Protein Alignment MAGI3 and RSP5

DIOPT Version :9

• Sequence 1: NP_001136254.1
• Gene: MAGI3 / 260425
• HGNCID: 29647
• Length: 1481
• Species: Homo sapiens
• Sequence 2: NP_011051.3
• Gene: RSP5 / 856862
• SGDID: S000000927
• Length: 809
• Species: Saccharomyces cerevisiae
• Alignment Length: 404
• Identity: 88/404 - (21%)
• Similarity: 129/404 - (31%)
• Gaps: 95/404 - (23%)

Human     3 KTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREE-------------PGG 54
            |..|||......|....|      ||    :.|..:.......||.|||             ...
Yeast    74 KKFKKKDQGFLGVVNVRV------GD----VLGHLDEDTATSSGRPREETITRDLKKSNDGMAVS 128

Human    55 GTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSL 119
            |...||..|.||........:|...|..||..:              |.:.........|::.:.
Yeast   129 GRLIVVLSKLPSSSPHSQAPSGHTASSSTNTSS--------------TTRTNGHSTSSTRNHSTS 179

Human   120 QFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLESG--- 181
            ...:|:     .|.:...|...|...|..|.....  ..:....:..|:.:.|:....|..|
Yeast   180 HPSRGT-----AQAVESTLQSGTTAATNTATTSHR--STNSTSSATRQYSSFEDQYGRLPPGWER 237

Human   182 -------TY--DGNFYGTP-KPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSL 236
                   ||  |.|...|. |.|.         :||    .|.:..:|....|.:.:.:....:|
Yeast   238 RTDNFGRTYYVDHNTRTTTWKRPT---------LDQ----TEAERGNQLNANTELERRQHRGRTL 289

Human   237 PEEEEDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWEM 301
            |....|.....:...|.:              .:|..|.. ::..|.........|..||..||.
Yeast   290 PGGSSDNSSVTVQVGGGS--------------NIPPVNGA-AAAAFAATGGTTSGLGELPSGWEQ 339

Human   302 AYTDTGMIYFIDHNTKTTTWLDPRLCK--KAKAPED--------CEDGELPYGWEKIEDPQYGTY 356
            .:|..|..||:||||:||||:|||..:  :...|.:        .:.|.||.|||.........|
Yeast   340 RFTPEGRAYFVDHNTRTTTWVDPRRQQYIRTYGPTNTTIQQQPVSQLGPLPSGWEMRLTNTARVY 404

Human   357 YVDHLNQKTQFENP 370
            :|||..:.|.:::|
Yeast   405 FVDHNTKTTTWDDP 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAGI3	NP_001136254.1	Interaction with ADRB1 and TGFA. /evidence=ECO:0000250	18..106		20/100 (20%)
		PDZ_signaling	24..101	CDD:238492	18/89 (20%)
		NK	123..>197	CDD:327404	17/86 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..273		17/93 (18%)
		WW	294..326	CDD:197736	18/31 (58%)
		WW	342..372	CDD:238122	10/29 (34%)
		Interaction with PTEN. /evidence=ECO:0000269|PubMed:10748157	410..492
		PDZ	413..493	CDD:214570
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..570
		PDZ	575..656	CDD:214570
		Interaction with ADGRB1. /evidence=ECO:0000269|PubMed:10748157	726..808
		PDZ_signaling	726..807	CDD:238492
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..843
		PDZ_signaling	849..935	CDD:238492
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000269|PubMed:10748157, ECO:0000269|PubMed:16904289	851..938
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	939..976
		PDZ_signaling	1022..1100	CDD:238492
		Red1	<1132..1461	CDD:311769
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1170..1481
RSP5	NP_011051.3	HUL4	3..809	CDD:227354	88/404 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900