Protein Alignment ASPM and asp

DIOPT Version :10

• Sequence 1: NP_060606.3
• Gene: ASPM / 259266
• HGNCID: 19048
• Length: 3477
• Species: Homo sapiens
• Sequence 2: NP_524488.3
• Gene: asp / 42946
• FlyBaseID: FBgn0000140
• Length: 1954
• Species: Drosophila melanogaster
• Alignment Length: 2188
• Identity: 494/2188 - (22%)
• Similarity: 875/2188 - (39%)
• Gaps: 640/2188 - (29%)

Human    32 EASSPPVLSLSHFCRSPFLCFGDVLLGASRTLSLALDNPNEEVAEVKISHFPAADLGFSVSQRCF 96
            |...|.|:.::.|.....:.|.||.:..:....:.:.||:::..|||:......:...|:.....
  Fly    20 EGREPAVVVMAPFSAKAIVQFEDVPITKTARRQVRVLNPSDDDIEVKVMKAIREEHNLSLEWMEH 84

Human    97 VLQPKEKIVISVNWTPLKEGRVREIMTFLVN-DVLKHQAILLGNAEEQKKKKRSLWDTI------ 154
            .:..::::.:.:.|:|:.|...:|.:..:.| :..|...|:|.:...|..|....:.|:
  Fly    85 TVPARDEVSMELVWSPVLEVACKETLQLIDNRNFRKEVMIILKSKSNQPVKNPRKFPTVGKTLQL 149

Human   155 ---------KKKKISASTSHNRRVSNIQNVNKTFSVSQKVDRVRSPLQACENLAMNEGGPPTENN 210
                     .|..:||:....:|:|     ......|::..||.:|.:...........|..|.|
  Fly   150 KSPTGAGKTMKSVVSAAVQQKKRMS-----AAAAPPSKQTWRVTAPSRPAAWAHPPPQAPLVEKN 209

Human   211 SL-ILEENKIPISPISPAFNECHGATCLPLSVRRSTTYSSLHASENRELLNVHSANVSKVSFNEK 274
            .. ..:|..:.|||             .|.|::     .:|.......||:|    :..:.|.
  Fly   210 VYKTPQEEPVYISP-------------QPRSLK-----ENLSPMTPGNLLDV----IDNLRFT-- 250

Human   275 AVTETSFNSVNVNGQRGENSKL------------SLTPNCSSTLNITQSQIHFLSPDSF------ 321
            .:|||          ||:....            :|..|..|..|  ..:...::||..
  Fly   251 PLTET----------RGKGQATIFPDNLAAWPTPTLKGNVKSCAN--DMRPRRITPDDLEDQPAT 303

Human   322 -----VNNSHGANNELELVTCLSSDMFMKDNSQPVHLESTIAHEIYQKIL---------SP---- 368
                 |.:|...|..|:.:.|...|   .....|::..:||.|..:.:.|         ||
  Fly   304 NKTFDVKHSETINISLDTLDCSRID---GQPHTPLNKTTTIVHATHTRALACIHEEEGPSPPRTP 365

Human   369 -DSFIKDNYGLNQDLESESVNPILSPNQFLKDNMAYMCTSQQTCKVPLSNENSQVPQSPED---W 429
             .|.|.|   |.:|::... :|:...::.:||.......::...:..:.|.|....:|.|.   :
  Fly   366 TKSAIHD---LKRDIKLVG-SPLRKYSESMKDLSLLSPQTKYAIQGSMPNLNEMKIRSIEQNRYY 426

Human   430 RKSEVSPRIPECQGSKSPKAIFEELVEMKSNYYSFIKQNNPKFSAVQDISSHSHNKQPKRRPILS 494
            ::.::..:..:...|.|.:|......|...|:...:.|:: :|: :.::...|....|.:.|
  Fly   427 QEQQIQIKAKDLNSSSSSEASLAGQQEFLFNHSEILAQSS-RFN-LHEVGRKSVKGSPVKNP--- 486

