|
Human 28 PPPGPGAGPGAGGAGGAGAGAGDPQLVAMIVNHLKSQGLFDQFRRDCLADVDTKPAYQNLRQRVD 92
||| |||:||:.||||||||||||||||||||||||||||||||||||
Frog 4 PPP------------------GDPKLVSQIVNHLKSQGLFDQFRRDCLADVDTKPAYQNLRQRVD 50
Human 93 NFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGMLESGIDRIISQVVDPKINHTFRPQVEKAVHE 157
||||:|||:||||||||||||||||||||||||||||||||||||||||||||.|||||||.|.|
Frog 51 NFVASHLASHTWSPHLNKNQLRNNIRQQVLKSGMLESGIDRIISQVVDPKINHLFRPQVEKVVKE 115
Human 158 FLATLNHKEEGSGNTAPDDEKPDTSLITQG-VPTPGPSANVANDAMSILETITSLNQEASAARAS 221
:||.:|:||:|:.||..::|:.:.|:...| :|..|||.|||:|||||||||:||||||:||||.
Frog 116 YLAMMNNKEDGNVNTEQNEERSEASISVPGSLPAVGPSTNVASDAMSILETISSLNQEATAARAF 180
Human 222 TETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCP 286
.||.|.|.|::.||: ..|.:.|.:.:|:||.|:..:.|||..|......|...|:|:.:|:...
Frog 181 IETPNNKNSDKVSKR-TIQQSFDATEEKDRTLEETQEVEKSIPDMLVAETEPDIKTEDSNDISST 244
Human 287 VEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKE-KTEKKFDHSK 350
||..|...... |..:||:..|:.|||.|:.: .|||.:.:|..::|::||| ||||:.::.|
Frog 245 VEAFKQPDAVG---ISQSKDIPNENEEQKPKAVE-SEKKNEVSEIAQKKEDKKEAKTEKRNEYPK 305
Human 351 KSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSD 415
|.:|..|||::|..||:|.| .||:|:|.|.....|||...:|||:|..||:|||||||||
Frog 306 KGDDVVKVKEDKTVKERENE-----PEKSSSKQKATSTLKEDNLSVDSDIDDYTDVTVSSVHTSD 365
Human 416 LSSFEEDTEEEVVTSDSMEEGEITSDDEEK--NKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYS 478
||||||::||:.|.|||.|||||||||||. :.:|..|.:| |.:|.|.||.|..|||||||||
Frog 366 LSSFEEESEEDPVVSDSTEEGEITSDDEEDKVDGKNIAKPET-DQNEVKAKSSRQIYVHKPYLYS 429
Human 479 KYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQK-AEKTKSSKTKGQGRSSVDLE 542
||||||||||:|||||||:|||||||||:||:.||:|||||||| |||||:.|. .||::
Frog 430 KYYSDSDDELSVEQRRQSVAKEKEERLLKRQVKRERLEEKRKQKAAEKTKNLKI-SQGKA----- 488
Human 543 ESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQ-YEEDSKETLKTSEH 606
.::|.::.|:..|||||||:..||||||.|||:.:.|||.:...|.|.. .|||.|:::|...|
Frog 489 -VTSKHVKAKSTSIKEVLKEQMFLEKKVARSKKKIRASRNEKNTLKSKSDLLEEDMKDSIKNESH 552
Human 607 CEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEET 671
:|...|||.||...:|: ||::.::| :.:|.|.:.:.|::.|:||
Frog 553 ---DKTLLSKEAKHNIGRSD--KPSKVIAE---LAEECKTDIRTEKDFKKRT------------- 596
Human 672 DTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKD--DSETPHLKSLLKKEVKSSKEKPEREKTP 734
.:|::|...||.|:|||..|.|| |||: |||:|.:|...||:.|..:. |||:|.
Frog 597 -------PLEKNETNVEEQQRQKSAHKTEK-LKKESHDSESPSMKVAQKKDPKMHRN--ERERTV 651
Human 735 SEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKL 799
|||:.|.|::||.:.::||.|:::...|:|..|.::...|:| |:|..|:::::|||||::|.|.
