DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTPN23 and CG42327

DIOPT Version :9

Sequence 1:	NP_056281.1	Gene:	PTPN23 / 25930	HGNCID:	14406	Length:	1636	Species:	Homo sapiens
Sequence 2:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster

Alignment Length:	1329	Identity:	263/1329 - (19%)
Similarity:	428/1329 - (32%)	Gaps:	347/1329 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   308 KYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHE--ASS 370
            :|:|..:::.    .:.||  ::.|:|..||  |:...|:....|...:....|..|::|  ...
  Fly   261 QYSSTTEESS----RSSPA--SVTPMKLIPL--PMTSTPSSTTSTSTPLPTTAVSFASNENVIEE 317

Human   371 LYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLD-PETVDNLDAYSHIPPQLMEKCAALSVRPDT 434
            ..|:.:.:.|.|..||...:|..     ::.||. |.|.:            :...|.:...|..
  Fly   318 STSKSEVRQLPEKRAKFISENST-----NAQQLTLPNTAE------------VWSLAGMKAVPKA 365

Human   435 VRNLVQSMQVL--SGVFTDVEASLKDIRDLLEEDELL------------EQKFQEAV-----GQA 480
            ......|:.:|  :.:..|::..|.. .:|.:|..||            |.:.:..|     ...
  Fly   366 PLTTTTSVPLLNHTDLANDIDMPLNK-TELHKEKNLLDWMNIAMLPLTPENRTEFVVRTTLDATE 429

Human   481 GAISITSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLL--------SGPLD--- 534
            ||...|::| |.|         |.|.|:..|       :.|...|:...        .|.:|
  Fly   430 GATQATTEA-LVE---------ETHSKSDIT-------VGLEQDNVTTARTMPSTPDPGSMDLNM 477

Human   535 ---QVRA-ALPTPALSPEDKAVLQNLKRILAKVQEMRDQR--------VSLEQQL---------- 577
               .||. .|..|.:.....|.  |.|.|.|..:..|:..        |:|.::|
  Fly   478 TTTTVRTQQLEVPLVKKMSDAA--NAKLIEAVTEPQRETEAATEAATFVTLPEKLATFGITARVD 540

Human   578 ---RELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYA- 638
               .||:   ::|.:...|:..||.|                    |.....|.|:|......|
  Fly   541 STQTELL---NVTTAAAATESGEMSK--------------------ANSTDTLSAMTSTTTTTAR 582

Human   639 --AVRRVLSDLDQKWNSTLQTLVA------------SYEAYEDLMKKSQEGRDFYADLESKVAAL 689
              :|..|..:.|.:..::|.|..|            |..|...::.::....:..|..|:..||.
  Fly   583 PMSVEHVTPEQDMEAATSLATTAATSSGTTEAAATSSTTAATPVVSEAATAAEASATSEATTAAT 647

Human   690 LERTQSTCQAREAARQQLLDRELKKKPPPRPT---APKPLLPRREESEAVEAGDPP--------- 742
            |....:.....|.|.:......::........   ......|..|::....:.:|.
  Fly   648 LSVATTAASTTEIAMKATQISNIRDDNDDNSNDVIVATTKFPESEQAATTASVEPTTTSVSVRVA 712

Human   743 -EELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSSTGPGPHYLSGPLPPGTYSGPTQLIQPR 806
             |...|:.|:::.......|.:.::|          |:|              :.:.|||....:
  Fly   713 GEVSTSIRPEIIVTSTRNSTIVDTST----------SAT--------------SVATPTQTEIAQ 753

Human   807 APGP---HAMPVAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQF 868
            ....   .|:.|.....|    :.|.||....::  .:.|.:|  |.:..:...|
  Fly   754 ISNEVNLEAVTVKTRDGL----SDTNELRTAEKT--DNAVNNS--VAITESDLGA---------- 800

Human   869 SGPELAMAVRPATTTVDSIQAPIP------SHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAG 927
                ||.||....||.:|:.:.:.      ..:....|...|||....|.       .|.|....
  Fly   801 ----LATAVETNPTTTNSLLSDVSKLSKEHESSLETNNIGEAPPESTTPA-------APATVAVA 854