Human   495 ATVTKRKATCTRENQTEINKPKAKRCLNSAVGEHEKVINNQKEKEDFHSYLPIIDPILSKSKSYK 559
               .||::                         ||...::....|..                |:
  Fly   487 ---HKRRS-------------------------HELSFSDAPSNESL----------------YR 507

Human   560 NEVTPSSTTASVARKRKSDGSMEDANV-RVAITEHTEVREIKRIHFSPSEPKTSAVKKTKNVTTP 623
            ||      |.:::..:|.  .:||..: |.|...:...|. ...|..|...
  Fly   508 NE------TVAISPPKKQ--RVEDTTLPRSAAPANASARS-SSAHAWPHAQ-------------- 549

Human   624 ISKRISNREKLNLKKKTDLSIFRTPISKTNKRTKPIIAVAQSSL---TFIKP----LKTDIPRHP 681
             ||:....:.::|.||.     .||....:...:|.:.:..|.|   |.|.|    ..|.|.
  Fly   550 -SKKFKLAQTMSLMKKP-----ATPRKVRDTSIQPSVKLYDSELYMQTCINPDPFAATTTID--- 605

Human   682 MPFAAKNMFYDERWKEKQEQGFTWWLNFILT-PDDFTVKTNISEVNAATLLLGIENQHKISVPRA 745
             ||.|..|:.||:..::.:..|..|||.::: |.|.....| ::::...|...:.|:..:.   |
  Fly   606 -PFLASTMYLDEQAVDRHQADFKKWLNALVSIPADLDADLN-NKIDVGKLFNEVRNKELVV---A 665

Human   746 PTKEEMSLRAYTARCRLNRLRRAACRLFTSEKMVKAIKKLEIEIEARRLIVRKDRHLWKDVGERQ 810
            |||||.|:. |..:.||..||:||..||.||:|.....|:.:.:..:.|.:|.||:|..||..::
  Fly   666 PTKEEQSMN-YLTKYRLETLRKAAVELFFSEQMRLPCSKVAVYVNKQALRIRSDRNLHLDVVMQR 729

Human   811 KVLNWLLSYNPLWLRIGLETTYGELISLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPHLYR 875
            .:|..||.:||||||:|||..:||.|.::.|.|:.||:.||||||..|   ..|.:..:..:...
  Fly   730 TILELLLCFNPLWLRLGLEVVFGEKIQMQSNRDIVGLSTFILNRLFRN---KCEEQRYSKAYTLT 791

Human   876 DGHEEALSKFTLKKLLLLVCFLDYAKISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDL 940
            :.:.|.:.|.:|:|:|.|:.|||.||..|::.|:||||.|.:..|.:|:|||.||.:.|:..||:
  Fly   792 EEYAETIKKHSLQKILFLLLFLDQAKQKRIVKHNPCLFVKKSPHKETKDILLRFSSELLANIGDI 856

Human   941 SRHLGLLGLPVNHVQTPFDEFDFAVTNLAVDLQCGVRLVRTMELLTQNWDLSKKLRIPAISRLQK 1005
            :|.|..||..:.|.||..||||:|..||||||:.||||.|.||::....||:::||:|||||||:
  Fly   857 TRELRRLGYVLQHRQTFLDEFDYAFNNLAVDLRDGVRLTRVMEVILLRDDLTRQLRVPAISRLQR 921

Human  1006 MHNVDIVLQVLKSRGIELSDEHGNTILSKDIVDRHREKTLRLLWKIAFAFQVDISLNLDQLKEEI 1070
            :.||.:.|..|.....:|    |..|.::||||.||||||.|||::.:.|:
  Fly   922 IFNVKLALGALGEANFQL----GGDIAAQDIVDGHREKTLSLLWQLIYKFR-------------- 968

