DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SNED1 and Ser

DIOPT Version :9

Sequence 1:	XP_011509233.1	Gene:	SNED1 / 25992	HGNCID:	24696	Length:	1437	Species:	Homo sapiens
Sequence 2:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster

Alignment Length:	1119	Identity:	265/1119 - (23%)
Similarity:	392/1119 - (35%)	Gaps:	379/1119 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   278 RIDDAQVRVGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECAS- 341
            |..:.:.|.|..|...:.|:....|.:|     .|  ...::.|.|.:.:.|..|..|:|.|.:
  Fly   300 RPGECECRPGWRGPLCNECMVYPGCKHG-----SC--NGSAWKCVCDTNWGGILCDQDLNFCGTH 357

Human   342 QPCQNGGTCTH-GINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQC----------------- 388
            :||::||||.: ..:.:||.|..|..|..||..:.||.|:.|::||.|
  Fly   358 EPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSH 422

Human   389 -------------------------QVENGSA--------------------VCVCQAGYTGAAC 408
                                     |..|||:                    .|.|.||:||..|
  Fly   423 GRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTC 487

Human   409 EMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCET------------------------- 448
            |:::|:|:..||.:||:|:||:|.:.|.|...:.|..|:.
  Fly   488 EINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATA 552

Human   449 --GDHPVPDACLSA-------------PCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDC-- 496
              |.:....|.|:|             ||.|...|.:....:.|.|.||:.|:.|.|.: |||
  Fly   553 IIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENL-DDCVG 616

Human   497 ECRNGGRCLG-ANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHN 560
            :||||..|:. .|...|.|..||.|..||.:|.  .| ..:.|.:||.|::..|.:.|:|...::
  Fly   617 QCRNGATCIDLVNDYRCACASGFKGRDCETDID--EC-ATSPCRNGGECVDMVGKFNCICPLGYS 678

Human   561 AS-------HSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNG-- 616
            .|       :..||||....|.|      ..:.|.|.||....|||||:.|| |||..||..|
  Fly   679 GSLCEEAKENCTPSPCLEGHCLN------TPEGYYCHCPPDRAGKHCEQLRP-LCSQPPCNEGCF 736

Human   617 ------------------------------------GTCKEAGGEYHCSCPYRFTGRHCEIGKPD 645
                                                |:|:.:.....|.|....||..|| ...:
  Fly   737 ANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTFCKCHVGHTGTFCE-HNLN 800

Human   646 SCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTC----EDRDTDFFCH 706
            .|:..||.|||.|....|.:.|:|..|::|:.|....:.|:...|.|||||    .|:.....|.
  Fly   801 ECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMPGAPDKALQPHCR 865

Human   707 CQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSE 771
            |..|:.|..| ||.
  Fly   866 CAPGWTGLFC-AEA--------------------------------------------------- 878

Human   772 PPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGA 836
                  ||:||.|||.:||:|:.....:.|:|:.|:.|..|.:..:||...||:.|.:|.:..|.
  Fly   879 ------IDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGG 937

Human   837 YVCRCPAGFVGVHCETEVDACDSSPCQHG----------------------GRCESGGGAYLCVC 879
            |.|.||.|..|:.||..: :...|.||:.                      ||.|.......|||
  Fly   938 YSCICPPGRHGLRCEILL-SDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVC 1001

Human   880 ------------------------PESFFGYHCE-------TVSDPCFSSPCGGRGYCLASNGSH 913
                                    ..|.....|:       .:|:.|.||||..||.|.|...|.
  Fly  1002 ENGTSRCTNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSR 1066

Human   914 -----------SCTCKVGYTGEDCAKELFPPTALKMERV-------------------------- 941
                       ||........|:||:...   .|.:|||
  Fly  1067 RVAPPRLPAKSSCWPNQAVVNENCARLTI---LLALERVGKGASVEGLCSLVRVLLAAQLIKKPA 1128

Human   942 ----EESGV--------------------SISWNPPNGPAARQMLDGYAVTYVSSDGSYRRTDFV 982
                ::.|:                    |...|.|..|.|..:| |..:::...:|..||
  Fly  1129 STFGQDPGMLMVLCDLKTGTNDTVELTVSSSKLNDPQLPVAVGLL-GELLSFRQLNGIQRR---- 1188

Human   983 DRTRSSHQLQALAAGRAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVEGFEVTNVTAST-IS 1046
                  .:|:...|..|...|:..||..:....|.|..::|:.     .:.|..:..|..|. ||
  Fly  1189 ------KELELQHAKLAALTSIVEVKLETARVADGSGHSLLIG-----VLCGVFIVLVGFSVFIS 1242

Human  1047 VQWALHRIRHATVSGVRV-----SIRHPEALRDQATDVDRSVDRFTFRALLPGKRYTIQLTTLSG 1106
            :.|. .|:.:.|.||:.:     ::||.|...:...: :.::.|:|    .|.|..|..|...:|
  Fly  1243 LYWK-QRLAYRTSSGMNLTPSLDALRHEEEKSNNLQN-EENLRRYT----NPLKGSTSSLRAATG 1301

Human  1107 LRGEEHPTESLATA 1120
            :....:|...||.:
  Fly  1302 MELSLNPAPELAAS 1315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNED1	XP_011509233.1	NIDO	128..284	CDD:214712	1/5 (20%)
		EGF_CA	296..332	CDD:238011	7/35 (20%)
		EGF_CA	335..371	CDD:238011	14/37 (38%)
		EGF_CA	411..447	CDD:238011	13/35 (37%)
		EGF_CA	455..488	CDD:238011	12/45 (27%)
		EGF_CA	569..601	CDD:238011	10/31 (32%)
		EGF_CA	609..640	CDD:238011	10/68 (15%)
		EGF_CA	645..679	CDD:238011	12/33 (36%)
		EGF_CA	<688..717	CDD:238011	11/32 (34%)
		Sushi	722..775	CDD:278512	0/52 (0%)
		EGF_CA	778..813	CDD:238011	14/34 (41%)
		EGF_CA	817..851	CDD:238011	13/33 (39%)
		EGF_CA	854..889	CDD:238011	10/80 (13%)
		fn3	932..1012	CDD:278470	21/129 (16%)
		fn3	1031..1106	CDD:278470	19/80 (24%)
		fn3	1130..1208	CDD:278470
		EGF_CA	1336..1367	CDD:238011
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011	14/37 (38%)
		EGF_CA	490..526	CDD:238011	13/35 (37%)
		EGF_CA	610..645	CDD:238011	14/35 (40%)
		EGF_CA	647..683	CDD:238011	10/38 (26%)
		EGF_CA	798..833	CDD:238011	12/34 (35%)
		EGF_CA	879..913	CDD:238011	14/33 (42%)
		EGF_CA	916..952	CDD:238011	13/35 (37%)
		VWC_out	<993..1053	CDD:214565	9/59 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920