DRSC/TRiP Functional Genomics Resources

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Protein Alignment CNTNAP2 and nlr-1

DIOPT Version :10

Sequence 1:NP_054860.1 Gene:CNTNAP2 / 26047 HGNCID:13830 Length:1331 Species:Homo sapiens
Sequence 2:NP_502312.2 Gene:nlr-1 / 178167 WormBaseID:WBGene00003772 Length:1180 Species:Caenorhabditis elegans


Alignment Length:1423 Identity:341/1423 - (23%)
Similarity:543/1423 - (38%) Gaps:346/1423 - (24%)


- Green bases have known domain annotations that are detailed below.


Human     7 AGCGAALLLWIV----SSCLCRAWTAPSTSQKCDEPLVSGLPHVAFSSSSSISGSYSPGYAKINK 67
            :|....|||.|.    ||..|...:..|.:.|.|     ||..|   :..|:||..|..:.|:  
 Worm     2 SGLCLVLLLSIFAVSQSSGECSDVSFSSVASKLD-----GLKRV---TRLSVSGHISAYHVKV-- 56

Human    68 RGGAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGN 132
                   |.||.| :|.:::..||.                     .:|||.........|.|  
 Worm    57 -------SISDDD-FQLVRLSNGNP---------------------LVLYSTLSNTPSWTHVD-- 90

Human   133 IWAFPGNINSDGVVRHELQHPIIARYVRIVP-LDWNGEGRIGLRIEVYGCSYWADVINFDG---- 192
                                 .:|..|||.| .:...|...|..:.:..|.|...:..||.    
 Worm    91 ---------------------FLATEVRIFPAFEQATEDVRGPLLILTICDYDTPITAFDDSSYT 134

Human   193 ----HVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGS 253
                |..|...:.|.        :.:.|:|..| ||.......|||.:..::....:.:..:.||
 Worm   135 VEAHHAGLVSMYEND--------LCVVFRTYRS-GVFFFSMADQGDVLIAQIIHGTVHVIFDFGS 190

Human   254 NQLGPIYGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLDR-SMQHFRTNGEFDYLDLDYEITFG 317
              |.|    :.:..|..|||..||.:....|..|:.|::|. .:......|.:..|||...:..|
 Worm   191 --LTP----SRISAGKALDDGRWHEMRWLHQFDSVQLSIDGVLLNQTAPTGLYRKLDLHSVVHIG 249

Human   318 GIPFSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLEPSNVGNLSFSCVEPYTVPVFFNATS 382
            |.| :...|......|.||:..:..|..::.      :|.|:.|.|   .|..|.......:.:|
 Worm   250 GRP-NDDFSQGIETTFTGCIARLQLNNADLL------QLSPNEVHN---QCQMPKPPSFTLHNSS 304

Human   383 YLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADN--LGNVEIDLTESKVGVHINITQTKMS-- 443
            ...:|    ......||:||....||.||....|:|  |.:|.|| .|||:.:..|||:.|.:  
 Worm   305 RAVLP----FTFLPFSFEFRIVPINGPLVTLFDAENGTLVDVVID-EESKLHLVSNITKFKQAAN 364

Human   444 -QIDISSGSGLNDGQWH----EVRFLAKE----NFAILTIDGDEASAVRTNSPLQVKTGEKYFFG 499
             .||::      ||.||    .:|.:..|    .:.:|.::|.|...|                 
 Worm   365 PAIDVA------DGAWHSFSLRIRGVRMEIDIDGYTVLWLEGHEVRRV----------------- 406

Human   500 GFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVPNHCE 564
                 ....|:.:|..|  ||.:.:.:|...|       |..|   ||:...|...::|:||.||
 Worm   407 -----SQRLSNFILSAS--GCYRSVTIDLTSV-------RVDG---NVTRGECTFQEKCLPNPCE 454

Human   565 HGGKCSQT-WDSFKCTCDETGYSGATCHNSIYEPSCEAY------KHLGQTSNYYWIDPDGSGPL 622
            :||.|.|: .|.:.|.|.| ||.|..||.:....|||.:      |..........||.||.|.:
 Worm   455 NGGGCVQSALDDYVCNCKE-GYKGKNCHTTDLPHSCEEWVFTKGNKQKAVQGRKVLIDIDGGGEM 518

Human   623 GPLKVYCNMTEDK-----VWTIVSHDLQMQTPVVGYNPE---KYSVTQLVYSASMDQISAITDSA 679
            .|:.|.|....|:     |.||:.|||.....|.|.|..   :||:|   |..|.:|:..:.:..
 Worm   519 QPINVTCKTERDEIGIDGVSTILEHDLLRPMIVTGDNKPGAVRYSLT---YGISTEQMDRLVEGF 580

Human   680 EYCEQYVSYFCK-MSRLLNTPD-GSPYTWWVGKANEKHYYWGGSGPGIQKCACGIERNCTDPKYY 742
            |.|.|::.|.|: .:||:...| .||.:|:..::::....||.:.|..:.|:|.|..:|...: .
 Worm   581 EACSQFMRYTCRGGARLMTQGDERSPSSWYSTRSDKHGLQWGEAPPYSRMCSCAINGSCLHNR-M 644

