DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF167 and gzl

DIOPT Version :9

Sequence 1:	NP_001357232.1	Gene:	RNF167 / 26001	HGNCID:	24544	Length:	374	Species:	Homo sapiens
Sequence 2:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	332	Identity:	110/332 - (33%)
Similarity:	169/332 - (50%)	Gaps:	60/332 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    37 DFADLPALFGATLSQEGLQGFLVEA-HPDNACSPIAPPPPAPVNGSV-FIALLRRFDCNFDLKVL 99
            :|.||||.||..|...||:.::|.| .|...|..:..||......|. |:||:.|.:|.|:.|:.
  Fly    41 EFNDLPAQFGPNLPSNGLKVYVVPARRPYYGCDSLDRPPHLKYPPSAKFVALVARGECVFERKIR 105

Human   100 NAQKAGYGAAVVHNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSSEYLRALFVYEKGARVLLVP 164
            .||.|.|.|.:|:|...::|..|   |.|....|.|||||:|..:.:.|...|..|    |:|:.
  Fly   106 VAQNASYSAVIVYNNEGDDLEQM---SAENITGIRIPSVFVGHTTGKALATYFTTE----VVLII 163

Human   165 DNTFPLG---YYLIPFTGIVGLLVLAMGAVMIARCIQHRKRLQRNRLTKEQLKQIPTHDYQKALN 226
            ::..|..   ..::||:.::|:..:.|...||.:||:.::||:|:||.|..||::|...|.|  |
  Fly   164 NDELPFNINTQLILPFSILIGMCFIIMVIYMIYKCIREQRRLRRHRLPKSMLKKLPVLRYTK--N 226

Human   227 SSMFCPDLILPTCLISSTGFVGDQYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKT 291
            ::                   .::||.|.|||:::.:.||||||||:|.||:.|:|||||:.|:.
  Fly   227 NA-------------------NNKYDTCVICLEDFIEDDKLRVLPCSHPYHTHCIDPWLTENRRV 272

Human   292 CPICKQPV----------HRGPG-------DED-----QEEETQGQEEGDEGEPRDHPASERTPL 334
            |||||:.|          .|.|.       |:|     |::::.|::.|....     ||.....
  Fly   273 CPICKRKVFTKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGRQVGQVSS-----ASSAGGA 332

Human   335 LGSSPTL 341
            .|||.::
  Fly   333 AGSSSSV 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF167	NP_001357232.1	PA_C_RZF_like	20..170	CDD:239038	47/134 (35%)
		RING-H2_RNF167	252..297	CDD:319711	27/44 (61%)
		RING-H2 finger (C3H2C3-type)	254..295	CDD:319711	24/40 (60%)
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	48/136 (35%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	26/43 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8867
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3672
Isobase	1	0.950	-	0	Normalized mean entropy	S4419
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		otm41191
orthoMCL	1	0.900	-	-		OOG6_103040
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.680