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Protein Alignment LRIG1 and Dscam2

DIOPT Version :9

Sequence 1:	NP_056356.2	Gene:	LRIG1 / 26018	HGNCID:	17360	Length:	1093	Species:	Homo sapiens
Sequence 2:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster

Alignment Length:	949	Identity:	197/949 - (20%)
Similarity:	319/949 - (33%)	Gaps:	257/949 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   126 KIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSL 190
            ::|....:.::..:|..||.:.:....|.|.....:|.|:...|:...:.|. :|.:...:..:|
  Fly   322 ELRLTVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYKDGR-QLPSSGRVEDTL 385

Human   191 LTLRLSKNRITQLPVRAFKLPRLTQLDLNRNR----IRLIEGLTFQGLNSLEVLKLQRNNISKLT 251
            :..|:|:.                    ||..    :|..||.|||....|::
  Fly   386 VVPRVSRE--------------------NRGMYQCVVRRPEGDTFQATAELQL------------ 418

Human   252 DGAFWGLSKMHVLHLEYNSLVE--VNSGSLYGLTALHQLHLSNNSIARIHRKGWSF--------- 305
                 |.:...:|:    |.:|  :..|....|    :...:.|...:|   .|:.
  Fly   419 -----GDAPPVLLY----SFIEQTLQPGPAVSL----KCSAAGNPTPQI---SWTLDGFPLPSNG 467

Human   306 ------CQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDH 364
                  ...:|..|:|..|::.:..|...|.:.::..|...  :.|.|.....||..:|::.
  Fly   468 RFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGR--VQHAARLNIYGLPYIRLIP--- 527

Human   365 NEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAI-----RSVQFD 424
                 .:...||....|    |..:.|..|:.:            |...||..:     :.||.|
  Fly   528 -----KVTAVSGETLNL----KCPVAGYPIEEI------------HWERGGRELPDDIRQRVQPD 571

Human   425 AFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVC 489
            ..:.:..:::   :|||.:..|       |...:.         .|.....|:....|||:
  Fly   572 GSLTISPVQK---NSDSGVYTC-------WARNKQ---------GHSARRSGEVTVIVPPK---- 613

Human   490 DDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
               |.|   .|.......:|.....|||.. ....|:|..|:||...:....       |....:
  Fly   614 ---LSP---FQTNILQLNMGDRASLTCSVV-KGDLPLTINWRKDGRPIDPTQ-------HMSVKQ 664

Human   555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLE 619
            |.:|.:||.:..:...|.|.|.||:.|......:.:| |.|||.|.:...|.|..:.......|.
  Fly   665 VDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQA-LLVNVPPRWIVEPVDANVERNRHIMLH 728

Human   620 CAATGHPNPQIAWQKDGGT---DFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGS- 680
            |.|.|.|.|.|.|:|..|:   ::...|||....:..:....:..||.|..|.|.|.|.|..|:
  Fly   729 CQAQGVPTPSIVWKKATGSKSGEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQANNGIGTG 793

Human   681 ISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFK-GDRPLS------LTER 738
            |.....|.|..:|.........:|..|:|..|||..:|:.|..|.|.: |...|:      ::.:
  Fly   794 IGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISVK 858

Human   739 HHLTPD--NQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV----LPAAGCRKDGTTVGIFT 797
            ...|||  :..|.::.|.|.|:|.|.|..||..|.::...||.|    ||.:          :..
  Fly   859 QEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPS----------VLE 913

Human   798 IAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPSYL--------SSQGTLSDRQE 854
            .|::||..: ::.|                  ..:|:...||..|:        |....|...|.
  Fly   914 AAMISSRSV-NIKW------------------QPKTLGTGDVTKYIVEFREADHSLPPALFVDQW 959

Human   855 TVVRTEGGPQANGHIE-------------SNGVCPRDASHFPEPDTHSVACRQPKLCAGS--AYH 904
            ..:..:..|..|..||             :.|...|.|     |....:...:|:..||.  :..
  Fly   960 QQIEVKDPPHFNAMIENLKPATRYAFRVIAEGSAGRSA-----PSQELIVRTEPQRPAGPPLSLS 1019

Human   905 KEPWKAMEKAEGTPGP-HKMEHG-------GRVVCSDCNTEVDCYSRG----------------- 944
            ..|..:.|.......| .::.||       |..:.|..||..:..|..
  Fly  1020 ARPLSSTELLISWVAPLPELRHGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAK 1084

Human   945 --------QAFH---PQPVSRDSAQ------PSAPNGPE 966
                    |||:   |.|:|..:|.      ||.|  ||
  Fly  1085 FARYTVVVQAFNQVGPGPLSEPTAAQTMEDVPSRP--PE 1121

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.