DRSC/TRiP Functional Genomics Resources

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Protein Alignment GEMIN5 and rbc-2

DIOPT Version :10

Sequence 1:NP_056280.2 Gene:GEMIN5 / 25929 HGNCID:20043 Length:1508 Species:Homo sapiens
Sequence 2:NP_001368042.1 Gene:rbc-2 / 190267 WormBaseID:WBGene00004314 Length:1373 Species:Caenorhabditis elegans


Alignment Length:1627 Identity:292/1627 - (17%)
Similarity:502/1627 - (30%) Gaps:589/1627 - (36%)


- Green bases have known domain annotations that are detailed below.


Human    38 LVRVGPGAGESPG----------TPP------FRVIGE--------------------------- 59
            :|.|.|...:||.          .||      .||:.:                           
 Worm     1 MVEVAPAGTKSPALSVPVVIWGPKPPENKICAIRVLPDGATIITGAENGHIIIWKLAEGLMPKQL 65

Human    60 LVGHTERVSGFTFSHHPGQYNLCATSSDDGTVKIWDVE-------TKTVVTEHALHQHTI-STLH 116
            ::||:::::..:.:.:........::|.||.|.:|:::       |.::.....::.:|. |:.|
 Worm    66 MIGHSQKITAISQTTNTPTNTRFVSASADGRVCLWEIQDGRCIDSTSSIAIHRYIYPYTYKSSRH 130

Human   117 WSPRVKDLIVSGDEKGVVFCYWFNRNDSQHLF--------IEPRTIFCLTCSPHHE--------- 164
              .|...|...||...:...      |.|.|.        :||..|.|.|...|.|         
 Worm   131 --TRATRLFCIGDYSDIQVM------DPQDLTVVFSISSRVEPDWISCFTIISHPEKEDQLIGMT 187

Human   165 --------DLVAIGYKDGIVVII-DISKKGEVIHRLRGHDDEIHSIAW-CP------LPGEDC-L 212
                    .|..:..||....:. |.||:.|:.|        |.|::: |.      :....| :
 Worm   188 LSGMMKVWTLTELEKKDPATSLYEDESKRLEIQH--------IRSVSYICSTRRMLLIIASTCWM 244

Human   213 SINQEETS----EEAEITNGNAVAQAPVTKGCYLATGSKDQTIRIWSCSRGRGVMILKLPFLKRR 273
            .|:.::.|    .:.|||....|| ..:|....:..|..|::|.::           :||....:
 Worm   245 IIDMDDLSTVVFHKNEITTKRCVA-GYLTDLDKVTIGYTDESIHVF-----------QLPIESLQ 297

Human   274 GGGIDPTVKERLWLTLHWPSNQPTQLVSSCFGGELLQWDLTQSWRRKYTLFSASSEG-QNHSR-- 335
            ..|:.|.|          .:|:||   |:.|.             :......|:..| |.|||  
 Worm   298 KEGVPPVV----------ANNRPT---SNYFD-------------QPNPFIVATVNGVQEHSRSC 336

Human   336 ---IVFNLCPLQTEDDKQLLLSTSMDRDVKCWDIATLECSWTLPSLGGFAYSLAFSSVDIGSLAI 397
               :.|...|..:.:.   |.|:|...:.:                   .:|:..||        
 Worm   337 LNDVQFAFLPYNSSNS---LESSSSSYEKR-------------------RFSVVRSS-------- 371

Human   398 GVGDGMIRVWNTLSIKNNYDVKNFWQGVKSKVTALCWHPTKEGCLAFGTDDGKVGLYDTYSNKPP 462
             ..||.:.|||.....:.:         ...|.|:                         .|.|.
 Worm   372 -RRDGSVLVWNMPPFDHQF---------MKAVPAI-------------------------RNLPF 401

Human   463 QISSTYHKKTVYTLAWGPPVPPMSLGGEGDRPSLALYSCGGEGIVLQHNPWKLSGEAFDINKLIR 527
            :.:.||                        |.|||             :.|:...|..|.:..:.
 Worm   402 KFNGTY------------------------RESLA-------------SIWQTINECEDGSMPVL 429

Human   528 DTNSIKYKLPVHTEISWKADGKIMALGNEDGSI-----------EIFQIPNLKLICTI-QQHHKL 580
            :::::...|.|.::      ||:. ||..||.|           :..::|..:....| ..|...
 Worm   430 NSDAVCCSLFVTSQ------GKLF-LGRSDGVIVMTYACETLARQWLRVPAERATSRILTGHDAA 487

