Protein Alignment SH2B1 and Lnk

DIOPT Version :10

• Sequence 1: NP_001139267.1
• Gene: SH2B1 / 25970
• HGNCID: 30417
• Length: 756
• Species: Homo sapiens
• Sequence 2: NP_001287536.1
• Gene: Lnk / 43130
• FlyBaseID: FBgn0028717
• Length: 728
• Species: Drosophila melanogaster
• Alignment Length: 883
• Identity: 251/883 - (28%)
• Similarity: 347/883 - (39%)
• Gaps: 316/883 - (35%)

Human     3 GAPSPEDGASPSSPPLPPP--------------PPPSWREFCESHARAAALDFARRFRLYLASH- 52
            |..|....|:..|..:|.|              ...||.||||.|||.||.|||:....|:..:
  Fly    31 GTSSAAAAAAAGSDLIPAPIGTGNAMGVSSYAYGGTSWEEFCERHARVAASDFAKACITYINGNL 95

Human    53 -PQYAGPGAEAAFSRRFAELFLQHFEAE-------VARASGSLS-------PPILAPLSPGAEIS 102
             |:.|......:|:::|.|.|..|::.|       :...:|||.       |.:|      ::..
  Fly    96 PPEEARNIQHRSFAQKFVESFSAHYDTEFFKRRSTLKSGAGSLDFEEEHEVPKLL------SKSL 154

Human   103 PHDLSLESCRVGGPLAVLGP--SRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGS 165
            ...||.:..| .|.:::|..  .::|:||.|      |..|...||.||.|.
  Fly   155 LRRLSFKGLR-KGKISLLQAFFHKNSDDLDG------SGGSGKQSKTKLAKI------------- 199

Human   166 VRGILQWR--GTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRF 228
               :::.|  |||                                       :..:|
  Fly   200 ---VVECRKEGTV---------------------------------------NNLTP-------- 214

Human   229 ERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLL 293
                                           |:...|.                |..:|:||||:
  Fly   215 -------------------------------ESLDQPT----------------GSQKWEKCRLV 232

Human   294 LRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMET 358
            |   .:..||..|||:.|.||::||..:.|..|::.|.|||||||||.||||:|.:...||::|.
  Fly   233 L---VKAVGGYMLEFYTPHKATKPRSGVFCFLISEARETTALEMPDRLNTFVLKADNNMEYVIEA 294

Human   359 VDAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPSQDL 423
            ..|:.:::|::.|:.|:.                .|.|...|.| :|.:..|.:..|.:|||.:.
  Fly   295 ESAEEMRSWLATIRYCMR----------------TPPTQQPTIE-SDGVMASAMQTSPTLPSPNP 342

Human   424 LLG---PSESNDRLSQGAYGGLSDRPSASISPSSA-----SIAASHFDSMELL---PPELPPRIP 477
            :.|   |.....|.|.|...|.....::|:|..||     :.:||..:.:..|   |...||.||
  Fly   343 IGGIQNPQYQQQRGSNGNLVGGGAPLTSSLSADSALGQGGATSASELNVINELGTSPTSGPPDIP 407

Human   478 IEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGD-------QPLSGYPWFHGMLSRL 535
            :.  |..|              .:..:.|..|.| .||.|.|       ..:|.:|||||.|:|.
  Fly   408 VR--PHRG--------------EQRLSASSNFDG-IEGTENDADVADLTAEMSVFPWFHGTLTRS 455

Human   536 KAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
            :||::||......||.||||||||||||:||||||||:||||||:::|:||||||||||.||.:|
  Fly   456 EAARMVLHSDAAGHGYFLVRQSETRRGEFVLTFNFQGRAKHLRLTISEKGQCRVQHLWFPSIQEM 520

Human   601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQEPTT--SHDPPQPPEPPSWTDPPQPG------- 656
            |||||.:||||||||:|||.|..:|.|..|..:|||  :||..|      ..|....|
  Fly   521 LEHFRHNPIPLESGGTSDVTLTEWVHSHSRLNDPTTAANHDSGQ------LNDLSTNGNGNGNGN 579

Human   657 ----AEEASRAPEVAAAAAAAAKERQEKEKAGGG------------------------GVPEE-- 691
                .:.:|.|...|...|:.|        ||||                        .:|:|
  Fly   580 GYDNGQGSSTASNAAGGTASGA--------AGGGHPSPRHCNEVITMNLSVRLKTNEIELPQEPT 636

Human   692 -----------LVPVVELV-------------PVVELEEAIAPGSEAQGAGSGGD---------- 722
                       |.|....|             |.:....|....:....|||.|:
  Fly   637 HVYFPEQVYFHLDPTTLTVHGSPPPAQNFLDQPHLRASNASLQAAAHHQAGSSGNRHPSDGGSNS 701

Human   723 --AGVPPMVQLQQSPLGGDGEEGGHP---RAINNQYSF 755
              ||            ||.|..||..   ||::|||||
  Fly   702 GGAG------------GGSGSSGGAECTGRAVDNQYSF 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SH2B1	NP_001139267.1	Interaction with JAK2 (low-affinity binding, independent of JAK2 phosphorylation). /evidence=ECO:0000250	1..555		151/603 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		7/37 (19%)
		Required for self-association	24..85		23/69 (33%)
		Phe_ZIP	26..81	CDD:462631	22/63 (35%)
		Interaction with RAC1. /evidence=ECO:0000250	85..196		25/121 (21%)
		Required for NGF signaling. /evidence=ECO:0000250	100..243		21/146 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	123..154		11/30 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..222		5/54 (9%)
		Required for nuclear localization. /evidence=ECO:0000250	224..233		0/8 (0%)
		PH_SH2B_family	246..378	CDD:269938	43/131 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	263..286		2/22 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..455		9/37 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	468..491		8/25 (32%)
		SH2_SH2B_family	518..614	CDD:198209	65/102 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	626..688		19/98 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	709..756		18/62 (29%)
Lnk	NP_001287536.1	Phe_ZIP	67..125	CDD:462631	23/57 (40%)
		PH_SH2B_family	202..313	CDD:269938	48/223 (22%)
		SH2_SH2B_family	438..534	CDD:198209	64/95 (67%)