Protein Alignment L3MBTL1 and l3mbtl1

DIOPT Version :10

• Sequence 1: NP_001364232.1
• Gene: L3MBTL1 / 26013
• HGNCID: 15905
• Length: 862
• Species: Homo sapiens
• Sequence 2: XP_002666454.2
• Gene: l3mbtl1 / 100321295
• ZFINID: ZDB-GENE-090313-102
• Length: 815
• Species: Danio rerio
• Alignment Length: 813
• Identity: 436/813 - (53%)
• Similarity: 528/813 - (64%)
• Gaps: 83/813 - (10%)

Human    20 EVSMHLVAGDSPGSGPHLPATAF---IIPASSATLGLPSSALDVSCFPREPIHVGAPEQVAGCEP 81
            :|..|...|.|..|..|.|..:.   :.|..:.|:..|:||..:   |:..:...|.:.:.|.|
Zfish     8 DVLPHNADGPSESSVSHAPIDSSAHRLKPQDTTTIIFPASAHPL---PKVELPQNAIKAIKGSE- 68

Human    82 VSATVLPQLSAGPASSSTSTVRLLEWTEAAAPPPGGGLRFRISE-----------YKPLNM--AG 133
            :.||.||....|      :.|.:|.|.|..|..||..|:..:|:           ..|.|:  .|
Zfish    69 LEATSLPAQVGG------TIVHVLGWKEGMAILPGSNLKLCVSDTGALEVISEGKIGPTNLPTEG 127

Human   134 VE-QPPSPELRQEGVTEYEDG--GAPAGDGEAGP-QQAEDHPQNPPEDPNQDPPEDDSTCQCQAC 194
            .: :|.:.|.:|...::...|  |.||...||.. .:|....|:.|..              ..|
Zfish   128 AQMKPANMEFKQAEKSDVSAGGNGRPAAFLEADRLHRARIEVQDSPVH--------------SRC 178

Human   195 GPHQAAGPDLGSSNDGCPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAM 259
            |.:.......|......|....|..|:...       .:::|||||||||||.||||::|:.|.|
Zfish   179 GQNMHMTELRGEPMSEIPAGLAEAQVMYRE-------HDMMKPMKKRKRREYNSPSEDDSDAEPM 236

Human   260 EKQEEGKDPEGQPTASTPESEEWSSSQPATGE---KKECWSWESYLEEQKAITAPVSLFQDSQAV 321
            :::.|....:|:              |..||.   |.|.|||..|||.||||.|||.|||::|.|
Zfish   237 DEKSEALKIDGR--------------QIKTGSAETKLEPWSWPQYLELQKAIAAPVRLFQETQRV 287

Human   322 THNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWF 386
            ...:|.|:.||||||||||||||||:|||||||||||||||||||:|||||||||..|||||||.
Zfish   288 PLIRNSFRQGMKLEGIDPQHPSMYFVLTVAEVCGYRLRLHFDGYSDCHDFWVNANCADIHPAGWC 352

Human   387 EKTGHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSL 451
            |.|.|||..|||.||||||||.||:.||:|||||.||:|........||:|||||||||||||||
Zfish   353 ESTAHKLHTPKGCKEEEFSWSNYLKITRSQAAPKELFISSVKPETDCGFEVGMKLEAVDRMNPSL 417

Human   452 VCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDNFCWEK 516
            :|||:|||.|..||||||||||||||||||.|||||||:|||.::|.|||||||||:.|.|.||:
Zfish   418 ICVATVTDRVADRFLVHFDNWDDTYDYWCDSSSPYIHPIGWCHERGLPLTPPQDYPEVDRFSWER 482

Human   517 YLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYD 581
            ||||||::||...||:|||.|||.|.|||||||:|.|.|||||:|::|:.:|||||||||||.||
Zfish   483 YLEETGSTAVAAEAFRVRPAHSFQVQMKLEAVDKRCPGLIRVATVQEVDTYRIKIHFDGWSHLYD 547

Human   582 FWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYR---------SLPHTR-TSK 636
            .|:|:|||||||||||..|||||:||  |.:|:...||....|:.|         |||..| |||
Zfish   548 EWMDSDHPDIHPAGWCESTGHPLKPP--PCQPTVPKPGPRESLAVRQPSFSMSCKSLPQPRNTSK 610

Human   637 YSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPR- 700
            |||||||||||||||||||||:|||||||||||||||||.||||:|||:|.|  ::||..|..|
Zfish   611 YSFHHRKCPTPGCDGSGHVTGRFTAHHCLSGCPLAERNQGRLKADLSDTEGS--RRNLLVFGQRA 673

Human   701 KKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSALSAHPDRSLSVCWEQHCKLLPGVAGI 765
            ||.|:||||||||||||..|.:.|::|.:.::.||||:|.:|:.:|:||:|||||||||||||||
Zfish   674 KKSRYHGRIGRPPKYRKSQQRNCQSMTSEGMYSSLFMTAFTANSERTLSLCWEQHCKLLPGVAGI 738

Human   766 SASTVAKWTIDEVFGFVQTLTGCEDQARLFKDE 798
            .|..||.|||:||||||..|.|||:|||:||||
Zfish   739 HAGQVATWTIEEVFGFVNNLIGCEEQARIFKDE 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
L3MBTL1	NP_001364232.1	PRK07764	<27..188	CDD:236090	43/180 (24%)
		MBT_L3MBTL1_rpt1	315..423	CDD:439121	82/107 (77%)
		MBT_L3MBTL1_rpt2	430..522	CDD:439124	70/91 (77%)
		MBT_L3MBTL1_rpt3	535..609	CDD:439127	54/73 (74%)
		zf-C2HC	643..671	CDD:460240	26/27 (96%)
		SAM_superfamily	770..>798	CDD:472832	20/27 (74%)
l3mbtl1	XP_002666454.2	MBT_L3MBTL1_rpt1	281..389	CDD:439121	82/107 (77%)
		MBT_L3MBTL1_rpt2	396..488	CDD:439124	70/91 (77%)
		MBT_L3MBTL1_rpt3	501..575	CDD:439127	54/75 (72%)
		zf-C2HC	617..645	CDD:460240	26/27 (96%)
		SAM_Scm-like-3MBT3,4	743..808	CDD:188981	22/29 (76%)