Human  1071 AFLKHTKSIKKTISLLSCHSDDLINKKKGKRDSGSFEQYSENIKLLMDWVNAVCAFYNKKVENFT 1135
                                                                             
  Fly   969 ----------------------------------------------------------------- 968

Human  1136 VSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTQTGSVVLNSSSESDDSSLDMSLKAFDHE 1200
                                                                             
  Fly   969 ----------------------------------------------------------------- 968

Human  1201 NTSELYKELLENEKKNFHLVRSAVRDLGGIPAMINHSDMSNTIPDEKVVITYLSFLCARLLDLRK 1265
                         ...||
  Fly   969 -------------SPKFH----------------------------------------------- 973

Human  1266 EIRAARLIQTTWRKYKLKTDLK---RHQE---REKAARIIQLAVINFLAKQRLR----KRVNAAL 1320
              .||.::|..||::.|...::   ||:|   |.:||.:||........::.::    :|..||:
  Fly   974 --AAATVLQKWWRRHWLHVVIQRRIRHKELMRRHRAATVIQAVFRGHQMRKYVKLFKTERTQAAI 1036

Human  1321 VIQKYWRRVLAQRKLLMLKKEKLEKVQNKAASLIQGYWRRYSTRQRFLKLKYYSIILQSRIRMII 1385
            ::||:.||.|||::|..                                 .|:|||
  Fly  1037 ILQKFTRRYLAQKQLYQ---------------------------------SYHSII--------- 1059

Human  1386 AVTSYKRYLWATVTIQRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKQRKMQSQVKATVILQ 1450
                         ||||.|||....:|.:||:..|:.:.:.:|   |.|::|....::.|.....
  Fly  1060 -------------TIQRWWRAQQLGRQHRQRFVELREAAIFLQ---RIWRRRLFAKKLLAAAETA 1108

Human  1451 RAFREWHLRKQAKEENSAIIIQSWYRMHK----ELRKYIYIRSCVVIIQKRFR----CFQAQKLY 1507
            |      |::..|::.:|..||..:|.::    :.::::..|..::.:|:|.|    ..:.:|.:
  Fly  1109 R------LQRSQKQQAAASYIQMQWRSYQLGRIQRQQFLRQRDLIMFVQRRMRSKWSMLEQRKEF 1167

Human  1508 KRRKESILTIQKYYKAYLKGKIERTNYLQKRAAAIQLQAAFRRLKAHNLCRQIRAACVIQSYWRM 1572
            ::.|.:.:.||:.::|.|..:....:||..|::.:::||             .|.|.:     :|
  Fly  1168 QQLKRAAINIQQRWRAKLSMRKCNADYLALRSSVLKVQA-------------YRKATI-----QM 1214

Human  1573 RQDRVRFLNLKKTII----KFQAHVRKHQQRQKYKKMKKAAVIIQTHFRAYIFAMKVLASYQKTR 1633
            |.||..:.:|:|.:|    :.:|.::..:||:.|.:::.|::::|..:|.....::...:|.:||
  Fly  1215 RIDRNHYYSLRKNVICLQQRLRAIMKMREQRENYLRLRNASILVQKRYRMRQQMIQDRNAYLRTR 1279

Human  1634 SAVIVLQSAYRG----MQARKMYIHILTSVIKIQSYYRAYVSKKEFLSLKNATIKLQSTVKMKQT 1694
            ..:|.:|..:|.    .:.||.|:|:.|:..:||..:||   |:|                ||:.
  Fly  1280 KCIINVQRRWRATLQMRRERKNYLHLQTTTKRIQIKFRA---KRE----------------MKKQ 1325

Human  1695 RKQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQR------- 1752
            |.::|.|:...|.:|:..|:.....::|:||:.:||..||||   |.:..:|.||..|
  Fly  1326 RAEFLQLKKVTLVVQKRRRALLQMRKERQEYLHLREVTIKLQ---RRFHAQKSMRFMRAKYRGTQ 1387