Human   581 VNTISWHHEHGSQPELSYLMASGSNNAVIYVHNLKTVIESSPESPVTITEPYRTLSGHTAKITSV 645
            |.::.:..||.::.:..|.: |||::..:.|.|:.:.           |..:| .:.|...:.|.
 Worm   488 VRSMFYPFEHDTRYDPQYFV-SGSDDFSVIVWNINSG-----------TRIHR-FTVHGGPVKSF 539

Human   646 AWSPHHDGR-----LVSASYDGTAQVWDALREEPLCNFRGHRGRLLC---------VAWSPLDPD 696
            ...|.:..:     :.|.:.|.|.         .|.|.|..:..||.         |.|.|||..
 Worm   540 MLPPSNCSKQVTKCIASLAADNTI---------ALLNIRDSKCMLLASRHPFPIIQVKWRPLDDF 595

Human   697 CIYSGADDFCVHKWLTSMQDHSRPPQGKKSIELEKKRLSQPKAKPKKKKKPTLRTPVKLESIDGN 761
            .:...||. .|:.|.....:..|...|..:.::......|...:....:.........:.::...
 Worm   596 MLVKLADG-SVYVWQMETANLDRIATGLLAEDIMTACDEQIGVEEGTDETSAHHAVQLIRALKNK 659

Human   762 EEESMKEN--SGPVENGVSDQEGEEQAREPELP--CGLAPAVSREPVICTPV---SSG-----FE 814
            ..|::|:.  .|.|....:      .:...|||  ||.|..:. .|:...|:   :.|     ||
 Worm   660 NMEAVKQKVVGGSVSGAAT------PSSHHELPTNCGTAVQLG-SPMSILPLPGCAQGAHLVQFE 717

Human   815 KSKVTINNKVILLKKEPPKEKPE--TLIKKRKAR-------SLLPLSTSLDHRSKEELHQD-CLV 869
            .|.:...    :|..:...|.||  |..:|..|.       |...||..|..:.:..|:.| ..:
 Worm   718 ISALIAG----ILHLDSSAEAPEGKTTAQKLDAAAAAGASDSATGLSRKLTWQFEANLYLDVARL 778

Human   870 LATAKHSRELNEDVSADVEERFHLGLFTDRATLYRMIDIEGKGHLENGHPELFHQLMLWKGDLKG 934
            :.:..|:..|:||:....::|  |.|...|..:|                               
 Worm   779 MLSMLHAWCLDEDMDEVCDKR--LSLHRPRHQVY------------------------------- 810

Human   935 VLQTAAERGELTDNLVAMAPAAGYHVWLWAVEAFAKQLCFQDQYVKAASHLLSIHKVYEAVELLK 999
             ....:.:|||:.:|.... ||.:       |:|.|:..:|..:....||||::......:..:|
 Worm   811 -FGNVSRQGELSVSLPTRF-AADF-------ESFCKKSRWQASHSLNTSHLLAVIATSNTLMAMK 866

Human  1000 SNHFYREAIAIAKARLRPEDPVLKDLYLSWGTVLERDGHYAVAAKCYLGATCAYDAAKVLAKKGD 1064
            ::     |:.:||.|               .:|:|::            .:..:...:...|:| 
 Worm   867 NS-----ALQLAKIR---------------KSVVEQN------------QSTIHQPDRQQIKQG- 898

Human  1065 AASLRTAAELAAIVGEDELSASLALRCAQELLLANNWVGAQEALQLHESLQGQRLVFCLLELLSR 1129
               ....|.|..::..|.:....:.......:|...|  ....|::.|:.|.         ||.|
 Worm   899 ---WSLVAALHCVLLPDHVRPRSSYAPPSIEMLVRRW--QDSCLEIREAAQA---------LLIR 949

Human  1130 HLEEKQLSEGKSSSSYHTWNTGTEGPFVERVTAVWKSIFSLDTPEQYQEAFQKLQNIKYPSA--- 1191
            .| .:..:||: .....:|.     ||:..:.....|||.    .:.|.:...:|    |||   
 Worm   950 EL-TRLGAEGR-RRLIESWT-----PFLPPLLDDSLSIFG----SKLQSSVPTVQ----PSAPAP 999

Human  1192 -----TNNTP----------------------------AKQLLLHICHDLTLAVLSQQMASWDEA 1223
                 |.|.|                            |..::|       |.|:..|..  ||.
 Worm  1000 PIPPRTKNAPPDVEPVRGSEPPTAEGGEAGIQQVRRNQATSIIL-------LGVIGSQFG--DEL 1055