Frog 652 SEDRSSSKYRYKTENINKTNDDSDAQKSKKNSKDDDTPHKRS-QSKSGSEERSDRKSKHKSEGKS 715
Human 800 SVLGKDGKPV-SEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRS-SDSKIQKDS-LGSKQHG 861
|...|:.|.. :|:..||.|:|.:| :|:|||.|.||:::|||.:|| |||:..:|| :.|:||.
Frog 716 SSYNKEEKTSGTEHSSKTGESVHRE-SKRERRQSEEKSRSEHKYKRSLSDSRTHRDSQIDSRQHS 779
Human 862 ITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVET 926
:.|::|...|:||.:.|... :|.|.||..|::|||:.|..||::.||.|||:.||..|:.:.
Frog 780 -SSQKKSRISSDDKTESDLAR--TNAKQEESTHRDKRRSYSCSEERVSLKVKSKSSGKSSKLSDQ 841
Human 927 ELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHR 991
| |.|.|. ||:|...||.:||.:|.|.|| .|...:.|...||| :..||.:::
Frog 842 E--EPAQKN------DKDKTLLENYAEKYQKLKSED---HEEAKDAVTTQASS---TVSKDVNYK 892
Human 992 AKLPLAKEKYKSDKDS---TSTRLERK-LSDGHKSRSLKHSSKDIKKKDE-NKSDDKDGKEVDSS 1051
:|....|||.||..|: :|::|::| :.:..|..|.|||.||:|:|.| :|.|||..|..|
Frog 893 SKHSGDKEKEKSRSDNRERSSSKLDKKHIGENIKGISSKHSHKDLKRKGESSKPDDKGSKVTD-- 955
Human 1052 HEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQ--------RPKK- 1107
||.....|:::||.|::.....:| |.:|| ::::..||.|: |.:|
Frog 956 -EKRAQERSILDKKSSKKTPMEFKG----ESSKG-------SVTSKKGSKLENDGNDHAGRKRKL 1008
Human 1108 ------SGDMTLIPEQE-------PMEIDSEPGVEN---------VFEVSKTQDNRN-------- 1142
|.||:.|..:| ...|..|.|.|. :||::....|.|
Frog 1009 SSCSSDSKDMSSIMNEELSRDSVKSERISVEKGFETAESVAVSEPLFELNSICPNANATSIDGGY 1073
Human 1143 ---NNSQQDI----------------------------------DSENMKQKTSATVQKDELRTC 1170
|..:||. |:....:..:|||.....||.
Frog 1074 GKENRLKQDSSIRGVNAASVCSRIFSGEHSENKPVDDFTQPSEDDTRQYSETAAATVGNCSERTP 1138
Human 1171 TADSKATAP---------------------AYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSAVS 1214
...::.:.| :.||.....:||.... .|..:.:|..: |.:..:
Frog 1139 VTSAECSTPISDVIDLQHVSGGEHFALEQTSPKPESCVTINSTFSP-VDISTEITNDV-ISTTAT 1201
Human 1215 KMNPGEKEPIHRGTTEVNIDSETVHRM--------LLSAPSENDRVQKNLKNTAAEEHVAQGDAT 1271
......||.:....|..:.|:..|..: ::...|:||..:.|.::...|...|.|...
