||||||||||||:.||||||:||||
 Frog   843 SPIPGGERFPYPSFHWDPMRDPLRDPYRGLDIHRRDPLGRDFLLRNDPLHRLTAPRLYEAERSFR 907

Human  1125 DREPHDYSHHHHHHHHPLSVDPRREHERGGHLDERERLHMLREDYEHTRLHSVHPASLDGHLPHP 1189
            |||||||:|||||    |:|||||||||..||:||||||||||||||.|||:||||:||||||||
 Frog   908 DREPHDYNHHHHH----LAVDPRREHERVSHLEERERLHMLREDYEHARLHAVHPAALDGHLPHP 968

Human  1190 SLITPGLPSMHYPRISPTAGNQNGLLNKTPPTAALSAPPPLISTLGGRPVSPRRTTPLSAEIRER 1254
            ||||||||||||.|:|||.|:|||:||||||||||||||||||||||||.|||||||||.|||:|
 Frog   969 SLITPGLPSMHYARVSPTTGHQNGILNKTPPTAALSAPPPLISTLGGRPGSPRRTTPLSTEIRDR 1033

Human  1255 PPSHTLKDIEAR 1266
            ||||||||||||
 Frog  1034 PPSHTLKDIEAR 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AUTS2	XP_011514312.1	PHA03247	<298..456	CDD:223021	82/165 (50%)
		Auts2	652..864	CDD:464656	180/214 (84%)
		PTZ00121	<846..>1009	CDD:173412	101/163 (62%)
auts2	XP_031752079.1	Auts2	437..649	CDD:464656	180/214 (84%)