DRSC/TRiP Functional Genomics Resources

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Protein Alignment PPP1R16B and Mbs

DIOPT Version :10

Sequence 1:XP_011527070.1 Gene:PPP1R16B / 26051 HGNCID:15850 Length:571 Species:Homo sapiens
Sequence 2:NP_001246786.1 Gene:Mbs / 49070 FlyBaseID:FBgn0005536 Length:1273 Species:Drosophila melanogaster


Alignment Length:473 Identity:139/473 - (29%)
Similarity:205/473 - (43%) Gaps:98/473 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   102 NEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLA 166
            |.||||||||.|||:..::|:.|:..||::|.:|||.||||||.|:||.:::.:.||:.|||:.|
  Fly    76 NVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSIARYLVENGADVAA 140

Human   167 VNSDGNMPYDLCEDEPTLDVIETCMAYQGITQE---KINEMRVAPEQQMIADIHCMIAAGQDLDW 228
            |||||::..||..|...:.:|:   ..:.:.||   .::|.|.|.|..|:.|....:.:  |...
  Fly   141 VNSDGDLALDLAIDVQHMAMID---YMEKMVQELNINVDEARKAEELAMLNDAKKWLRS--DAAE 200

Human   229 ID----AQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHG 289
            :|    ..|||.||:|.|.||.:...|||.....||.:|.|||.|||||:.|||.:.||:||...
  Fly   201 VDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRETAEMLVESL 265

Human   290 ASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRAS 354
            |.:..|....:..||:.:.:..|.|             .:||......||.||         :..
  Fly   266 ADMDIRNYAGQSCIDVADRKIVKFL-------------EELRANKRNKRRPSS---------QIR 308

Human   355 LSDRTNLYRKEYEGEAILWQRSAAEDQRTSTYNGDIRETRT-DQENKDPNPRL---EKPVLLSEF 415
            :||.               ..:..|...|.....::|...| |.||..||.::   |.|| ..|.
  Fly   309 ISDA---------------MENHVEKTPTKLVRVEVRTDATKDAENVKPNQQIHAVEHPV-EEEA 357

Human   416 P--TKIPRGELDMPVENGLRAPVSAYQYALANGDVWKVHEVPDYSMAYGNPGVA-DATPPWSSYK 477
            |  .|:||...|.|..|                      :|||..:...:...| |.....:...
  Fly   358 PWRRKLPRTPSDSPTNN----------------------QVPDRELGTNSSETANDVILRRTQSF 400

Human   478 EQSPQTLLELKRQRAAAKLLSHPFLSTHLGSSMARTGES---------------SSEGKAPLIGG 527
            |...:...:....||..|..|.|.|..:..::.|...:|               ::..|:.|:.|
  Fly   401 ENDQKFYQKYNELRARIKANSCPILPANANANAAAANKSNNNNNLSSNNYHNNNNNNNKSDLLLG 465

Human   528 RTSPYSSNGTSVYYTVTS 545
                |::..|:...|.|:
  Fly   466 ----YAAGTTTTTSTPTT 479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PPP1R16BXP_011527070.1 ANKYR <87..319 CDD:440430 90/223 (40%)
ANK repeat 104..135 CDD:293786 16/30 (53%)
ANK repeat 137..168 CDD:293786 16/30 (53%)
ANK repeat 170..263 CDD:293786 30/99 (30%)
PHA02876 <246..>401 CDD:165207 42/155 (27%)
ANK repeat 265..296 CDD:293786 16/30 (53%)
ANK repeat 298..322 CDD:293786 4/23 (17%)
MbsNP_001246786.1 ANKYR 50..300 CDD:440430 92/241 (38%)
ANK repeat 78..109 CDD:293786 16/30 (53%)
ANK repeat 111..142 CDD:293786 16/30 (53%)
ANK repeat 209..239 CDD:293786 14/29 (48%)
ANK repeat 241..272 CDD:293786 16/30 (53%)
IPD_PPP1R12 606..648 CDD:412018
PRKG1_interact 1177..1273 CDD:464927
Blue background indicates that the domain is not in the aligned region.

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