Frog 1202 GETDANKEAVKIKHTSSDCDTLAVDNIVTGNDVEEVMQITSDNDMAENNCESVGEESVSAVGTCF 1266
Human 1272 LEH------STNLDSSPSLSSVTVVPLRESY--------DPDVIPLFDKRTVLEGSTASTSPADH 1322
:.: ||.:::|...:.:.|..|.|.| |.::....|. :|:|.|..:|
Frog 1267 VPYRESSTDSTIVETSSERNDIVVAELNERYAFPSSRAQDRNMSECEDT------ATSSCSTIEH 1325
Human 1323 -------------SALPNQSLT---VRESEVLKTSDSK----EGGEG-FTVDTPA------KASI 1360
::|...|.| |....|:.|:.|: .|..| .|..|.| :|.|
Frog 1326 TENVSLRGTIIYTNSLGENSATSTNVHLDNVMATNRSEYAVGVGNSGECTATTSADFENLGEADI 1390
Human 1361 T-----SKRHIPEAHQATLLDGKQGKVIMPLGSKL-TGVIVENENI---------TKEGGLVDMA 1410
| |......:..:|....::.:...|..|:. .|.::|.|.| :.:|.:...|
Frog 1391 TMLSENSFEVATTSSVSTACSPERSRESAPTSSQRGIGAVLEAEAICDVLLKPATSSDGNMASSA 1455
Human 1411 KKENDLNAEPNLKQTIKATVENGKKDGIAVDHVVGLNTEKYAETVK--LKHKRSPGKVKDISIDV 1473
....:.....|.:: :..||| ..:|..| .:|..|. |:..
Frog 1456 GTPKNAATSSNSQE---SDTENG----------------DVSEATKYFTRHAASS------SVSA 1495
Human 1474 ERRNENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATST-EGKDKDVTLSPVKAGP 1537
|..::......:..:.||.|.:|....:..|:.: ..:..:.|||: ...:||....|.....
Frog 1496 EDNDDRFPTSENIITHSATSSIHAVENKAADLIS---ENDSINAATSSYNALEKDSLSIPENVMM 1557
Human 1538 ATTTSSE-------------TRQSEVALPCTS---IEADEGLIIGTH-SRNNPLHVGAEASE--- 1582
...:||: ...|::|.|.:: :..|.|:| || |.::.:.|..|..:
Frog 1558 LAASSSDNVEIHDDHSGLVAATSSDIAAPLSNPDGVSHDIGII--THASTSSDVRVDNEVLQGSD 1620
Human 1583 -CTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAAD----------LLAVHAV 1636
.:|.||......|...|..:. .|:.....|.|.|...| :||..|.
Frog 1621 IFSVNAATSSDSTVEDNGILQG---------SENAHAHAATSSDIIVDNSGALQASENVLANAAT 1676
Human 1637 KIEANVNSVVTEEKDDAVTSAGSEEKCD--------GSLSRD----------SEIVEGTITFISE 1683
..::...:||.|..::.:::|.|....| ||:|.: |.|:|.::...|.
Frog 1677 SSDSLAENVVLEVSENVLSAASSSSAIDSSRILHFEGSISSEIDNENVAASSSNIMESSLADASG 1741
Human 1684 V-----ESDGAVTSAG----------TEIRAGSI-SSEEVDGSQGNMMRMGPKKETEGTVTC-TG 1731
| ..|...:|:| ..|:.||. .|:.|..:...:..:|..:.....::. |.
Frog 1742 VWLQNPSGDNTASSSGYLDRDSRFQHNTIQFGSAEESKNVRATSTTLKDIGVSERCSSVISSGTH 1806
Human 1732 AEGRSDNFVI-------------------CSVTGAGPREERMVTGAGVVLGDNDAPPGTSASQEG 1777
....||:.|: ||.:||....|.......:...:|.| |:|...
Frog 1807 VVNSSDSLVMDSSTEVSVISQVDGGDAASCSSSGAEQGHEDQKHADHLKERENTA----SSSCAL 1867
Human 1778 DGSVNDGTEGESAVTSTGITEDGEGPASCTGSEDSSEGFAISSESEENGESAMDSTVA----KEG 1838
|.|:.|........:..|..|.....:|...|.....|.. ||.|..|...|..|:|| .:.
