Protein Alignment CNTNAP2 and Cntnap2

DIOPT Version :10

• Sequence 1: NP_054860.1
• Gene: CNTNAP2 / 26047
• HGNCID: 13830
• Length: 1331
• Species: Homo sapiens
• Sequence 2: NP_001004357.2
• Gene: Cntnap2 / 66797
• MGIID: 1914047
• Length: 1332
• Species: Mus musculus
• Alignment Length: 1328
• Identity: 1248/1328 - (93%)
• Similarity: 1286/1328 - (96%)
• Gaps: 3/1328 - (0%)

Human     6 RAGCGAALLLWIVSSCLCRAWTAPSTSQKCDEPLVSGLPHVAFSSSSSISGSYSPGYAKINKRGG 70
            |||..|||.|||:||.:|||||||||.|||||||:||||||:||||||:|.||:|||||||||||
Mouse     6 RAGYRAALSLWILSSFICRAWTAPSTFQKCDEPLISGLPHVSFSSSSSLSSSYAPGYAKINKRGG 70

Human    71 AGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWA 135
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    71 AGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWA 135

Human   136 FPGNINSDGVVRHELQHPIIARYVRIVPLDWNGEGRIGLRIEVYGCSYWADVINFDGHVVLPYRF 200
            ||||:|||.||||:|||.::|||||:|||||||||.||||.|||||:|||||||||||.||||||
Mouse   136 FPGNVNSDSVVRHDLQHAVVARYVRVVPLDWNGEGHIGLRAEVYGCAYWADVINFDGHGVLPYRF 200

Human   201 RNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSV 265
            ||||||||||||||.|||||||||:||||||||||||||||||||||||||||||||||||||||
Mouse   201 RNKKMKTLKDVIALKFKTSESEGVLLHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSV 265

Human   266 MTGSLLDDHHWHSVVIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSSR 330
            .:||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||:|
Mouse   266 TSGSLLDDHHWHSVLIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSNR 330

Human   331 KNFKGCMESINYNGVNITDLARRKKLEPSNVGNLSFSCVEPYTVPVFFNATSYLEVPGRLNQDLF 395
            ||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||
Mouse   331 KNFKGCMESINYNGVNITDLARRKKLEPSNMGNLSFSCVEPYTVPVFFNATSYLEVPGRLNQDLF 395

Human   396 SVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHE 460
            |||||||||||:|||:|||||||||||||||.|||||||||.||||.||||||||||||||||||
Mouse   396 SVSFQFRTWNPSGLLLFSHFADNLGNVEIDLVESKVGVHINNTQTKTSQIDISSGSGLNDGQWHE 460

Human   461 VRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQ 525
            ||||||||||:||||||||||||||||||||||||||||||||.|||:|:|.|||||||||||||
Mouse   461 VRFLAKENFAVLTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNHMNNASYSALQPSFQGCMQLIQ 525

Human   526 VDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATC 590
            ||||||||||||.|||||||||:||||||||||||||||||||||||||||||||||||||||||
Mouse   526 VDDQLVNLYEVAHRKPGSFANVTIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATC 590

Human   591 HNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIVSHDLQMQTPVVGYNP 655
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||
Mouse   591 HNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIVSHDLQMQTTVVGYNP 655

Human   656 EKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRLLNTPDGSPYTWWVGKANEKHYYWGG 720
            ||||||||:||||||||||||.|||||||||||||:|||||||||||||||||||||||||||||
Mouse   656 EKYSVTQLIYSASMDQISAITSSAEYCEQYVSYFCRMSRLLNTPDGSPYTWWVGKANEKHYYWGG 720

Human   721 SGPGIQKCACGIERNCTDPKYYCNCDADYKQWRKDAGFLSYKDHLPVSQVVVGDTDRQGSEAKLS 785
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   721 SEPGIQKCACGIERNCTDPKYYCNCDADYKQWRKDAGFLSYKDHLPVSQVVVGDTDRQGSEAKLS 785

Human   786 VGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKEDFIKLEL 850
            |||||||||||||||||||||||||||||||||||||||||||||.|.||||||:|..|||||||
Mouse   786 VGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLIPRGVFLENLGNTDFIKLEL 850

Human   851 KSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTR 915
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
Mouse   851 KSATEVSFSFDVGNGPVEIVVRSPSPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTR 915

Human   916 LELYSQLFVGGAGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGFISGCSGHCTSYGTNCENGGKC 980
            ||||||||||||||||||||||||||||||||||||||||||||.|||||||||||.||||||||
Mouse   916 LELYSQLFVGGAGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGFKSGCSGHCTSYGANCENGGKC 980

Human   981 LERYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQQNSH-- 1043
            :|:||||||||||||||||||||||||||||||||||||||||..|||:.||.:|:.||| .|
Mouse   981 IEKYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPAVTARDTGSRAENSADQQ-QHLA 1044

Human  1044 PDLAQEEIRFSFSTTKAPCILLYISSFTTDFLAVLVKPTGSLQIRYNLGGTREPYNIDVDHRNMA 1108
            ||||||:|.||||||||||||||:||.|||||||||||||:|||||||||||||:||||||||||
Mouse  1045 PDLAQEQIHFSFSTTKAPCILLYVSSLTTDFLAVLVKPTGNLQIRYNLGGTREPFNIDVDHRNMA 1109

Human  1109 NGQPHSVNITRHEKTIFLKLDHYPSVSYHLPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTP 1173
            |||||||||||||:||.|||||||:|.||||||||||||||||||||||||||||||||||||||
Mouse  1110 NGQPHSVNITRHERTIILKLDHYPAVGYHLPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTP 1174

Human  1174 GFTGCLSRVQFNQIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMSSATDPWHLDHLDS 1238
            ||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1175 GFTGCLSRVQFNHIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMSSATDPWHLDHLDS 1239

Human  1239 ASADFPYNPGQGQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAES 1303
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1240 ASADFPYNPGQGQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAES 1304

Human  1304 AESADAAIMNNDPNFTETIDESKKEWLI 1331
            ||||||||||||||||||||||||||||
Mouse  1305 AESADAAIMNNDPNFTETIDESKKEWLI 1332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNTNAP2	NP_054860.1	FA58C	<70..180	CDD:238014	100/109 (92%)
		Laminin_G_2	216..345	CDD:460494	123/128 (96%)
		LamG	375..527	CDD:238058	141/151 (93%)
		EGF_CA	555..590	CDD:238011	34/34 (100%)
		GGGWT_bact	598..634	CDD:468872	35/35 (100%)
		LamG	800..943	CDD:238058	136/142 (96%)
		EGF	967..>992	CDD:394967	21/24 (88%)
		Laminin_G_2	1055..1187	CDD:460494	123/131 (94%)
		4.1m	1282..1300	CDD:128590	17/17 (100%)
Cntnap2	NP_001004357.2	FA58C	58..180	CDD:238014	111/121 (92%)
		LamG	187..343	CDD:238058	148/155 (95%)
		LamG	375..527	CDD:238058	141/151 (93%)
		EGF_CA	555..590	CDD:238011	34/34 (100%)
		GGGWT_bact	598..634	CDD:468872	35/35 (100%)
		LamG	800..943	CDD:238058	136/142 (96%)
		EGF	967..>992	CDD:394967	21/24 (88%)
		Laminin_G_2	1056..1188	CDD:460494	123/131 (94%)
		4.1m	1283..1301	CDD:128590	17/17 (100%)