Human   928 AKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLL 992
            ..:        |:..||......|..:.|.|   ...|....|..:|.|......:.........
  Fly   855 TDE--------STAAPAATGGQEIVREGQHH---DGQQVADEQDTEQQLAKTTMAVTTTTTSATT 908

Human   993 PPQSPYPYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPST 1057
            ...|......:        .||.|.... |.:..|...|......:|.||       .|..:.:
  Fly   909 TTTSTTTTTTE--------TPLTTTTMQ-PVEISLLDDSTTTTTTTPAPP-------VYFESST- 956

Human  1058 RPMGPQAAPLTIRG-----PSSAGQSTPSPHLVPSPAPSPGPGPVPPRPPAAEPP---------- 1107
                  .|..|||.     |.:...||.||..:|....:|.|..:......|:..
  Fly   957 ------VASTTIRSSTTMLPETTTASTQSPSEMPPTFMAPYPNELDHMQTNAQDNGTDVNVIIAI 1015

Human  1108 PCLRRGAAAADLLSSSPESQHGGTQSPGGGQPLLQPTKVDA----------AEGRRPQALRLIER 1162
            .....|..|..||.:.........:....|| ..:|..:||          :..|:.:.:|..:|
  Fly  1016 TVSVIGVVALILLVAFLYLMRKRQKQTSYGQ-RCRPVSLDAYSLDNVSVLGSVRRKGRDMRASKR 1079

Human  1163 D----PYEHPERLRQL--QQELEAFRGQLGDVGALDTVWRELQDAQEHDARGRSIAIARCYSLKN 1221
            .    .::.|.....|  ..||..|..:..|      |:.|.:|..:..||...:. ..|.. ||
  Fly  1080 TYGNAAFDDPSLRHNLLTASELARFVERRSD------VFEEFRDVPQIIARADEVP-PGCED-KN 1136

Human  1222 RHQDVMPYDSNRVVL-RSGKDD---YINASCVEGLSPYCPP--LVATQAPLPGTAADFWLMVHEQ 1280
            |:.:|:|....|||| |.|.||   ||||:.|.|  |...|  .:|.||||..|.:|||.|:.||
  Fly  1137 RYANVIPLPETRVVLQRQGDDDKTEYINANYVRG--PRDAPNYYIACQAPLESTTSDFWRMIWEQ 1199

Human  1281 KVSVIVMLVSEAEMEKQKVARYFPTER--GQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSL 1343
            :..||:.....:|...::.|.|.|...  .....:|...:.|......:.:....|.|:..|...
  Fly  1200 QSRVIIQATDLSENGIERCAEYLPPSATLDNHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEE 1264

Human  1344 KRSLVHLHFPTWPELGLPDSPSNLLRFIQE----VHAHYLHQ----------------------- 1381
            .|.|.| ::..|||.|:|...:.::..:.|    :.::.|.|
  Fly  1265 SRELTH-YWYKWPEAGVPAEEAPIIAMLLEARSSLKSYSLEQANELREKSATLETSMDADGSKAE 1328

Human  1382 -------------------RPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRR 1427
                               |....|:.||||.|.||||.......|::.:|......::||||..
  Fly  1329 AGSTSSHEINGNISSRSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVYY 1393

Human  1428 MRQQRKHMLQEKLHLRFCYEAVVRHVEQV 1456
            :|:.|...:|.|....|.|:....:..::
  Fly  1394 VRRGRASAVQTKEQYEFIYKVASMYAAKI 1422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPN23	NP_056281.1	BRO1_HD-PTP_like	2..357	CDD:185762	11/48 (23%)
		TPR 1	250..283
		V_HD-PTP_like	362..700	CDD:185747	76/410 (19%)
		TPR 2	374..407		8/33 (24%)
		ALIX_LYPXL_bnd	417..701	CDD:290660	64/353 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..812		15/126 (12%)
		His	770..1130		67/383 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	888..1151		50/293 (17%)
		6 X 2 AA approximate tandem repeats of P-Q	953..964		2/10 (20%)
		Y_phosphatase	1220..1450	CDD:278528	78/283 (28%)
		PTPc	1220..1449	CDD:238006	78/282 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1513..1636
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	78/284 (27%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	78/284 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900