DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRIG1 and haf

DIOPT Version :9

Sequence 1:	NP_056356.2	Gene:	LRIG1 / 26018	HGNCID:	17360	Length:	1093	Species:	Homo sapiens
Sequence 2:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster

Alignment Length:	971	Identity:	237/971 - (24%)
Similarity:	361/971 - (37%)	Gaps:	258/971 - (26%)

- Green bases have known domain annotations that are detailed below.

Human     3 RPVRGGLGAP-RRSPCLLLLWLLLLRLEPVTAAAGPRAP-------CAAACTCAGDSLDCGGRGL 59
            ||.|.....| ..:|.||||.|:|.||.    .|..:.|       ...:|.||.:.    ||.|
  Fly     2 RPGRTTTALPAATTPLLLLLPLILGRLH----VAHAQCPWQRDVPDLQTSCICAYNL----GREL 58

Human    60 AALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQH 124
             ::..|...:::.| .:.|..:.:.|.   ||     :|:||:.::.:|.
  Fly    59 -SVQCDQVDFSQLL-AAMNTHARLKPV---DL-----LYVNNSTISELPD--------------- 98

Human   125 NKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAG-NRIGTLELGAFDGLSR 188
                        |..|    :|||:|:               :|:..| .||.|   |||.|...
  Fly    99 ------------AVFS----NLSLHNL---------------QLSSCGIQRIAT---GAFKGQES 129

Human   189 SLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTD 252
            .|..|.|..|.:..:||.|.| |.:|..|||::|::..|....|.||..|..|||..||:: |..
  Fly   130 VLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVT-LAS 193

Human   253 GAFWGLSK-MHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKG----WSFCQKLHEL 312
            .||.||.: :..|:|:.....:|.. |:.||.:|..|.||.|.|..:...|    :.....|..|
  Fly   194 NAFRGLEQSLKNLNLKGTKQRKVPE-SIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTAL 257

Human   313 VLSFNNLTRLDEESLA----ELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIED 373
            .|..|.:..:.|.:.|    .|||||:|   :|.::....||...|:.|||||:..|.::...|
  Fly   258 NLERNLIQSIGETAFAGVRKTLSSLSLL---NNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPE- 318

Human   374 TSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEG-LEHLNLGGNAIRSVQFDAFVKMKNLKELHI 437
              .||.|...::.|.|.||.:.||.:.||:.|.. |..|:|||                 :.||
  Fly   319 --AAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGG-----------------RFLH- 363

Human   438 SSDSFLCDCQLKWLPPWLIGRMLQAFVTAT------CAHPESLKGQSIFSVPPESFVCDDF---- 492
                  |||:|:|:..|:....||  ||:.      |..|...:.:..:|:.||...|.|.
  Fly   364 ------CDCKLRWVAEWIRNGDLQ--VTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDIADAA 420

Human   493 ----------LKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVH 547
                      |||.:.:.|::.....|.... |....:::|:|:|.:........|....
  Fly   421 LRGPVGLADNLKPTLPSSPDSVEYETGTGTG-TVGTGTAASAPVTSSVSSSTSTTTPTTT----- 479

Human   548 VHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRT 612
                       ||.......|.....|.....|....:|.:..|.   |...:.|.|....:|.|
  Fly   480 -----------TTTTTAEPTTRRSTTRPPTKSTTTISATTASPAS---NPPVNGTGTVQATSITT 530

Human   613 TTMARLECA-ATGHPNPQIA--WQKD-------------GGTDFPAARERRMHVMPDDDVFFITD 661
            ::.:....: :|||.|.:.|  |::.             ||...|......:...|.      ..
  Fly   531 SSSSSSSSSTSTGHGNGKQAPGWRQGVTNGNGNSGVGGAGGLHKPQRPPLVLGYPPQ------RG 589

Human   662 VKIDDAG---VYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVV--SVGETVALQCKATGNPP 721
            .:||||.   |.....|:|:..|..::     :|.::   |..|||  ..||      ||
  Fly   590 TRIDDANEVQVKHAFRQDSSVIIQWDS-----DTANI---LGFRVVYRLFGE------KA----- 635