Frog 1868 DNSIEDMCVDPEVPSQNGSDEAASSSSSLNTSSVQRSGHK-SSLSPNNINVAASSSVAMNSSSDS 1931
Human 1839 TNVPLVAAGPCDDEG---------------------IVTSTGAKEEDEEGEDVVTSTGRGNEIGH 1882
.|..::..|...|.. ..||:....:...|||:...|.:
Frog 1932 LNFSVLCPGNSTDNAATSSSNITVSGADCVLSNNTLATTSSNISMDSSTGEDLELDTEK------ 1990
Human 1883 ASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMN---ANENNVDS---MSGTEKGS 1941
|||.| |...|: .:.:....|||..:.:.|.:...|.| |||....| :||....|
Frog 1991 ASTST-----SSSTLL-NNDKRAQDIGTEKDSITASSSTTIENCPIANEETAGSSFTVSGNAATS 2049
Human 1942 KDTDICSSAKGI----VESSVTSAVSGK----DEVTPVPGGCEGPMTSAASDQSDSQLEKVEDTT 1998
.||...|..|.. :.::.||.|..: ||.|.....|....:.|.:..|.:.:|.
Frog 2050 SDTTSSSKNKNTSTPDINTATTSTVIAEILTADERTENVNICCDINSEATAASSSNNMES----- 2109
Human 1999 ISTGLVGG---SYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDITN--- 2057
|:|.||| |.|.::. |..|.|::..:.:||| |.::||..||
Frog 2110 -SSGSVGGNATSSDYMMD-------------SSLEGENVSETQKNEE-----AASSSGLSTNIRL 2155
Human 2058 ---QNSLAGGKNQGKVLIISTSTTNDYTPQVS--------------AITDVEGGLSDALRTEENM 2105
|....|.:| :..:||:..|.:.: :..:||..:..:..:.::.
Frog 2156 QEIQTVTVGSQN------LEDATTSSSTERANTSFVYSSNNSESNVSYHNVEATVESSFASSQSD 2214
Human 2106 EGTRVTTEEF--------EAPMPSAVSGDDS-QLTASRSEEKDECAMISTSIGEEFEL----PIS 2157
..|..|:||. .|.|...::.||: .....|::||::. :|::..:|::| |..
Frog 2215 IDTSGTSEETLVLSASGKNAAMHPVLNSDDNVNQDYERADEKEDA--VSSASSQEYKLCSNAPRQ 2277
Human 2158 SATTIKCAE---SLQPVAAAVEERATGPVLISTADF-----------EGPMPSAPPEAESPLAST 2208
:....:..| ::....|.|.|.|..|....|.|. :|.:...|.| ::|::.|
Frog 2278 NIKQTRDGEVDGAVTSGGAEVSESAMAPENFETFDHVTCAKAGAIVDDGDVLLVPVE-DTPVSHT 2341
Human 2209 SKEEKDECALISTSI-------AEECEASVS-GVVVESENERAGTVMEEKDGSGIISTSSVEDCE 2265
|:.:..|.:|::... :..||...| |...|:|.......:||.:|: :.||...|:.:
Frog 2342 SRTDPSEESLVAEDTENNASFESANCETPASIGNAYEAETPNEQFTLEEGEGA-VTSTGITEESD 2405
Human 2266 GPVSSAVPQE--EGDPSVTPAE-EMGDTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLSDA 2327
.:.|.|: :.|.|.|.|| |.|..||.....::. .|:.:|: ::
Frog 2406 ---RAKVRQDIRKSDSSCTEAEIEPGGHAMSRQEVTDS------NAITEDD------------ES 2449
Human 2328 AIISTSTAECMPISASIDRHEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAEN-NCRCPGPVR 2391
||.||...| :..||.|.:::|..:.......|...|| || ..:.
