DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRRTM2 and CG18095

DIOPT Version :9

Sequence 1:NP_056379.1 Gene:LRRTM2 / 26045 HGNCID:19409 Length:516 Species:Homo sapiens
Sequence 2:NP_001188805.1 Gene:CG18095 / 34823 FlyBaseID:FBgn0028872 Length:564 Species:Drosophila melanogaster


Alignment Length:323 Identity:92/323 - (28%)
Similarity:149/323 - (46%) Gaps:39/323 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFT 130
            |.||:|.|:::|.|.|...|.|..|:|:.||::.:....|:||::|..|.|..|:|.::...:|.
  Fly   140 LDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFE 204

Human   131 QLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRS 195
            ...:|::|.|..|.||||......||.:|..|:|.||.|:.:...:|.....|:.||||.|.:..
  Fly   205 SNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITK 269

Human   196 LARNGFAGLIKLRELHLEHNQLTKI--------------------------NFAHFLRLSSLHTL 234
            |.:...:||..|..|::.||.:.||                          |..||  .:.|..:
  Fly   270 LNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHF--NTQLEEI 332

Human   235 FLQWNKISNLTCGMEWTWGTLEKLDLTGNEIK-AIDLTVFETMPNLKILLMD--NNKLNSLDSKI 296
            .|..|||..::..|.:....|..:.|:||.|. |..|.......|...|.:|  :|:|.||:   
  Fly   333 ILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRFTLYVDLSSNRLKSLN--- 394

Human   297 LNSLRSLTTVGLSGNLWECSARICALASWLG---SFQGRWEHSILCHSPDHTQGEDILDAVHG 356
            |:||.....:.|:.|.|.|:..:..|...|.   :|...|  :::.:..::|...:.:|.:.|
  Fly   395 LSSLLHFRYINLADNNWSCNWLVANLVQKLPNSVNFARPW--TVINNLSENTTNVEGIDCIEG 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRRTM2NP_056379.1 LRR 1 63..83 8/16 (50%)
LRR <65..312 CDD:227223 82/274 (30%)
leucine-rich repeat 66..86 CDD:275380 8/19 (42%)
LRR 2 86..107 6/20 (30%)
leucine-rich repeat 87..110 CDD:275380 8/22 (36%)
LRR 3 110..131 6/20 (30%)
leucine-rich repeat 111..134 CDD:275380 6/22 (27%)
LRR 4 134..155 8/20 (40%)
leucine-rich repeat 135..158 CDD:275380 10/22 (45%)
LRR 5 158..179 7/20 (35%)
leucine-rich repeat 159..182 CDD:275380 7/22 (32%)
LRR 6 182..203 7/20 (35%)
leucine-rich repeat 183..206 CDD:275380 9/22 (41%)
LRR 7 206..227 9/46 (20%)
leucine-rich repeat 207..230 CDD:275380 9/48 (19%)
LRR 8 230..251 6/20 (30%)
leucine-rich repeat 231..254 CDD:275380 6/22 (27%)
LRR 9 254..275 7/21 (33%)
leucine-rich repeat 255..278 CDD:275380 7/23 (30%)
LRR 10 278..299 8/22 (36%)
leucine-rich repeat 279..300 CDD:275380 7/22 (32%)
PCC 284..>351 CDD:188093 17/71 (24%)
Involved in DLG4-binding. /evidence=ECO:0000250 513..516
CG18095NP_001188805.1 leucine-rich repeat 41..64 CDD:275380
LRR_8 64..123 CDD:290566
leucine-rich repeat 65..88 CDD:275380
leucine-rich repeat 89..112 CDD:275380
leucine-rich repeat 113..136 CDD:275380
LRR_RI 115..384 CDD:238064 73/245 (30%)
LRR_8 135..195 CDD:290566 21/54 (39%)
leucine-rich repeat 137..160 CDD:275380 8/19 (42%)
leucine-rich repeat 161..184 CDD:275380 8/22 (36%)
LRR_8 184..243 CDD:290566 21/58 (36%)
leucine-rich repeat 185..208 CDD:275380 6/22 (27%)
leucine-rich repeat 209..232 CDD:275380 10/22 (45%)
LRR_8 232..289 CDD:290566 18/56 (32%)
leucine-rich repeat 233..256 CDD:275380 7/22 (32%)
leucine-rich repeat 257..280 CDD:275380 9/22 (41%)
LRR_8 280..339 CDD:290566 12/60 (20%)
leucine-rich repeat 281..304 CDD:275380 6/22 (27%)
leucine-rich repeat 305..328 CDD:275380 3/24 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45712
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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