Protein Alignment CNTNAP2 and cntnap2

DIOPT Version :10

• Sequence 1: NP_054860.1
• Gene: CNTNAP2 / 26047
• HGNCID: 13830
• Length: 1331
• Species: Homo sapiens
• Sequence 2: XP_031759324.1
• Gene: cntnap2 / 780189
• XenbaseID: XB-GENE-956230
• Length: 1338
• Species: Xenopus tropicalis
• Alignment Length: 1346
• Identity: 1021/1346 - (75%)
• Similarity: 1159/1346 - (86%)
• Gaps: 36/1346 - (2%)

Human    14 LLWI-----------VSSCL-CRAWTAPSTSQKCDEPLVSGLPHVAFSSSSSISGSYSPGYAKIN 66
            ::||           :.||: |.|.:|..||.|||||||.||||.:|.|||..||||:|||||:|
 Frog     1 MVWIFRDRCTVPFLGILSCIYCMARSASPTSMKCDEPLVLGLPHPSFRSSSIKSGSYAPGYAKLN 65

Human    67 KRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTQYRMLYSDTGRNWKPYHQDG 131
            ||..||||||.||||||||||||||||||.:|||||||||||||:||||||||||||||||||||
 Frog    66 KRDEAGGWSPLDSDHYQWLQVDFGNRKQIRSIATQGRYSSSDWVSQYRMLYSDTGRNWKPYHQDG 130

Human   132 NIWAFPGNINSDGVVRHELQHPIIARYVRIVPLDWNGEGRIGLRIEVYGCSYWADVINFDGHVVL 196
            ||||||||:|||.||||:||||:|||||||||||||.||:||||.|:|||.||||||||||:..|
 Frog   131 NIWAFPGNVNSDTVVRHDLQHPVIARYVRIVPLDWNEEGQIGLRTELYGCPYWADVINFDGNSGL 195

Human   197 PYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYG 261
            .|||:|||||||||||:|.||:|||||||.|||||:|||||||||||||||.|||||||.|.|||
 Frog   196 SYRFKNKKMKTLKDVISLKFKSSESEGVIFHGEGQEGDYITLELKKAKLVLQLNLGSNQYGSIYG 260

Human   262 HTSVMTGSLLDDHHWHSVVIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPS 326
            ||||.:||||||||||:|:|||.||:|||||||.||||:|||:|:.||||:|:||||:|||||||
 Frog   261 HTSVTSGSLLDDHHWHTVIIERHGRNINLTLDRHMQHFKTNGDFESLDLDFELTFGGMPFSGKPS 325

Human   327 SSSRKNFKGCMESINYNGVNITDLARRKKLEPSNVGNLSFSCVEPYTVPVFFNATSYLEVPGRLN 391
            ||||||||||||||||||:||||||||||:||.|:.||||:|||..:|||||||||||||.||.|
 Frog   326 SSSRKNFKGCMESINYNGINITDLARRKKVEPYNMANLSFTCVESRSVPVFFNATSYLEVRGRPN 390

Human   392 QDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDG 456
            :||.|||||||||||:|||:::.|:|.||||||||||.||.||||:|::|.::||||||||||||
 Frog   391 EDLLSVSFQFRTWNPSGLLLYNTFSDELGNVEIDLTEGKVSVHINMTKSKKNRIDISSGSGLNDG 455

Human   457 QWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCM 521
            ||||||..|||||||||:||||||:||||||||.:||.:||||||.:..|.:.||:||.||||||
 Frog   456 QWHEVRLTAKENFAILTVDGDEASSVRTNSPLQFQTGSRYFFGGFYSLSNYTDHSLLQHSFQGCM 520

Human   522 QLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYS 586
            |||.||||||:|:.|.|.|.||:||:||||||||||||||:|||||:|:|||||..|.|:.|||:
 Frog   521 QLIHVDDQLVDLHAVEQGKHGSYANISIDMCAIIDRCVPNNCEHGGRCTQTWDSMTCNCEGTGYT 585

Human   587 GATCHNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIVSHDLQMQTPVV 651
            ||||||||||.|||||||||::|::||||||||||||||||:||||||||||.:.|||.:|||:|
 Frog   586 GATCHNSIYELSCEAYKHLGKSSDWYWIDPDGSGPLGPLKVFCNMTEDKVWTTLFHDLSLQTPIV 650

Human   652 GYNPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRLLNTPDGSPYTWWVGKANEKHY 716
            ..:.:|..|..|.|||||:||||||.||||||||:||.|:||||||||||:||||||||.||||:
 Frog   651 AASLDKPVVLNLNYSASMEQISAITGSAEYCEQYISYSCRMSRLLNTPDGNPYTWWVGKGNEKHH 715

Human   717 YWGGSGPGIQKCACGIERNCTDPKYYCNCDADYKQWRKDAGFLSYKDHLPVSQVVVGDTDRQGSE 781
            |||||.||||||||||||||:|.|::||||||.:|||||||||||||||||||||||||.|..||
 Frog   716 YWGGSSPGIQKCACGIERNCSDSKFHCNCDADQRQWRKDAGFLSYKDHLPVSQVVVGDTFRSSSE 780