Human   743 CNCDADYKQWRKDAGFLSYKDHLPVSQVVVGDTDRQGSEAKLSVGPLRCQGDRNYWNAASFPNPS 807
            ||||:.  :...|.|...|...|||:.:.:|.|.: .|..::.:|||:|: :|..::..:|.|.:
 Worm   645 CNCDSG--EDSTDEGVNPYSQLLPVTGLFLGGTTK-SSSIEVEIGPLKCR-NRATFDPVTFSNRN 705

Human   808 SYLHFSTFQGETSADISFYFK------TLTPWGVFLENMGKEDFIKLELKSATEVSFSFDVGNGP 866
            :.|..:....:.:.|:|.:.|      ::..|    .:.....:..|.:.....|.   :|.||.
 Worm   706 AKLSGAQTFNQRTFDVSLHVKFSHSQMSILSW----HSTDDLHWFHLYVNDGKIVG---EVVNGG 763

Human   867 VEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKA---PTEGHTRLELYSQLFVGGA- 927
            ....:.|....:|.::|.:..|.:.....|:||...:.::.:   ||       :|  :::.|: 
 Worm   764 ESQQIVSEHRYDDGKFHAIYWEADSTGMFLKVDGQRKSVKTSFILPT-------VY--MWIVGSR 819

Human   928 --GGQQGFLGCIRSLRMNGVTLDLEE--RAKVTSGFISGCSGHCTSYGTNCENGGKCLERYHGYS 988
              .|..||.|.||::.:.||.|.|.:  |.:...|...|..|:|..  ..|:|||:|:::|.||.
 Worm   820 TEKGSTGFAGVIRNVHLCGVELALGQYARKETERGVAIGDDGYCRP--DLCQNGGQCVDKYDGYV 882

Human   989 CDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQQNSHPDLAQEEIRF 1053
            ||||.|.:.|:.|.|:.|.....|..::..:|.||              .|...|        |.
 Worm   883 CDCSMTPFGGSDCTKEYGMMVPAGSSIQIPWQNPA--------------HQAMCH--------RI 925

Human  1054 SFSTT-KAPCILLYISSFTTDFLAVLVKPTGSLQI---------------RYNLGGTREPYNIDV 1102
            :..|| :...||...:.|......:.|...|:||:               |:||..       |:
 Worm   926 AIQTTSRNTTILRSKALFADSTFNMTVDDNGNLQMMAYDGFFFHFKRQSKRHNLSD-------DI 983

Human  1103 DHRNMANGQPHSVNITRHEKTIFLKLDHYPSVSYHLPSSSDTLFNSPKSLFLGKVIETGKIDQEI 1167
            .|........|..|::         :|....::.   ..:.|.|.|                ..:
 Worm   984 MHDISFCASKHHFNVS---------VDGMQVITI---EGNWTFFES----------------FNV 1020

Human  1168 HKYNTPGFTGCLSRVQFNQIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMSSATDPWH 1232
            ..:....|.||:||:|.....|||     ...:|.::..|::....|....::...|        
 Worm  1021 WHFLDENFEGCVSRIQTGSAFPLK-----NPKTARLNYSGKIRFGTCPIEAVSRQQM-------- 1072

Human  1233 LDHLDSASADFPYNPGQGQAIRN------------GVNRN------SAIIGGVIAVVIFTILCTL 1279
                      :.:|| |...|.:            .|::|      .|||||.|..:...||| :
 Worm  1073 ----------YDFNP-QPDLISSTIKTSTEDIKIFSVSQNKQDLVSKAIIGGGILALSLFILC-M 1125

Human  1280 VFLIRYM-FRHKGTYHTNEAKGAESAESADAAIM-------NNDPNFTETIDESKKEW 1329
            ..||.|| .|.:|.|.|||.....|...::..::       ||:|.:.     |.||:
 Worm  1126 SSLICYMRSRPEGVYKTNETGENCSPSRSEEPLVHNTTSNNNNNPTYA-----SNKEY 1178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CNTNAP2NP_054860.1 FA58C <70..180 CDD:238014 19/110 (17%)
Laminin_G_2 216..345 CDD:460494 34/129 (26%)
LamG 375..527 CDD:238058 40/164 (24%)
EGF_CA 555..590 CDD:238011 16/35 (46%)
GGGWT_bact 598..634 CDD:468872 12/41 (29%)
LamG 800..943 CDD:238058 29/154 (19%)
EGF 967..>992 CDD:394967 11/24 (46%)
Laminin_G_2 1055..1187 CDD:460494 26/147 (18%)
4.1m 1282..1300 CDD:128590 10/18 (56%)
nlr-1NP_502312.2 Laminin_G_2 154..275 CDD:460494 33/128 (26%)
EGF 448..479 CDD:394967 16/31 (52%)
LamG 717..836 CDD:238058 26/134 (19%)
hEGF 868..>885 CDD:463660 9/16 (56%)

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