Human  1224 VQA-LLRAVVRSYDSGSFTIMQEVYSAFLPDGCDHLRDKLGDHQSPATPAFKSLEAFFLYGRLYE 1287
            .:| |.||...|.    ..::....|..:|            ..||...|     |..|.||.:.
 Worm  1056 NRADLTRATAVSL----LELLVAAPSNLIP------------VHSPLRRA-----AIDLLGRGFV 1099

Human  1288 FWWSLSRPCPNSSVWVRAGHRTLSVEPSQQLDTASTEETDPETSQPEPNRPSELDLRLTEEGERM 1352
            .|    .|           |..:|......||.||..| .|.|.:.....|    |...|:..|.
 Worm  1100 HW----EP-----------HLEISKVVLGLLDLASNNE-KPGTQRRITGAP----LNAIEDAART 1144

Human  1353 LSTFKELFSEKHASLQNSQRTVAEVQETLAEMIR-----QHQKSQLCKSTANGPDKNEPEVEAEQ 1412
                    |.:..||....|..|.:.....|:.|     |||..|               .....
 Worm  1145 --------SRQALSLIALARPPALITSLSMEVARYNAAAQHQTIQ---------------HTVVS 1186

Human  1413 PLCSSQSQ--------CKEEKNEPLSLPELTKRLTEANQRMAKFPESIKAWPFPDVLECCLVLLL 1469
            ||..|:|:        |::..|:.:::                      ..|..|:|..||.:.:
 Worm  1187 PLLKSRSEVLRIIEELCEKRYNDIIAM----------------------LLPVGDILVHCLDITI 1229

Human  1470 IR 1471
            ::
 Worm  1230 LK 1231

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GEMIN5NP_056280.2 Important for interaction with U1 snRNA. /evidence=ECO:0000269|PubMed:19377484 1..124 21/136 (15%)
Interaction with U4 snRNA. /evidence=ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0007744|PDB:5GXH, ECO:0007744|PDB:5GXI, ECO:0007744|PDB:5H1K, ECO:0007744|PDB:5H1L 13..15
WD40 55..456 CDD:441893 81/479 (17%)
WD40 repeat 68..107 CDD:293791 6/45 (13%)
WD 2 107..148 9/41 (22%)
WD40 repeat 112..149 CDD:293791 9/45 (20%)
WD 3 150..189 14/56 (25%)
WD40 repeat 154..193 CDD:293791 13/56 (23%)
WD 4 193..264 15/82 (18%)
WD40 repeat 228..279 CDD:293791 9/50 (18%)
WD 5 280..321 6/40 (15%)
WD40 repeat 288..325 CDD:293791 5/36 (14%)
WD40 repeat 331..377 CDD:293791 9/50 (18%)
WD 6 333..374 8/45 (18%)
WD40 <348..710 CDD:441893 66/387 (17%)
WD 7 377..417 8/39 (21%)
WD40 repeat 382..422 CDD:293791 8/39 (21%)
WD 8 424..464 4/39 (10%)
WD40 repeat 429..468 CDD:293791 4/38 (11%)
WD 9 468..509 5/40 (13%)
WD40 repeat 474..538 CDD:293791 8/63 (13%)
WD 10 533..573 10/50 (20%)
WD40 repeat 542..575 CDD:293791 9/44 (20%)
WD 11 576..622 10/45 (22%)
WD40 repeat 582..636 CDD:293791 10/53 (19%)
WD 12 637..677 7/44 (16%)
WD40 repeat 642..679 CDD:293791 7/41 (17%)
WD 13 680..720 11/48 (23%)
WD40 repeat 685..722 CDD:293791 12/45 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..790 7/76 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1313..1343 8/29 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1389..1428 8/46 (17%)
rbc-2NP_001368042.1 WD40 27..>118 CDD:475233 10/90 (11%)
WD40 repeat 33..68 CDD:293791 2/34 (6%)
WD40 repeat 73..108 CDD:293791 5/34 (15%)
WD40 repeat 112..160 CDD:293791 10/55 (18%)
WD40 repeat 168..211 CDD:293791 8/42 (19%)
WD40 repeat 264..291 CDD:293791 6/38 (16%)
WD40 373..621 CDD:475233 62/348 (18%)
WD40 repeat 488..530 CDD:293791 11/54 (20%)
WD40 repeat 584..610 CDD:293791 9/26 (35%)
WD40 <1248..>1314 CDD:441893
WD40 repeat 1286..1337 CDD:293791
Blue background indicates that the domain is not in the aligned region.

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