Frog 2450 AITSTGAKE------------------EEEEGEGFVTSTGTASEDSSFSSGTDENSNC---AQMF 2493
Human 2392 GGKEPGPVLAVSTEEGHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHL 2456
.....|..:||::||.....:.|:.: :...|||.....| |.| |.| |||..:|:.|
Frog 2494 NFNSKGQPIAVNSEERREPKTNHELT--EEIKSAVILITTE--GSE-PSI---AGRSTEENNL-- 2548
Human 2457 INAEEKNVLLNSLQKEDKSPETGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSV 2521
:|.||. |..||:..| .|.:| |: |.:.|||:
Frog 2549 -----ENALLL------------TPDGSAVLS---------TAENP-HM----QENNQTAE---- 2578
Human 2522 SIRYLAAVNTGAIKADDMPPVQGTVAEHS-------FLPAEQQG------SEDNLKTSTTKCITG 2573
..::|.. :.:::..|:..||.|| .|.|:.|. :||||:|| .|
Frog 2579 -----MEIDTSQ-RTEEIFEVETCVAIHSAADDETTTLNAQGQNLLTSETNEDNLRTS-----AG 2632
Human 2574 QESKI-APSHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNST-RKSFPEEG 2636
:.|.: |.||....| |...::...:.:.:|.|.... .::.|:|..||:. ..:...|.
Frog 2633 ENSLVDAASHLQENP-TADKSVTHDQEDGNLNISEQV------PSNDEQTVVDNTVPNPTIKPED 2690
Human 2637 DIMVTVSSEENVCDIGNEESPLNVL--GGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPS 2699
..:|:|| |..|.|.: |||.:....... .....|.|::...|| :..
Frog 2691 SPLVSVS----------ESIPSNTVPSGGLSVDHGRSFS----DHGSINREVVEETES----RAP 2737
Human 2700 GIAELQREPLLV-----NESLNVENSGFRTNE-EIHSESYNKGEISSGRKDNAEAISGHSV-EAD 2757
|:..:.....|| |::|..|.....|.| |...|:.:...:...:..:.::::..|. :.:
Frog 2738 GVRSVHFADELVADVSGNDALQDEQEKITTEEKEECLETTSGSAVLESKNQDEDSVTAESENDVN 2802
Human 2758 PKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEP-------HDTKEENS 2815
|...:|||:.. :||......|:...|..|...||..|:.. .:|.:.|
Frog 2803 PTNNQEEEKSE----------ASEISLMQPPETGSSESEAVLRQAHESSDLGKGQSFVETTDSN- 2856
Human 2816 RDLEELPKTSSETNSTTSRVME-------EKDEYSSSETTG-EKPE------------------- 2853
||.|..|:...|:| .::|.::.||:| |.||
Frog 2857 --------TSEEQQSSEQNVLETIKDEDVPREEKATCETSGPEAPEVPCSEESSPKVKKPRGRKS 2913
Human 2854 ---------QNDDDTIKSQEEDQPIIIKRKRGR-PRKYPV--ETTLKMKDDSKT-DTGIVTVEQS 2905
..|..|.:..||.:| ..|||||| |:|.|: :|.|.:|:.|:. .|....:.|.
Frog 2914 LEKLKEESLAKDKPTEEIPEEPKP-PEKRKRGRPPKKRPLVPDTELSVKESSEEGKTSNARLRQE 2977
Human 2906 PSSSKLKVMQTVSENCNICRKQMHKEYESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSL 2970
.|:|..|.::|: |....|:| |::::. |:|...:|.||||||||||
Frog 2978 ESTSTKKDVRTL-EKTEQCQK-----------TSDVRL--------EDKSGQTVPRRGRKPKRSL 3022
Human 2971 TVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRKQHSKPS 3035
:.|: ||||:||.||||: :|:.::..|:.:.||:..|||||:.:|.||:|....||:
Frog 3023 STSE----SEPEKKRMKSVSE-----EEENAEHTEDTDNEDDHKGATTRAASRLEAERNLPHKPT 3078
Human 3036 ARATSKLGSPDTVSPRNRQKLAKEKLPTSEKVSNSPPLGRSKTQLSPSIKRKREVSPPGARTRGQ 3100
.||.|||.||:. |.|.|:|........|.|.:|. |.||||| ..||.||.|||.|::|||
Frog 3079 TRAASKLSSPEP-SSRKRRKNKNSLESKSPKNTNI----RMKTQLS-GTKRCREPSPPLAKSRGQ 3137
Human 3101 QRVEEAPVKKAKR 3113
|..||...|:|||
Frog 3138 QTSEEITPKRAKR 3150
| 
