Protein Alignment ASPM and aspm-1

DIOPT Version :10

• Sequence 1: NP_060606.3
• Gene: ASPM / 259266
• HGNCID: 19048
• Length: 3477
• Species: Homo sapiens
• Sequence 2: NP_492467.1
• Gene: aspm-1 / 172746
• WormBaseID: WBGene00008107
• Length: 1186
• Species: Caenorhabditis elegans
• Alignment Length: 1317
• Identity: 241/1317 - (18%)
• Similarity: 487/1317 - (36%)
• Gaps: 317/1317 - (24%)

Human   608 EPKTSAVKKTKNVTTPISKRISNREKLNLKK----KTDLSIFRTPISKTNKRTKPIIAVAQSSLT 668
            |.|..|:  .|.:.....||:.::.|.|.||    .|:.:...:..:..|.|| |:.....||:
 Worm     6 EDKKEAM--LKRLANRHEKRLLDQVKSNTKKIDLRATERAFLESSPTSMNMRT-PLNPSISSSV- 66

Human   669 FIKPLKTDIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNAATLLLG 733
                  :|.|         .:.|||: ..||......|.|.::.. |.:.:.::.|..|.    .
 Worm    67 ------SDSP---------ILSYDEK-ANKQIIALATWCNTMMEL-DVSEEMDLGESKAE----A 110

Human   734 IENQHKISVPRAPTKEEMSLRAYTARCRLNRL---------RRAACRLFTSEKMVKAIKKLEIEI 789
            ..|..|:...|:.|.|..:.:. .||.|..|:         ::...:|.....|..:||.|   :
 Worm   111 CRNIQKMLKKRSDTSEVENTQE-NARRRYQRIFEKNDPEVVKKKCKQLLDDSGMDASIKDL---L 171

Human   790 EARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETTYGELISLEDNSDVTGLAMFILNR 854
            ....:.:||:..::.|:|.:..:|:..||::|.||:..||..:...|..:....:..|:.|.|:.
 Worm   172 SKNNVAIRKEHAVYNDIGLQTTLLHTFLSFHPAWLKTALEAIFNTRIDAQPKHLMKKLSQFFLDL 236

Human   855 LLWNPDIA--AEYRHPTVPHLYRDGHEEALSKFTLKKLLLLVCFLDYAKISRLIDHDPCLFCKDA 917
            :..||.:.  .::...:...:..:..:|||.|..|...:.|:..::.|...|:|.:...:|.|.:
 Worm   237 VFSNPTMLKNKKFAQGSGKPIITEAGKEALHKHFLSVSMKLMFLIETAHTHRVIPNLTRIFTKSS 301

Human   918 EFKASKEILLAFSRDFLSG-EGDLSRHLGLLGLPVNHVQTPFDEFDFAVTNLAVDLQCGVRLVRT 981
            .|....::....:::.|:| .....:....:|....:.|:..:.:|:.....: |...|:.|.:.
 Worm   302 HFNCLDDVFSELTKELLTGSSATFKKAFAKVGFIPTYRQSFIENYDYQAKGFS-DFSDGLILAKL 365

Human   982 MELLTQ--NWDLSKKLRIPAISRLQKMHNVDIVLQVLKSRGIELSDEHGNTILSKDIVDRHREKT 1044
            :|.:.:  :..:..|||.||..|::|:.||.||||.:.|.|:..     :.:.::.||...:::.
 Worm   366 LETVGEMPHGQILLKLRDPAGDRIRKIGNVKIVLQEMSSLGVPT-----DNVNAESIVGGKKDEI 425

Human  1045 LRLLWKIAFAFQVDISLNLDQLKEEIAFLKHTKSIKKTISLLSCHSDDLINKKKGKRDSGSFEQY 1109
            |.:||.|         :.:...||:        .||.|..     |::...||  :|.:...:..
 Worm   426 LSILWAI---------IGVRVAKEQ--------RIKVTRV-----SEERTPKK--RRSAVHDDMS 466

Human  1110 SENIKLLMDWVNAVCAFYNKKVENFTV---SFSDGRVLCYLIHHYHPCYVPFD-----AICQRTT 1166
            ||.:|:        |..|.:::|...:   |.|||.:|..|...:.....|..     ::.::..
 Worm   467 SEVLKM--------CKIYGRQMEIEVMDLDSLSDGCLLAKLWTTFGTNSTPIQDYDGLSLWEKVV 523

Human  1167 QTVE---CTQTG-----SVVLNSSSESDDSSLDMSLKAFDHENTSELYKELLENEKKNFHLVRSA 1223
            ...|   |.|.|     ::.:....|......|::.||...:...:.|.: .:|..|.:.:|:..
 Worm   524 SVAELELCIQRGLDQNMALFVKMFLERLGMIQDLNEKATKIQRMWKAYVQ-RKNTPKLYFIVQQL 587