Human  1753 KAVISLQSYFR----MRKARQYYLKMYKAIIVIQNYYHAYKAQVNQRKNFLQVKKAATCLQAAYR 1813
            .||..||.::|    .::.|..:|::.:|.|.:|..|.|....:.|.|::.|:|:||..:|..||
  Fly  1388 AAVSCLQMHWRNHLLRKRERNSFLQLRQAAITLQRRYRARLNMIKQLKSYAQLKQAAITIQTRYR 1452

Human  1814 GYKVRQ----LIKQQSIAALKIQSAFRG---YNKRVK-YQSVLQSIIKIQRWYRAYKTLHDTRTH 1870
            ..|..|    |.::|..|.:|:|..:||   ..|::: ||...|::|::|:|:|:.:.:...:..
  Fly  1453 AKKAMQKQVVLYQKQREAIIKVQRRYRGNLEMRKQIEVYQKQRQAVIRLQKWWRSIRDMRLCKAG 1517

Human  1871 FLKTKAAVISLQSAYRGWKVRKQIRREHQ----------------------------------AA 1901
            :.:.:.:.:|:|   |.|:...|.||:.:                                  ||
  Fly  1518 YRRIRLSSLSIQ---RKWRATVQARRQREIFLSTIRKVRLMQAFIRATLLMRQQRREFEMKRRAA 1579

Human  1902 LKIQSAFR----MAKAQKQFRLFKTAALVIQQNFRAWTAGRKQCMEYIELRHAVLVLQSMWKGKT 1962
            :.||..||    |.||::.::|.:::.:::|:.|||..:.::...|:::||...:.||..::||
  Fly  1580 VVIQRRFRARCAMLKARQDYQLIQSSVILVQRKFRANRSMKQARQEFVQLRTIAVHLQQKFRGK- 1643

Human  1963 LRRQLQRQHKCAIII-------QSYYRMHVQQKKWKIM-----------KKAALLIQKYYRAYSI 2009
              |.:..|..|..::       |:..|..:.:|:::.:           |:||.:||:|:|.|.|
  Fly  1644 --RLMIEQRNCFQLLRCSMPGFQARARGFMARKRFQALMTPEMMDLIRQKRAAKVIQRYWRGYLI 1706

Human  2010 GREQNHLYLKTKAAVVTLQSAYRGMKVRKRIKDCNKAAVTIQS 2052
            .|.|.|..|               :.:||||....:.|..:.|
  Fly  1707 RRRQKHQGL---------------LDIRKRIAQLRQEAKAVNS 1734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASPM	NP_060606.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		ASH	37..134	CDD:464865	17/97 (18%)
		Sufficient for interaction with KATNA1:KATNB1. /evidence=ECO:0000250|UniProtKB:Q8CJ27	308..409		23/125 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..443		4/30 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	559..581		4/21 (19%)
		CH_ASPM_rpt1	940..1053	CDD:409072	56/112 (50%)
		CH_ASPM_rpt2	1112..1261	CDD:409073	2/148 (1%)
		COG5022	<1268..>1451	CDD:227355	45/192 (23%)
		COG5022	<1480..>1609	CDD:227355	28/136 (21%)
		COG5022	<1549..>1705	CDD:227355	38/163 (23%)
		COG5022	<1809..>1972	CDD:227355	50/208 (24%)
		COG5022	<2138..>2322	CDD:227355
		COG5022	<2257..>2433	CDD:227355
		COG5022	<2908..>3083	CDD:227355
asp	NP_524488.3	ASH	26..122	CDD:464865	17/95 (18%)
		CH_ASPM_rpt1	856..964	CDD:409072	56/111 (50%)
		IQCD	999..1028	CDD:467745	6/28 (21%)
		COG5022	<1076..>1419	CDD:227355	93/391 (24%)
		IQ	1689..1711	CDD:197470	10/21 (48%)