Protein Alignment NALCN and CCH1

DIOPT Version :9

• Sequence 1: XP_024305104.1
• Gene: NALCN / 259232
• HGNCID: 19082
• Length: 1786
• Species: Homo sapiens
• Sequence 2: NP_011733.3
• Gene: CCH1 / 853131
• SGDID: S000003449
• Length: 2039
• Species: Saccharomyces cerevisiae
• Alignment Length: 1743
• Identity: 380/1743 - (21%)
• Similarity: 697/1743 - (39%)
• Gaps: 429/1743 - (24%)

Human   150 DIVDQMSPW-GM------------LRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVS 201
            |:|..:|.| ||            :||.:||.::|..|: ...:.....|...||....|:.:||
Yeast   498 DLVSSVSFWLGMFLSIKSYDTKTGIRIFKPLAILRILRL-VNVDTGMPSILRGLKYGIPQLVNVS 561

Human   202 IFLLFFLLLYGILGVQMF-GTFTYHCV-VNDTKPGNVTWNSLAIPDTHCSP-------------- 250
            ..|::|.:.:||||||:| |:|...|| .|...|.:.....:.....:..|
Yeast   562 SMLVYFWIFFGILGVQIFQGSFRRQCVWFNPEDPTDTYQYDMQFCGGYLDPVTKRKQNYIYEDGS 626

Human   251 --ELEEGYQCPPGFKCMDLEDLGLSRQELGYSG---FNEIGTSIFTVYEAASQEGWVFLMYRAID 310
              .:.:|:.||...||:...:        .|:|   |:.|..|:..|:...|...:..|||..:|
Yeast   627 EGSVSKGFLCPQYSKCVSNAN--------PYNGRISFDNIVNSMELVFVIMSANTFTDLMYYTMD 683

Human   311 SFPRWRSYFYFITLIFFLA-WLVKNVFIAVIIETFAEIRVQFQQ---MWGSRSSTTSTATTQMFH 371
            | ....:..:||..||.|. ||: |:.|||::.:|.....::::   ::|||.       |....
Yeast   684 S-DEMAACLFFIVCIFVLTIWLL-NLLIAVLVSSFEIANEEYKKKKFIYGSRK-------TGYVA 739

Human   372 EDAAGGWQLVAVDVNKPQGRAPACLQKMMR-----SSVFHMFILSMVTVDVIVAASNYYKGENFR 431
            ....|.|:...:..|  |.:.|...||.:.     ..:|.:.|:..:.:...|..|......|..
Yeast   740 RIVTGYWKYFKLKAN--QTKFPNWSQKGLAIYSHVEFIFVILIICDIGMRASVKVSTSANCNNIL 802

Human   432 RQYDE-----FYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVI-----------GT 480
            .:.|.     .::..:|..||:    |..:|     .:::...:.::.::.|           |.
Yeast   803 LKTDRGISIVLFIESLARLVLY----LPNMW-----KFLTKPSYVYDFIISIITLVISCLAVEGV 858

Human   481 TLHVYPDLYHSQFTYFQVLRVVRLIKISPALEDFVYK-IFGPGK---KLGSLVVFTASLLIVMSA 541
            ..|:|     :..:.|.:.|..|:| ||..|...::| |...|.   .|.|...|...|:.::.|
Yeast   859 LGHMY-----AWLSIFHISRFYRVI-ISFNLTKKLWKQILSNGVMIWNLSSFYFFFTFLVAIIMA 917

Human   542 ISLQMFCFVEEL-DR---FTTFPRAFMSMFQILTQEGWVDVM----DQTLNAVGHMWAPVVAIYF 598
            :..:.....||: |:   ..:.|.:|:|:|.|.:.|.|.|::    ..:.|.....:.   :::|
Yeast   918 VYFEGVIPPEEMADQPFGMYSLPNSFLSLFIIGSTENWTDILYALQKHSPNISSTFFC---SVFF 979

