Protein Alignment NECTIN3 and nectin3

DIOPT Version :10

• Sequence 1: XP_011510965.1
• Gene: NECTIN3 / 25945
• HGNCID: 17664
• Length: 580
• Species: Homo sapiens
• Sequence 2: XP_002940155.1
• Gene: nectin3 / 100496233
• XenbaseID: XB-GENE-963226
• Length: 524
• Species: Xenopus tropicalis
• Alignment Length: 548
• Identity: 324/548 - (59%)
• Similarity: 394/548 - (71%)
• Gaps: 37/548 - (6%)

Human    38 PLLLLLFPLLLFSRLCVWHPGDCFSCKTIDCPPFILLNKLSREDLLHCALAGPIIVEPHVTAVWG 102
            |.|.....|||..|||                               .:.|||:.|:||||||||
 Frog     9 PSLSAALALLLLCRLC-------------------------------GSFAGPVHVDPHVTAVWG 42

Human   103 KNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLH 167
            ||::|||||||||||||||||:|.||.:||:|||||.||.|....||.|..|||.||:||||.:.
 Frog    43 KNITLKCLIEVNETITQISWERIIGKGAQTIAVHHPIYGTSFDESYQQRTTFKNTSLHDATIVIS 107

Human   168 NIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPV 232
            ||.|||:|:||||||||||||.|||||:|||||||||::|||:.|:||.||||||.|.||||||.
 Frog   108 NIEFSDAGEYICKAVTFPLGNVQSSTTLTVLVEPTVSILKGPEPLLDGANETVAAYCSAATGKPA 172

Human   233 AHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQ 297
            |.:.|||.||.||:..||:||:|.|::|||:|.|:||||||.|||||||||||.||||.|.||||
 Frog   173 AEVSWEGSLGRMETNVTSYPNKTVTVMSQYRLVPSRFARGRNITCVVKHPALENDIRYPFTLDIQ 237

Human   298 YAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFN 362
            ||||||:||||.||||||..|.||||:||||.|.:..|:||||.||:||.:.:|||.|..|||.|
 Frog   238 YAPEVSITGYDDNWFVGRTDVYLKCNSDANPSPTEIKWTRLDGIWPEGLQSVNNTLLFSLPLTHN 302

Human   363 YSGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLSTLAT 427
            .||:|.|||.|:|||:||||:|.|.|||.||. .|||....||.||..:.|..||:..|.|||||
 Frog   303 VSGIYECKVANALGQKSDQKIITILDPPATTP-PPTIPQTHSTTDIVGIETSSKKIHIPASTLAT 366

Human   428 IKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQQD 492
            ::|....||:.|||||.||::|:.|:.||..|||::|||||||.|:|||||||||||||||||.:
 Frog   367 LQDGNFGTIVGSVVGGCLFLILLIVIFGIIYYRRKQTFRGDYFTKSYIPPSDMQKESQIDVLQPE 431

Human   493 ELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLNR----FERPMDYYEDLKMGMKFVS 553
            :||.:|::.||:.....|:.|..:||::.|.:.||||...:|    |:|||..|.|.:|.:....
 Frog   432 DLDPFPENPKKDINIKANDHIYNEYLQDVENSGWNNVITYDRYQEHFDRPMTNYPDKQMPVVSRY 496

Human   554 DEH-YDENEDDLVSHVDGSVISRREWYV 580
            ::: :::||||||||||||:||||||||
 Frog   497 NKNCFNDNEDDLVSHVDGSLISRREWYV 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NECTIN3	XP_011510965.1	IgV_1_Nectin-3_like	89..198	CDD:409470	79/108 (73%)
		FR1	89..112	CDD:409470	17/22 (77%)
		Ig strand A	89..93	CDD:409470	2/3 (67%)
		Ig strand A'	95..99	CDD:409470	3/3 (100%)
		Ig strand B	104..112	CDD:409470	5/7 (71%)
		CDR1	113..117	CDD:409470	3/3 (100%)
		FR2	118..124	CDD:409470	5/5 (100%)
		Ig strand C	119..124	CDD:409470	4/4 (100%)
		CDR2	125..144	CDD:409470	12/18 (67%)
		Ig strand C'	134..139	CDD:409470	4/4 (100%)
		Ig strand C'	141..145	CDD:409470	2/3 (67%)
		FR3	145..183	CDD:409470	23/37 (62%)
		Ig strand D	152..156	CDD:409470	1/3 (33%)
		Ig strand E	161..168	CDD:409470	4/6 (67%)
		Ig strand F	175..183	CDD:409470	6/7 (86%)
		CDR3	184..187	CDD:409470	2/2 (100%)
		Ig strand G	187..197	CDD:409470	7/9 (78%)
		FR4	188..198	CDD:409470	7/9 (78%)
		IgC1_2_Nectin-3-4_like	201..296	CDD:409501	65/94 (69%)
		Ig strand A	201..207	CDD:409501	4/5 (80%)
		Ig strand B	220..227	CDD:409501	4/6 (67%)
		Ig strand C	232..238	CDD:409501	1/5 (20%)
		Ig strand C'	240..242	CDD:409501	0/1 (0%)
		Ig strand D	244..251	CDD:409501	3/6 (50%)
		Ig strand E	256..264	CDD:409501	4/7 (57%)
		Ig strand F	274..281	CDD:409501	5/6 (83%)
		Ig strand G	287..293	CDD:409501	4/5 (80%)
		Ig	300..386	CDD:472250	56/85 (66%)
		Ig strand B	318..322	CDD:409353	2/3 (67%)
		Ig strand C	332..336	CDD:409353	0/3 (0%)
		Ig strand E	351..356	CDD:409353	3/4 (75%)
		Ig strand F	366..371	CDD:409353	2/4 (50%)
		Ig strand G	381..384	CDD:409353	2/2 (100%)
		TM_EGFR-like	435..463	CDD:213052	16/27 (59%)
nectin3	XP_002940155.1	Ig	29..138	CDD:472250	79/108 (73%)
		Ig strand B	45..49	CDD:409353	1/3 (33%)
		Ig strand C	59..63	CDD:409353	3/3 (100%)
		Ig strand E	102..106	CDD:409353	3/3 (100%)
		Ig strand F	116..121	CDD:409353	3/4 (75%)
		Ig strand G	130..133	CDD:409353	2/2 (100%)
		IgC1_2_Nectin-3-4_like	141..236	CDD:409501	65/94 (69%)
		Ig strand A	141..147	CDD:409501	4/5 (80%)
		Ig strand B	160..167	CDD:409501	4/6 (67%)
		Ig strand C	172..178	CDD:409501	1/5 (20%)
		Ig strand C'	180..182	CDD:409501	0/1 (0%)
		Ig strand D	184..191	CDD:409501	3/6 (50%)
		Ig strand E	196..204	CDD:409501	4/7 (57%)
		Ig strand F	214..221	CDD:409501	5/6 (83%)
		Ig strand G	227..233	CDD:409501	4/5 (80%)
		Ig	240..326	CDD:472250	56/85 (66%)
		Ig strand B	258..262	CDD:409353	2/3 (67%)
		Ig strand C	272..276	CDD:409353	0/3 (0%)
		Ig strand E	292..296	CDD:409353	2/3 (67%)
		Ig strand F	306..311	CDD:409353	2/4 (50%)
		Ig strand G	321..324	CDD:409353	2/2 (100%)
		ECM27	347..>408	CDD:440296	31/60 (52%)