Protein Alignment SETBP1 and set-19

DIOPT Version :10

• Sequence 1: XP_024306917.1
• Gene: SETBP1 / 26040
• HGNCID: 15573
• Length: 1622
• Species: Homo sapiens
• Sequence 2: NP_001379854.1
• Gene: set-19 / 180834
• WormBaseID: WBGene00020919
• Length: 953
• Species: Caenorhabditis elegans
• Alignment Length: 650
• Identity: 124/650 - (19%)
• Similarity: 215/650 - (33%)
• Gaps: 217/650 - (33%)

Human    56 EPEEEDELGSGRDVDSNSNADSEKWVAGDGLEEQEFSIKEANFTEGSL----------KLKIQTT 110
            ||..|.|        ....|.....:|.:.:|.:   |:||:....:|          ||:....
 Worm   354 EPTPESE--------RCKRARDRSIIAAETIEAE---IEEAHEKRMALKARKAFLLKRKLRKSNV 407

Human   111 KRAKKPPKNLENYICPPEIKITIKQSGDQKVSRAGKNSKATKEEERSHSKKKGVTVTYSDLPSCV 175
            :|.:.|    ||...|    :....|.....:....:|..::.:.|..::..||..:.|
 Worm   408 RRTESP----ENKRSP----VQSSSSSSSGSTEGNVSSLRSRSDVRKSTRLVGVRSSSS------ 458

Human   176 WHSAVIAEDCLGILLTASDLAASDLKGFQPQAYERPQKHSTLHYDTGLPQDFTGDTLKPKHQQKS 240
                         :..|::.|.|...||||        ||      |:.:     |||.:..::|
 Worm   459 -------------ISVATNHAQSQDPGFQP--------HS------GVTR-----TLKGRFCRQS 491

Human   241 S------------SQNHMDWSTNSDSGPVTQN-------------------------CFIS-PES 267
            .            :......||..|:..|.:|                         ||:. ..|
 Worm   492 GRIAVSRSLLQLRANKRRQQSTEGDASGVRKNEGLVARKERERKELMLFSKRSRPQTCFMGVKSS 556

Human   268 GRETASTS-------KIPAL--EPVASFAKAQGKK-GSAG--------------NTWSQLSNNNK 308
            ||:::.:|       :.|:|  .||.|....:|.. .|:|              .|..|.:....
 Worm   557 GRDSSMSSTTSSERERSPSLTESPVRSRNHVRGSSPQSSGLNERASRCRERVTRRTRLQTTPARV 621

Human   309 DLLLGGVAPSPS--SHSSP---APPS-----SSAECNGLQPLVDQDGGGTKEPPEPPTVGSKKKS 363
            .:.|..|:|.|:  ...||   :|.|     |.|.|:|..  |::|                 :|
 Worm   622 PVELESVSPIPARVRQRSPEVQSPKSEMRTRSRARCDGYD--VERD-----------------QS 667

Human   364 SKKDVISQTIPNPDLDWVKNAQKAFDNTE--GKREGYSADSAQEASPARQNVSSASNPENDSSHV 426
            ...||:     ..|:|......::..|..  |.|:.......::|.|..:.:....:||.:.|.|
 Worm   668 KTGDVV-----QIDVDGSPRITRSHANNHPMGHRKIQEKPIVEDAIPHLEPIIDGYHPERNESVV 727

Human   427 RIT---IPIKAPSLD---------PTNHKRKKRQSIKAVVEKIMPEKALAS----GITMSSEVVN 475
            |..   :.::.|.::         ||::|..:|..:::....::...|..|    |: ..::.:|
 Worm   728 RDVMEPLDVQIPQMNGEHHQTFVSPTSNKSLRRCGLRSDYSSVLNSPASTSQESTGM-RDTQRLN 791

Human   476 RILS-NSEGNKKDPRV--------PKLSKMIENESPS-------VGLETGGNAEKVIPGGVSKPR 524
            ::|| |:.|..:.||:        |:....|.|...|       |..:......::|......||
 Worm   792 KVLSKNNIGELESPRLNGTRVLSPPRTRHQISNAIDSDAFNDMPVLTQEPVQERRMIAQVFEIPR 856

Human   525 KPPMVMTPPTCTDHSPSRKLPEIQHPKFAAKRRWTCSKPKPSTMLREAVMATSDKLMLEPPSAYP 589
            |        |...:.||....: ||.:|.     .||.........:...:     |:.||...|
 Worm   857 K--------TTAYNQPSSSNSQ-QHGQFQ-----VCSNGSLGFFHPQIYQS-----MMTPPGIVP 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SETBP1	XP_024306917.1	None
set-19	NP_001379854.1	SET	175..322	CDD:214614