Protein Alignment PARS2 and ProRS-m

DIOPT Version :10

• Sequence 1: NP_689481.2
• Gene: PARS2 / 25973
• HGNCID: 30563
• Length: 475
• Species: Homo sapiens
• Sequence 2: NP_647737.1
• Gene: ProRS-m / 38331
• FlyBaseID: FBgn0027082
• Length: 458
• Species: Drosophila melanogaster
• Alignment Length: 410
• Identity: 185/410 - (45%)
• Similarity: 258/410 - (62%)
• Gaps: 9/410 - (2%)

Human    43 SRVFQPQNLREDRVLSLQDKSDDLTCKSQRLMLQVGLIYPASPGCYHLLPYTVRAMEKLVRVIDQ 107
            ||:|.|..:.....:.   |..:...:||:|:.::||:...|.|.|.::|...|:::|.:.::..
  Fly     5 SRIFCPALITPKNAVV---KQTEQLSRSQKLLTELGLVKSGSNGTYQIMPMAQRSVDKCIDLVQS 66

Human   108 EMQAIGGQKVNMPSLSPAELWQATNRWDLMGKELLRLRDRHGKEYCLGPTHEEAITALIASQKKL 172
            .||..||||:.:|.|:|..||:.|.|.|....|...:|||.||::.:.||||||:||::|:...:
  Fly    67 NMQQAGGQKITLPILTPTGLWKKTGRLDGDISEFYMVRDRSGKQFLMSPTHEEAVTAMLATTSPI 131

Human   173 SYKQLPFLLYQVTRKFRDEPRPRFGLLRGREFYMKDMYTFDSSPEAAQQTYSLVCDAYCSLFNKL 237
            ||:|||..|:|:..|||||.:.||||:|.:||.|||||:||.|.|.|.:||:||..||..||.:|
  Fly   132 SYRQLPLRLFQIGPKFRDELKTRFGLMRAKEFLMKDMYSFDVSEETAMETYTLVNAAYDRLFKQL 196

Human   238 GLPFVKVQADVGTIGGTVSHEFQLPVDIGEDRLAICPRCSFSANMETLDLSQMNCPAC-QGPLTK 301
            .:|||||.|..|.:||:||||:.....:|||.|..|..|.|:.|.|.:. :..:||:| ...|.:
  Fly   197 EVPFVKVNAATGIMGGSVSHEYHYVSPVGEDNLLQCSSCGFAGNSEVVK-APASCPSCNSSDLKE 260

Human   302 TKGIEVGHTFYLGTKYSSIFNAQFTNVCGKPTLAEMGCYGLGVTRILAAAIEVLSTEDCVRWPSL 366
            .:|:||.|||.||.|||....|.|.|..|||....|||||:|:||::|||:||||::..:|||.|
  Fly   261 VRGVEVAHTFLLGDKYSKPLGATFLNTTGKPQSLVMGCYGIGITRVIAAALEVLSSDHELRWPKL 325

Human   367 LAPYQACLIPPKKGSKEQAASELI-GQLYDHITEAVPQLHGEVLLDDRTHLTIGNRLKDANKFGY 430
            ||||..|||.||:|||||..:|:| .:|..::.|...  |.|:|.|||..||||.||.:|.:.|:
  Fly   326 LAPYDVCLIGPKQGSKEQPEAEVIENELLLNVGEICG--HQELLHDDRKELTIGKRLLEAKRLGH 388

Human   431 PFVIIAG-KRALEDPAHFEV 449
            |..|:.| |.|..|....||
  Fly   389 PLTIVVGAKSARLDSPKLEV 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PARS2	NP_689481.2	ProRS_core_prok	65..354	CDD:238402	132/289 (46%)
		HGTP_anticodon	369..470	CDD:469699	38/83 (46%)
ProRS-m	NP_647737.1	ProRS_core_prok	24..313	CDD:238402	132/289 (46%)
		ProRS_anticodon_short	328..428	CDD:238438	38/83 (46%)