Human   599 ILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMV 663
            |::.|.:..::|::|:|:|.:::|:.|:                 ||.|.:::.:.||. .||
Yeast   980 IIWFLLSNSVILNIFIALISESMEVKEE-----------------EKRPQQIKHYLKFV-YPQ-- 1024

Human   664 KISKLPSDFTVPKIRESF-----------MKQFIDRQQQDTCCLLRSLPTTSSSSCDHSKRSAIE 717
            ||.:......|.:||:.|           .|||:.|.     ..:.::........|..|....|
Yeast  1025 KIQEYTHASLVARIRKKFFGGHRNEDTRDFKQFLMRG-----TAIMNIAQNMGELADEFKEPPSE 1084

Human   718 DNKYIDQKLRKSVFSIRARNLLEKETAVTKILSKRPLPTSSPISIRCCLYLGRSHCHSSGVRACT 782
                               ||.:|.      |||..:                      ||.:..
Yeast  1085 -------------------NLFKKG------LSKLTI----------------------GVPSLK 1102

Human   783 RQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGKSLETLTQDHSNTVRYRNAQ 847
            |.||.                                                  :|...|:|:.
Yeast  1103 RLRMF--------------------------------------------------ANNPFYKNSD 1117

Human   848 REDSEIKMIQEKKEQAEMKRKVQEEEL--RENHPYFDKPLFIVGREHRFRNFCRVVV-------- 902
            ...:|...|..:....|: .:.::|:|  .:.:|.|:...:....:||||.||:.:|
Yeast  1118 VVFTETNDINGRTYILEL-NEYEDEKLDYLKKYPLFNYSYYFFSPQHRFRRFCQRLVPPSTGKRT 1181

Human   903 -RARFNASKTDPVTGAVKNTKYHQL-YDLLGLVTYLDWVMIIVTICSCISMMFESPFRRVMH--- 962
             .:||....||...   |.:.:|.: .|:...:..|..:::||  |||    :.:|..|:.|
Yeast  1182 DGSRFFEDSTDLYN---KRSYFHHIERDVFVFIFALATILLIV--CSC----YVTPLYRMHHKMG 1237

Human   963 ----APTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQN 1023
                :..|..|   |:...|||..:|.:|||..::|.|.:|:....:| |..|:|:    |:...
Yeast  1238 TWNWSSALDCA---FIGAFSIEFIVKTVADGFIYSPNAYLRNPWNFID-FCVLISM----WINLI 1294

Human  1024 VPAESGAQL------LMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASF 1082
            ...::...|      |..||.||.|.|.....|...:|  :|.|..:||...::.|:|:..|..:
Yeast  1295 AYLKNNGNLSRIFKGLTALRALRCLTISNTARQTFNLV--MFDGLNKIFEAGLISLSLLFPFTVW 1357

Human  1083 GVQLFAGKLAKCNDPNIIRREDC-----NGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPR 1142
            |:.:|.|:|..|||.: :.|.||     |.:|:.::                   ..|||:..|
Yeast  1358 GLSIFKGRLGTCNDGS-LGRADCYNEYSNSVFQWDI-------------------MSPRVYQQP- 1401

Human  1143 NFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG---PI-------HGIYIHVFVFLGCMIGLT 1197
            ..:.|:..:|..:|::::||:|||::.:.:::..|   |.       :.:::.:|.||..:..|.
Yeast  1402 YLHLDSFASAFSSLYQIISLEGWVDLLENMMNSSGIGTPATVMGSAGNALFLVLFNFLSMVFILN 1466

Human  1198 LFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYD--ITQHPFF 1260
            |||..::.|.....|:|..|::::.|.:.:..|..|:|..:|...:....|...|.  :.:..|:
Yeast  1467 LFVSFIVNNQARTTGSAYFTIEEKAWLESQKLLSQAKPKAIPNLIELSRVRQFFYQLAVEKKNFY 1531