Human   722 PRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGC 786
                 ||...||..:||.        ..::||.|::     |.:...:..|..|.....:|...|
  Fly   636 -----FKQGPPLESSERE--------FKIKNVPAQE-----CIIVCVISLEELHVTPETVPYQQC 682

Human   787 RK-----------DGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRK--KSEEYSVTNTDETVV--- 835
            |:           |..|:.. :.|:..:|::..:|::....::||  .|::.|........|
  Fly   683 REVRTVASQASNMDKITIAA-SAAICGTIIVAVIVFIAASRRSRKLQSSQQKSPLPIGGLPVNCC 746

Human   836 -PPDVPSYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQP 895
             |...|..|.|..|||             ..|.|.|.:.|........|.|..:.|  .||
  Fly   747 GPTGSPGPLGSIATLS-------------AFNNHKEWDQVSAYSGRSIPRPRIYPV--EQP 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRIG1	NP_056356.2	leucine-rich repeat	51..69	CDD:275380	4/17 (24%)
		LRR_RI	<53..176	CDD:238064	22/123 (18%)
		leucine-rich repeat	70..93	CDD:275380	5/22 (23%)
		LRR_8	71..127	CDD:290566	9/55 (16%)
		leucine-rich repeat	117..140	CDD:275378	1/22 (5%)
		LRR_RI	131..416	CDD:238064	96/296 (32%)
		LRR_8	140..223	CDD:290566	28/84 (33%)
		leucine-rich repeat	141..164	CDD:275380	4/22 (18%)
		leucine-rich repeat	165..197	CDD:275380	12/32 (38%)
		LRR_8	211..271	CDD:290566	22/60 (37%)
		leucine-rich repeat	213..236	CDD:275380	9/22 (41%)
		leucine-rich repeat	237..260	CDD:275380	11/22 (50%)
		LRR_8	259..319	CDD:290566	17/64 (27%)
		leucine-rich repeat	261..284	CDD:275380	6/22 (27%)
		leucine-rich repeat	285..308	CDD:275380	7/26 (27%)
		LRR_8	308..367	CDD:290566	22/62 (35%)
		leucine-rich repeat	309..332	CDD:275380	7/26 (27%)
		leucine-rich repeat	333..356	CDD:275380	7/22 (32%)
		leucine-rich repeat	357..381	CDD:275380	9/23 (39%)
		LRR_8	383..442	CDD:290566	16/59 (27%)
		leucine-rich repeat	384..405	CDD:275380	8/20 (40%)
		leucine-rich repeat	408..431	CDD:275380	5/22 (23%)
		LRRCT	442..490	CDD:214507	15/53 (28%)
		I-set	495..595	CDD:254352	15/99 (15%)
		Ig	512..586	CDD:143165	10/73 (14%)
		I-set	599..689	CDD:254352	22/108 (20%)
		Ig_1	616..690	CDD:143240	18/92 (20%)
		I-set	693..780	CDD:254352	20/88 (23%)
		IGc2	707..770	CDD:197706	14/62 (23%)
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	70/264 (27%)
		leucine-rich repeat	86..105	CDD:275380	6/49 (12%)
		leucine-rich repeat	106..129	CDD:275380	11/40 (28%)
		LRR_8	131..189	CDD:338972	23/57 (40%)
		leucine-rich repeat	131..154	CDD:275380	9/22 (41%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		leucine-rich repeat	179..202	CDD:275380	11/23 (48%)
		leucine-rich repeat	203..225	CDD:275380	6/22 (27%)
		leucine-rich repeat	226..253	CDD:275380	7/26 (27%)
		LRR_8	254..337	CDD:338972	30/88 (34%)
		leucine-rich repeat	254..302	CDD:275380	16/50 (32%)
		leucine-rich repeat	303..326	CDD:275380	10/25 (40%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		PCC	332..>413	CDD:188093	30/106 (28%)
		PRK10927	<1061..>1097	CDD:236797
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910