Protein Alignment GAPDH and Gapdh2

DIOPT Version :10

• Sequence 1: NP_002037.2
• Gene: GAPDH / 2597
• HGNCID: 4141
• Length: 335
• Species: Homo sapiens
• Sequence 2: NP_542445.1
• Gene: Gapdh2 / 32545
• FlyBaseID: FBgn0001092
• Length: 332
• Species: Drosophila melanogaster
• Alignment Length: 331
• Identity: 252/331 - (76%)
• Similarity: 288/331 - (87%)
• Gaps: 1/331 - (0%)

Human     5 KVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVI 69
            |:|:||||||||||.|||.:.| .::||:||||||:|||||:|::|||||:|.|||.||.|.||:
  Fly     3 KIGINGFGRIGRLVLRAAIDKG-ANVVAVNDPFIDVNYMVYLFKFDSTHGRFKGTVAAEGGFLVV 66

Human    70 NGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMG 134
            ||..||:|.||||:.|.|..|||||:|||||||||::||..||:||||:||||||||||||||.|
  Fly    67 NGQKITVFSERDPANINWASAGAEYIVESTGVFTTIDKASTHLKGGAKKVIISAPSADAPMFVCG 131

Human   135 VNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDG 199
            ||.:.|...:|::|||||||||||||||||:|||.|||||||||||.||||||||||||||||||
  Fly   132 VNLDAYKPDMKVVSNASCTTNCLAPLAKVINDNFEIVEGLMTTVHATTATQKTVDGPSGKLWRDG 196

Human   200 RGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQ 264
            |||.|||||||||||||||||||.||||||||||||||.||||||||.||.|.|.||:||..|::
  Fly   197 RGAAQNIIPASTGAAKAVGKVIPALNGKLTGMAFRVPTPNVSVVDLTVRLGKGASYDEIKAKVQE 261

Human   265 ASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMA 329
            |:.||||||||||:.:|||:||.||||||.|||.|||:|||.||||||||||||||||||:||:.
  Fly   262 AANGPLKGILGYTDEEVVSTDFLSDTHSSVFDAKAGISLNDKFVKLISWYDNEFGYSNRVIDLIK 326

Human   330 HMASKE 335
            :|.||:
  Fly   327 YMQSKD 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPDH	NP_002037.2	PLN02272	2..332	CDD:177912	249/326 (76%)
		Interaction with WARS1. /evidence=ECO:0000269|PubMed:15628863	2..148		96/142 (68%)
		[IL]-x-C-x-x-[DE] motif. /evidence=ECO:0000305|PubMed:25417112	245..250		3/4 (75%)
Gapdh2	NP_542445.1	PLN02272	<2..328	CDD:177912	249/325 (77%)