Protein Alignment KANK2 and Kank2

DIOPT Version :10

• Sequence 1: NP_056308.3
• Gene: KANK2 / 25959
• HGNCID: 29300
• Length: 859
• Species: Homo sapiens
• Sequence 2: NP_663586.3
• Gene: Kank2 / 235041
• MGIID: 2384568
• Length: 843
• Species: Mus musculus
• Alignment Length: 864
• Identity: 712/864 - (82%)
• Similarity: 754/864 - (87%)
• Gaps: 26/864 - (3%)

Human     1 MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQ 65
            ||||||||||||||||.|||.|||:|:||||||||||||||||||||||||||||||||||||||
Mouse     1 MAQVLHVPAPFPGTPGQASPAAFPSKEPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQ 65

Human    66 RRPRLSSLPRGPGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGALETRGGFNPRVERTLLD 130
            |||||.||||||||||||||||||:|||||||||||||||||||||||||||.|.||||||||||
Mouse    66 RRPRLGSLPRGPGSWWTSTESLCSDASGDSRHSAYSYCGRGFYPQYGALETRIGSNPRVERTLLD 130

Human   131 ARRRLEDQAATPT--GLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVPPSAGHLAHVREQMA 193
            ||||||||||.|:  |||||||||||||:||.||||.|||||||||||||.||||||||||||||
Mouse   131 ARRRLEDQAAAPSSGGLGSLTPSAAGSTSSLAGVGLLPPTPRSSGLSTPVAPSAGHLAHVREQMA 195

Human   194 GALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPTAGRGRSELCLDLPDPPED 258
            ||||||||||||||||||||||||||||||||||||||||||||||:..|.|||||||||:.|:|
Mouse   196 GALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPSGTRSRSELCLDLPEAPDD 260

Human   259 PVALETRSVGTWVRERDLGMPDGEAALAAKVAVLETQLKKALQELQAAQARQADPQPQAWPPPDS 323
            |.|||||||||||||||||:|||||||.|||||||||||||||||:|||.:|.|.|||||||||:
Mouse   261 PAALETRSVGTWVRERDLGIPDGEAALVAKVAVLETQLKKALQELRAAQTQQVDLQPQAWPPPDT 325

Human   324 PVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLEPYGTGLRALAMPGRPESPPVFRSQEVVETM 388
            .|||||||||||||||||.|||||||.||||||||||||||:||...|.||:..||||.||||||
Mouse   326 QVRVDTVRVVEGPREVEVAASTAAGALAQRAQSLEPYGTGLKALTTSGGPENTLVFRSHEVVETM 390

Human   389 CPVPAAATSNVHMVKKISITERSCDGAAGLPEVPAESSSSPPGSEVASLTQPEKSTGRVP-TQEP 452
            ||:|.|.|.|||..||||||||||.||..:    .|.||..|....||:.|||..   || .|:.
Mouse   391 CPLPTATTGNVHTAKKISITERSCTGAPRM----TEPSSVNPRPAAASVVQPENP---VPAAQDT 448

Human   453 THREPTR-QAASQESEEAGGTAPPLSSPPGGPPAGVRSI-MKRKEEVADPTAHRRSLQFVGVNGG 515
            |.::||| .||||:|:.|.|             ||..|: .||||:.|||..::|:|||||||||
Mouse   449 TDKKPTRPAAASQDSQAADG-------------AGRASLATKRKEDPADPEVNQRNLQFVGVNGG 500

Human   516 YESSSEDSSTAENISDNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIP 580
            |||.||||||||| |:::|||||.|||..||.|.||.|||||.|.|.|.||.:..|||:|||.:|
Mouse   501 YESPSEDSSTAEN-SEHESTENEGPEPPARVLSPAECPQLRPPGAAVATTSLEGPQLSQESQRVP 564

Human   581 TAEGASGSNTEEEIRMELSPDLISACLALEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAH 645
            ..|.|||.:.||||||:||||||||||||||||:|||||||||||||||||||||||||||||||
Mouse   565 APEVASGPDPEEEIRMDLSPDLISACLALEKYLENPNALTERELKVAYTTVLQEWLRLACRSDAH 629

Human   646 PELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGY 710
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||||.|||.|||||
Mouse   630 PELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVCHVDKLNRAGY 694

Human   711 SPIMLTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNV 775
            |||||||||||||||||||:||||||||:||||||||||||||||||||||||:||||||||||:
Mouse   695 SPIMLTALATLKTQDDIETILQLFRLGNVNAKASQAGQTALMLAVSHGRVDVVRALLACEADVNI 759

Human   776 QDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIK 840
            ||:|||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||
Mouse   760 QDEDGSTALMCACEHGHKEITGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIK 824

Human   841 CSFAPMSDDESPTSSSAEE 859
            ||||||||.|||.||||||
Mouse   825 CSFAPMSDYESPASSSAEE 843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KANK2	NP_056308.3	Interaction with AIFM1. /evidence=ECO:0000269|PubMed:22371500	1..72		66/70 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		24/28 (86%)
		KN_motif	31..69	CDD:432311	37/37 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..182		36/44 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	304..325		14/20 (70%)
		LGT	<450..593	CDD:469786	80/144 (56%)
		ANK 0, degenerate. /evidence=ECO:0000269|PubMed:29183992	622..659		36/36 (100%)
		ANK repeat	636..672	CDD:293786	35/35 (100%)
		ANKYR	<658..833	CDD:440430	165/174 (95%)
		ANK repeat	674..706	CDD:293786	29/31 (94%)
		ANK 1. /evidence=ECO:0000255	674..704		27/29 (93%)
		Interaction with NCOA1. /evidence=ECO:0000269|PubMed:17476305	677..843		156/165 (95%)
		ANK repeat	708..743	CDD:293786	32/34 (94%)
		ANK repeat	747..777	CDD:293786	27/29 (93%)
		ANK repeat	779..811	CDD:293786	30/31 (97%)
Kank2	NP_663586.3	Interaction with AIFM1. /evidence=ECO:0000250	1..72		66/70 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		25/29 (86%)
		KN_motif	31..69	CDD:432311	37/37 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..182		18/20 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..577		98/187 (52%)
		ANK 0, degenerate. /evidence=ECO:0000250|UniProtKB:Q63ZY3	606..643		36/36 (100%)
		ANK repeat	620..656	CDD:293786	35/35 (100%)
		ANKYR	<642..817	CDD:440430	165/174 (95%)
		ANK repeat	658..727	CDD:293786	63/68 (93%)
		Interaction with NCOA1. /evidence=ECO:0000250	661..827		156/165 (95%)
		ANK repeat	731..761	CDD:293786	27/29 (93%)
		ANK repeat	763..795	CDD:293786	30/31 (97%)
		ANK 5. /evidence=ECO:0000255	812..842		27/29 (93%)