Human  1261 KRTIALLVLAQSV--LLSVKWDVEDPVTVPLATMSVVFTF---IFVLEVTMKIIAMSPAGFWQSR 1320
            ..:...:||...:  |||..:   :|..: :....|.|.|   :|:::..:.:....|..:::.:
Yeast  1532 YASFLQVVLYLHIIMLLSRSY---NPGNL-IGYQGVYFMFSTSVFLIQEALHMCGEGPRLYFRQK 1592

Human  1321 RNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA------------CVIVFRFFSICGKHVTLKMLL 1373
            .|...|.:       :::.| ::||..:.:.|            .:::|.|  |..::.||..||
Yeast  1593 WNSIRLSI-------IIIAF-IMNAVAFHVPASHYWFHNIKGFFLLVIFLF--IIPQNDTLTELL 1647

Human  1374 LTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGED 1438
            .|.:.|:.....:.....:|.|.||.|...:||..:.|.|...:.||.:..|::.||||...||.
Yeast  1648 ETAMASLPPILSLTYTWGVLFLVYAIALNQIFGLTRLGSNTTDNINFRTVIKSMIVLFRCSFGEG 1712

Human  1439 WNKIMHDCMVQPPFCTPDE-FTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFY 1502
            ||.||.|..|..|:|:.|: .||  ||||:...|.:...|:.:|..||.:|:.|::|:.|||..|
Yeast  1713 WNYIMADLTVSEPYCSSDDNSTY--TDCGSETYAYLLLMSWNIISMYIFVNMFVSLIIGNFSYVY 1775

Human  1503 STEEDQL-LSYNDLRHFQIIWNMVDDKREG---------VIPTFRVKFLLRLLRGRL-------- 1549
            .:...:. ::.::::.:...|:..|....|         ::.:|......::..|||
Yeast  1776 RSGGSRSGINRSEIKKYIEAWSKFDTDGTGELELSYLPRIMHSFDGPLSFKIWEGRLTIKSLVEN 1840

Human  1550 ------------EVDL----------DKDKLLFKHMCYE--MERLH----NGGDVTFHDVLSMLS 1586
                        ::||          ||.|::.:.:.|.  ::.:|    ..|.:.|.|:|..:.
Yeast  1841 YMEVNPDDPYDVKIDLIGLNKELNTIDKAKIIQRKLQYRRFVQSIHYTNAYNGCIRFSDLLLQIP 1905

Human  1587 -YRSVDIRKSLQLEE------LLAR--EQLEYTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSII 1642
             |.:...|:.|.:::      :|.:  :.||.....:|.:..:..|...|  |::...:....:.
Yeast  1906 LYTAYSARECLGIDQYVHHLYILGKVDKYLENQRNFDVLEMVVTRWKFHC--RMKRTIEPEWDVK 1968

Human  1643 HSLRESQQQELSRFLNP-PSI----ETTQPSEDTNAN--------SQDNSMQP 1682
            .....|....::..|.| |.|    ....|..|...|        :||::|:|
Yeast  1969 DPTVSSHISNINVNLEPAPGILEREPIATPRMDYGVNNFMWSPRMNQDSTMEP 2021

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NALCN	XP_024305104.1	Ion_trans	55..350	CDD:306908	63/234 (27%)
		Ion_trans	402..622	CDD:306908	49/247 (20%)
		Ion_trans	935..1209	CDD:306908	78/301 (26%)
		Ion_trans	1257..1506	CDD:306908	72/266 (27%)
CCH1	NP_011733.3	Ion_trans	<483..722	CDD:395416	63/234 (27%)
		Ion_trans	769..1010	CDD:395416	52/275 (19%)
		Ion_trans	1210..1480	CDD:395416	78/306 (25%)
		Ion_trans	1529..1776	CDD:395416	71/262 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I1897
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004135
OrthoInspector	1	1.000	-	-		otm53071
orthoMCL	1	0.900	-	-		OOG6_104443
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.740