Human   782 AKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKEDFI 846
            |||||.||||.||:||||||||..||||||||||||||||||||||||..|.||||||.||.|||
 Frog   781 AKLSVEPLRCHGDKNYWNAASFTTPSSYLHFSTFQGETSADISFYFKTSAPDGVFLENRGKTDFI 845

Human   847 KLELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTE 911
            ||||||.|||||:|||||||||::||||:||||||||||.||||||:||||||:||.|:.||||:
 Frog   846 KLELKSNTEVSFAFDVGNGPVELIVRSPSPLNDDQWHRVRAERNVKEASLQVDQLPWQLHKAPTQ 910

Human   912 GHTRLELYSQLFVGGAGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGFISGCSGHCTSYGTNCEN 976
            ||||||||||||||.||.|:|||||||||||||:|||||||||:|.|...||||||||:|..|:|
 Frog   911 GHTRLELYSQLFVGAAGDQRGFLGCIRSLRMNGMTLDLEERAKITPGVKPGCSGHCTSFGMYCQN 975

Human   977 GGKCLERYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQQN 1041
            ||||:|:|:||:||||.|||||.:||||||.:||||.||||||.:.:|.|..|:....|.|....
 Frog   976 GGKCVEKYNGYTCDCSRTAYDGPYCNKDVGGYFEEGTWLRYNFHSASTAAVVSTKETGNIPQSSA 1040

Human  1042 SHPDLAQEEIRFSFSTTKAPCILLYISSFTTDFLAVLVKPTGSLQIRYNLGGTREPYNIDV-DHR 1105
            |...||:||:.|||||||:|||||||||::.|:||||:|.:|.||||||||||::|||||: ||:
 Frog  1041 SDIGLAKEELLFSFSTTKSPCILLYISSYSQDYLAVLLKASGILQIRYNLGGTKDPYNIDISDHK 1105

Human  1106 NMANGQPHSVNITRHEKTIFLKLDHYPSVSYHLPSSSDTLFNSPKSLFLGKVI------------ 1158
            |||||||||:||||..:.:..:|||||...|:|||:|||.||.||:|||||||
 Frog  1106 NMANGQPHSINITRSGRNVIFQLDHYPPAVYNLPSASDTQFNGPKALFLGKVIETQQFGGQSQHQ 1170

Human  1159 ---ETGKIDQEIHKYNTPGFTGCLSRVQFNQIAPLKAALRQTNASAHVHIQGELVESNCGASPLT 1220
               |||..||:||.||||||:|||||||||.|||||||||.:| ::.|.||||||||||||||||
 Frog  1171 ILKETGTKDQDIHSYNTPGFSGCLSRVQFNLIAPLKAALRSSN-NSQVFIQGELVESNCGASPLT 1234

Human  1221 LSPMSSATDPWHLDHLDSASADFPYNPGQGQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLIRY 1285
            :.||:|.|||||     |.|.:||.|  :||||::|||||||||||:||||||||||||||||||
 Frog  1235 IPPMTSNTDPWH-----SESPEFPNN--EGQAIKDGVNRNSAIIGGIIAVVIFTILCTLVFLIRY 1292

Human  1286 MFRHKGTYHTNEAKGAESAESADAAIMNNDPNFTETIDESKKEWLI 1331
            |||||||||||||||||||::|||||:|||||||||||||||||||
 Frog  1293 MFRHKGTYHTNEAKGAESADTADAAIINNDPNFTETIDESKKEWLI 1338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNTNAP2	NP_054860.1	FA58C	<70..180	CDD:238014	96/109 (88%)
		Laminin_G_2	216..345	CDD:460494	108/128 (84%)
		LamG	375..527	CDD:238058	114/151 (75%)
		EGF_CA	555..590	CDD:238011	25/34 (74%)
		GGGWT_bact	598..634	CDD:468872	30/35 (86%)
		LamG	800..943	CDD:238058	120/142 (85%)
		EGF	967..>992	CDD:394967	16/24 (67%)
		Laminin_G_2	1055..1187	CDD:460494	96/147 (65%)
		4.1m	1282..1300	CDD:128590	17/17 (100%)
cntnap2	XP_031759324.1	FA58C	41..179	CDD:238014	116/137 (85%)
		LamG	186..342	CDD:238058	128/155 (83%)
		LamG	374..526	CDD:238058	114/151 (75%)
		EGF	557..588	CDD:394967	21/30 (70%)
		GGGWT_bact	597..633	CDD:468872	30/35 (86%)
		LamG	799..942	CDD:238058	120/142 (85%)
		EGF_CA	966..1000	CDD:238011	23/33 (70%)
		Laminin_G_2	1054..1200	CDD:460494	94/145 (65%)
		4.1m	1289..1307	CDD:128590	17/17 (100%)