Human  1224 VRDLGGIPAMINHSDMSN----TIP--------DEKVVITYL---------SFLCARLLDLRKEI 1267
            :.| ..||...:.|..||    |:|        .|:..::.:         :|..|.....|..|
 Worm   588 LAD-SSIPRNRSVSPFSNNVTFTVPRTPRNNILTERPSLSQIPSSRQSMDSTFNDATFTVSRDSI 651

Human  1268 RAARLIQTTWRKYKLKTDLKRHQEREKAARIIQ--------LAVINFLAKQR--LRKRVNAALVI 1322
            .:...:|        ||.|:....|:..|.:|:        ..|:....|:|  :|...||.:.
 Worm   652 ESMNKMQ--------KTPLRGTFTRKTIAMVIEEEDDSENNETVVPSTLKKRTVVRMEHNAEVF- 707

Human  1323 QKYWRRVLAQRKLLMLKKEKLEKVQNKAASLIQGYWRRYSTRQRFLKLKYYSII---LQSRIRMI 1384
                             :|:.|..:|:....:........:....:.|:..|.|   .||.|.:.
 Worm   708 -----------------REQDEDDENQDKDTVAPSAENLDSPPSDIPLETLSSIPSASQSAIFLQ 755

Human  1385 IAVTSYKRYL--------------WATVTIQRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWK 1435
            .:.|..:.::              .:.|.::.:..|    ..|.|:.|.|::..:         |
 Worm   756 DSETGKEMHVPKAEDVGVVVLEASDSPVALEGNNEA----SYDGQKIENLETFEI---------K 807

Human  1436 QRKMQ-----------SQVKATVILQRAFREWHLRKQAKEENSAIIIQSWYRMHKELRKYIYIRS 1489
            :.|.|           :|...:.:::       .|...::|...::.||   :.::.:.::...:
 Worm   808 EGKTQEDLPSKSPMDPTQTSGSPLVE-------FRMTEEQERLEMLFQS---LSEDQKNFVKTNN 862

Human  1490 CVVIIQ------KRFRCFQAQKLYKRRKESILTIQKYYKAYLKGKIERT---------------- 1532
            ..|.|:      :..|..:..:..||:::.|        |...|.|||.
 Worm   863 LSVSIEDDANTPELRRILRQTRELKRKQQEI--------ARKLGNIERNALAVRDGGEDSSDSRS 919

Human  1533 -------------NYLQKRAAAIQLQAAFRRLKAHNLCRQIRAACVIQSYWR----MRQDRVRFL 1580
                         :.|.:.:..:..::..:..:...|..:.:||.|||...|    .|:.::...
 Worm   920 DAGHDVAILHGDDSQLFENSMQLDQKSQLQNDETQILENKKKAAVVIQKMIRGFIARRKFQMEIS 984

Human  1581 NLKKTIIKF---------QAHVRKHQQRQKYKKMKKAAVIIQTHFRAYIFAM------------- 1623
            |::..:|::         |..:.:.:.:....|:||.|:...|:...::..:
 Worm   985 NIRNRMIQYNHILAQEDEQIGIEEMEDKSVEAKLKKCALHGLTNDNLHVVHVAATVIDRVTDLVP 1049

Human  1624 ----KVLASYQKTRSAVIVLQSAYRGMQARKMYIHILTSVIK--------------IQSYYRAYV 1670
                |::......:|...||..|.||.....: :|.|.:|::              |..:.:...
 Worm  1050 SLLEKLVVELNGIKSITDVLIVADRGFSYTSI-LHPLLNVLEKLFTKIPEEVTNSHILPHLKILS 1113

Human  1671 SKKEFLSLKNATIK---------LQSTVKMKQTRKQYLHLRAAALFIQQCYRSKKIAAQKREEYM 1726
            .:...|.||::.:|         |.|..:....:||       :.|....|..|:  :.|:.:..
 Worm  1114 PRLMLLMLKHSEVKELFIPIINTLTSIARRFPDKKQ-------SSFSSSSYSIKQ--SLKKVKDQ 1169

Human  1727 QMRESCIKLQAFVRGYL 1743
            :.|...::|::.....|
 Worm  1170 ECRNKLVRLESICEDML 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASPM	NP_060606.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		ASH	37..134	CDD:464865
		Sufficient for interaction with KATNA1:KATNB1. /evidence=ECO:0000250|UniProtKB:Q8CJ27	308..409
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..443
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	559..581
		CH_ASPM_rpt1	940..1053	CDD:409072	28/114 (25%)
		CH_ASPM_rpt2	1112..1261	CDD:409073	34/185 (18%)
		COG5022	<1268..>1451	CDD:227355	33/220 (15%)
		COG5022	<1480..>1609	CDD:227355	26/176 (15%)
		COG5022	<1549..>1705	CDD:227355	35/208 (17%)
		COG5022	<1809..>1972	CDD:227355
		COG5022	<2138..>2322	CDD:227355
		COG5022	<2257..>2433	CDD:227355
		COG5022	<2908..>3083	CDD:227355
aspm-1	NP_492467.1	CH_SF	327..434	CDD:469584	28/121 (23%)
		IQ	959..980	CDD:197470	7/20 (35%)